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Сибирское медицинское обозрение. 2017. № 5 View full text Количество просмотров : 8447Artukhov I.P., Shul'min A.V., Obukhov A.A., Tihonova N.V. LIVE MEMORY OF THE SAINT LUKA (VOINO-YASENETSKY) Pages: 6-9 Artyukhov IP, Shul’min AV, Obukhov AA, Tihonova NV. Live memory of the Saint Luka (Voino-Yasenetsky). Siberian Medical Review. 2017;
(5): 6-9. DOI: 10.20333/2500136-2017-5-6-9.. DOI 10.20333/2500136-2017-5-6-9 Authors Artukhov Ivan Pavlovich MD, Professor; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; rector@krasgmu.ru Shul'min Audrey Vladimirovich Candidate of Medical Sciences, Associate Professor, Head of Department of Public Health and Health Care; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; аndreyshumn@gmail.com Obukhov Anatoly A. ; Krasnoyarsk Orthodox Metropolis of the Russian Orthodox Church, The temple in the name of St. Luke, Archbishop of Krasnoyarsk; svt-Luka@mail.ru Tihonova Natalia V. ; Professor V. F. Voino-Yasenetsky Krasnoyarsk State Medical University; nvt24@mail.ru Annotation The study of the life of high-spiritual people, such as St. Luka (Voino-Yasenetsky), allows us to find the facts that make contribution to the formation of a holistic humane personality of the future medical specialist and citizen of the country. Keywords: meaning of life, morality, destiny, service, conscience, profession of doctor Reference List: 1. Lisichkin VA. Lukа, beloved physician. M.: Publishing Council of the Russian Orthodox Church; 2009:313-326 p. 2. Luka (Voino-Yasenetsky). ≪I fell in love with suffering...≫. Autobiography. M.: ≪Russian Chronograph≫; 1995. 205 p. 3. Popovsky MA. Life and existence of Voino-Yasenetsky, Archbishop and Surgeon. M.: The peak; 2001. 476 p. 4. Kruglova EI. ≪St. Luke (Voino Jasenetzky)≫. M.: The Blagovest.; 2014. 21 p. 5. Metropolitan Tashkentsky, Vladimir Sredneazyatsky. St. Luke, Archbishop of Simferopol and the Crimea. M.: Siberian Blagozvonnitsa; 2007. 768 p. Comments Visits: 11629 Kobyakova O.S., Deev I.A., Kulikov E.S., Pimenov I.D., Tyufilin D.S. NATURAL COURSE OF BRONCHIAL ASTHMA: FACTORS THAT DON’T ALLOW TO ACHIEVE THE CONTROL IN A LONG-TERM PERSPECTIVE Pages: 9-18 Kobyakova OS, Deev IA, Kulikov ES, Pimenov ID, Tyufilin DS. Natural course of bronchial asthma: factors that don’t allow to achieve the control in a long-term perspective. Siberian Medical Review. 2017;(5): 9-18. DOI: 10.20333/2500136-2017-5-9-18.. DOI 10.20333/2500136-2017-5-9-18. Authors Kobyakova Olga S. ; Siberian State Medical University; olga_kobyakova@rambler.ru Deev Ivan A. ; Siberian State Medical University; ivandeyev@yandex.ru Kulikov Evgeny S. ; Siberian State Medical University; evgeny.s.kulikov@gmail.com Pimenov Igor D. ; Siberian State Medical University; igor.d.pimenov@gmail.com Tyufilin Denis. S. ; Siberian State Medical University; dtufilin@gmail.com Annotation Bronchial asthma has the leading position in prevalence among the nosologies of the respiratory system, and is a socially significant disease. According to controlled studies, regular use of basic anti-inflammatory therapy ensures control in 40-70% of cases already in the first 6 months of treatment, while the level of current control of asthma in the population does not exceed 23%. The discrepancy of these data may indicate the presence of factors limiting the achievement of control in the conditions of real clinical practice. This review presents the results of studies devoted to the natural course of bronchial asthma in the context of factors associated with a change in the control of this pathology in the long term perspective. Keywords: bronchial asthma, natural course of asthma, asthma control, overweight, smoking, gender differences, age changes Reference List: 1. Asthma fact sheet [Internet]. Available: http:// www.who.int/mediacentre/factsheets/fs307/en/ (cited 27.08.2017) 2. Kulikov ES, Ogorodova LM, Belevskiy AS, Petrovskiy FI, Chuchalin AG. The effectiveness of strategies for achieving and maintaining control over bronchial asthma in conditions of real clinical practice: data from a multicenter study of STRELA-ACT. Pulmonologiya. 2010;1:80-6. (In Russian) 3. Camargo CA Jr, Weiss ST, Zhang S, Willett WC, Speizer FE. Prospective study of body mass index, weight change, and risk of adult-onset asthma in women. Archives of internal medicine. 1999;159(21):2582-8. DOI: 10.1001/ archinte.159.21.2582. 4. Shaheen SO, Sterne JA, Montgomery SM, Azima H. Birth weight, body mass index and asthma in young adults. Thorax. 1999;54(5):396-402. 5. Stenius-Aarniala B, Poussa T, Kvarnstrom J, Gronlund EL, Ylikahri M, Mustajoki P. Immediate and long term effects of weight reduction in obese people with asthma: randomised controlled study. BMJ: British medical journal / British Medical Association. 2000;320(7238):827-32. 6. Aaron SD, Fergusson D, Dent R, Chen Y, Vandemheen KL, Dales RE. Effect of weight reduction on respiratory function and airway reactivity in obese women. Chest. 2004;125(6):2046-52. 7. Saint-Pierre P, Bourdin A, Chanez P, Daures JP, Godard P. Are overweight asthmatics more difficult to control? Allergy. 2006;61(1):79-84. DOI: 10.1111/j.1398- 9995.2005.00953.x 8. Maniscalco M, Zedda A, Faraone S, Cerbone MR, Cristiano S, Giardiello C, Sofia M. Weight loss and asthma control in severely obese asthmatic females. Respiratory medicine. 2008;102(1):102-8. DOI: 10.1016/j. rmed.2007.07.029. 9. Haselkorn T, Fish JE, Chipps BE, Miller DP, Chen H, Weiss ST. Effect of weight change on asthma-related health outcomes in patients with severe or difficult-to- treat asthma. Respiratory medicine. 2009; 103(2) :274- 83. DOI: 10.1016/j.rmed.2008.08.010. DOI: 10.1016/j. rmed.2008.08.010. 10. Lange P, Parner J, Vestbo J, Schnohr P, Jensen G. A 15-year follow-up study of ventilatory function in adults with asthma. The New England journal of medicine. 1998;339:1194-200. DOI: 10.1056/ NEJM199810223391703. 11. Dijkstra A, Vonk JM, Jongepier H, Koppelman GH, Schouten JP, ten Hacken NH, Timens W, Postma DS. Lung function decline in asthma: association with inhaled corticosteroids, smoking and sex. Thorax. 2006;61(2):105-10. DOI: 10.1136/thx.2004.039271. 12. Kauppi P, Kupiainen H, Lindqvist A, Haahtela T, Laitinen T. Long-term smoking increases the need for acute care among asthma patients: a case control study. BMC pulmonary medicine. 2014;14:119. [Internet] DOI. 10.1186/1471-2466-14-119. URL: https://www.ncbi. nlm. nih.gov/pmc/articles/PMC4108236/ 13. Ali Z, Dirks CG, Ulrik CS. Long-term mortality among adults with asthma: a 25-year follow-up of 1,075 outpatients with asthma. Chest. 2013; 143(6):1649-1655. DOI: 10.1378/chest.12-2289. 14. Emerman CL, Woodruff PG, Cydulka RK, Gibbs MA, Pollack CV Jr, Camargo CA Jr. Prospective multicent¬er study of relapse following treatment for acute asthma among adults presenting to the emergency department. MARC investigators. Multicenter Asthma Research Col¬laboration. Chest. 1999;115(4):919-27. DOI: http://dx.doi. org/10.1378/chest.12-2289. 15. McCarren M, McDermott MF, Zalenski RJ, Jovanovic B, Marder D, Murphy DG, Kampe LM, Misiewicz VM, Rydman RJ. Prediction of relapse within eight weeks after an acute asthma exacerbation in adults. Journal of clini¬cal epidemiology. 1998;51(2):107-18. DOI: http://dx.doi. org/10.1016/S0895-4356(97)00246-1. 16. Adams RJ, Smith BJ, Ruffin RE. Factors associated with hospital admissions and repeat emergency depart¬ment visits for adults with asthma. Thorax. 2000;55(7):566- 73. DOI: 10.1136/thorax.55.7.566. 17. Turner MO, Noertjojo K, Vedal S, Bai T, Crump S, Fitzgerald JM. Risk factors for near-fatal asthma. A case-control study in hospitalized patients with asth¬ma. American journal of respiratory and critical care medicine. 1998;157(6Pt1):1804-9. DOI: 10.1164/ajrc- cm.157.6.9708092. 18. Crane J, Pearce N, Burgess C, Woodman K, Rob¬son B, Beasley R. Markers of risk of asthma death or re¬admission in the 12 months following a hospital admis¬sion for asthma. International journal of epidemiology. 1992;21(4):737-44. 19. Miller MK, Lee JH, Miller DP, Wenzel SE; TENOR Study Group. Recent asthma exacerbations: a key predic¬tor of future exacerbations. Respiratory medicine. 2007; 101(3):481-9. DOI: 10.1016/j.rmed.2006.07.005. 20. Schatz M, Meckley LM, Kim M, Stockwell BT, Cas¬tro M. Asthma exacerbation rates in adults are unchanged over a 5-year period despite high-intensity therapy. The journal of allergy and clinical immunology. In practice. 2014;2(5):570-4.e1. DOI: 10.1016/j.jaip.2014.05.002. 21. Sturdy PM, Victor CR, Anderson HR, Bland JM, But- land BK, Harrison BD, Peckitt C, Taylor JC; Mortality and Severe Morbidity Working Group of the National Asthma Task Force. Psychological, social and health behaviour risk factors for deaths certified as asthma: a national case- control study. Thorax. 2002;57(12):1034-9. DOI: 10.1136/ thorax.57.12.1034. 22. Wissow LS, Gittelsohn AM, Szklo M, Starfield B, Mussman M. Poverty, race, and hospitalization for childhood asthma. American journal of public health. 1988;78(7):777-82. 23. Lang DM, Polansky M. Patterns of asthma mortal¬ity in Philadelphia from 1969 to 1991. The New England journal of medicine. 1994;331(23):1542-6. DOI: 10.1056/ NEJM199412083312302. 24. Eisner MD, Katz PP, Yelin EH, Shiboski SC, Blanc PD. Risk factors for hospitalization among adults with asthma: the influence of sociodemographic factors and asthma severity. Respiratory research. 2001 ;2( 1 ):53-60. DOI: 10.1186/rr37. 25. Apter AJ, Wan F, Reisine S, Bender B, Rand C, Bogen DK, Bennett IM, Bryant-Stephens T, Roy J, Gonzalez R, Priolo C, Have TT, Morales KH. The association of health literacy with adherence and outcomes in moderate-severe asthma. The Journal of allergy and clinical immunology. 2013;132(2):321-7. DOI: 10.1016/j.jaci.2013.02.014. 26. Paasche-Orlow MK, Riekert KA, Bilderback A, Chanmugam A, Hill P, Rand CS, Brancati FL, Krishnan JA. Tailored education may reduce health literacy disparities in asthma self-management. American journal of respira¬tory and critical care medicine. 2005;172(8):980-6. DOI: 10.1164/rccm.200409-1291OC. 27. Adams RJ, Appleton SL, Hill CL, Ruffin RE, Wilson DH. Inadequate health literacy is associated with increased asthma morbidity in a population sample. The Journal of allergy and clinical immunology. 2009;124(3):601-3. DOI: 10.1016/j.jaci.2009.05.035. 28. Curtis LM, Wolf MS, Weiss KB, Grammer LC. The impact of health literacy and socioeconomic status on asthma disparities. The Journal of asthma : official journal of the Association for the Care of Asthma. 2012;49(2):178- 83. DOI: 10.3109/02770903.2011.648297. 29. Javed A, Yoo KH, Agarwal K, Jacobson RM, Li X, Juhn YJ. Characteristics of children with asthma who achieved remission of asthma. The Journal of asthma: of¬ficial journal of the Association for the Care of Asthma. 2013;50(5):472-9. DOI: 10.3109/02770903.2013.787625. 30. Boulet LP Is asthma control really more difficult to achieve in the elderly patient? International archives of allergy and immunology. 2014;165(3):149-51. DOI: 10.1159/000368966. 31. Griswold SK, Nordstrom CR, Clark S, Gaeta TJ, Price ML, Camargo CA Jr. Asthma exacerbations in North American adults: who are the «frequent fliers» in the emergency department? Chest. 2005;127(5):1579-86. DOI: 10.1378/chest.127.5.1579. 32. Banerji A, Clark S, Afilalo M, Blanda MP, Cydulka RK, Camargo CA Jr. Prospective multicenter study of acute asthma in younger versus older adults presenting to the emergency department. Journal of the American Geriatrics Society. 2006;54(1):48-55. DOI: 10.1111/j.1532- 5415.2005.00563.x 33. Sharma G, Goodwin J. Effect of aging on respiratory system physiology and immunology. Clinical interventions in aging. 2006;1(3):253-60. 34. Boulet LP. Asthma in the elderly patient. Asthma re-search and practice. 2016;2:3. DOI: 10.1186/s40733-015- 0015-1. 35. Xia S, Zhang X, Zheng S, Khanabdali R, Kalionis B, Wu J, Wan W, Tai X. An Update on Inflamm-Aging: Mech¬anisms, Prevention, and Treatment. Journal of immunology research. 2016;2016:8426874. DOI: 10.1155/2016/8426874. 36. Turner JM, Mead J, Wohl ME. Elasticity of human lungs in relation to age. Journal of applied physiology. 1968;25(6):664-71. 37. Brooks CR, Gibson PG, Douwes J, Van Dalen CJ, Simpson JL. Relationship between airway neutrophilia and ageing in asthmatics and non-asthmatics. Asian Pa¬cific Society of Respirology. 2013;18(5):857-65. 38. Chotirmall SH, Burke CM. Aging and the microbi- ome: implications for asthma in the elderly? Expert Review of Respiratory Medicine. 2015;9(2):125-8. DOI:10.1586/17 476348.2015.1002473. 39. Hardaker KM, Downie SR, Kermode JA, Farah CS, Brown NJ, Berend N, King GG, Salome CM. Predictors of airway hyperresponsiveness differ between old and young patients with asthma. Chest. 2011;139(6):1395-1401. DOI: 10.1378/chest.10-1839. Epub 2011 Mar 31. 40. Talreja N, Baptist AP Effect of age on asthma con¬trol: results from the National Asthma Survey. Annals of allergy, asthma and immunology: official publication of the American College of Allergy, Asthma, and Immunology. 2011;106(1):24-9. DOI: 10.1016/j.anai.2010.10.017. 41. Slavin RG, Haselkorn T, Lee JH, Zheng B, Deniz Y, Wenzel SE; TENOR Study Group. Asthma in older adults: observations from the epidemiology and natural history of asthma: outcomes and treatment regimens (TENOR) study. Annals of allergy, asthma and immunology : official publication of the American College of Allergy, Asthma, and Immunology. 2006;96(3):406-14. 42. Ponte EV, Stelmach R, Franco R, Souza-Machado C, Souza-Machado A, Cruz AA. Age is not associated with hospital admission or uncontrolled symptoms of asthma if proper treatment is offered. International ar¬chives of allergy and immunology. 2014;165(1):61-7. DOI: 10.1159/000367924. 43. Diette GB, Krishnan JA, Dominici F, Haponik E, Skinner EA, Steinwachs D, Wu AW. Asthma in older pa¬tients: factors associated with hospitalization. Archives of internal medicine. 2002;162(10):1123-32. 44. Quadrelli SA, Roncoroni AJ. Is asthma in the elderly really different? Respiration; international review of tho¬racic diseases. 1998;65(5):347-53. 45. Zureik M, Orehek J. Diagnosis and severity of asthma in the elderly: results of a large survey in 1,485 asthmatics recruited by lung specialists. Respiration; international re-view of thoracic diseases. 2002;69(3):223-8. 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BRADYARRHYTHMIAS IN THE OBSTRUCTIVE SLEEP APNEA SYNDROME: TREATMENT TACTICS Pages: 18-28 Korostovtseva LS, Varenitsyna SYu, Bochkarev MV, Semenov AP, Sviryaev YuV. Bradyarrhythmias in the obstructive sleep apnea syndrome: treat¬ment tactics. Siberian Medical Review. 2017; (5): 18-28. DOI 10.20333/2500136-2017-5-18-28. Authors Korostovtseva Lyudmila S. ; V. A. Almazov Federal North-West Medical Research Centre; korostovtseva_ls@almazovcentre.ru Varenitsyna Svetlana Y. V. ; A. Almazov Federal North-West Medical Research Centre; somnology@almazovcentre.ru Bochkarev Mikhail. V. V. ; A. Almazov Federal North-West Medical Research Centre; bochkarev_mv@almazovcentre.ru Semenov Andrey P. V. ; A. Almazov Federal North-West Medical Research Centre; somnology@almazovcentre.ru Sviryaev Yurii V. V. ; A. Almazov Federal North-West Medical Research Centre; somnology@almazovcentre.ru Annotation The syndrome of obstructive sleep apnea (SOSA) is a common pathology with a proven connection with cardiovascular diseases, including arterial hypertension, coronary heart disease, cardiac rhythm and conduction disorders. In the lecture the emphasis is on bradyarrhythmias, associated with breath¬ing disorders during sleep. In addition to general information on the occurrence of cardiac conduction disorders in persons with SOSA and pathogenetic mechanisms, approaches to diagnosis and possible difficulties, associated with the identification of cause-effect relationships between respiratory distur¬bances during sleep and heart rhythm disturbances are discussed. It is suggested the algorithm for the tactics of treatment the patients with bradyarrhythmias at night and the risk of breathing disorders during sleep. Keywords: obstructive sleep apnea syndrome, breathing disorders during sleep, cardiovascular mortality and morbidity, bradyarrhythmias, sinus arrest, atrioventricular blockade Reference List: 1. Lacedonia D, Carpagnano GE, Sabato R, lo Storto MM, Palmiotti GA, Capozzi V, Pia Foschino Barbaro M, Gallo C. Characterization of obstructive sleep apnea-hy-popnea syndrome (OSA) population by means of cluster analysis. Journal of Sleep Research. 2016:25(6):724-30. DOI: 10.1111/jsr.12429. 2. Platek AE, Karpinski G, Szymanski FM. Can continuous positive airway pressure therapy have antiarrhythmic properties? Kardiologia Polska. 2015;73(8):671. DOI: 10.5603/KP2015.0155. 