Сибирское медицинское Обозрение. 2021. № 6 View full textКоличество просмотров : 5900
Zamay T.N., Tolmacheva T.V.
New strategies in bone tissue regeneration via application of magnetomechanical transduction
may TN, Tolmacheva TV. New strategies in bone tissue regeneration via application of megnetomechanical transduction. Siberian Medical Review. 2021;(6):5-11. DOI 10.20333/25000136-2021-6-5-11
Zamay Tatiana Nikolaevna Dr.Biol.Sc., Laboratory For Biomolecular and Medical Technologies; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; email@example.com
Tolmacheva Tatiana Vladimirovna Cand.Med.Sc., Department of Physiology; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; firstname.lastname@example.org
Reparative regeneration is one of the key problems in traumatology and orthopaedics. Despite the fact that bone regeneration is a self-regulatory physiological process of bone formation, complex clinical conditions require additional enhancement of bone regeneration – either local or systemic. This review provides a concise description of main stages of reparative regeneration. The search was performed in PubMed and e-LIBRARY databases among papers published between 2000 and 2021. Main strategies presently used for acceleration of bone tissue regeneration and limitations of their application are presented. This review gives a detailed description of one of the most promising means for bone tissue regeneration enhancement. Namely, magnetomechanic transduction of magnetic nanoparticles using functionalised targeted agents in an alternating magnetic field that induces osteogenic differentiation of mesenchymal stem cells.
Keywords: reparative regeneration, bone tissue, mesenchymal stem cells, magnetic nanoparticles, magnetomechanical transduction
Eniseeva E.S., Protasov K.V.
Colchicine in patients with coronary heart disease: new possibilities in reduction of the residual inflammatory risk
Eniseeva ES, Protasov KV. Colchicine in patients with coronary heart disease: new possibilities in reduction of the residual inflammatory risk. Siberian Medical Review. 2021;(6):12-21. DOI 10.20333/25000136-2021-6-12-21
Eniseeva Elena S ; Irkutsk State Medical Academy of Postgraduate Education;
Protasov Konstantin V Dr.Med.Sci, Professor, Head of Cardiology and Functional Diagnostics Chair; Irkutsk State Medical Academy of Postgraduate Education – Branch of Russian Medical Academy of Continuing Professional Education; email@example.com
Inflammation plays an important role in atherosclerotic plaque destabilisation and the development of cardiovascular complications. Suppression of its activity in order to reduce residual inflammatory risk in atherosclerotic cardiovascular diseases remains an urgent and unresolved problem to the date. Over the recent years, evidence of the effectiveness of such an approach in secondary prevention of coronary heart disease has been obtained. The purpose of this review was to analyse modern literature on the effect of anti-inflammatory therapy with colchicine on the prognosis of patients with coronary heart disease. The review was carried out using the search for papers published in the PubMed and ClinicalTrials databases within the period from 2007 to 2021. The search was carried out using the keywords «colchicine», «inflammation», «atherosclerosis», «coronary heart disease» and «acute coronary syndrome». The anti-inflammatory and antiatherogenic effects of colchicine are discussed. The paper presents results of studies devoted to the use of colchicine in chronic and acute coronary syndrome, including the key ones LoDoCo2 (2020) and COLCOT (2019) which provided evidence of the effect of the drug on the disease outcome. The issues of safety and prospects of colchicine application in clinical practice for reduction of the residual inflammatory risk in patients with coronary heart disease are addressed.