3. Ge X, Han F, Huang Y, Zhang Y, Yang T, Bai C, Guo X. Is obstructive sleep apnea associated with cardiovascular and all-cause mortality? PLoS One. 2013;8(7):e69432. 4. Padeletti M, Zaca V, Mondillo S, Jelic S. Sleep-disordered breathing increases the risk of arrhythmias. Journal of Cardiovascular Medicine (Hagerstown). 2014;15(5):411-6. DOI: 10.2459/JCM.0000000000000019. 5. Gami AS, Olson EJ, Shen WK, Wright RS, Ballman KV, Hodge DO, Herges RM, Howard DE, Somers VK. Obstructive sleep apnea and the risk of sudden cardiac death: a longitudinal study of 10,701 adults. Journal of the American College of Cardiology. 2013;62(7):610-6. DOI: 10.1016/j.jacc.2013.04.080. 6. Gami AS, Somers VK. Implications of obstructive sleep apnea for atrial fibrillation and sudden cardiac death. Journal ofCardiovascular Electrophysiology. 2008;19(9):997- 1003. DOI: 10.1111/j.1540-8167.2008.01136.x. 7. Koehler U, Fus E, Grimm W, Pankow W, Schafer H, Stammnitz A, Peter JH. Heart block in patients with ob-structive sleep apnoea: pathogenetic factors and effects of treatment. European Respiratory Journal. 1998;11(2):434-9. 8. Guilleminault C, Connolly SJ, Winkle RA. Cardiac ar-rhythmia and conduction disturbances during sleep in 400 patients with sleep apnea syndrome. American Journal of Cardiology. 1983;52(5):490-4. 9. Roche F, Xuong AN, Court-Fortune I, Costes F, Pichot V, Duverney D, Vergnon JM, Gaspoz JM, Barthelemy JC. Relationship among the severity of sleep apnea syndrome, cardiac arrhythmias, and autonomic imbalance. Pacing and Clinical Electrophysiology. 2003;26(3):669-77 10. Marti Almor J, Felez Flor M, Balcells E, Cladellas M, Broquetas J, Bruguera J. Prevalence of obstructive sleep apnea syndrome in patients with sick sinus syndrome. Revista Espanola of Cardiologia. 2006;59(1):28-32. 11. Guilleminault C, Eldridge F, Dement W. Insomnia with sleep apnea: a new syndrome. Science; 1973;181:856- 858. 12. Korostovtseva L, Sviryaev Y, Zvartau N, Druzhkova T, Tikhonenko V, Konradi A. New insights into the management of rhythm and conduction disorders after acute myocardial infarction. American Journal of Case Reports. 2014;15:159-162. DOI:10.12659/AJCR.890357. 13.Shepard Jr JW. Hypertension, cardiac arrhythmias, myocardial infarction, and stroke in relation to obstructive sleep apnea. Clinical Chest Medicine. 1992;13:437-8. 14. Guilleminault C, Pool P, Motta J, Gillis AM. Sinus arrest during REM sleep in young adults. New England Journal of Medicine. 1984;31Щ6):1006-10. DOI: 10.1056/ nejm198410183111602. 15. Dyavanapalli J, Jameson H, Dergacheva O, Jain V, Alhusayyen M, Mendelowitz D. Chronic intermittent hy-poxia-hypercapnia blunts heart rate responses and alters neurotransmission to cardiac vagal neurons. Journal of Physiology. 2014;592(13):2799-811. DOI: 10.1113. 16. Holty J-E C, Guilleminault C. REM-related bradyarrhythmia syndrome. Sleep Medical Reviews. 2011;15(3):143-51. DOI: 10.1016/j.smrv.2010.09.001. 17. Velasco A, Hall C, Perez-Verdia A, Nugent K. As-sociation of high-risk scores for obstructive sleep apnea with symptomatic bradyarrhythmias. Journal of Cardiovascular Medicine. 2014, 15:407-10. DOI: 10.2459/ JCM.0b013e3283630d07. 18. Kwon Y, Picel K, Adabag S, Vo T, Taylor BC, Redline S, Stone K, Mehra R, Ancoli-Israel S, Ensrud KE. Osteoporotic fractures in men (MrOS) Study Group. Sleep Breathing. 2016;20(4):1161-68. DOI:10.1007/s11325-016- 1326-z. 19. Lotze U, Rothhagen B, Neubauer K, Mader I. Dizziness and near syncope due to sinus bradycardia and sinoatrial block associated with obesity and daytime tiredness. A clear indication for pacemaker implantation? Herz. 2008;33:455-9. DOI 10.1007/s00059-008-3096-2. 20.Serafini A, Dolso P, Gigli GL, Fratticci L, Cancelli I, Facchin D, Gigli M, Valente M. Rem sleep brady-arrhyth- mias: An indication to pacemaker implantation? Sleep Medicine. 2012;13(6):759-62. DOI: 10.1016. 21. Nishimura Y, Saito Y, Kondo N, Matsuda E, Fujiyama M, Morizane R, Maegaki Y. Ictal central apnea and brady-cardia in temporal lobe epilepsy complicated by obstructive sleep apnea syndrome. Epilepsy and Behavior Case Reports. 2015;4:41-4. DOI:10.1016/j.ebcr.2015.05.001. 22. Pavlova M, Abdennadher M, Singh K, Katz E, Llewellyn N, Zarowsly M, White DP, Dworetzky BA, Kothare SV. Advantages of respiratory monitoring during video-EEG evaluation to differentiate epileptic seizures from other events. Epilepsy and Behavior. 2014;32:142-44. DOI:10.1016/j.yebeh.2013.12.031. 23. Блоцкий АА, Медведева ИП, Крамаренко ОА. Кардиореспираторное холтеровское мониторирова- ние в диагностике синдрома обструктивного апноэ. Материалы межрегиональной научно-практической конференции оториноларингологов Сибири и Дальнего Востока с международным участием «Актуальные вопросы оториноларингологии». 2016:40-51. 24. Hayano J, Watanabe E, Saito Y., Sasaki F, Fujimoto K, Nomiyama T, Kawai K, Kodama I, Sakakibara. Screening for obstructive sleep apnea by cyclic variation of heart rate. Circulation: Arrhythmia and Electrophysiology. 2011;4(1):64-72. 25. Parati G, Lombardi C, Hedner J, Bonsignore MR, Grote L, Tkacova R, LRvy P, Riha R, Bassetti C, Narkiewicz K, Mancia G, McNicholas WT; EU COST Action B26 members. Recommendations for the management of patients with obstructive sleep apnoea and hypertension. European Respiratory Journal. 2013;41 (3):523-38. DOI: 10.1183/09031936.00226711. 26. Беленков ЮН, Пальман АД. Синдром обструк-тивного апноэ сна и нарушения сердечного ритма. Эффективная фармакотерапия. 2015;53:56-63. 27. Heneghan C, de Chazal P, Ryan S, Chua CP, Doherty L, Boyle P, Nolan P, McNicholas WT. Electrocardiogram recording as a screening tool for sleep disordered breathing. Journal of Clinical Sleep Medicine. 2008;4(3):223-28. 28. Kwon Y, Picel K, Adabag S, Vo T, Taylor BC, Redline S, Stone K, Mehra R, Ancoli-Israel S, Ensrud KE, for the Os-teoporotic Fractures in Men (MrOS) Study Group. Sleep- disordered breathing and daytime cardiac conduction ab-normalities on 12-lead electrocardiogram in community-dwelling older men. Sleep Breathing. 2016;20(4):1161-68. DOI:10.1007/s11325-016-1326-z. 29. Defaye P, de la Cruz I, Marti-Almor J, Villuendas R, Bru P, Sunuchal J, Tamisier R, Pepin JL. Heart Rhythm pacemaker transthoracic impedance sensor with an advanced algorithm to identify severe sleep apnea: the DREAM. European study. 2014;11(5):842-8. DOI:10.1016/j.hrthm.2014.02.011. 30.2013 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy / The Task Force on cardiac pacing and resynchronization therapy of the European Society of Cardiology (ESC). Developed in collaboration with the European Heart Rhythm Association (EHRA). European Heart Journal. 2013;34:2281-329. DOI:10.1093/ eurheartj/eht150. 31. ACC/AHA/HRS 2008 Guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities /A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the ACC/AHA/NASPE 2002 Guideline Update for Implantation of Cardiac Pacemakers and Antiarrhythmia Devices). Circulation. 2008;117:e350- e408. DOI: 10.1161/CIRCUALTION AHA.108.189742 32. Яковлев АВ, Бузунов РВ, Андрюшина НА, Туров AH, Яковлева НФ. Успешное лечение брадиаритмии, ассоциированной с синдромом обструктивного апноэ сна, методом создания постоянного положительного давления в дыхательных путях. Кардиология. 2013;53(8):93-96. 33. Pataka A, Daskalopoulou E, Papastefanou S, Baltatzi C, Aggelopulos P, Vlachogiannis E. Multiple heart pauses during sleep in a patient with obstructive sleep apnoea syndrome. Sleep Breathing. 2013;17:19-23. DOI 10.1007/ s11325-012-0648-8. 34. Maeno K, Kasai A, Setsuda M, Nishiyama A, Sakabe S, Ohnishi T, Saito K, Nishikawa H. Advanced atrioven-tricular block induced by obstructive sleep apnea before oxygen desaturation. Heart Vessels. 2009;24:236-40. DOI 10.1007/s00380-008-1113-2 35. Mataciuniene D, Masaitiene R, Mameniskiene R, Bu- drys VA. Heavy snorer with multiple prolonged asystoles during the night-reversably CPAP therapy. Sleep Breathing. 2013;17:25-8. DOI: 10.1007/s11325-012-0690-6. 36. Voigt L, Saul BI, Lombardo G, Reddy CV, Kassotis J. Correction of AV-nodal block in a 27-year-old man with severe obstructive sleep apnea - a case report. Angiology. 2003;54(3):363-7. DOI:10.1177/000331970305400314. 37. Becker H, Brandenburg U, Peter JH, Von Wichert P. Reversal of sinus arrest and atrioventricular conduction block in patients with sleep apnea during nasal continu¬ous positive airway pressure. American Journal of Respiratory and Critical Care Medicine. 1995;151 (1 ):215-8. DOI:10.1164/ajrccm.151.1.7812557. 38. Литвин АЮ, Певзнер АВ, Голицын ПВ, Галяви РА, Мазыгула ЕП, Нестеренко ЛЮ, Чазова ИЕ, Голицын СП. Новые подходы к лечению брадиаритмий у больных с синдромом обструктивного апноэ во сне. Терапевтический архив. 2006;8:41-7. 39. Doherty LS, Kiely JL, Swan V, McNicholas WT. Long-term effects of nasal continuous positive airway pres¬sure therapy on cardiovascular outcomes in sleep apnea syndrome. Chest. 2005;127(6):2076-84. DOI: 10.1378/ chest.127.6.2076 . 40. Белов АМ, Каллистов ДЮ, Воронин ИМ, Мо- лашенко НП, Чучалин АГ. Кардиологические про¬явления синдрома обструктивного апноэ во время сна. Клинические случаи. Терапевтический архив. 1998;70(3):44-9 41. Bradley TD, Shapiro CM. ABC of sleep disorders. Unexpected presentations of sleep apnoea: use of CPAP in treatment. British Medical Journal. 1993;306(6887):1260-62. 42.Sahadevan J, Srinivasan D. Treatment of obstruc¬tive sleep apnea in patients with cardiac arrhythmias. Current Treatment Options in Cardiovascular Medicine. 2012;14:520-28. 43.Somiah M, Taxin Z, Keating J, Mooney AM, Norman RG, Rapoport DM, Ayappa I. Sleep quality, short-term and long-term CPAP adherence. Journal of Clinical Sleep Medicine. 2012;8(5):489-500. DOI: 10.5664/jcsm.2138. 44.Opic P, van Kranenburg M, Yap SC, van Dijk A. Complications of pacemaker therapy in adults with con-genital heart disease: a multicenter study. International Journal of Cardiology. 2013;168:3212-216. DOI: 10.1016/j. ijcard.2013.04.114 . 45. Aizawa Y, Kunitomi A, Nakajima K, Kashimura S, Kat- sumata Y, Nishiyama T, Kimura T, Nishiyama N, Tanimoto Y, Kohsaka S, Takatsuki S, Fukuda K. Risk factors for early replacement of cardiovascular implantable electronic de¬vices. International Journal of Cardiology. 2015;178:99-101. 46. Belvin D, Hirschl D, Vineet R.J., Godelman A, Marjorie WS, Jay NG, Linda BH. Chest radiographs are valuable in demonstrating clinically significant pacemaker complications that require reoperation. Canadian Association of Radiologists Journal. 2011:62:288e295.DOI:10.1016/j. carj.2010.04.016. 47. Wolkove N, Baltzan M, Kamel H, Dabrusin R, Pa-layew M. Long-term compliance with continuous positive airway pressure in patients with obstructive sleep apnea. Canadian Respiratory Journal. 2008;15(7):365-69. 48. Garrigue S, Bordier P, Ja'is P, Shah DC, Hocini M, Raherison C, Tunon De LM, Haissaguerre M, Clementy J. Benefit of atrial pacing in sleep apnea syndrome. New England Journal of Medicine. 2002;346(6):404-12. DOI: 10.1056/NEJMoa011919. 49. Floras JS, Bradley T.D. Atrial overdrive pacing for sleep apnea: a door now closed. American Journal of Respi¬ratory and Critical Care Medicine. 2005;172(1):1-3. 50. Krahn AD, Yee R, Erickson MK, Markowitz T, Gula LJ, Klein GJ, Skanes AC, George CF, Ferguson KA. Physi¬ologic pacing in patients with obstructive sleep apnea: a prospective, randomized crossover trial. Journal of the American College of Cardiology. 2006;47(2):379-83. D0I:10.1016/j.jacc.2005.09.026. 51. Pepin JL, Defaye P, Garrigue S, Poezevara Y, Levy P. Overdrive atrial pacing does not improve obstructive sleep apnoea syndrome. European Respiratory Journal. 2005;25(2):343-7. D0I:10.1183/09031936.05.00132703 52. Unterberg C, Luthje L, Szych J, Vollmann D, Hasen- fuss G, Andreas S. Atrial overdrive pacing compared to CPAP in patients with obstructive sleep apnoea syndrome. European Heart Journal. 2005;26(23):2568-75. DOI:10.1093/eurheartj/ehi448. 53.Simantirakis EN, Schiza SE, Chrysostomakis SI, Chlouverakis GI, Klapsinos NC, Siafakas NM, Vardas PE. Atrial overdrive pacing for the obstructive sleep apnea- hypopnea syndrome. New England Journal of Medicine. 2005;353(24):2568-77. D0I:10.1056/NEJMoa050610. 54.Baranchuk A, Jeff SH, Christopher SS, Damian PR, Carlos AM, Stuart JC, Fitzpatrick M. Atrial over¬drive pacing in sleepapnoea: a meta-analysis. Euro¬pace. 2009;11:1037-40. DOI:10.1093/europace/eup165. DOI:10.1093/europace/eup165. 55.Simantirakis EN, Vardas PE. Cardiac pacing in sleep apnoea: diagnostic and therapeutic implications. Europace. 2006;8(11):984-7. 56. Peled N, Abinader EG, Pillar G, Sharif D, Lavie P. Nocturnal ischemic events in patients with obstructive sleep apnea syndrome and ischemic heart disease: effects of continuous positive air pressure treatment. Journal of the American College of Cardiology. 1999;34(6):1744-9. 57. Chow AW, Segal OR, Davies DW, Peters NS. Mecha-nism of pacing-induced ventricular fibrillation in the in-farcted human heart. Circulation. 2004;110(13):1725-30. D0I:10.1161/01.CIR.0000143043.65045.CF. 58. Daoulah A, Ocheltree S, Al-Faifi SM, Ahmed W, Alsheikh-Ali AA, Asrar F, Lotfi A. Sleep apnea and se¬vere bradyarrhythmia - an alternative treatment option: a case report. Journal of Medical Case Reports. 2015;9:113. DOI:10.1186/s13256-015-0596-6. 59. Wolf J, Drozdowski J, Czechowiczi K, Winklewski P, Jassem E, Kara T, Somers VK, Narkiewicz K. Effect of be-ta-blocker therapy on heart rate response in patients with hypertension and newly diagnosed untreated obstructive sleep apnea syndrome. International Journal of Cardiology. 2016;202:67-72. DOI:10.1016/j.ijcard.2015.08.139. 60. Huettner M, Koehler U, Nell C, Kesper K, Hildeb- randt O, Grimm W. Heart rate response to simulated obstructive apnea while awake predicts bradycardia during spontaneous obstructive sleep apnea. International Journal of Cardiology. 2015;186:216-8. DOI: 10.1016/j.ij- card.2015.03.245. 61. Куликов АН, Кучмин АН, Казаченко АА, Галак-тионов ДА, Уманская ЕП. Кардиологические маски синдрома обструктивного апноэ во время сна. Арте-риальная гипертензия. 2015;21(3):309-18. 62.Suda S, Kasai T, Kato M, Kawana F, Kato T, Ichikawa R, Hayashi H, Kawata T, Sekita G, Itoh S, Daida H. Bradyar- rhythmias may induce central sleep apnea in a patient with obstructive sleep apnea. Heart Vessels. 2015;30(4):554-7. DOI: 10.1007/s00380-014-0511-x. Comments Warning: mysqli_query(): (42S02/1146): Table 'site57.sys_comment' doesn't exist in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 10 Table 'site57.sys_comment' doesn't exist Warning: mysqli_query(): (42S02/1146): Table 'site57.sys_comment' doesn't exist in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 53 Table 'site57.sys_comment' doesn't exist Warning: mysqli_num_rows() expects parameter 1 to be mysqli_result, bool given in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 33 Table 'site57.sys_comment' doesn't exist Warning: mysqli_fetch_assoc() expects parameter 1 to be mysqli_result, bool given in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 39 Table 'site57.sys_comment' doesn't exist Visits: 11581 Ovcharenko S.I., Galetskayte Y.K., Volel B.A. PULMONARY REHABILITATION OF PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND THE TYPE OF DISEASE–RELATED RESPONSE Pages: 28-35 Ovcharenko SI, Galetskayte YK, Volel BA. Pulmonary rehabilitation of patients with chronic obstructive pulmonary disease and the type of diseaserelated
response. Siberian Medical Review. 2017; (5): 28-35. DOI: 10.20333/2500136-2017-5-28-35.. DOI 10.20333/2500136-2017-5-28-35 Authors Ovcharenko Svetlana I. ; I. M. Sechenov First Moscow State Medical University; svetftk@mail.ru Galetskayte Yanina K. ; I. M. Sechenov First Moscow State Medical University; galetskayte@gmail.com Volel Beatrisa A. ; I. M. Sechenov First Moscow State Medical University; beatrice.volel@gmail.com Annotation The aim of the research. To develop, apply and evaluate the effectiveness of pulmonary rehabilitation (PR) programs adapted to the types of response to the disease (anxiety about disease/ depression and hyponosognosia) in patients with chronic obstructive pulmonary disease (COPD). Material and methods. The study included 30 patients with COPD (Group A - 20 patients with anxiety about the disease or depression, Group B - 10 patients with hyponosognosia) to participate in the developed differentiated 3-week programs of pulmonary rehabilitation. The course of the PR consisted of sessions on the formation of motivation for participation, typical physical training, individual and group differentiated training sessions, as well as psychotherapeutic techniques aimed both at creating a strategy of self-management, and on correcting a disadaptive type of response to the disease; psychopharmacotherapy (if necessary). All patients immediately after the completion of the program, at 1, 3, 6 months after the end of the course of PR, were initially evaluated FVD, 6-MT, CAT, mMRC, SF-36, SGRQ, level of knowledge of COPD, depression level on the Beck scale. Results. At the stage of patient recruitment, the complexity of the formation of motivation in patients with hyponosognosia was established. In patients of both groups differentiated PR programs showed their effectiveness in relation to FEV1, 6-MT, CAT, mMRC, physical component of SF-36, all SGRQ scales, knowledge of the disease, BDI. However, the improvement in indices persisted for a longer time in group A. The conclusion. Differentiated depending on the type of response to the disease of the PR program are effective for all types of response to the disease. At the same time, patients with hyponosognosia require more efforts to create motivation, to maintain the improvements achieved, and, possibly, additional activities in the period after the passage of the PR program and the early repetition of the course. Keywords: chronic obstructive pulmonary disease (COPD), pulmonary rehabilitation, coping with the disease, types of response to the disease, anxiety about the disease, depression, hypnosognosia, disadaptive denial of physical well-being Reference List: 1. Rochester CL, Vogiatzis I, Holland AE, Lareau SC, Marciniuk DD, Puhan MA, Spruit MA, et al. An Official American Thoracic Society/European Respiratory Society Policy Statement: Enhancing Implementation, Use, and Delivery of Pulmonary Rehabilitation. American Journal of Respiratory and Critical Care Medicine. 2015;192(11):1373-86. DOI:10.1164/rccm.201510-1966ST. 2. Federal clinical guidelines on diagnosis and treatment of chronic obstructive pulmonary disease. Russian respiratory society, 2014. [Internet]. Available at: http:// www.pulmonology.ru/download/COPD2014may.doc. Accessed August 30, 2017. (In Russian) 3. Spruit MA, Singh SJ, Garvey C, ZuWallack R, Nici L,Rochester C, Hill K, Holland A, Lareau S, Man WD-C, Pitta F, et al. An official American Thoracic Society/European Respiratory Society statement: key concepts and advances in pulmonary rehabilitation. American Journal of Respiratory and Critical Care Medicine. 2013;188:e13-e64. DOI:10.1164/rccm.201309-1634st. 4. Bolton CE, Bevan-Smith EF, Blakey JD, Crowe P, Elkin SL, Garrod, NJ Greening NJ, Heslop K, Hull JH, D-C Man W, Morgan MD, Proud D, Roberts CM, Sewell L, Singh SJ, Walker PP, Walmsley S. British Thoracic Society guideline on pulmonary rehabilitation in adults. Thorax. 2013;68:ii1-ii30. DOI:10.1136/thoraxjnl-2013-203808. 5. Ovcharenko SI, Galetskayte YaK, Volel’ BA, Pushkarev DF, Las ЕА. Disease coping styles in patients with chronic obstructive pulmonary disease or rheumatoid arthritis. Clinicist. 2013;1:21-29.(In Russian) 6. Ovcharenko SI, Galetskayte YaK, Volel’ BA, Pushkarev DF, Las ЕА. Patterns of personality disorders and diseaserelated responses in patients with chronic obstructive pulmonary disease. Pulmonology. 2013;2:74-80.(In Russian) 7. Cafarella PA, Effing TW, Barton C, Ahmed D, Frith PA. Management of depression and anxiety in COPD. European Respiratory Monograph. 2013;59:144-163. DOI:10.1183/1025448x.10012112. 8. Ovcharenko SI, Galetskayte YaK, Volel’ BA. Predictors of disadaptive disorders in patients with chronic obstructive pulmonary disease. Pulmonology. 2014;2:60-68. (In Russian) 9. Pushkarev DF, Volel’ BA, Ovcharenko SI, Galetskayte YaK, Las EA. Personality disorders and chronic medical disease: a comparative analysis of rheumatoid arthritis and chronic obstructive pulmonary disease. Psychic Disorders in General Medicine. 2012;3:7-15.(In Russian) 10. Smulevich AB, Volel’ BA. Personality disordres and somatic disease (hypohondriac personality development problem). Neuroscience and Behavioral Physiology. 2008;5:4-12.(In Russian) 11. Beauchamp MK, Janaudis-Ferreira T, Goldstein RS, Brooks D. Optimal duration of pulmonary rehabilitation for individuals with chronic obstructive pulmonary disease - a systematic review. Chronic Respiratory Disease. 2011;8:129-140. DOI:10.1177/1479972311404256. 12. Ries AL, Bauldoff GS, Carlin BW, Casaburi R, Emery CF, Mahler DA, Make B, Rochester CL, Zuwallack R, Herrerias C. Pulmonary rehabilitation: Joint ACCP/ AACVPR evidence-based clinical practice guidelines. Chest. 2007;131(5):4-42. DOI:10.1378/chest.06-2418. 13. Pitta F, Troosters T, Probst VS, Langer D, Decramer M, Gosselink R. Are patients with COPD more active after pulmonary rehabilitation? Chest. 2008;134:273-280. DOI:10.1378/chest.07-2655. 14. Rossi G, Florini F, Romagnoli M, Bellantone T, Lucic S, Lugli D, Clini E. Length and clinical effectiveness of pulmonary rehabilitation in outpatients with chronic airway obstruction. Chest. 2005;127:105-109. DOI:10.1378/ chest.127.1.105. 15. Redelmeier DA, Bayoumi AM, Goldstein RS, Guyatt GH. Interpreting small differences in functional status: the six minute walk test in chronic lung disease patients. American Journal of Respiratory and Critical Care Medicine. 1997;155:1278-1282. DOI:10.1164/ajrccm.155.4.9105067. 16. Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2017 [Интернет]. Доступно: http://goldcopd.org/gold-2017-global-strate- gy-diagnosis-management-prevention-copd/. Comments Warning: mysqli_query(): (42S02/1146): Table 'site57.sys_comment' doesn't exist in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 10 Table 'site57.sys_comment' doesn't exist Warning: mysqli_query(): (42S02/1146): Table 'site57.sys_comment' doesn't exist in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 53 Table 'site57.sys_comment' doesn't exist Warning: mysqli_num_rows() expects parameter 1 to be mysqli_result, bool given in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 33 Table 'site57.sys_comment' doesn't exist Warning: mysqli_fetch_assoc() expects parameter 1 to be mysqli_result, bool given in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 39 Table 'site57.sys_comment' doesn't exist Visits: 11570 Antonov V.N. ETIOLOGICAL AND CLINICAL ASPECTS OF MANIFESTATION THE VARIOUS VARIANTS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE COURSE Pages: 35-40 Antonov VN. Etiological and clinical aspects of manifestation the various variants of chronic obstructive pulmonary disease course. Siberian Medical Review. 2017; (5): 35-40. DOI 10.20333/2500136-2017-5-35-40 Authors Antonov V. N. ; South Ural State Medical University; ant-vn@yandex.ru Annotation The aim of the research. The article discusses the problems of early manifestation of clinical development of COPD depending on the effect of etiological factors, in particular tobacco smoking. Material and methods. 249 patients with isolated COPD and 250 patients with combined course of COPD and IHD were examined. All patients had complex clinical examination. The revealed risk factors for the development of IHD and COPD were analyzed, in particular, the fact of smoking, the length of time and the index of the smoker was estimated. The following indices are estimated: age of appearance of the first symptoms of COPD, duration of the disease, cough anamnesis. Functional indices: volume of forced expiration in the first second (FEV1), ratio of FEV1 to forced vital capacity of lungs (FVC). Results. The index of the smoker in both groups exceeded 200 units. In the COPD + IHD group, the smokers' index significantly exceeded this figure compared to patients with isolated COPD by 9% (p <0.05) The conclusion. The severity of patients with combined course of COPD and IHD depends on the length of smoking and its intensity, especially in patients with GOLD 3 and GOLD 4 according to the COPD classification of 2011. In patients with comorbid course of COPD and IHD, the main clinical manifestations of the disease are registered earlier than in patients with isolated COPD and associated with a shorter smoking experience. In patients with COPD and IHD, the functional parameters of the respiratory system are significantly lower than those of patients with isolated COPD. Keywords: COPD, IHD, comorbidity, risk factors, smoking, smoker index Reference List: 1. Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2016. [Internet] Available from: http://goldcopd.org/. 2. Aisanov ZR, Avdeev SN, Arkhipov VV, Belevsky AS, Leschenko IV, Ovcharenko SI, Shmelev EI, Chuchalin AG National clinical guidelines for the diagnosis and treatment of chronic obstructive pulmonary disease: an algorithm for making clinical decisions. Pulmonology. 2017;27(1):13-20. DOI:10.18093/0869-0189-2017-27-1-13-20 (In Russian) 3. Avdeev SN. Phenotypes of chronic obstructive pulmonary disease: features of therapy. Diseases of the respiratory system. Consilium (adj.). 2010;1:23-8. (In Russian) 4. Pistolesi M, Bigazzi F, Cestelli L, Paoletti M, Camiciottoli G. COPD: Complex disease: Phenotypes of chronic obstructive pulmonary disease. [Internet]. Available at https://medi.ru/info/4869 (reference 28.07.2017) 5. Kutsenko MA, Chuchalin AG The paradigm of comorbidity: the syndrome of COPD and IHD. RMJ. 2014;5:389. (In Russian) 6. Boev SS, Dotsenko N.Ya., Shehunova IA, Dedova V.O. Combination of chronic obstructive pulmonary disease and coronary heart disease. Issues of rational therapy. [Internet]. Available at http://therapia.ua/therapia/2015-/2-95. (reference July 28, 2017). (In Russian) 7. Correia LL, Lebedev TYu, Efremova OA. The problem of polymorbidity in a combination of chronic obstructive pulmonary disease and certain cardiovascular diseases. Scientific Bulletin of Belgorod State University. 2013;4(147):12-17. (In Russian) 8. Sin DD, Wu L, Man SF. The relationship between reduced lung function and cardiovascular mortality. Chest. 2005;127:1952-9. DOI:http://dx.doi.org/10.1378/chest.127.6.1952 9. Sin DD, Man SF. Chronic obstructive pulmonary disease as a risk factor for cardiovascular morbidity and mortality. Proceedings of the American Thoracic Society. 2005;2(1):8-11. DOI:http://dx.doi.org/10.1513/pats.200404-032ms. 10. Global strategy for diagnosis, treatment and prevention of chronic obstructive pulmonary disease (2011 revision). M: Russian Respiratory Society, 2012. 80 p. (In Russian) 11. National guidelines for the diagnosis and treatment of stable angina pectoris. Cardiovascular therapy and prevention. 2008;7(6): 37. (In Russian) 12. Aisanov ZR, Kokosov AN, Ovcharenko SI, Khmelkova NG, Tsoi AN, Chuchalin AG, Shmelev EI Chronic obstructive pulmonary disease. The federal program. RM1. 2001;1:9 (In Russian) 13. Ovcharenko S.I. Anti-inflammatory therapy of chronic bronchitis. RM2. 2001;5:201. (In Russian) Comments Warning: mysqli_query(): (42S02/1146): Table 'site57.sys_comment' doesn't exist in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 10 Table 'site57.sys_comment' doesn't exist Warning: mysqli_query(): (42S02/1146): Table 'site57.sys_comment' doesn't exist in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 53 Table 'site57.sys_comment' doesn't exist Warning: mysqli_num_rows() expects parameter 1 to be mysqli_result, bool given in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 33 Table 'site57.sys_comment' doesn't exist Warning: mysqli_fetch_assoc() expects parameter 1 to be mysqli_result, bool given in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 39 Table 'site57.sys_comment' doesn't exist Visits: 11558 Vizel A.A., Vafina A.R., Vizel I.Y., Salakhova I.N., Dyakova E.V., Kudryavtseva E.Z. CHARACTERISTICS OF PATIENTS WITH BRONCHIAL ASTHMA HAVE ADMITTED TO THE STATIONARES OF THE CITY OF KAZAN Pages: 40-47 Vizel AA, Vafina AR, Vizel IYu, Salakhova IN, Dyakova EV, Kudryavtseva EZ. Characteristics of patients with bronchial asthma have admitted to the stationares of the city of Kazan. Siberian Medical Review. 2017; (5): 40-47. DOI 10.20333/2500136-2017-5-40-47 Authors Vizel Alexander A. ; Kazan State Medical University; lordara@inbox.ru Vafina Adelia R. ; Kazan State Medical University; adelyavafina@gmail.com Vizel Irina Yu. ; Kazan State Medical University; tatpulmo@mail.ru Salakhova Irina N. ; Kazan State Medical University; iboroznova@gmail.com Dyakova Ekaterina V. ; Republican Clinical Hospital; vrkaty.dyakowa@yandex.ru Kudryavtseva Elvira Z. ; 16-city Clinical Hospital; Annotation The aim of the research. To study the clinical manifestations, peculiarities of treatment, preferences of patients with bronchial asthma (BA) and compliance of care for these patients with clinical recommendations. Material and methods. It was conducted the survey, clinical, laboratory and functional examination of 100 patients with asthma, that have admitted to the hospitals in Kazan until July 2017. The database was created and processed by the SPSS-18 program. Results. According to GINA 2017, 96% of patients had uncontrolled asthma and 4% had partially controlled; according to the results of the ACQ questionnaire, 94% of patients had poorly controlled BA. Patients said the worst time of the day evening and night, and also reported that morning symptoms had a negative effect on daytime activity. The most effective and convenient devices were called metered dose powder inhalers. The most effective combination the patients named budesonide with formoterol. Treatment, conducted at the outpatient and inpatient, corresponded to domestic and foreign clinical recommendations for diagnosis and treatment of asthma. However, only 43% of patients had adequate therapeutic cooperation, and 20% - were not sufficiently trained in the use of aerosol delivery. Modification and strengthening of therapy during hospitalization also corresponded to domestic and international recommendations. The conclusion. The work showed that the level of care for patients with BA in Kazan is up-to-date. Among the prescribed drugs, a significant proportion began to occupy the generics. The work showed that there are opportunities to further development the treatment of asthma by improving patient compliance, more complete training and regular monitoring of the technique of using various inhalation drugs. Keywords: bronchial asthma, control, questionnaires, treatment, inhalers, bronchodilators, inhaled corticosteroids, therapeutic cooperation Reference List: 1. Global Strategy for Asthma Management and Preven-tion. Global Initiative for Asthma (GINA). Updated 2017 [Internet]. Available: http://www.ginasthma.org 2. Chuchalin AG, Aisanov ZR, Belevskiy AS, Bushmanov AYu, Vasileva OS, Volkov IK, Geppe NA, Knyazheskaya NP, Kondyurina EG, Kolosova NG, Mazitova NN, Malak-hov AB, Meshcheryakova NN, Nenasheva NM, Revyakina VA, Shubin IV Russian respiratory society. Federal clinical recommendations for diagnosis and treatment of bronchial asthma, 2016 [Internet]. Available: http:// spulmo.ru. (In Russian). 3. Fedoseev GB, Trofimov VI, Shaylieva VG, Eliseeva MV, Kryakunov KN The many faces of asthma-phenotypes and clinical pathogenetic variants. Rossijskij allergologicheskij zhurnal. 2012;1:50-5. (In Russian) 4. Ovsyannikova LV, Petrov DV Bronchial asthma in the Omsk region: Dynamics of morbidity and prevalence. Omskij nauchnyj vestnik. 2015;1(138):18-20. (In Russian). 5. Titova ON, Kulikov VD Trends of incidence of bronchial asthma in the adult population of St. Petersburg. Medicinskij al’jans. 2017;1:59-67. (In Russian) 6. Habriev RU, Arinina EE, Rashid MA. Epidemiological burden of chronic obstructive pulmonary diseases and bronchial asthma in RF. Sovremennaja organizacija lekarstvennogo obespechenija. 2015;4:19-31. (In Russian) 7. Vafin AJu, Vizel’ AA, Sherputovskiy VG, Lysenko GV, Kolgin RA, Vizel’ IYu, Shaymuratov RI, Amirov NB Respiratory diseases in the Republic of Tatarstan: longterm epidemiological analysis. Vestnik Sovremennoi Klinicheskoi Mediciny [The Bulletin of Contemporary Clinical Medicine]. 2016;9(1):24-31. (In Russian) 8. Chuchalin AG Bronchial asthma: new perspectives in therapy. Kazan Medical Journal. 2011;92(5):676-684. (In Russian) 9. Nevzorova VA, Maystrovskaya YuV, Konovalova EN, Luk’yanov PA, Chikalovets IV. Modern technologies in the treatment and rehabilitation of patients with bronchial asthma. Tihookeanskij medicinskij zhurnal. 2001;1:25-37. (In Russian) 10. Ovsyannikov NV, Antonov NS, Lyapin VA, Shukil’ LV. Bronchial asthma in the industrial region: pharmacoepidemiological aspects. 2012;6:31-4. (In Russian) 11. Kulbaisov AM, Polumordvintsev TV, Zhestkov AV. Pharmacotherapy of the patients with bronchial asthma: problems and possible solutions. Vestnik Sovremennoi Klinicheskoi Mediciny [The Bulletin of Contemporary Clinical Medicine]. 2017;10(3):18-23. DOI: 10.20969/ VSKM.2017.10(3).18-23. (In Russian) 12. Demko IV, Gordeeva NV, Bochanova EN, Kraposhi- na AYu, Solovieva IA, Gaygol’nik TV. Analysis of drug supply patients with bronchial asthma in Krasnoyarsk region. Sovremennye problemy nauki i obrazovanija. 2016; 5:167-72. (In Russian) 13. Anisimov DA, Goncharova LN, D’yachkova AA. Analysis of diagnostic parameters of respiratory failure in patients with bronchial asthma. Samarskij nauchnyj vestnik. 