Keywords: inflammation, atherosclerosis, colchicine, stable coronary artery disease, acute coronary syndrome, secondary prevention
Ostroumova OD, Listratov AI, Kochetkov AI, Sychev DA. Drug-induced hyponatremia. Siberian Medical Review. 2021;(6):22-34. DOI 10.20333/25000136-2021-6-22-34
Ostroumova Olga D Dr.Med.Sci., Professor; Russian Medical Academy of Continuing Professional Education; firstname.lastname@example.org
Listratov Alexander I ; Russian Medical Academy of Continuous Professional Education;
Kochetkov Aleksey I ; Russian Medical Academy of Continuous Professional Education;
Sychev Dmitry Alekseevich MD, D. Med. Sci., Prof., Head of the Department of Clinical Pharmacology and Therapy; Russian Medical Academy of Postgraduate Education of the Health Ministry of Russia; email@example.com
Hyponatremia (HN) is one of the most important water-electrolyte disorders in clinical practice. A decrease in sodium levels leads to various complications, including neurological ones. One of the important etiological factors of HN is the intake of a number of drugs. The purpose of the review was to analyze data on those drugs, the intake of which is associated with the development of DI GN, its pathophysiological mechanisms, risk factors, methods of treatment and prevention. The search for the specified keywords was carried out in the databases eLIBRARY.RU, PubMed®, MEDLINE, EMBASE, manuals and methodological recommendations, materials of databases of adverse reactions, instructions for the medical use of drugs in the period from 1971 to 01.07.2021. According to the results obtained, the main culprit drugs include thiazide diuretics, antipsychotic drugs, antidepressants, antiepileptic drugs, antineoplastic drugs. The incidence of HN during the use of antidepressants reaches 40%, with the use of oxcarbazepine occurs in 73.3% of patients. Most often, these drugs lead to HN by the development of a syndrome of inadequate secretion of antidiuretic hormone. During the review, it was found that drugs from a wide variety of groups lead to the development of HN, the mainstay of treatment is drug withdrawal and restriction of fluid intake, and for prevention, dynamic monitoring of sodium levels is required.
Keywords: hyponatremia, drug-induced hyponatremia, drugs, adverse drug reactions
Ziganshin A.M., Mulykov A.R.
Immunopathological mechanisms in sepsis of viral etiology in COVID-19
Ziganshin AM, Mulykov AR. Immunopathological mechanisms in sepsis of viral etiology in COVID-19. Siberian Medical Review. 2021;(6):35-43.. DOI 10.20333/25000136-2021-6-35-43
Ziganshin Aydar M ; Bashkir State Medical University;
Mulykov Airat R ; Bashkir State Medical University;
The article provides information on immunopathology in sepsis and the commonality between immunopathogenetic processes of sepsis and the new coronavirus infection (COVID-19). As a result of the inability of the immune system to cope with aggression of the pathogen, inadequate immune activity occurs manifested by the systemic inflammatory response syndrome, resulting in damage to tissues of the host organism. In response, compensatory antiinflammatory response syndrome is activated, which is manifested by inhibition of the immune response. One of its main mechanisms is signals produced by membrane receptors and their ligands. Against the background of inability of the host organism to neutralise the pathogen, numerous pathological phenomena and complications occur leading to damage to human tissues.
Keywords: sepsis, viral sepsis, immunopathology, COVID-19, checkpoints, ARDS, DIC, NETosis.
Nechaeva E.A., Kharkova O.A., Postoev V.A., Grjibovski A.M., Odland J.Ø.
Knowledge on postpartum depression among midwives and nurses: a systemic review
Nechaeva EA, Kharkova OA, Postoev VA, Grjibovski AM, Odland JO. Knowledge on postpartum depression among midwives and nurses: a systemic review., Siberian Medical Review. 2021;(6):44-52.. DOI 10.20333/25000136-2021-6-44-52
Nechaeva Elena A ; Norwegian University of Science and Technology;
Kharkova Olga A ; Northern State Medical University;
Postoev Vitaly A ; Northern State Medical University;
Grjibovski Andrej M ; Northern State Medical University;
Odland Jon Øyvind ; Norwegian University of Science and Technology;
Postpartum depression (PPD) is a form of non-psychotic disorder that develops after childbirth with negative consequences for physiological, social and psychological development of the children. The global prevalence of PPD today equals approximately 17.22%. However, almost one half of all cases remain undetected. Healthcare providers can help to reduce the prevalence of PPD by identifying and educating women about the risks and treatment of PPD. The review is the first Russian-language study of systematic selection and qualitative synthesis of the studies in the field of nursing staff knowledge about PPD published from January 2000 to November 2020. The search was conducted in such eligible databases as MEDLINE, PsychINFO, EMBASE, Cinahl, eLIBRARY using the keywords “postpartum depression”, “knowledge”, “detection of postpartum depression”. As a result of the search, it was revealed that knowledge on postpartum depression was superficial in over one half of the midwives and nurses participating in the reviewed studies (n=1777). This result indicates the need to develop and implement training programmes for prevention of postpartum depression among medical personnel. The small amount of unique results underlines the need for further research on the knowledge of postpartum depression among midwives and nurses
Keywords: postpartum depression, knowledge, detection of postpartum depression, obstetrics, medical personnel, systematic review
Zamay SS. The «nanoscalpel» for microsurgery of glial brain tumours. Siberian Medical Review. 2021;(6):53-59.. DOI 10.20333/25000136-2021-6-53-59
Zamay Sergey Sergeevich Cand.Phis.-Mat.Sc.; Krasnoyarsk Scientific Center Siberian Branch of the Russian Academy of Sciences; firstname.lastname@example.org
Glial tumours are among the most common primary brain tumours of neuroectodermal origin characterised by infiltrative growth and widespread invasion of tumour cells into healthy tissue. A highly demanded method for therapy of such tumours may become magnetomechanical microsurgery substituting the scalpel with the «nanoscalpel» consisting of: (1) nanostructures converting the magnetic moment into the mechanical one, and (2) targeted ligands. Suitable structures for the nanoscalpel are magnetic disks with a high degree of saturation magnetisation and absent remanent magnetisation. The search for publications dated 1992-2021 was carried out in the PubMed and e-LIBRARY databases. The search keywords were «magnetic discs», «glial tumors», «microsurgery» and «magnetomechanical transduction». This review discusses biological effects of magnetic disks, their mechanism of action and toxicity. It has been concluded that a «nanoscalpel» remotely controlled using a magnetic field may become an effective and safe tool for microsurgery of glial brain tumours.
Keywords: magnetomechanical microsurgery, glial brain tumors, nanoscale, magnetic disks, alternating magnetic field.
Tseimakh I.Y., Kostyuchenko G.I., Bogachev D.E., Zubova O.A., Konovalova O.G., Kornilova T.A., Kharlova A.G., Tseimakh A.E., Shoikhet Y.N.
Effect of folic acid in patients with lung damage caused by coronavirus SARS-CoV-2
Tseimakh IYa, Kostyuchenko GI, Bogachev DE, Zubova OA, Konovalov VK, Kornilova TA, Kharlova AG, Tseimakh AE, Shoikhet YaN. Effect of folic acid in patients with lung damage caused by coronavirus SARS-CoV-2. Siberian Medical Review. 2021;(6):60-69. DOI 10.20333/25000136-2021-6-60-69
Tseimakh Irina Ya Dr.Med.Sci., Associate Professor; Altai State Medical University; email@example.com
Kostyuchenko Gennadij I ; Regional Clinical Hospital;
Bogachev Dmitry E ; Altai State Medical University;
Zubova Olga A ; Altai Regional Hospital for War Veterans;
Konovalova O. G. ; Chita State Medical Academy; konoraIoraoIgagen@yandex.ru
Kornilova Tatyana A. ; City Hospital No. 5, Barnaul;
Kharlova Alena G ; Altai Regional Hospital for War Veterans;
Tseimakh Alexander E graduate student; Altai State Medical University; firstname.lastname@example.org
Shoikhet Yakov N Dr.Med.Sci., Professor; Altai State Medical University; email@example.com