2015;2(11):10-12. (In Russian) 14. Leshchenko IV, Esaulova NA. Bronchial asthma: current issues of basic therapy (to help the practical doctor). RMJ. 2015;18:1074-1079. (In Russian) 15. Leshchenko IV, Baranova II. The choice of the basic therapy of bronchial asthma in real clinical practice. Terapevticheskij arhiv. 2015;3:92-7. (In Russian) Comments Warning: mysqli_query(): (42S02/1146): Table 'site57.sys_comment' doesn't exist in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 10 Table 'site57.sys_comment' doesn't exist Warning: mysqli_query(): (42S02/1146): Table 'site57.sys_comment' doesn't exist in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 53 Table 'site57.sys_comment' doesn't exist Warning: mysqli_num_rows() expects parameter 1 to be mysqli_result, bool given in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 33 Table 'site57.sys_comment' doesn't exist Warning: mysqli_fetch_assoc() expects parameter 1 to be mysqli_result, bool given in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 39 Table 'site57.sys_comment' doesn't exist Visits: 11555 Sergeevа I.V., Demko I.V., Korchagin E.E. CLINICAL-LABORATORY CHARACTERISTICS OF PATIENTS WITH EXTRAMURAL PNEUMONIA AGAINST THE BACKGROUND OF FLU A(H1N1)PDM09 Pages: 47-53 Sergeeva IV, Demko IV, Korchagin EE. Clinical-laboratory characteristics of patients with extramural pneumonia against the background of FLU A(H1N1)pdm09. Siberian Medical Review. 2017; (5): 47-53. DOI 10.20333/2500136-2017-5-47-53 Authors Sergeevа Irina Vladimirovna Cand.Med.Sc., Associate Professor, the Department of Infectious Diseases and Epidemiology with the course of Postgraduate Education; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; infeccia7979@mail.ru Demko Irina Vladimirovna Dr.Med.Sc, Professor, Head of the Department of Internal Diseases N 2; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; 660022, Красноярск, ул. Партизана Железняка, 1; e-mail: demko64@ mail.ru Korchagin Egor Evgenievich Associate Professor; Professor V. F. Voino-Yasenetsky Krasnoyarsk State Medical University; Regional Clinical Hospital; maxipime@mail.ru Annotation The aim of the research. To study the clinical and laboratory features of the course of community-acquired pneumonia against the background of flu A(H1N1)pdm09. Material and methods. The article presents the features of the course of community-acquired pneumonia against the background of influenza A(H1N1) pdm09 in 169 patients between 2009 and 2016, aged 18 to 85 years old. The diagnosis of community-acquired pneumonia was verified on the basis of clinical and epidemiological data at the time of admission to the hospital; X-ray and laboratory diagnostic methods. Criteria for the severity were: the degree of respiratory failure, the severity of the intoxication syndrome, the volume of inflammatory infiltration, the presence of complications, the decompensation of concomitant diseases. Results. In 96 (56.8%) patients, severe community-acquired pneumonia was registered, 73 patients (43.2%) had non-severe community-acquired pneumonia. The course of community-acquired pneumonia on the background of influenza A(H1N1)pdm09 in the patients examined by us was characterized by an acute onset, manifested by a severe intoxication syndrome and lesions of the respiratory tract, the degree of manifestation of which was depended on the severity of the disease. In 56.8% of cases, pneumonia occurred with severe course, mainly in young people aged 18-29 years old with a burdened premorbid background with a predominance of metabolic syndrome, which determined the leading role in the development of severe pneumonia with influenza A (H1N1) pdm09. According to the X-ray examination in patients with severe pneumonia, bilateral pneumonia was more often diagnosed (64.6%) with total and fractional lesion, unilateral pneumonia prevailed in the group of patients with moderate pneumonia (83.5%), with predominant localization in the right lung (68,5%). A feature of hematological parameters in severe pneumonia was a slight leukocytosis with thrombocytopenia, which increased depending on the day of admission to the hospital. In biochemical parameters in severe pneumonia, there was an increase in CRP, creatinine, AsT, CPC, a decrease in total protein, which was regarded as a manifestation of multiple organ failure in the context of endogenous intoxication. The conclusion. Thus, out-of-hospital pneumonia against the background of influenza A (H1N1) pdm09 occurs in severe form, which is based on the syndrome of a pronounced systemic inflammatory response. Keywords: influenza A(H1N1)pdm09, extramural pneumonia, patients, severity of the course, premorbid background, laboratory diagnostic methods Reference List: 1. Tsybalova LM, Pokrovsky VI, eds. Flu: epidemiology, diag-nostics, treatment, prevention. M.: Meditsinskoye informatsionnoye agentstvo; 2012. 496 p. (In Russian) 2. Malyi VP. Andreychin MA. Gripp and other SARS. M.: GEOTAR-Media; 2012. 320 p. (In Russian) 3. Chuchalin AG, Chernyaev AL, Zayratyants OV, Kelly EI, Rogov KA, Mikhaleva LM, Trusov AE, Samsonova MV, Chartorizhskaya NN. Pathological anatomy of lungs at flu A (H1N1), according to autopsies. Pulmonology. 2010;1:5-11. (In Russian) 4. Khamitov RF, Pal’mova LYu, Sulbayeva KR. Heavy pneumonia in clinical practice. Kazan medical journal. 2016;97(6):994- 99. (In Russian) 5. Khamitov RF, Malova AA, Grigorieva IV. Treatment of extra hospital pneumonia: reannouncers of lethal outcomes. Kazan medical journal. 2014;95(3):356-61. (In Russian). 6. Chuchalin AG. Pneumonia: an urgent problem of medicine of the XXI century. Pulmonology. 2015;25(2):133-42. (In Russian) 7. Govorin AV, Serebryakova OM, Filev AP, Romanova EN. Clinical features of community-acquired pneumonia in patients with influenza A / H1N1. Pulmonology. 2010;(5):27-9. (In Russian). 8. Boon HA. Pulmonology. M.: Reed Elsiver; 2009. 140 p. (In Russian) 9. Mizernitsky Yul. Place of macrolides in modern therapy of community-acquired pneumonia in children. Consilium medi- cum. 2011;13 (4):18-21. (In Russian) 10. Gorbunov VV, Govorin AB, Lukyanov SA, Romanova EN. Early diagnosis and etiotropic therapy of pneumonia during influenza A (H1N1) pandemic. Siberian Medical Journal. 2011;(7):79-82. (In Russian) 11. Zil’ber EC. Emergency pulmonology : guide. M.: GEOTAR-Media; 2009. 264 p. (In Russian) 12. Kolosov VP. Community-acquired pneumonia (clinical course, prognosis of outcomes). Blagoveshchensk; 124 p. (In Russian) 13. Avdeev CH. Pneumonia and acute respiratory distress syndrome caused by the influenza A / H1N1 virus. Pulmonology. 2010; Appendix Influenza A / H1N1: Pandemic Lessons:32-46. (In Russian) 14. Leshchenko IV, Krivonogov AV. Features of the course of pneumonia in pandemic influenza A / H1N1 / 09. Pulmonology. 2011;(6):62-8. (In Russian) 15. Cunha BA. Swine influenza (H1N1) pneumonia: clinical considerations. Clinical Infectious Diseases. 2010;(24):203-28. Comments Warning: mysqli_query(): (42S02/1146): Table 'site57.sys_comment' doesn't exist in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 10 Table 'site57.sys_comment' doesn't exist Warning: mysqli_query(): (42S02/1146): Table 'site57.sys_comment' doesn't exist in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 53 Table 'site57.sys_comment' doesn't exist Warning: mysqli_num_rows() expects parameter 1 to be mysqli_result, bool given in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 33 Table 'site57.sys_comment' doesn't exist Warning: mysqli_fetch_assoc() expects parameter 1 to be mysqli_result, bool given in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 39 Table 'site57.sys_comment' doesn't exist Visits: 11535 Narkevich A.N., Vinogradov K.A., Koretskaya N.M. PARAMETERIZATION OF OBJECTS ON DIGITAL MICROSCOPIC IMAGES OF SPUTUM,STAINED BY THE ZIEHL–NEELSEN METHOD Pages: 53-59 Narkevich AN, Vinogradov KA, Koretskaya NM. Parameterization of objects on digital microscopic images of sputum, stained by the Ziehl-Neelsen method. Siberian Medical Review. 2017; (5): 53-59. DOI 10.20333/2500136-2017-5-53-59 Authors Narkevich Artem N. Cand. Med. Sci.; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; narkevichart@gmail.com Vinogradov Konstantin Anatolevich MD, Professor; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; vinogradovl6@yandex.ru Koretskaya Nataliya Mikhailovna ; Medical-sanitary Department № 24; fkuzmsch24@mail.ru Annotation The aim of the research. To study the differences in objects that are acid-fast mycobacteria and other objects, and their parametrization for use in the recognition of such objects on digital microscopic images of sputum stained by the Ziehl-Neelsenmethod. Material and methods. Data on 343 687 objects isolated using the methods developed by us on digital images of microscopic sputum preparations stained using the Ziehl-Neelsenmethod were used: 6 708 objects of acid-fast mycobacteria, 336,979 objects - other objects. Comparison of these objects was carried out for 240 color and morphometric parameters, divided into 3 groups: the basic morphometric parameters of objects, the radial dimensions of objects and their relationships and color parameters of objects. Results. It was found that the greatest differences between acid-fast mycobacteria and other objects are in the main morphometric parameters, such as the pixel area, the X and Y axis dimensions, and also the color parameters of the objects. It is shown that the separation of objects into classes according to the individual parameters is rather difficult. The conclusion. The results of studying the differences in acid-fast mycobacteria and other objects indicate quite significant differences in the main morphometric parameters of objects: the per-pixel area and the size of the objects along the X and Y axes, as well as the different color parameters of the objects. There are no significant differences between the studied classes of objects by the radial dimensions of objects and their relationships, however, differences in these parameters require further study using multidimensional mathematical methods of analysis. Keywords: parametrization, bacterioscopy, acid-fast mycobacteria, detection, pulmonary tuberculosis, image analysis Reference List: 1. Mordyk AV, Puzyreva LV, Aksyutina LP. Modern international and national concept of TB. Dal’nevostochnyy zhurnal infektsionnoy patologii. 2013;22:92-97. (InRussian) 2. Filimonova ES, Tarasenko SL, DykhnoYuA, Khlebnikova FB. Evaluation of the effectiveness of cytological diagnosis of malignant tumors of the lungs. Siberian medical review. 2014;3:65-9. DOI: 10.20333/25000136-2014-3-65-69 (In Russian) 3. Xu Z, Bagci U, Mansoor A, Kramer-Marek G, Luna B, Kubler A, Dey B, Foster B, Papadakis GZ, Camp JV, Jonsson CB, Bishai WR, Jain S, Udupa JK, Mollura DJ. Computer-aided pulmonary image analysis in small animal models. Medical Physics. 2015;7:3896-910. 4. Barbova AI. A comparative analysis of some modern bac-teriological and genetic methods of diagnostics of tuberculosis. Tuberkulez, legochnye bolezni, VICh-infektsiya. 2010;2:024-028. (InRussian) 5. Punin AA, Guseva II, Korotkova EA, Punin DA, Gulyaeva SA, Pikalova OS, Khoruzhenko OM, Strelkov AN, Sakharitova EA. The detection of tuberculosis among General patients of the hospital. Vestnik Smolenskoy gosudarstvennoy meditsinskoy akademii. 2016;4:58-63. (InRussian) 6. Dantsev VV, Golota AS, Karpushchenko VG, Krassiy AB, Kuzin AA. Current status and prospects for improving the differential diagnosis of community-acquired pneumonia and pulmonary tuberculosis. Voenno-meditsinskiy zhurnal. 2015;5:29-36. (InRussian) 7. Cherednichenko AG, Revyakina OV, Petrenko TI. The state laboratory service for the diagnosis of tuberculosis in the Siberian and far Eastern Federal districts. Tuberkulez i bolezni legkikh. 2014;5:16-20. (InRussian) 8. Eremeeva NI, Vakhrusheva DV. The efficiency of detection of tuberculosis with bacterial excretion in clinical diagnostic laboratories of the primary health-care services in the Urals in 2010¬2012. Tuberkulez i bolezni legkikh. 2015;7:40-42. (InRussian) 9. Mezentseva NI, Evgushchenko GV, Puzanov VA, Popov SA, Freyman GE. Assessment of the quality of TB diagnosis by microscopy in Russia in 2011-2014 at the Federal system of quality control results. Tuberkulez i bolezni legkikh. 2015;6:96- 97. (InRussian) 10. Kosykh NE, Smagin SI, Gostyushkin VV, Savin SZ, Litvinov KA. Automated computer analysis of medical images. Informatsionnye tekhnologii i vychislitelnye sistemy. 2011;3:51-6. (InRussian) 11. Porev VN. Computer graphics. SPb.:BKhV-Peterburg; 2002.432 p. (In Russian) 12. Agoston MK. Computer graphics and geometric mod¬eling: implementation and algorithms. London: Springer; 2005.907 p. 13. Eruslanov RV, Orekhova MN, Dubrovin VN. Image seg-mentation of the retroperitoneum on computed tomographic images based on a function level. Kompyuternaya optika. 2015;4:592-599. (In Russian) 14. Mar’yanova AV. Study on the quality of segmentation algorithms depending on the size of the objects in the image. Sovremennyeproblemymatematikiieeprilozheniy: trudy 46-y Mezhdunarodnoymolodezhnoyshkoly-konferentsii. Ekaterinburg: Institut matematiki i mekhaniki UrO RAN; 2015:129-34. (In Russian) 15. Prakash A, Hewko MD, Sowa M, Sherif SS. Detection of atherosclerotic plaques in images of optical coherence tomog¬raphy using the method of structural segmentation. Sovremen- nye tekhnologii v meditsine. 2015;1:21-8. (InRussian) 16. Soyfer VA. Computer processing of images. Part 2. Methods and algorithms. Sorosovskiy obrazovatelnyy zhurnal. 1996;3:110-21. (InRussian) 17. Liu D, Wang S, Huang D, Deng G, Zeng F, Chen H. Medical image classification using spatial adjacent histogram based on adaptive local binary patterns. Computersin Biolo- gyand Medicine. 2016;72:185-200. DOI: 10.1016/j.compbi- omed.2016.03.010. 18. Korablev DS, Nikitaev VG, Pronichev AN. The system for automatic recognition and classification of white blood cells in the image. NauchnayasessiyaNIYaU MIFI-2013: annotatsii- dokladov. M.: Natsional’nyy issledovatel’skiy yadernyy univer- sitet «MIFI»; 2013:271. (InRussian) 19. Pivtoratskaya SV, KulyabichevYuP. About the features of the structural approach to pattern recognition on digital images. VestnikNatsionalnogo issledovatel’skogoyadernogo universiteta MIFI. 2012;1:125. (InRussian) 20. Limanova NI, Ataev SG. Software parameterization of the objects computed tomography. Informatsionnyetekhnologii v nauke, upravlenii, sotsial’noy sfere i meditsine: sbornik nauch- nykh trudov II Mezhdunarodnoy konferentsii. Tomsk: Natsio-nal’nyy issledovatel’skiy Tomskiy politekhnicheskiy universitet; 2015: 870-871. (InRussian) 21. Doronicheva AV, Burkov SM, Savin SZ. Cross-browser web technologies for pattern recognition of low contrast objects in medical images. Informatsionnye tekhnologii v nauke, upravlenii, sotsial’noy sferei meditsine: sbornik nauchnykh trudov II Mezhdunarodnoy konferentsii. Tomsk: Natsional’nyy issledovatel’skiy Tomskiy politekhnicheskiy universitet; 2017:378-89. (InRussian) 22. Novikov IA, Makhotin SS, Surnina ZV. Calculation of coefficients of anisotropy and the symmetry orientation of the nerves of the cornea based on the automated recognition of digital confocal images. Biomedical Engineering. 2015;3:23-5. (InRussian) 23. Dmitriev GA, Kirsanova AV, Al’bakheliVaselAkhmed- Akhmed. Automation edge detection of brain stroke on the basis of threshold processing for magnetic resonance imaging. Biomedical Engineering. 2015;3:31-3. (InRussian) 24. Samorodov AV. Automated morphological analysis of cytologic preparations. Biomeditsinskaya radioelektronika. 2009; 10:35-40. (InRussian) 25. Narkevich AN. Algorithms for segmenting digital microscopic images of sputum stained by the method of Ziehl-Nielsen. World Science: Proceedings of articles the international scientific conference. Kirov: MCNIP LLC; 2017:431-36. (InRussian) Comments Warning: mysqli_query(): (42S02/1146): Table 'site57.sys_comment' doesn't exist in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 10 Table 'site57.sys_comment' doesn't exist Warning: mysqli_query(): (42S02/1146): Table 'site57.sys_comment' doesn't exist in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 53 Table 'site57.sys_comment' doesn't exist Warning: mysqli_num_rows() expects parameter 1 to be mysqli_result, bool given in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 33 Table 'site57.sys_comment' doesn't exist Warning: mysqli_fetch_assoc() expects parameter 1 to be mysqli_result, bool given in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 39 Table 'site57.sys_comment' doesn't exist Visits: 11537 Savchenko A.A., Grinshtein Y.I., Grinshtein I.Y., Gvozdev I.I., Petrova M.M. DEPENDENCE OF THROMBOCYTES METABOLISM FROM THE CHEMILUMINESCENT ACTIVITY OF NEUTROPHILES IN PATIENTS WITH DIFFERENT SENSITIVITY TO ACETYLSALICYLIC ACID IN ACUTE CORONARY SYNDROME Pages: 59-66 Savchenko AA, Grinshtein YuI, Grinshtein IYu, Gvozdev II, Petrova MM. Dependence of thrombocytes metabolism from the chemiluminesent activity of neutrophils in patients with different sensitivity to acetylsalicylic acid in acute coronary syndrome. Siberian Medical Review. 