Aim of study. To evaluate the influence exerted by additional use of a fixed combination of folic acid with pyridoxine hydrochloride and cyanocobalamin in complex therapy for hospitalised patients with COVID-19-associated lung damage on parameters of inflammation and clinical outcomes. Material and methods. A comparative prospective interventional study included 117 patients with a lung lesion volume caused by the SARS-CoV-2 coronavirus corresponding to CT-1 and CT-2. The study group included 78 patients who additionally received a fixed combination of 5mg folic acid, 4mg pyridoxine hydrochloride, and 6μg cyanocobalamin three times a day in combination with standard therapy. The comparison group included 39 patients. Results. By days 14-21 of hospitalisation, the main group showed a decrease in the proportion of patients with CT symptoms of “cobblestone appearance” by 26% (p = 0.005) and an increase in the proportion of patients with transformation of viral lung lesions into areas of consolidation of the pulmonary parenchyma by 23% (p <0.001). The effect of a fixed combination of folic acid with vitamins B6, B12 on the achievement of the level of C-reactive protein <20 mg / l by day 7 depending on the red blood parameters and the number of platelets was established (likelihood ratio test in the logistic regression model: 13.925; P = 0.084) as well as the shortening of the time period required to reach the first negative result of the SARS-CoV-2 RNA test (in the linear regression model, R = 0.437; R2 = 0.191; F = 4.552; p = 0.006). Conclusion. The use of a fixed combination of folic acid with vitamins B6, B12 for patients with COVID-19 is associated with earlier achievement of positive dynamics in CT symptoms of lung damage. The additional use of these micronutrients in combination with restoration of red blood count and platelet count improves the odds ratio of an early decrease in serum C-reactive protein, negative result of the SARS-CoV-2 RNA test.
Keywords: lung damage, SARS-CoV-2, COVID-19, folic acid, pyridoxine hydrochloride, cyanocobalamin.
Malyarchikov A.V., Shapovalov K.G.
The role of the CD27/CD70 signalling pathway in development of systemic inflammatory response in patients with influenza A/H1N1 virus-associated pneumonia
Malyarchikov AV, Shapovalov KG. The role of the CD27/CD70 signalling pathway in development of systemic inflammatory response in patients with influenza A/H1N1 virus-associated pneumonia. Siberian Medical Review. 2021;(6):70-73.. DOI 10.20333/25000136-2021-6-70-73
Malyarchikov Andrey V ; Chita State Medical Academy;
Shapovalov Konstantin G Dr.Med.Sci.,Professor, Head of the Department; Chita state medical academy; firstname.lastname@example.org
Aim of study. To evaluate the role of the CD27/CD70 signalling pathway in development of systemic inflammatory response in patients with pneumonia associated with influenza A (H1N1). Material and methods. A total of 85 patients with pneumonia associated with influenza A (H1N1) were examined. Among them, 30 patients had severe pneumonia and 55 patients had non-severe pneumonia. The patients’ age was 48±15 years. Men accounted for 47.8% and women 52.2% of the sample. The exclusion criteria were: unstable haemodynamics, BMI>30, diabetes mellitus, HIV, tuberculosis, oncopathology. The control group was constituted by 15 healthy donors. The diagnosis of influenza A (H1N1) was confirmed by a positive PCR test. The CURB / CRB-65 scales were used to diagnose and assess the severity of pneumonia; SMART-COP as well as the Federal Clinical Guidelines of the Ministry of Health of the Russian Federation «Community-acquired pneumonia in adults» 2019 and the IDSA / ATS criteria (in the presence of one «major» or three «minor» criteria, the pneumonia was regarded as «severe»). The plasma level of CD27 was evaluated via flow cytometry using the Beckman Coulter analyser (USA) using the LEGENDplex™ HU Immune Checkpoint Panel 1 Beckman Coulter (USA) kit for multiplex analysis. Results. It has been established that the plasma level of CD27 increased 1.8-fold in patients with severe pneumonia and underlying influenza A (H1N1) and 1.5-fold in patients with non-severe pneumonia compared to the control group, which is associated with the severity of the condition and the mortality rate. Conclusion. The CD27/CD70 signalling pathway is actively involved in the cascade of innate and adaptive immunity reactions in patients with pneumonia associated with influenza A (H1N1). CD27 activity is associated with the severity of the disease and the increase in mortality
Keywords: CD27; influenza A (H1N1), pneumonia, organ dysfunction.