2017; (5): 59-66. DOI 10.20333/2500136-2017-5-59-66 Authors Savchenko Andrey Anatolievich Dr. Med.Sc, Professor, Head of the Department of Physiology named after Prof. A.T. Pshonik; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; aasavchenko@yandex.ru Grinshtein Yuriy Isaevich Dr.Med.Sc. , Professor, Head of the Department of Therapy PE; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; grinstein.yi@gmail.com Grinshtein I. Yu. ; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; grinst@rambler.ru Gvozdev Ivan Igorevich ; Institute of Medical Problems of the North; leshman-mult@mail.ru Petrova Marina Mikhailovna MD, PhD, Prof., Head of the Department of Outpatient Therapy, Family Medicine and HL with a course of Postgraduate Education; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; 660022, Красноярск, ул. Партизана Железняка, 1;тел.:8 (391)2200628; e-mail: stk99@yandex.ru Annotation The aim of the research. To study the peculiarities of the relationship between the parameters of hemostasis and the functional activity of neutrophils in patients with different sensitivity to acetylsalicylic acid (ASA) in acute coronary syndrome (ACS). Material and methods. Patients were examined in the first 24 hours from the development of ACS. All patients before the start of treatment and revascularization were examined for resistance to ASA and divided into groups of sensitive (AC) and resistant to ASA (AR). Assessment of resistance / sensitivity to ASA was carried out in vitro by sequential incubation of platelet-rich plasma with ASA. The control group is formed from 50 healthy volunteers. The activity of dehydrogenases in platelets was studied by bioluminescent method. The state of respiratory explosion of neutrophils was investigated by the chemiluminescent method Results. Metabolism of platelets in AC patients with ACS is characterized by inhibition of initial reactions of the tricarboxylic acid cycle and a decrease in NADP-dependent substrate metabolism between amino acid exchange reactions and the lemon cycle. In AP patients, the substrate flow through the Krebs cycle is more pronounced, but with the inhibition of the malate dehydrogenase reaction. At AC patients, minimal changes in the chemiluminescence kinetics are detected, which are determined by the accelerated synthesis of primary active oxygen species (ROS) with antigenic induction and slowing down the synthesis of secondary ROS. In AR patients with ACS, the state of respiratory explosion is determined by a decrease in the rate of synthesis of primary ROS, a slowdown in the synthesis of secondary ROS and a decrease in the activation index of neutrophils. In AC patients, the levels of synthesis of primary and secondary ROS depend on the intensity of energy and antioxidant processes, as well as substrate flows to the pentose phosphate cycle and glycolysis. In AC patients with ACS, the intensity of respiratory explosion of neutrophils co-directs only in the activity of energy processes in platelets. The conclusion.The mechanism of an inadequate response to ASA is caused not only by the metabolic state of thrombocytes in the conditions of acute ischemia, but also by the formation of a narrow spectrum of interrelations in the system of platelet-neutrophil association. Keywords: acute coronary syndrome, acetylsalicylic acid, platelets, neutrophils, NAD (F)-dependent dehydrogenases, respiratory burst Reference List: 1. Bae MH, Lee JH, Yang DH, Park HS, Cho Y, Chae SC. White blood cell, hemoglobin and platelet distribution width as short-term prognostic markers in patients with acute myocardial infarction. Journal of Korean Medical Science. 2014;29(4):519-26. DOI: 10.3346/jkms.2014.29.4.519. 2. Savchenko AA, Zdzitoveckij DJe, Borisov AG, Luzan NA. Chemiluminescent activity of neutrophils and concentration levels of cytokines in patients with widespread purulent peritonitis. Cytokines and inflammation. 2013;12(1-2):115-9. (In Russian) 3. Shkapova EA, Kurtasova LM, Savchenko AA. Lucigenin and luminol-dependent chemiluminescence of blood neutrophils in patients with renal cancer. Bulletin of Experimental Biology and Medicine. 2010;149(2):201-3. (In Russian) 4. El-Benna J, Hurtado-Nedelec M, Marzaioli V, Marie JC, Gougerot-Pocidalo MA, Dang PM. Priming of the neutrophil respiratory burst: role in host defense and inflammation. Immunological Reviews. 2016;273(1):180-93. DOI: 10.1111/ imr.12447. 5. Parenti A, Indorato B, Paccosi S. Minocycline affects human neutrophil respiratory burst and transendothelial migration. Inflammation Research. 2017;66(2):107-109. DOI: 10.1007/s00011-016-0999-x. 6. Moschos MM, Chatziralli IP, Stamatakis G, Papakonstantinou VD, Tsatsos M, Demopoulos CA. In Vitro Effects of Anti-Glaucomatous Eye Drops on Platelet-Activating Factor and its Metabolism. Seminars in Ophthalmology. 2017;32(2):198-203. DOI: 10.3109/08820538.2015.1053622. 7. Grinshtein YuI, Kosinova AA, Grinshtein IYu. Possible causes and mechanisms of development of secondary resistance to acetylsalicylic acid. Russian medical news. 2013;2:4-13. (In Russian) 8. ESC Guidelines For the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. The Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC). European Heart Journal. 2011;32:2999-3054. DOI:10.1093/eurheartj/ehr236 9. Grinshtein YuI, Filonenko IV, Savchenko AA, Savchenko EA, Grinshtein IYu. A method for diagnosing resistance to acetylsalicylic acid. Patent № 2413953 Russia, MPK G01N 33/86 (2006.01). Published 10.03.2009, Bul. № 7: 8 p. (In Russian) 10. Savchenko EA, Savchenko AA, Gerasimchuk AI, Grishchenko DA. Evaluation of the metabolic status of platelets in normal and ischemic heart disease. Klinichescheskaya Laboratornaya Diagnostika. 2006;5:33-6. (In Russian) 11. Kurtasova LM, Savchenko AA, Manchuk VT. Metabolic aspects immunorehabilitation of children with atopic diseases. Novosibirsk: Nauka, 2006; 222 p. (In Russian) 12. Engel PC. Glutamate dehydrogenases: the why and how of coenzyme specificity. Neurochemical Research. 2014;39(3):426-32. DOI: 10.1007/s11064-013-1089-x. 13. Rostami-Far Z, Ghadiri K, Rostami-Far M, Shaveisi- Zadeh F, Amiri A, Rahimian Zarif B. Glucose-6-phosphate dehydrogenase deficiency (G6PD) as a risk factor of male neonatal sepsis. Journal of Medicine and Life. 2016;9(1):34- 38. 14. Sharkey MA, Oliveira TF, Engel PC, Khan AR. Structure of NADP(+)-dependent glutamate dehydrogenase from Escherichia coli-reflections on the basis of coenzyme specificity in the family of glutamate dehydrogenases. 15. Federation of European Biochemical Societies Journal. 2013;280(18):4681-92. DOI: 10.1111/febs.12439. 16. Wang C, Chen H, Zhang J, Hong Y, Ding X, Ying W. Malate-aspartate shuttle mediates the intracellular ATP levels, antioxidation capacity and survival of differentiated PC12 cells. International Journal of Physiology, Pathophysiology and Pharmacology. 2014;6(2):109-14. Comments Warning: mysqli_query(): (42S02/1146): Table 'site57.sys_comment' doesn't exist in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 10 Table 'site57.sys_comment' doesn't exist Warning: mysqli_query(): (42S02/1146): Table 'site57.sys_comment' doesn't exist in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 53 Table 'site57.sys_comment' doesn't exist Warning: mysqli_num_rows() expects parameter 1 to be mysqli_result, bool given in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 33 Table 'site57.sys_comment' doesn't exist Warning: mysqli_fetch_assoc() expects parameter 1 to be mysqli_result, bool given in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 39 Table 'site57.sys_comment' doesn't exist Visits: 11497 Shimohina N.Y., Petrova M.M., Savchenko A.A. TREADMILL TEST INDICATORS IN PATIENTS WITH ACUTE CORONARY SYNDROME AND ANXIETY-DEPRESSIVE DISORDERS Pages: 66-72 Shimohina NYu, Petrova ММ, Savchenko АА. Treadmill test indicators in patients with acute coronary syndrome and anxiety-depressive disorders. Siberian Medical Review. 2017; (5): 66-72. DOI 10.20333/2500136-2017-5-66-72 Authors Shimohina Natalya Yurievna Cand. Med.Sc., Doctoral Student of the Department of Polyclinic Therapy, Family Medicine and Healthy Lifestyle with Postgraduate Courses; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; doctorkardiolog99@rambler.ru Petrova Marina Mikhailovna MD, PhD, Prof., Head of the Department of Outpatient Therapy, Family Medicine and HL with a course of Postgraduate Education; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; 660022, Красноярск, ул. Партизана Железняка, 1;тел.:8 (391)2200628; e-mail: stk99@yandex.ru Savchenko Andrey Anatolievich Dr. Med.Sc, Professor, Head of the Department of Physiology named after Prof. A.T. Pshonik; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; aasavchenko@yandex.ru Annotation The aim of the research. To evaluate the functional parameters of the cardiovascular system according to the sample with the measured physical activity in patients with acute coronary syndrome in combination with anxietydepressive disorders. Material and methods. 315 patients were examined in the first 24 hours after the development of acute coronary syndrome (ACS). In the first 72 hours after the transfer from the reanimation chamber to determine anxiety-depressive disorders (TDR), all patients underwent psychometric examination. On the 7-10th day to the hospital discharge, a sample with a measured physical activity was made. The following parameters were analyzed: the total duration of the activity, the threshold power of the work performed, the metabolic equivalent, the duration of the activity, the initial blood pressure and heart rate, the maximum heart rate, maximum systolic and diastolic blood pressure. Results. A positive result of treadmill test was observed more often in patients with ACS in combination with TDR in comparison with patients without affective disorders. The occurrence of pain angina pectoris was more common in patients with ACS in combination with TDR. In patients with ACS and TDR, obliquely downward depression of the ST segment was more common. The threshold of exercise tolerance, as well as the threshold load power in the ACS group with concomitant TDRs, were lower both in the control indicators and in the results of ACS patients without affective disorders. The duration of the load in the ACS and TDR group was significantly lower than that of patients with ACS without affective disorders. The conclusion. In patients with ACS, the presence of concomitant DDR has a negative effect on the functional parameters of the cardiovascular system, which may be one of the reasons for the high risk of repeated cardiovascular disasters. Keywords: ischemic heart disease, acute coronary syndrome, exercise test, treadmill test, anxiety, depression Reference List: 1. Samorodskaya IV, Kondrikova NV, Kazachek YaV, Barbarash OL, Boitsov SA. The Nosological structure of mortality circulatory system in 2006 and 2013. Kompleksnye problemy serdechno-sosudistykh zabolevanii. 2015;4:67-72. (In Russian) 2. Pilyugina M, Shimokhina N, Petrova M, Savchenko A, Pavlova N. Depression as a risk factor for thrombotic events in acute coronary syndrome. Vrach. 2014;12:60-63. (In Russian) 3. Chernyaeva MS, Petrova MM, Savchenko AA, Shimokhina NYu, Kaskaeva DS, Pronina EA. Acute myocardial infarction and affective spectrum disorders. Siberian Medical Review. 2015;(3):5-14. (In Russian) 4. Pogosova GV. Depressiona Risk Factor for Coronary Heart Disease and a Predictor of Coronary Death: 10 Years of Scientific Research. Kardiologiya. 2012;52(12):4-11. (In Russian) 5. Pinchuk AF. Depressive disorders and risk of cardiovascular events among patients after myocardial infarction. Meditsinskij zhurnal. 2015;1(51):34-38. (In Russian) 6. Batelaan NM, Seldenrijk A, Bot M, van Balkom AJ, Penninx BW. Anxiety and new onset of cardiovascular disease: critical review and meta-analysis. The British journal of psychiatry. 2016;208(3):223-31. DOI: 10.1192/bjp.bp.114.156554. 7. Celano CM, Millstein RA, Bedoya CA, Healy BC, Roest AM, Huffman JC. Association between anxiety and mortality in patients with coronary artery disease: A meta-analysis. American Heart Journal. 2015;170(6):1105-15. DOI: 10.1016/j. ahj.2015.09.013. 8. Shimokhina NYu, Pilyugina MS, Petrova MM, Savchenko AA, Eremina NP. Peculiarities of parameters of echo- cardiographic in patients with acute coronary syndrome with comorbid anxiety and depressive disorders. Bulletin of Siberian Medicine. 2014;6:34-39. (In Russian) 9. Kozhokar’ KG, Urvantseva IA, Nikolaev KYu. The influence of psychosocial factors on the development of ischemic heart disease and acute coronary syndrome. Kardiovaskulyar. terapiya iprofilaktika. 2016;15(3):58-62. (In Russian) 10. Diagnosis and treatment of patients with acute myocardial infarction with ST-segment elevation ECG. National clinical guidelines. M.: Silitseya-Polygraph Publ.; 2009:416-500. (In Russian). 11. Lupanov VP, Nuraliev EYu. Functional loading tests in the diagnosis of coronary heart disease. M.; 2012. 224 р. (In Russian) 12. Sharma K, Kohli P, Gulati M. An update on exercise stress testing. Current problems in cardiology. 2012;37(5):177-202. DOI: 10.1016/j.cpcardiol.2011.11.004 13. Boyle SH, Samad Z, Becker RC, Williams R, Kuhn C, Ortel TL, Kuchibhatla M, Prybol K, Rogers J, O’Connor C, Velazquez EJ, Jiang W. Depressive symptoms and mental stress-induced myocardial ischemia in patients with coronary heart disease. Psychosomatic medicine. 2013;75(9): 822-31. DOI: 10.1097/ PSY.0b013e3182a893ae. 14. Wei J, Rooks C, Ramadan R, Shah AJ, Bremner JD, Quyyumi AA, Kutner M, Vaccarino V. Meta-analysis of mental stress-induced myocardial ischemia and subsequent cardiac events in patients with coronary artery disease. The American Journal of Cardiology. 2014;114(2):187-92. DOI: 10.1016/j. amjcard.2014.04.022. 15. Carney RM, Freedland KE. Depression and coronary heart disease. Nature Reviews Cardiology. 2017;14(3):145-155. DOI: 10.1038/nrcardio.2016.181. Comments Warning: mysqli_query(): (42S02/1146): Table 'site57.sys_comment' doesn't exist in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 10 Table 'site57.sys_comment' doesn't exist Warning: mysqli_query(): (42S02/1146): Table 'site57.sys_comment' doesn't exist in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 53 Table 'site57.sys_comment' doesn't exist Warning: mysqli_num_rows() expects parameter 1 to be mysqli_result, bool given in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 33 Table 'site57.sys_comment' doesn't exist Warning: mysqli_fetch_assoc() expects parameter 1 to be mysqli_result, bool given in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 39 Table 'site57.sys_comment' doesn't exist Visits: 11486 Pavlyukova E.N., Kuzhel D.A., Matyushin G.V., Yakovlev E.I., Novoselov O.V. CORRELATION ANALYSIS OF LEFT VENTRICLE TWISTING AT BLOCKADE OF VENTRICULONECTOR LEFT LEG Pages: 73-79 Pavlyukova EN, Kuzhel DA, Matyushin GV, Yakovlev EI, Novoselov OV. Correlation analysis of left ventricle twisting at blockade of ventriculonector left leg. Siberian Medical Review. 2017;(5):73-79. DOI 10.20333/2500136-2017-5-73-79 Authors Pavlyukova Elena N. ; Scientific-Research Institute of Cardiology Federal state budgetary scientific institution Tomsk National Research Medical Center of the Russian Academy of Sciences; pavlyukovaelena@yandex.ru Kuzhel D. A. ; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; ofdkkb2@4mail.ru Matyushin Gennady Vasilievich Doctor of Medical Sciences, Professor, Head of the Department of Cardiology and Functional Diagnostics; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; matyushinl@yandex.ru Yakovlev Evgeny Iosifovich Associated Professor, Department of Highest Mathematic; Sibitian State Space University named after Academic M.F. Reshetnev; yei@nm.ru Novoselov Oleg Vadimovich Associated Professor, Department of Highest Mathematic; Sibitian State Space University named after Academic M.F. Reshetnev; novoselov_oleg_v@mail.ru Annotation The aim of the research. To study the relationship between LV twisting and hemodynamic parameters in patients with BLNGH and systolic dysfunction. Material and methods. Thirty patients with BLNGH with ischemic and dilated cardiomyopathies and LV ejection fraction less than 40 % were examined. All patients were divided into two groups of 15 people: with physiological multidirectional rotation of the basal sections and apex (group 1) and anomalous unidirectional (group 2). All patients underwent echocardiography with determination of hemodynamic parameters, myocardial deformation and twisting. Correlation connections between pairs of quantitative characteristics were carried out using the nonparametric Spearman rank coefficient. Results. In the group of BLNPH and physiological (multidirectional) rotation, a correlation was observed between twisting and rotation at the level of the apex and basal sections. In the group of anomalous (unidirectional) rotation, such connection was absent. When analyzing the correlation of the apical and basal rotation, as well as the resulting twisting with the parameters of hemodynamics in the group of physiological rotation, connections with heart rate, LV ejection fraction, local contractility index, diastolic function indices, global circular deformation at the apical level were revealed. In the group with anomalous rotation, the correlations of rotation and twisting with hemodynamic parameters were presented only with circular deformation at basal level and with pulmonary veins. The conclusion. Weak connections of rotation and twisting with indices of hemodynamics in the group of anomalous rotation may indicate a lack of significant mutual dependence and loss of the physiological role of twisting in contraction of the left ventricle. Keywords: systolic dysfunction, echocardiography, deformation of the myocardium, rotation, twisting, complete blockage of the ventriculonector left leg Reference List: 1. Pavlyukova EN, Kuzhel DA, Matyushin GV, Savchenko EA, Filippova SA. Left ventricular rotation, twist and untwist: physiological role and clinical relevance. Rational Pharmacotherapy in Cardiology. 2015;11(1):68-78. (In Russian) 2. Beladan CC, Calin A, Rosca M, Ginghina C, Popescu BA. Left ventricular twist dynamics: principles and applications. Heart. 2014;100:731-40. DOI: 10.1136/heartjnl-2012-302064. 3. Sengupta PP, Tajik AJ, Chandrasekaran K, Khandheria BK. Twist Mechanics of the Left Ventricle. JACC: Cardiovascular Imaging. 2008;1:366-76. DOI: 10.1016/j. jcmg.2008.02.006. 4. Pavlukova EN, Kuzhel DA, Matyushin GV, Lytkina VS. Left His bundle branch block associated with left ventricular torsion and reduced ejection fraction. Klinicheskaya Meditsina (Mosk). 2015;.93(11):15-21. (In Russian) 5. Bertini M, Sengupta P, Nucifora G, Delgado V, Ng A, Marsan N, Shanks M, van Bommel R, Schalij M, Narula J, Bax J. Role of Left Ventricular Twist Mechanics in the Assessment of Cardiac Dyssynchrony in Heart Failure. JACC: Cardiovascular Imaging. 2009;2(12):1425-35. DOI: 10.1016/j.jcmg.2009.09.013. 6. Briceno N, Schuster A, Lumley M, Perera Ischaemic cardiomyopathy: pathophysiology, assessment and the role of revascularization. Heart. 2016;102:397-406. DOI: 10.1136/heartjnl-2015-308037. 7. Mestroni L, Maisch B, McKenna WJ, Sshwartz K, Charron P, Rocco C, Tesson F, Richter A, Wilke A, Komajda M. Guidelines for the study of familial dilated cardiomyopathies. Collaborative Research Group of the European Human and Capital Mobility Project on Familial Dilated Cardiomyopathy. European Heart Journal. 1999;20:93-102. DOI: org/10.1053/euhj.1998.1145. 8. Lang R, Badano L, Mor-Avi V, Afilalo J, Armstrong A, Ernande L, Flachskampf F, Foster E, Goldstein S, Kuznetsova T, Lancellotti P, Muraru D, Picard M, Rietzschel E, Rudski L, Spencer K, Tsang W, Voigt J. Recommendations for Cardiac Chamber uantification by Echocardiography in Adults: An Update from the American Society hocardiog- raphy and the European Association of Cardiovascular Imaging. Journal of the American Society of Echocardiography. 2015;28:1-39. DOI: 10.1016/j.echo.2014.10.003. 9. Helle-Valle T, Crosby J, Edvardsen T, Lysseggen E, Amundsen BH, Smith HJ, Rosen BD, Lima JA, Torp H, Ihlen H, Smiseth OA. New noninvasive method for assessment of left ventricular rotation: speckle tracking echocardiography. Circulation. 2005;112:3149-56. DOI: 10.1161/ circulationaha.104.531558. 10. Nagueh SF, Smiseth OF, Appleton CP, Byrdn BF, Dokainish H, Edvardsen T, Flachskampf FA, Gillebert TC, Klein AL, Lancellotti P, Marino P, Oh JK, Popescu BA, Waggoner AD. Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography: an update from the American Society of Echocardiography and the European Association of Cardiovascular imaging. Journal of the American Society of Echocardiography. 2016;29:277-314. DOI:10.1016/j.echo.2016.01.011. 11. Karaahmet T, Gurel E, Tigen K, Guler A, Dundar C, Fotbolcu H, Basaran Y. The effect of myocardial fibrosis on left ventricular torsion and twist in patients with non-ischemic dilated cardiomyopathy. Cardiology Journal. 2013;20(3):276-86. DOI: 10.5603/cj.2013.0073. 12. van Dalen BM, Caliskan K, Soliman OI, Nemes A, Vietter WB, Ten Cate FJ, Geleijnse ML. Left ventricular solid body rotation in non-compaction cardiomyopathy: a potential new objective and quantitative functional diagnostic criterion? European Journal Heart Failure. 2008;10(11):1088-93. DOI: 10.1016/j.ejheart.2008.08.006. 13. Setser RM, Kasper JM, Lieber ML, Starling RC, McCarthy PM, White RD. Persistent abnormal left ventricular systolic torsion in dilated cardiomyopathy after partial left ventriculectomy. The Journal of Thoracic and Cardiovascular Surgery. 2003;126:48-55. DOI: org/10.1016/S0022- 5223(03)00050-3. 14. Partridge JB, Smerup MH, Petersen SE. Linking left ventricular function and mural architecture: what does the clinician need to know? 2014;100:1289-1298. DOI: 10.1136/ heartjnl-2013-304571. 15. Song J-K. How Does the Left Ventricle Work? Ventricular Rotation as a New Index of Cardiac Performance. Korean Circulation Journal. 2009;39:347-351. DOI: 10.4070/ kcj.2009.39.9.347. Comments Warning: mysqli_query(): (42S02/1146): Table 'site57.sys_comment' doesn't exist in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 10 Table 'site57.sys_comment' doesn't exist Warning: mysqli_query(): (42S02/1146): Table 'site57.sys_comment' doesn't exist in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 53 Table 'site57.sys_comment' doesn't exist Warning: mysqli_num_rows() expects parameter 1 to be mysqli_result, bool given in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 33 Table 'site57.sys_comment' doesn't exist Warning: mysqli_fetch_assoc() expects parameter 1 to be mysqli_result, bool given in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 39 Table 'site57.sys_comment' doesn't exist Visits: 11481 Pripachkina E.A., Filev A.P., Govorin A.V., Mukha N.V., Vasilenko P.V., Socolova N.A. PECULIARITIES OF VARIABILITY OF HEART RHYTHM IN PREGNANT WOMEN WITH IDIOPATHIC VENTRICULAR EXTRASYSTOLE Pages: 80-84 Pripachkina EA, Filev AP, Govorin AV, Mukha NV, Vasilenko PV, Socolova NA. Peculiarities of variability of heart rhythm in pregnant women with idiopathic ventricular extrasystole. Siberian Medical Review. 2017; (5): 80-84. DOI 10.20333/2500136-2017-5-80-84 Authors Pripachkina Ekaterina A. ; Chita State Medical Academy; ekaterinapripachkina@mail.ru Filev Andrey P. ; Chita State Medical Academy; andfilev@mail.ru Govorin Anatoly Vasilyevich Dr. Med.Sc., Professor, Rector, Head of Faculty Therapy Department; Chita State Medical Academy, Ministry of Health of the Russian Federation; pochta@chitgma.ru Mukha Natalia V. ; Chita State Medical Academy; mushanatasha@inbox.ru Vasilenko Pavel V. ; Chita State Medical Academy; pavelvasilenkochita@mail.ru Socolova Natalia A. ; Chita State Medical Academy; natalasocolova@mail.ru Annotation The aim of the research. To assess the features of the vegetative status according to the heart rate variability in pregnant women with idiopathic ventricular extrasystole. Material and methods. To study the variability of the heart rate, 24-hour ECG recording was made in 40 pregnant women with ventricular arrhythmias. Control groups consisted of somatically healthy pregnant and non-pregnant women with no heart rhythm disturbances. Holter monitoring of the ECG was carried out according to a standard procedure using the 24-hour cardiovascular monitoring complex “Cardiotechnics-4000”. Statistical processing of the obtained data in the study was carried out using the STATISTICA 10.0 software package. Results. It was found that for pregnant women, the main temporal and spectral indices of cardiac rhythm variability are typically. The lower cardiac rhythm variability parameters, responsible for the total spectrum power (SDNN, TP), as well as the parameters characterizing the influence of the sympathetic part of the vegetative nervous system on the regulation of the heart rhythm (SDNNi, LF, VLF) and parasympathetic innervation (RMSSD, pNN50, HF ) were noted. These changes are more pronounced in the presence of idiopathic ventricular arrhythmias IV-V gradation by Ryan. In addition, in this category of patients it was noted a greater contribution of central neurohumoral influences (VLF %) and, on the contrary, less-peripheral vagal influences (HF%). The conclusion. In pregnant patients with idiopathic ventricular extrasystole of IV-V gradation by Ryanit was revealed overstrain of adaptation processes in the form of a predominant influence on the regulation of the heart rhythm of higher vegetative centers, as well as moderate hypersympathicotonia; it was noted smaller contribution of peripheral vagal influences against the background of a lower total cardiac rhythm variability. Keywords: children, newborns, infantile cerebral palsy, perinatal CNS lesion, family anamnesis Reference List: 1. Bukhonkina YuM. Cardiac arrhythmias in pregnant women - the current state of the problem. Zdravookhranenie Dalnego Vostoka. 2014;4:76-83. (In Russian) 2. Apresyan SV. Pregnancy and childbirth with extragenital diseases. M.: GEOTAR Media; 2009. 464 p. (In Russian) 3. Mravyan SR, Petrukhin VA. Cardiac arrhythmias and con¬duction disturbance in pregnant women. Moscow: Miklyush; 2011. 128 p. (In Russian) 4. Shekhtman MM. Guide extragenital pathology in pregnant women. M.: TriadaKh; 2013. 896 p. (In Russian) 5. Logutova LS, ed. Extragenital pathology and pregnancy. M. : Littera; 2012. 544 p. (In Russian)) 6. Gowda MR, Khan IA, Mehta NJ, Vasavada BC, Sacchi TJ. Cardiac arrhythmias in pregnancy: clinical and therapeutic con¬siderations. Journal of Cardiology. 2003;88:129-133. 7. Stryuk RI. Possible causes and character of cardiac arrhythmias during pregnancy. Problemy zhenskogo zdorov’ya. 2008;2:37-41 (In Russian). 8. Stryuk RI. Diagnosis and treatment of cardiovascular disease in pregnancy: national guidelines. Moscow; 2013.40 p. (In Russian) 9. Stryuk RI. Diseases of the cardio-vascular system and pregnancy. M.: GEOTAR Media; 2010.280 p. (In Russian). 10. Pagani M. Heart rate variability and pregnancy. Editorial commentaries. Journal of Hypertension. 2002;20:2125-126. 11. Kleshchenogov SA, Fleyshman AN. Spectral computer analysis of the cardiac rhythm of pregnant women: assessment of the course and prediction of complications of pregnancy: method. A manual for practicing doctors. Novokuznetsk; 2003. 40 p. (In Russian) 12. Revina NE. The variability of heart rhythm as an indicator of vegetative regulation of the heart with emotional stress of a person. Bulletin of the Russian Academy of Medical Sciences. 2006;2: 415. (In Russian) 13. Veyn AM. Vegetative disorders. Clinic, diagnosis, treat¬ment. M.: Meditsina; 2003. 752 (In Russian). 14. Akselrod AS, Chomakhidze PSh, Syrkin AL. Holter monitoring of ECG: possibilities, difficulties, errors. M.: MIA; 2007.187. (In Russian) 15. Baevskiy, RM, Ivanov GG.Heart rate variability: theoretical aspects and possibilities of clinical application. M.: Medicine, 2000. 240 p. (In Russian) 16. Mikhaylov VM. The variability of the rhythm of the heart. Practical experience. Ivanovo; 2000. 200 p. (In Russian) 17. Zakharova NYu, Mikhaylov VP. Physiological features of the variability of the rhythm of the heart in different age groups. Vestnik aritmologii. 2003;31:37-40. (In Russian) 18. Heart rate variability. Standards of measurement, physiological interpretation and clinical use. Working Group of the European Society of Cardiology and the North American So¬ciety of Stimulation and Electrophysiology. SPb.: AOOT Tipo- grafiya «Pravda»; 2000. 65 p. (In Russian) 19. Shubik YuV. Daily monitoring of ECG in cases of heart rhythm and conduction disorders. SPb.: INKART; 216 p. (In Russian) 20. Sokolova NA, Govorin AV, Khyshiktuev BS, Gorbunov VV. Predicting capabilities of some electrophysiological indices in pa¬tients with unstable angina. In VINITI; 2004. 84-B. (In Russian) 21. Sobolev AV. Methods for analyzing heart rate variability over long periods of time. M.: Medpraktika - M; 2009. 172 p. (In Russian) 22. Ryabykina GV. ECG monitoring with heart rate variability analysis. M.: Medpraktika-M; 2005.222 p. (In Russian) 23. Ryabykina GV, Sobolev AV. The variability of the rhythm of the heart. M.: Starko; 1998. 200 p. (In Russian) 24. Chamchad D, Horrow JC, Nakhamchik L. Heart rate variability changes during pregnancy: an observational study. International Journal of Obstetric Anesthesia. 2007;16:106-9. DOI: 10.1016/j .ijoa.2006.08.008. 25. Huikuri HV, Stein PK. Heart rate variability in risk strati¬fication of cardiac patients. Cardiovascular Disease. 2013;56 (2):153-59. DOI: 10.1016/j.pcad.2013.07.003. 26. Sookan T, McKune AJ. Heart rate variability in physically active individuals: reliability and gender characteristics. Cardiovascular Journal. 2012; 23(2):67-72. DOI: 10.5830/CVJA-2011.108. Comments Warning: mysqli_query(): (42S02/1146): Table 'site57.sys_comment' doesn't exist in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 10 Table 'site57.sys_comment' doesn't exist Warning: mysqli_query(): (42S02/1146): Table 'site57.sys_comment' doesn't exist in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 53 Table 'site57.sys_comment' doesn't exist Warning: mysqli_num_rows() expects parameter 1 to be mysqli_result, bool given in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 33 Table 'site57.sys_comment' doesn't exist Warning: mysqli_fetch_assoc() expects parameter 1 to be mysqli_result, bool given in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 39 Table 'site57.sys_comment' doesn't exist Visits: 11466 Dochkina E.S., Ustinova A.V., Taranushenko T.E. PECULIARITIES OF ANAMNESIS IN CHILDREN WITH INFANTILE CEREBRAL PALSY Pages: 85-90 Pripachkina EA, Filev AP, Govorin AV, Mukha NV, Vasilenko PV, Socolova NA. Peculiarities of variability of heart rhythm in pregnant women with idiopathic ventricular extrasystole. Siberian Medical Review. 2017; (5): 80-84. DOI 10.20333/2500136-2017-5-80-84 Authors Dochkina Elena S. ; Profmed Ltd. Clinic Elife; helenad.73@mail.ru Ustinova Alena V. ; Krasnoyarsk Regional Children`s Hospital; 2956959@mail.ru Taranushenko Tatyana Evgenyevna Dr.Med.Sc, Professor, Head of the Department of Pediatrics; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; tetar@rambler.ru Annotation The aim of the research. To assess the features of the vegetative status according to the heart rate variability in pregnant women with idiopathic ventricular extrasystole. Material and methods. To study the variability of the heart rate, 24-hour ECG recording was made in 40 pregnant women with ventricular arrhythmias. Control groups consisted of somatically healthy pregnant and non-pregnant women with no heart rhythm disturbances. Holter monitoring of the ECG was carried out according to a standard procedure using the 24-hour cardiovascular monitoring complex “Cardiotechnics-4000”. Statistical processing of the obtained data in the study was carried out using the STATISTICA 10.0 software package. Results. It was found that for pregnant women, the main temporal and spectral indices of cardiac rhythm variability are typically. The lower cardiac rhythm variability parameters, responsible for the total spectrum power (SDNN, TP), as well as the parameters characterizing the influence of the sympathetic part of the vegetative nervous system on the regulation of the heart rhythm (SDNNi, LF, VLF) and parasympathetic innervation (RMSSD, pNN50, HF ) were noted. These changes are more pronounced in the presence of idiopathic ventricular arrhythmias IV-V gradation by Ryan. In addition, in this category of patients it was noted a greater contribution of central neurohumoral influences (VLF %) and, on the contrary, less-peripheral vagal influences (HF%). The conclusion. In pregnant patients with idiopathic ventricular extrasystole of IV-V gradation by Ryanit was revealed overstrain of adaptation processes in the form of a predominant influence on the regulation of the heart rhythm of higher vegetative centers, as well as moderate hypersympathicotonia; it was noted smaller contribution of peripheral vagal influences against the background of a lower total cardiac rhythm variability. Keywords: pregnancy, cardiac rhythm disturbances, ventricular extrasystole, holter ECG monitoring, heart rate variability, hypersympathicotonia Reference List: 1. O’Callaghan ME, MacLennan AH, Gibson CS, McMi- chael GL, Haan EA, Broadbent JL, Baghurst PA, Goldwater PN, Dekker GA. Australian Collaborative Cerebral Palsy Research Group. Genetic and clinical contributions to cerebral palsy: a multi-variable analysis. Journal of paediatrics and child health. 