Estimation of the efficiency of using interferon inducer in children with Epstein-Barr viral infection
Makhmutov RF. Estimation of the efficiency of using interferon inducer in children with Epstein-Barr viral infection. Siberian Medical Review. 2021;(6):74-78.. DOI 10.20333/25000136-2021-6-74-78
Makhmutov Ravil F ; M. Gorki Donetsk national medical university;
The aim of the research. To evaluate the effectiveness of synthetic low-molecular interferon inducers in children with Epstein-Barr viral infection. Material and methods. The study included 68 children aged 7 to 17 years with primary Epstein-Barr viral infection: 38 children in the main group received basic therapy against the primary form of Epstein-Barr viral infection in age-specific dosages in combination with a synthetic low-molecular interferon inducer; 30 children of the control group received the conventional basic therapy with age-specific dosages. Results. It has been established that clinical manifestation of Epstein-Barr viral infection is based on immunopathological inflammation mediated by the factors of cellular immunity. As a result of the therapy, 78.95 % of children in the main group had a normal rate of functional recovery of the liver. In the control group, however, the recovery was delayed in 60.00 % of children: rapid recovery was only noted in the main group. Administration of synthetic lowmolecular weight interferon inducers in addition to basic symptomatic therapy facilitated the reduction of intoxication symptoms duration by 4.7±1.9 days (p < 0.05) and the duration of the icteric period by 5.3±0.9 days (p < 0.05), as well as 5.1±1.3 days earlier normalisation of liver size (p < 0.05). Conclusion. Thus, the use of synthetic low molecular weight interferon inducers in combination with basic therapy against the primary form of Epstein-Barr viral infection in children contributes to a faster restoration of the functional state of the liver. The conducted clinical and biochemical studies indicate high efficiency of synthetic low molecular weight interferon inducers in the complex therapy of Epstein-Barr viral infection in children.
Keywords: children, interferon inducer, liver functional state, Epstein-Barr viral infection.
Peregoedova V.N., Bogomolova I.K.
Serum vitamin D content in children with SARS-CoV-2 infection
Peregoedova VN, Bogomolova IK. Serum vitamin D content in children with SARS-CoV-2 infection. Siberian Medical Review. 2021;(6):79-82.. DOI 10.20333/25000136-2021-6-79-82
Peregoedova Valentina N ; Chita State Medical Academy;
Bogomolova Irina K ; Chita State Medical Academy;
Aim of study. To study the total level of 25-hydroxyvitamin D in children with SARS-CoV-2 infection (COVID-19). Material and мethods. A total of 82 children aged 0-17 diagnosed with SARS-CoV-2 infection were enrolled. Depending on the severity of clinical symptoms, all children were divided into three groups according to the COVID-19 severity: asymptomatic, mild and moderate. The serum level of vitamin D in all patients was tested via the immunochemical method. Results. It was found that children with SARS-CoV-2 infection had lower serum level of vitamin D (29.92 [22.22; 28.07] ng/ml) as compared with the control group (36.43 [32.05; 44.08] ng/ml; p<0.001). A total of 90% of the children with SARS-CoV-2 infection were diagnosed with insufficiency or deficiency of vitamin D (<30 ng/ml). Only 10 % of the patients had normal levels of vitamin D. The insufficiency of vitamin D was found more often amongst children aged 0-11 and deficiency of total 25-hydroxyvitamin D was more common for children aged 12-17. The difference in serum levels of vitamin D depending on the severity of SARS-CoV-2 infection was not found. Male children with SARS-CoV-2 infection showed lower levels of vitamin D (p=0.013). Conclusion. A total of 90 % of the children with SARS-CoV-2 infection had insufficiency or deficiency of vitamin D regardless of the severity of clinical symptoms.