2013;49 (7):575-81. 2. Studenikin VM, Buksh AA, Kuzenkova LM, Kurenkov AL. Children’s cerebral palsy and epilepsy: epidemiology and etiology. The treating doctor. 2016;3:68-72. (In Russian) 3. Ledyaykina LV, Balykova LA, Garina SV, Soldatova ON, Tolkunova AA, Stradina AA, Gerasimenko AV. Some aspects of the pathogenesis of ischemic-hypoxic lesions of the cen¬tral nervous system in newborns. Samara Scientific Bulletin. 2015;2(11):112-15. (In Russian) 4. Chen Chien-Yi, Sun Wei-Zen, Kang Kai-Hsiang, Chou Hung-Chieh, Tsao Po-Nien, Hsieh Wu-Shiun, Fu Wen-Mei. Hypoxic Preconditioning Suppresses Glial Activation and Neuroinflammation in Neonatal Brain Insults. Hindawi Publishing Corporation Mediators of Inflammation. 2015;2015:1-11. 5. Bryksina EYu, Bryksin VS, Bushtyreva VA, Onianget EP. Pathogenetic aspects of perinatal involvement of the central nervous system and features of neurological state of premature babies. Modern problems of science and education. 2015;4:4106. (In Russian) 6. Sitnikova LN, Lavlinskaya LI. Organization of medical care for pregnant high-risk groups. Bulletin of new medical technolo¬gies. 2014;1:65. (In Russian) 7. Xue J, Chen LZ, Xue L, Zhou Q. Meta-analysis of risk factors for childhood cerebral palsy during pregnancy. Zhongguo Dang Dai Er Ke Za Zhi. 2013;15(7):535-40. 8. Ahlin K, Himmelmann K, Hagberg G, Kacerovsky M, Cobo T, Wennerholm UB, Jacobsson B. Non-infectious risk factors for different types of cerebral palsy in term-born babies: a popula¬tion-based, case-control study. BJOG. 2013;120(6):724-31. 9. Semenova TV, Arzhanova ON, Bespalova ON, Milutina Yu.P., Prokopenko VM, Zubzhitskaya LB, Arutyunyan AV. Features of the course of pregnancy and the outcome of labor during tobacco smoking. Journal of Obstetrics and Women’s Diseases. 2014;LXIII(2):50-8. (In Russian) 10. Kovalev EV, Zanko YuV, Trubkina TYu. Risk factors for fetal growth retardation associated with the state of health and lifestyles of a pregnant woman. Mother and child in Kuzbass. 2014;4:24-8. (In Russian) 11. Popov AP, Kiselev OI. Influenza in pregnant women. Epidemiology and infectious diseases. 2013;3:40-3. (In Russian) 12. Sozaeva DI, Berezhanskaya SB. Immunopathogenetic mechanisms of formation of motor disorders in infants born from mothers with complicated course of pregnancy and childbirth. Modern problems of science and education. 2013;5:336. (In Russian) 13. Miller JM, Low LK, Zielinski R. Evaluating maternal recovey from labor and delivery: bone and levator and injuries. American journal of obstetrics and gynecology. 2015; 21(188):1-11. 14. Gulaya VS. The role of proteolytic enzyme activity in the development of delayed fetal growth against a background of chronic placental insufficiency. Almanac of modern science and education. 2014;9(87):42-5. (In Russian) 15. Ustinova SI, Taranushenko TE, Ustinova AV, Karpova L.N. Pathology of the placenta - as a risk factor for the realization of infantile cerebral palsy. Siberian Medical Review. 2010;6:72-5. (In Russian) Comments Warning: mysqli_query(): (42S02/1146): Table 'site57.sys_comment' doesn't exist in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 10 Table 'site57.sys_comment' doesn't exist Warning: mysqli_query(): (42S02/1146): Table 'site57.sys_comment' doesn't exist in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 53 Table 'site57.sys_comment' doesn't exist Warning: mysqli_num_rows() expects parameter 1 to be mysqli_result, bool given in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 33 Table 'site57.sys_comment' doesn't exist Warning: mysqli_fetch_assoc() expects parameter 1 to be mysqli_result, bool given in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 39 Table 'site57.sys_comment' doesn't exist Visits: 11447 Bezdenezhnykh A.V., Sumin A.N. EVALUATION OF CARDIAC-VASCULAR COMPLICATIONS RISK IN OUT-OF-CARDIAC SURGERY: COMORBIDITY AND USE OF CLINICAL EVALUATION SCALE Pages: 90-105 Bezdenezhnykh AV, Sumin AN. Evaluation of cardiac-vascular complications risk in out-of-cardiac surgery: comorbidity and use of clinical evaluation scale. Siberian Medical Review. 2017; (5): 90-105. DOI 10.20333/2500136-2017-5-90-105 Authors Bezdenezhnykh Andrey Viktorovich ; Research Institute for Complex Issues of Cardiovascular Diseases; Кемерово, ул. Сосновый бульвар, 6; тел.: +7(384)2645360; e-mail: bezdav@kemcardio.ru Sumin Aleksey Nikolaevich ; Research Institute for Complex Issues of Cardiovascular Diseases; Кемерово, ул. Сосновый бульвар, 6; тел.: +7(384)2644461; e-mail: sumian@ kemcardio.ru Annotation Cardiovascular complications with out-of-cardiac surgery are an urgent problem of modern medicine. A number of national and international recommendations have been established to manage the risk of such complications. As a basis for the decision of the physician in such guidelines algorithms are proposed, a significant part of which is the clinical evaluation of the perioperative risk of cardiac complications. To optimize the work of a doctor or a multidisciplinary team of specialists, a series of scales and indices have been proposed that allow to assess the probability of cardiovascular complications and help in making a decision. In this article practical aspects of the use of the scales of clinical risk assessment are considered, their comparative characteristics and application peculiarities are given, and practical approaches to management of perioperative cardiac risk of out-of-cardiac surgery are discussed in case of detection of individual comorbid conditions in the patient outside the recommendations algorithms. Keywords: noncardial operative interventions, cardiovascular complications, clinical assessment of risk Reference List: 1. Haynes AB, Weiser TG, Berry WR, Lipsitz SR, Breizat AH, Dellinger EP, Herbosa T, Joseph S, Kibatala PL, Lapitan MC, Merry AF, Moorthy K, Reznick RK, Taylor B, Gawande AA; Safe Surgery Saves Lives Study Group. A surgical safety checklist to reduce morbidity and mortality in a global population. The New England Journal of Medicine. 2009;360(5):491-9. DOI: 10.1056/ NEJMsa0810119. 2. Devereaux PJ, Chan MT, Alonso-Coello P, Walsh M, Berwanger O, Villar JC, Wang CY, Garutti RI, Jacka MJ, Sigamani A, Srinathan S, Biccard BM, Chow CK, Abraham V, Tiboni M, Pettit S, Szczeklik W, Lurati Buse G, Botto F, Guyatt G, Heels- Ansdell D, Sessler DI, Thorlund K, Garg AX, Mrkobrada M, Thomas S, Rodseth RN, Pearse RM, Thabane L, McQueen MJ, VanHelder T, Bhandari M, Bosch J, Kurz A, Polanczyk C, Malaga G, Nagele P, Le Manach Y, Leuwer M, Yusuf S. Vascular Events In Non-cardiac Surgery Patients Cohort Evaluation (VISION) Study Investigators Association between postoperative troponin levels and 30-day mortality among patients undergoing non-cardiac surgery. JAMA. 2012;307(21):2295-304. DOI: 10.1001/ jama.2012.5502. 3. ACC/AHA 2007 guidelines on perioperative cardiovascular evaluation and care for non-cardiac surgery: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines on Perioperative Cardiovascular Evaluation for Non-cardiac Surgery) developed in collaboration with the American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Rhythm Society, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, and Society for Vascular Surgery. Journal of the American College of Cardiology.2007;50(17):e159-241. DOI:10.1016/j. jacc.2007.09.003. 4. Poldermans D, Bax JJ, Boersma E, De Hert S, Eeckhout E, Fowkes G, Gorenek B, Hennerici MG, Iung B, Kelm M, Kjeld- sen KP, Kristensen SD, Lopez-Sendon J, Pelosi P, Philippe F, Pierard L, Ponikowski P, Schmid JP, Sellevold OF, Sicari R, Van den Berghe G, Vermassen F. Task Force for Preoperative Car¬diac Risk Assessment and Perioperative Cardiac Management in Non-cardiac Surgery; European Society of Cardiology (ESC). Guidelines for pre-operative cardiac risk assessment and perio¬perative cardiac management in non-cardiac surgery. European Heart Journal. 2009;30(22):2769-812. DOI: 10.1093/eurheartj/ ehp337. 5. Fleisher LA, Fleischmann KE, Auerbach AD, Barnason SA, Beckman JA, Bozkurt B, Davila-Roman VG, Gerhard-Herman MD, Holly TA, Kane GC, Marine JE, Nelson MT, Spencer CC, Thompson A, Ting HH, Uretsky BF, Wijeysundera DN; American College of Cardiology; American Heart Association. 2014 ACC/AHA guideline on perioperative cardiovascular evaluation and management of patients undergoing non-cardiac surgery: a report of the American College of Cardiology/American Heart Association task force on practice guidelines. Journal of the American College of Cardiology. 2014;64(22):e77-e137. DOI:10.1016/j.jacc.2014.07.944. 6. Kristensen SD, Knuuti J, Saraste A, Anker S, B0tker HE, Hert SD, Ford I, Gonzalez-Juanatey JR, Gorenek B, Heyndrickx GR, Hoeft A, Huber K, Iung B, Kjeldsen KP, Longrois D, Luscher TF, Pierard L, Pocock S, Price S, Roffi M, Sirnes PA, Sousa-Uva M, Voudris V, Funck-Brentano C. Authors/Task Force Members. 2014 ESC/ESA Guidelines on non-cardiac surgery: cardiovascular assessment and management: The Joint Task Force on non-cardiac surgery: cardiovascular assessment and management of the European Society of Cardiology (ESC) and the European Society of Anaesthesiology (ESA). European Heart Journal. 2014;35(35):2383-431. DOI: 10.1093/eurheartj/ehu282. 7.Shhukin JuV, Hohlunov SM, Surkova EA, Dupljakov DV, Vachjov AN, Germanov AV, Zemljanova ME, Kruglov VN, Kuz'min VP, Ljas MN, Pavlova GA, Pavlova TV, Poljakov VP, Rjabov AE, Skuratova MA, Chomahidze PSh, Shvarc JuG, Boj- cov SA, Veselkova NS, Gendlin GE. Prediction and prevention of cardiac complications of non-cardiac surgery. Cardiovascular Therapy and Prevention. 2011;10(6)S3:1-28. (In Russian) 8. Biccard BM. Relationship between the inability to climb two flights of stairs and outcome after major non-cardiac surgery: implications for the pre-operative assessment of functional capacity. Anaesthesia. 2005;60(6):588-93. 9. Salzwedel A, Reibis R, Wegscheider K, Eichler S, Buhlert H, Kaminski S, Vdller H. Cardiopulmonary exercise testing is predictive of return to work in cardiac patients after multicomponent rehabilitation. Clinical Research in Cardiology. 2016;105(3):257-67. DOI: 10.1007/s00392-015-0917-1. 10. Senthong V, Wu Y, Hazen SL, Tang WH. Predicting longterm prognosis in stable peripheral artery disease with baseline functional capacity estimated by the Duke Activity Status Index. American Heart Journal. 2017;184:17-25. DOI: 10.1016/j. ahj.2016.10.009. 11. Hlatky MA, Boineau RE, Higginbotham MB, Lee KL, Mark DB, Califf RM, Cobb FR, Pryor DB.A brief self-administered questionnaire to determine functional capacity (the Duke Activity Status Index). The American Journal of Cardiology. 1989;64(10):651-4. 12. Barbarash LS, Sumin AN, Evdokimov DO, Bezdenezhnykh AV, Korok EV, Ivanov SV, Moiseenkov GB, Barbarash OL. Role of coronary angiography in decreasing cardiac complications rate during vascular operations. Angiology and Vascular Surgery. 2012;18(4):33-41. (In Russian) 13. Lee TH, Marcantonio ER, Mangione CM, Thomas EJ, Po- lanczyk CA, Cook EF, Sugarbaker DJ, Donaldson MC, Poss R, Ho KK, Ludwig LE, Pedan A, Goldman L. Derivation and pro¬spective validation of a simple index for prediction of cardiac risk of major non-cardiac surgery. Circulation. 1999;100(10):1043-9. 14. Goldman L, Caldera DL, Nussbaum SR, Southwick FS, Krogstad D, Murray B, Burke DS, O'Malley TA, Goroll AH, Ca- plan CH, Nolan J, Carabello B, Slater EE. Multifactorial index of cardiac risk in non-cardiac surgical procedures. The New Eng¬land Journal of Medicine. 1977;297(16):845-50. DOI: 10.1056/ NEJM197710202971601. 15. Detsky AS, Abrams HB, Forbath N, Scott JG, Hilliard JR. Cardiac assessment for patients undergoing non-cardiac surgery. A multifactorial clinical risk index. Archives of Internal Medicine. 1986;146(11):2131-4. 16. Simeoni R, Breitenstein K, Efier D, Guntinas-Lichius O. Cardiac comorbidity in head and neck cancer patients and its influence on cancer treatment selection and mortality: a pro¬spective cohort study. European Archives of Oto-rhino-laryngology. 2016;273(9):2765-72. DOI: 10.1007/s00405-015-3836-x. 17. Roshanov PS, Walsh M, Devereaux PJ, MacNeil SD, Lam NN, Hildebrand AM, Acedillo RR, Mrkobrada M, Chow CK, Lee VW, Thabane L, Garg AX. External validation of the Revised Cardiac Risk Index and update of its renal variable to predict 30- day risk of major cardiac complications after non-cardiac surgery: rationale and plan for analyses of the VISION study. BMJ Open. 2017;7(1):e013510. DOI: 10.1136/bmjopen-2016-013510. 18. Bertges DJ, Goodney PP, Zhao Y, Schanzer A, Nolan BW, Likosky DS, Eldrup-Jorgensen J, Cronenwett JL; Vascular Study Group of New England. The Vascular Study Group of New England Cardiac Risk Index (VSG-CRI) predicts cardiac complications more accurately than the Revised Cardiac Risk Index in vascular surgery patients. Journal of Vascular Surgery. 2010;52(3):674-83:e1-683.e3. DOI: 10.1016/j.jvs.2010.03.031. 19. Waterman BR, Belmont PJ Jr, Bader JO, Schoenfeld AJ. The Total Joint Arthroplasty Cardiac Risk Index for Predicting Perioperative Myocardial Infarction and Cardiac Arrest After Primary Total Knee and Hip Arthroplasty. The Journal of Arthroplasty. 2016;31(6):1170-4. DOI: 10.1016/j.arth.2015.12.013. 20. Gupta PK, Gupta H, Sundaram A, Kaushik M, Fang X, Miller WJ, Esterbrooks DJ, Hunter CB, Pipinos II, Johanning JM, Lynch TG, Forse RA, Mohiuddin SM, Mooss AN. Develop¬ment and validation of a risk calculator for prediction of cardiac risk after surgery. Circulation.2011;124(4):381-7. DOI:10.1161/ CIRCULATIONAHA.110.015701. 21. Cuvillon P, Nouvellon E, Marret E, Albaladejo P, Fortier LP, Fabbro-Perray P, Malinovsky JM, Ripart J. American Society of Anesthesiologists' physical status system: a multicentre Francophone study to analyse reasons for classification disagreement. European Journal of Anaesthesiology. 2011;28(10):742-7. DOI: 10.1097/EJA.0b013e328348fc9d. 22. Theivanayagam S, Lopez KT, Matteson-Kome ML, Bechtold ML, Asombang AW. ASA Classification Pre-Endoscopic Procedures: A Retrospective Analysis on the Accuracy of Gastroenterologists. Southern Medical Journal. 2017;110(2):79-82. DOI: 10.14423/SMJ.0000000000000610. 23. Lee TH, Goldman L. Letter by Lee and Goldman regarding article, Development and validation of a risk calculator for prediction of cardiac risk after surgery. Circulation. 2012;125(7):e385; author reply e386. DOI: 10.1161/CIRCULATIONAHA.111. 068999. 24. Bilimoria KY, Liu Y, Paruch JL, Zhou L, Kmiecik TE, Ko CY, Cohen ME. Development and evaluation of the universal ACS NSQIP surgical risk calculator: a decision aid and informed consent tool for patients and surgeons. Journal of the American College of Surgeons. 2013;217(5):833-42.e1-3. DOI: 10.1016/j. jamcollsurg.2013.07.385. 25.Sumin AN, Bezdenezhnykh AV, Evdokimov DO, Ivanov SV, Moiseenkov GV, Barbarash OL. Potential of coronary angiography in the assessment of cardiac complication risk during non-cardiac interventions. Russian Journal of Cardiology. 2013;100(2):38-44 (In Russian) 26. Eslami MH, Rybin D, Doros G, Kalish JA, Farber A; Vascular Study Group of New England. Comparison of a Vascular Study Group of New England risk prediction model with established risk prediction models of in-hospital mortality after elective abdominal aortic aneurysm repair. Journal of Vascular Surgery. 2015;62(5):1125-33.e2. DOI: 10.1016/j.jvs.2015.06.051. 27. Eslami MH, Rybin D, Doros G, Farber A. An externally validated robust risk predictive model of adverse outcomes after carotid endarterectomy. Journal of Vascular Surgery. 2016;63(2):345-54. DOI: 10.1016/j.jvs.2015.09.003. 28. Bertges DJ, Neal D, Schanzer A, Scali ST, Goodney PP, Eldrup-Jorgensen J, Cronenwett JL; Vascular Quality Initiative. The Vascular Quality Initiative Cardiac Risk Index for predic¬tion of myocardial infarction after vascular surgery. Journal of Vascular Surgery. 2016;64(5):1411-1421.e4. DOI: 10.1016/j. jvs.2016.04.045. 29. Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JG, Coats AJ, Falk V, Gonzalez-Juanatey JR, Harjola VP, Jankowska EA, Jessup M, Linde C, Nihoyannopoulos P, Parissis JT, Pieske B, Riley JP, Rosano GM, Ruilope LM, Ruschitzka F, Rutten FH, van der Meer P; Authors/Task Force Members. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. European Heart Journal. 2016;37(27):2129-200. DOI: 10.1093/eurheartj/ehw128. 30. Cho DH, Park SM, Kim MN, Kim SA, Lim H, Shim WJ. Presence of preoperative diastolic dysfunction predicts postoperative pulmonary edema and cardiovascular complications in patients undergoing non-cardiac surgery. Echocardiography. 