Keywords: SARS-CoV-2 infection, COVID-19, vitamin D, children, deficiency of vitamin D, insufficiency of vitamin D, blood serum
Pakhomova R.A., Fedotov I.A.
Differential approach to suturing of diastasis of direct abdominal muscles
Pakhomova RA, Fedotov IA. Differential approach to suturing of diastasis of direct abdominal muscles. Siberian Medical Review. 2021;(6):83-90. DOI 10.20333/25000136-2021-6-83-90
Pakhomova Regina Alexandrovna Cand. Med. Sc., Assistant of the Department of General Surgery named after Prof. M.I. Gulman; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; PRA5555@mail.ru
Fedotov Ivan A. ; Russian Railways-Medicine;
Aim of study. To reduce the rate of recurrence after diastasis suturing. Material and methods. The study included 86 female patients. Abdominal volumes and diastasis levels were assessed. The presence of diastasis of rectus abdominis was confirmed (physically and by additional instrumental research methods: ultrasound of the anterior abdominal wall and electromyography of the direct abdominal muscles). All patients were divided into 4 groups based on the level of diastasis. In group 1, aponeurosis was normal, diastasis of the direct abdominal muscles was not observed. In group 2, diastasis of the direct abdominal muscles was observed in the epigastric region (from the xiphoid process to the navel, diastasis suturing was performed in the defect region). In group 3, diastasis of the direct abdominal muscles was observed in the hypogastrium (from the umbilicus to the womb, suturing of the diastasis was performed in the defect region). In group 4, diastasis was observed in straight abdominal muscles along the entire white abdominal line (from the umbilicus to the womb, diastasis suturing was performed in the defect area). Results. The surgery utilised a differential approach to diastasis suturing depending on the level of diastasis. In the long term, there was no relapse in the relapse groups. Improvement in the functional state of the anterior abdominal wall was also noted by the patients after surgery. A year after the intervention, patients underwent a survey and indicated a significantly smaller chronic pain syndrome in the umbilical ring and white line as well as significant improvement of cosmetic satisfaction. Conclusion. Application of differential approach and additional instrumental examination in the preoperative period (ultrasound examination of the anterior abdominal wall and electromyography of direct abdominal muscles) reduces the frequency of postoperative relapse of diastasis
Keywords: diastasis of direct abdominal muscles, aponeurosis, prevention, differential approach
Kokarev V.A., Shalin V.V.
Severe hand trauma with damage to the myotendinous structure in the hypothenar eminence and the neurovascular bundle
Kokarev VA, Shalin VV. Severe hand trauma with damage to the myotendinous structure in the hypothenar eminence and the neurovascular bundle. Siberian Medical Review. 2021;(6):91-93.. DOI 10.20333/25000136-2021-6-91-93
Kokarev Viktor A ; Clinical Hospital No. 6 named after G.A. Zakharin;
Shalin Vladislav V ; Ogarev National Research Mordovian State University;
The human hand is a unique tool, without which daily life is impossible. Violation of internal structures integrity leads to disturbance of connections and to functional impairments. Injuries, genetic diseases, infections – all these are but a few among many causes of pathology development. Mechanical damage occupies a separate place in this classification since damage is suffered by several structures. Statistically, the damage to internal components of the hand ranges from 1.9% to 18.8%. A clinical case describing observation of a patient with severe hand injury with damage to flexor tendons of the fingers, muscles of the hypothenar and violation of neurovascular bundle integrity obtained by the profiled sheeting is presented. The tactics of surgical treatment is subdivided into the general and the special ones. The general tactics consists in primary surgical treatment of the wound, the special one is decided upon drawing on the intraoperative data. Unfortunately, it was not possible to obtain data of long-term outcomes since the communication with the patient was lost. The case described below demonstrates the need to perform these surgical interventions on an emergency basis and improve knowledge in the field of hand surgery.
Keywords: hand, tendons, trauma, hypothenar, nerve, suture.
Berezhnoy A.G., Dunaevskaya S.S., Ershov A.V.
A clinical example of percutaneous nephrolitolapaxy of complete staghorn kidney stone in patient with lumbar renal dystopia
Berezhnoy AG, Dunaevskaya SS, Ershov AV. A clinical example of percutaneous nephrolitolapaxy of complete staghorn kidney stone in patient with lumbar renal dystopia. Siberian Medical Review. 2021;(6):94-98.. DOI 10.20333/25000136-2021-6-94-98
Berezhnoy Alexander Grigorievich Cand.Med.Sc., Asst. of the Urology, Andrology and Sexology Department of Post-Graduate Studies Institute; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; mailto:email@example.com
Dunaevskaya Svetlana Sergeevna Dr.Med.Sc, Professor of the Department of Common Surgery named after Prof. M.I. Gulman; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; firstname.lastname@example.org
Ershov Artem Vladimirovich Assistant of the Department of Urology, Andrology and Sexology IPO; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; email@example.com
Urinary stone disease (urolithiasis, UL) is one of the most prevalent diseases in the world affecting almost 3% of the population, mainly people of working age from 40 to 50 years, which determines the relevance of a comprehensive study of this disease. Meanwhile, few works devoted to the interrelation between UL and renal abnormalities have been published. The unusual nature of angioarchitectonics, location, shape, structure, number of kidneys and upper urinary tract make it difficult to perform both open and endoscopic surgery thus preconditioning the reduction of their effectiveness and increasing the number of complications. In recent years, the number of indications for open stone surgery has significantly decreased. Percutaneous surgery has become widely used in endourology, including treatment of abnormal kidneys. However, the issues of percutaneous nephrolitolapaxy (PCNL) in kidney abnormalities have not been completely resolved yet. The article presents a clinical case of successful percutaneous nephrolitolapaxy of complete coral-shaped kidney stone (Class 4) in a patient with lumbar renal dystopia.
Keywords: urolithiasis, staghorn stone, renal dystopia, nephrolitolapaxy, kidney stone
Tihonova N.V., Shul'min A.V., Sabanova A.O., Karaliou M.G.
Analysis of the assessment profile of KrasSMU students providing medical aid to COVID-19 patients
Tikhonova NV, Sabanova AO, Shulmin AV, Gerberg AA, Karaliou MG. Analysis of the assessment profile of KrasSMU students providing medical aid to COVID-19 patients. Siberian Medical Review. 2021;(6):99-105. DOI 10.20333/25000136-2021-6-99-105
Tihonova Natalia V. ; Professor V. F. Voino-Yasenetsky Krasnoyarsk State Medical University; firstname.lastname@example.org
Shul'min Audrey Vladimirovich Candidate of Medical Sciences, Associate Professor, Head of Department of Public Health and Health Care; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; аndreyshumn@gmail.com
Sabanova Anzhelika O ; Prof. V. F. Voino-Yasenetsky Krasnoyarsk State Medical University;
Karaliou Maxim G. ; Vitebsk State Order of Friendship of Peoples Medical University;
The aim of the research. To conduct a cluster analysis of the assessment profile of students who participated in work of medical organisations providing care to COVID-19 patients to develop recommendations for its correction. Material and methods. The study was carried out at the premises of Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University (KrasSMU). The study group was constituted by 66 students in 3-6 years of study of the Medical and the Paediatric faculties of the University who took part in activities of medical organisations providing healthcare to patients with COVID-19. The items were presented in the form of binary questions and ranking scales. The analysis of qualitative attributes was carried out in the form of relative values with calculation of the standard error of the proportion. For ranking and nonparametric quantitative characteristics, the mode, median, centiles (Me [P25; P75]) and other nonparametric criteria for comparative statistics and communication statistics were used. For segmentation of respondents according to some criteria, depending on the answers, the method “two-step cluster analysis” and the method of “decision tree” were used. Results. The results of the study indicate a high motivational component related to practical medical activity of medical students during the difficult epidemiological situation since 94.1% of the respondents declared the readiness to support practical healthcare. Almost half of the surveyed 47.0% of students included in cluster 2, in contrast to students of clusters 1 and 3, are characterised by a high opinion on the degree of their contribution to the struggle against the COVID-19 epidemic and a high level of knowledge and skills, rating themselves at about 9.0 points out of 10 possible. In addition, the results of the study indicate an association between the level of students’ self-esteem in regard to their contribution to the fight against COVID-19 with the level of the students’ self-esteem of knowledge and skills and the duration of work in a medical organisation. Conclusion. The analysis performed has made it possible to formulate guidelines for support of medical students’ professional attitudes within the framework of practice-oriented education, including distance learning.
Keywords: s, medical student, student profile, competence, practice-oriented and distance learning, medical organisations, COVID-19
Vinnic Y.S., Kochetova L.V., Tyukhteva N.M., Teplyakova O.V.
The 90th anniversary of professor Marx Izrailevich Gulman
Vinnik YuS, Kochetova LV, Tyukhteva NM, Teplyakova OV. The 90th anniversary of professor Marx Izrailevich Gulman. Siberian Medical Review. 2021;(6):106-112. DOI 10.20333/25000136-2021-6-106-112
Vinnic Yurij Semenovich Doctor of Medical Science, Professor, Head of the Department of general surgery, Chairman of the Dissertation Council D 208.037.05; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; email@example.com
Kochetova Lyudmila Victorovna Cand.Med.Sc., Associate Professor of the chair of general surgery, Academic Secretary of the Dissertation Council D 208.037.05; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; firstname.lastname@example.org
Tyukhteva Nadezhda M ; Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University;
Teplyakova Ol’ga V Cand.Med.Sci., Associate Professor; Professor V. F. Voino-Yasenetsky Krasnoyarsk State Medical University; Address: 1, Partizan Zheleznyak Str., Krasnoyarsk, Russian Federation 660022; Phone: +79029619780; email@example.com
The article casts light upon the creative path of an outstanding surgeon from Krasnoyarsk Region, a honorary professor of Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University dedicated to the 90th anniversary from the date of his birth (23 September 1931). Under M.I Gulman’s guidance in tandem with Yu.S. Vinnik, the scientific-practical school of surgeons of the Krasnoyarsk Region productively operating to the date was established, over 100 candidate theses and 23 doctoral theses have been defended. Marx Izrailevich Gulman was the founder of X-ray endovascular surgery in Krasnoyarsk and Krasnoyarsk Region. A total of 11 monographs, over 400 scientific papers on issues of abdominal surgery were written by the scientist, pedagogue and surgeon M.I. Gulman. The article presents the key information regarding his biography, milestones in the history of development of the Department of General Surgery within the period of 1980-2014. The most important scientific and practical achievements and awards are presented.
Keywords: Marx Izrailevich Gulman, 90th anniversary, contribution to surgery in Krasnoyarsk Region
90 years anniversary of a scientist, a physician, a medical science organizer, a corresponding member of the Russian Academy of Medical Sciences Konstantin Vladimirovich Orekhov
Manchuk VT. 90 years anniversary of a scientist, a physician, a medical science organizer, a corresponding member of the Russian Academy of Medical Sciences Konstantin Vladimirovich Orekhov. Siberian Medical Review. 2021;(6):113-116.. DOI 10.20333/25000136-2021-6-113-116
Manchuk Valeriy Timofeevich MD, Professor; Scientific research institute of medical problems of the North, Siberian department of the Russian Academy of Medical Sciences; firstname.lastname@example.org
The paper is dedicated to the memory of a famous scientist, a paediatrician, a corresponding member of the Russian Academy of Medical Sciences Orekhov Konstantin Vladimirovich, who made a significant contribution to the development of paediatrics at Krasnoyarsk, Irkutsk and Stavropol state medical universities. K. V. Orekhov was one of the organisers and the first director of Research Institute for Medical Problems of the North, the founder of new scientific directions in healthcare for the population of the Far North.
Keywords: history of paediatrics, scientific development, northern medicine, human ecology