2014;31(1):42-9. DOI: 10.1111/echo.12285. 31. Xu-Cai YO, Brotman DJ, Phillips CO, Michota FA, Tang WH, Whinney CM, Panneerselvam A, Hixson ED, Garcia M, Francis GS, Jaffer AK. Outcomes of patients with stable heart failure undergoing elective non-cardiac surgery. Mayo Clinic Proceedings. 2008;83(3):280-8. DOI: 10.4065/83.3.280. 32. Sumin AN, Bezdenezhnykh AV, Evdokimov DO, Korok EV, Ivanov SV, Barbarash OL, Barbarash LS. Left ventricle systolic dysfunction and postoperative complications risk of non-coronary vascular surgery. Russian Heart Failure Journal. 2010;11(6):347-354. (In Russian) 33. Kontogeorgos S, Thunstrdm E, Johansson MC, Fu M. Heart failure with preserved ejection fraction has a better longterm prognosis than heart failure with reduced ejection fraction in old patients in a 5-year follow-up retrospective study.International Journal of Cardiology. 2017;232:86-92. DOI: 10.1016/j. ijcard.2017.01.048. 34. Oren O, Goldberg S. Heart Failure with Preserved Ejection Fraction - Diagnosis and Management. American Medical Journal. 2017;130(5):510-6. DOI: 10.1016/j.amjmed.2016.12.031. 35. Mor-Avi V, Lang RM, Badano LP, Belohlavek M, Car- dim NM, Derumeaux G, Galderisi M, Marwick T, Nagueh SF, Sengupta PP, Sicari R, Smiseth OA, Smulevitz B, Takeuchi M, Thomas JD, Vannan M, Voigt JU, Zamorano JL. Current and evolving echocardiographic techniques for the quantitative evaluation of cardiac mechanics: ASE/EAE consensus statement on methodology and indications endorsed by the Japanese Society of Echocardiography. European Journal of Echocardiogra¬phy. 2011;12(3):167-205. DOI: 10.1093/ejechocard/jer021. 36. Wijeysundera DN, Beattie WS, Karkouti K, Neuman MD, Austin PC, Laupacis A. Association of echocardiography before major elective non-cardiac surgery with postoperative survival and length of hospital stay: population based cohort study. BMJ. 2011;342:d3695. DOI: 10.1136/bmj.d3695. 37. Brecher O, Gulati H, Roistacher N, Zhang H, Shi W, Thaler HT, Amar D. Preoperative Echocardiographic Indices of Diastolic Dysfunction and Brain Natriuretic Peptide in Predicting Postoperative Atrial Fibrillation After Noncardiac Surgery. Anesthesia and Analgesia. 2016;124(4):1099-104. DOI: 10.1213/ ANE.0000000000001471. 38. Malhotra AK, Ramakrishna H. N-terminal pro B type natriuretic peptide in high cardiovascular-risk patients for noncardiac surgery: What is the current prognostic evidence? Annals of Cardiac Anaesthesia. 2016;19(2):314-20. DOI: 10.4103/0971- 9784.179636. 39. Rodseth RN, Biccard BM, Le Manach Y, Sessler DI, Lurati Buse GA, Thabane L, Schutt RC, Bolliger D, Cagini L, Cardinale D, Chong CP, Chu R, Cnotliwy M, Di Somma S, Fahrner R, Lim WK, Mahla E, Manikandan R, Puma F, Pyun WB, Radovic M, Rajagopalan S, Suttie S, Vanniyasingam T, van Gaal WJ, Wal- iszek M, Devereaux PJ. The prognostic value of pre-operative and post-operative B-type natriuretic peptides in patients undergoing noncardiac surgery: B-type natriuretic peptide and N- terminal fragment of pro-B-type natriuretic peptide: a system¬atic review and individual patient data meta-analysis. Journal of the American College of Cardiology. 2014;63(2):170-80. DOI: 10.1016/j.jacc.2013.08.1630. 40. Raymer K, Yang H. Patients with aortic stenosis: cardiac complications in non-cardiac surgery. Canadian Journal of Anaesthesia. 1998;45(9):855-9. DOI: 10.1007/BF03012219. 41. Tarantini G, Nai Fovino L, Tellaroli P, Fabris T, Iliceto S. Asymptomatic Severe Aortic Stenosis and Noncardiac Sur¬gery. The American Journal of Cardiology. 2016;117(3):486-8. DOI: 10.1016/j.amjcard.2015.11.020. 42. Vahanian A, Alfieri O, Andreotti F, Antunes MJ, Baron- Esquivias G, Baumgartner H, Borger MA, Carrel TP, De Bonis M, Evangelista A, Falk V, Iung B, Lancellotti P, Pierard L, Price S, Schafers HJ, Schuler G, Stepinska J, Swedberg K, Takkenberg J, Von Oppell UO, Windecker S, Zamorano JL, Zembala M. Joint Task Force on the Management of Valvular Heart Disease of the European Society of Cardiology (ESC); European Association for Cardio-Thoracic Surgery (EACTS). Guidelines on the management of valvular heart disease (version 2012). European Heart Journal. 2012;33(19):2451-96. DOI: 10.1093/eurheartj/ ehs109. 43. Bajaj NS, Agarwal S, Rajamanickam A, Parashar A, Pod- dar KL, Griffin BP, Catacutan T, Tuzcu EM, Kapadia SR. Impact of severe mitral regurgitation on postoperative outcomes after noncardiac surgery. American Medical Journal. 2013;126(6):529- 35. DOI: 10.1016/j.amjmed.2012.12.005. 44. Mases A, Sabate S, Guilera N, Sadurni M, Arroyo R, Fau M, Rojo A, Castillo J, Bover J, Sierra P, Canet J; ANESCAR- DIOCAT Group. Preoperative estimated glomerular filtration rate and the risk of major adverse cardiovascular and cerebrovascular events in noncardiac surgery. British Journal of Anaesthesia. 2014;113(4):644-51. DOI: 10.1093/bja/aeu134. 45. Cywinski JB, Mascha EJ, Kurz A, Sessler DI. Estimated glomerular filtration rate better predicts 30-day mortality after noncardiac surgery than serum creatinine: a retrospective analysis of 92,888 patients. Canadian Journal of Anaesthesia. 2015;62(7):745-52. DOI: 10.1007/s12630-015-0398-8. 46. Wilson T, Quan S, Cheema K, Zarnke K, Quinn R, de Koning L, Dixon E, Pannu N, James MT. Risk prediction models for acute kidney injury following major noncardiac sur¬gery: systematic review. Nephrology, dialysis, transplantation. 2016;31(2):231-40. DOI: 10.1093/ndt/gfv415. 47. Vasivej T, Sathirapanya P, Kongkamol C. Incidence and Risk Factors of Perioperative Stroke in Noncardiac, and Nonaortic and Its Major Branches Surgery. Journal of Stroke and Cerebrovascular Diseases. 2016;25(5):1172-6. DOI: 10.1016/j. jstrokecerebrovasdis.2016.01.051. 48. Ng JL, Chan MT, Gelb AW. Perioperative stroke in noncardiac, nonneurosurgical surgery. Anesthesiology. 2011;115(4):879-90. DOI: 10.1097/ALN.0b013e31822e9499. 49. Pokrovsky AV, Beloyartsev DF. A role of carotid endarterectomy in prevention of cerebral ischemic damage. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2015;(9-2):4-14. DOI:10.17116/jnevro2015115924-14. (In Russian) 50. Hofmann R, Kypta A, Steinwender C, Kerschner K, Grund M, Leisch F. Coronary angiography in patients undergoing carotid artery stenting shows a high incidence of significant coronary artery disease. Heart. 2005;91(11):1438-41. DOI:10.1136/hrt.2004.050906.rt.2004.050906. 51. Steinvil A, Sadeh B, Arbel Y, Justo D, Belei A, Borenstein N, Banai S, Halkin A. Prevalence and predictors of concomitant carotid and coronary artery atherosclerotic disease. Journal of the American College of Cardiology. 2011;57(7):779-83. DOI: 10.1016/j.jacc.2010.09.047. 52. Illuminati G, Schneider F, Greco C, Mangieri E, Schiariti M, Tanzilli G, Barilla F, Paravati V, Pizzardi G, Calio' F, Mi- raldi F, Macrina F, Totaro M, Greco E, Mazzesi G, Tritapepe L, Toscano M, Vietri F, Meyer N, Ricco JB. Longterm results of a randomized controlled trial analyzing the role of systematic pre-operative coronary angiography before elective carotid endarterectomy in patients with asymptomatic coronary artery disease. European Journal of Vascular and Endovascular Surgery. 2015;49(4):366-74. DOI: 10.1016/j.ejvs.2014.12.030. 53. Barbarash LS, Sumin AN, Bezdenezhnykh AV, Zhuchkova EA, Barbarash OL. Prevalence of polyvascular disease in patients with ischemic heart disease. Complex Issues of Cardiovascular Diseases. 2013;(3):4-11. DOI:10.17802/2306-1278- 2013-3-4-11. (In Russian) 54. Marsico F, Ruggiero D, Parente A, Pirozzi E, Musella F, Lo Iudice F, Savarese G, Losco T, Giugliano G, Rengo G, Dellegrottaglie S, Leosco D, Esposito G, Trimarco B, Perrone- Filardi P. Prevalence and severity of asymptomatic coronary and carotid artery disease in patients with lower limbs arterial disease. Atherosclerosis. 2013;228(2):386-9. DOI: 10.1016/j. atherosclerosis.2013.03.025. 55. Imori Y, Akasaka T, Ochiai T, Oyama K, Tobita K, Shishi- do K, Nomura Y, Yamanaka F, Sugitatsu K, Okamura N, Mizu- no S, Arima K, Suenaga H, Murakami M, Tanaka Y, Matsumi J, Takahashi S, Tanaka S, Takeshita S, Saito S. Co-existence of carotid artery disease, renal artery stenosis, and lower extremity peripheral arterial disease in patients with coronary artery disease. The American Journal of Cardiology. 2014;113(1):30-5. DOI 10.1016/j.amjcard.2013.09.015. 56. Marsico F, Giugliano G, Ruggiero D, Parente A, Paolillo S, Guercio LD, Esposito G, Trimarco B, Filardi PP. Prevalence and severity of asymptomatic coronary and carotid artery disease in patients with abdominal aortic aneurysm. Angiology. 2015;66(4):360-4. DOI: 10.1177/0003319714540319. 57. Carmo GA, Calderaro D1, Gualandro DM, Pastana AF, Yu PC, Marques AC, Caramelli B. The Ankle-Brachial Index is Associated With Cardiovascular Complications After Noncardiac Surgery. Angiology. 2016;67(2):187-92. DOI: 10.1177/0003319715589684. 58. Ishihara T, Iida O, Tosaka A, Soga Y, Sakamoto Y, Hirano K, Nanto S, Uematsu M. Severity of coronary artery disease affects prognosis of patients with peripheral artery disease. An- giology.2013;64(6):417-22. DOI: 10.1177/0003319712452627. 59. Nakamura Y, Kunii H, Yoshihisa A, Takiguchi M, Shimizu T, Yamauchi H, Iwaya S, Owada T, Abe S, Sato T, Suzuki S, Oikawa M, Kobayashi A, Yamaki T, Sugimoto K, Nakazato K, Suzuki H, Saitoh S, Takeishi Y. Impact of peripheral artery disease on prognosis in hospitalized heart failure patients. Circulation Journal. 2015;79(4):785-93. DOI: 10.1253/circj.CJ-14- 1280. 60. Ramachandran SK, Nafiu OO, Ghaferi A, Tremper KK, Shanks A, Kheterpal S. Independent predictors and outcomes of unanticipated early postoperative tracheal intubation after nonemergent, noncardiac surgery. Anesthesiology. 2011;115(1):44-53. DOI: 10.1097/ALN.0b013e31821cf6de. 61. Pasin L, Nardelli P, Belletti A, Greco M, Landoni G, Cabrini L, Chiesa R, Zangrillo A. Pulmonary Complications After Open Abdominal Aortic Surgery: A Systematic Review and Meta-Analysis. Journal of Cardiothoracic and Vascular Anesthesia. 2017;31(2):562-8. DOI: 10.1053/j.jvca.2016.09.034. 62. Liang BM, Xu ZB, Yi Q, Ou XM, Feng YL. Association of chronic obstructive pulmonary disease with coronary artery disease. Chinese Medical Journal. 2013;126(17):3205-8. 63.Sumin AN, Bezdenezhnykh NA, Bezdenezhnyh AV, Ivanov SV, Barbarash OL, Barbarash LS. Risk factors major cardiovascular events in the long term coronary artery bypass grafting in patients with coronary heart disease in the presence of type 2 diabetes. Russian Journal of Cardiology. 2015; 6(122):30-7. (In Russian) 64. Canadian Diabetes Association. 2013 Clinical Practice Guidelines for the Prevention and Management of Diabetes in Canada. Canadian Journal of Diabetes. 2013;37(1):S4-7. DOI: 10.1016/j.jcjd.2013.01.010. 65. Dedov II, Shestakova MV., eds. Standards of specialized diabetes care. 7th edition. Diabetes Mellitus. 2015;18(1s):1- 112. DOI: 10.14341/dm20151s1-112. (In Russian) 66. American Diabetes Association. Standards of Medical Care in Diabetes - 2016. Diabetes Care. 2016;39(Suppl. 1):S3. DOI: 10.2337/dc16-S002. Comments Warning: mysqli_query(): (42S02/1146): Table 'site57.sys_comment' doesn't exist in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 10 Table 'site57.sys_comment' doesn't exist Warning: mysqli_query(): (42S02/1146): Table 'site57.sys_comment' doesn't exist in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 53 Table 'site57.sys_comment' doesn't exist Warning: mysqli_num_rows() expects parameter 1 to be mysqli_result, bool given in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 33 Table 'site57.sys_comment' doesn't exist Warning: mysqli_fetch_assoc() expects parameter 1 to be mysqli_result, bool given in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 39 Table 'site57.sys_comment' doesn't exist Visits: 11395 Kokh N.V., Slepukhina A.A., Lifshits G.I. APPROACHES TO PREVENTION AND TREATMENT OF METABOLIC SYNDROME: NUTRIGENETICS Pages: 105-109 Kokh NV, Slepukhina AA, Lifshits GI. Approaches to prevention and treatment of metabolic syndrome: nutrigenetics. Siberian Medical Review. 2017; (5): 105-109. DOI 10.20333/2500136-2017-5-105-109 Authors Kokh Natalya V. ; Institute of Chemical Biology and Fundamental Medicine SB RAS; slepukhina_aa@cnmt.ru Slepukhina Anastasiya A. ; Institute of Chemical Biology and Fundamental Medicine SB RAS; slepukhina_aa@cnmt.ru Lifshits Galina Israelevna 134, Lermontov Str., Irkutsk, Russian Federation 664033; Phone: +7 (913) 907-16-19; e-mail: gl62@mail.ru; Irkutsk Department of Scientific Center of the Siberian Branch of the Russian Academy of Sciences; Annotation Variations in the polymorphism of genes for susceptibility to excess body weight and associated conditions, in particular, predispositions to the metabolic syndrome: polymorphic variants of the lipid metabolism genes T-1131C and c. * 365 + 359C> G ApoA5, G-75A ApoA1, E2 / E3 / E4 and c.526C> T ApoE, C1791G LPL, c.300C> T LPR1, polymorphic variants of genes involved in the formation of food behavior g.87653T> A FTO, g.39272658T> C MC4R, c.178C> A GHRL; polymorphic variants of genes that affect the storage of fatty acids and lipolysis G2445A FABP2, c-1073C> G ADIPOQ, C34G PPARG are described in the article. Practical recommendations on the prevention of obesity in patients with genetic predisposition are discussed. The ways of modifying the risk factors of the metabolic syndrome due to the correction of the negative effect, caused by disturbance of the function or activity of the protein in cases of carriage of adverse allelic ariants are considered. A review of approaches to the selection of nutrients for the formation of a diet to reduce body weight in the prevention and treatment of metabolic syndrome is presented. Keywords: metabolic syndrome, polymorphic variants of genes, FTO, insulin resistance, overweight, hyperlipidemia, obesity Reference List: 1. Hebebrand J, Volckmar A-L, Knoll N, Hinney A. Chipping away the “missing heritability”: GIANT steps forward in the molecular elucidation of obesity - but still lots to go. Obesity Facts. 2010;3(5):294-303. DOI:10.1159/000321537. 2. Speliotes EK, Willer CJ, Berndt SI Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nature Genetics. 2010;42(11):937-48. DOI:10.1038/ ng.686. 3. Berna G, Oliveras-Lopez MJ, Jurado-Ruiz E, Tejedo J, Bedoya F, Soria B, Martin F. Nutrigenetics and nutrigenomics insights into diabetes etiopathogenesis. Nutrients. 2014;6(11):5338-69. DOI:10.3390/nu6115338. 4. Loos RJF, Yeo GSH. The bigger picture of FTO: the first GWAS-identified obesity gene. Nature Reviews. Endocrinology. 2014;10(1):51-61. DOI:10.1038/nrendo.2013.227. 5. Tung YC, Gulati P, Liu CH, Rimmington D, Dennis R, Ma M, Saudek V, O’Rahilly S, Coll AP, Yeo GS. FTO is necessary for the induction of leptin resistance by high-fat feeding. Molecular Metabolism. 2015;4(4):287-98. DOI:10.1016/j. molmet.2015.01.011. 6. Xi B, Chandak GR, Shen Y, Wang Q, Zhou D. Association between Common Polymorphism near the MC4R Gene and Obesity Risk: A Systematic Review and Meta-Analysis. PLoS One. 2012;7(9):e45731. DOI:10.1371/journal.pone.0045731. 7. Imaizumi T, Ando M, Nakatochi M, Yasuda Y, Honda H, Kuwatsuka Y, Kato S, Kondo T, Iwata M, Nakashima T, Yasui H, Takamatsu H, Okajima H, Yoshida Y, Maruyama S. Effect of dietary energy and polymorphisms in BRAP and GHRL on obesity and metabolic traits. Obesity Research and Clinical Practice. 2016; pii: S1871-403X(16)30032-1. DOI:10.1016/j. orcp.2016.05.004. 8. You Y, Yu Y, Wu Y, Rao W, Zhang Y, Liu Y, Yang G, Fu Y, Shi J, Kou C. Association Study between Ghrelin Gene Polymorphism and Metabolic Syndrome in a Han Chinese Population. Clinical Laboratory. 2017;63(1):175-81. 9. Abete I, Astrup A, Martinez JA, Thorsdottir I, Zulet MA. Obesity and the metabolic syndrome: role of different dietary macronutrient distribution patterns and specific nutritional components on weight loss and maintenance. Nutrition Reviews. 2010;68(4):214-31. DOI:10.1111/j.1753-4887.2010.00280.x. 10. Esteves A, Knoll-Gellida A, Canclini L, Silvarrey MC, Andre M, Babin PJ. Fatty acid-binding proteins have the potential to channel dietary fatty acids into enterocyte nuclei. Journal of Lipid Research. 2015;57(2):jlr.M062232. DOI:10.1194/jlr.M062232. 11. Liu P, Yu D, Jin X, Li C, Zhu F, Zheng Z, Lv C, He X. The association between the FABP2 Ala54Thr variant and the risk of type 2 diabetes mellitus: a meta-analysis based on 11 case- control studies. International Jurnal of Clinical and Experimental Medicine. 2015;8(4):5422-9. 12. Khattab SA, Abo-Elmatty DM, Ghattas MH, Mesbah NM, Mehanna ET. Intestinal fatty acid binding protein Ala54Thr polymorphism is associated with peripheral atherosclerosis combined with type 2 diabetes mellitus. Journal of Diabetes. 2016. DOI:10.1111/1753-0407.12496. 13. Bu G. Apolipoprotein E and its receptors in Alzheimer’s disease: pathways, pathogenesis and therapy. Nature Reviews. Neuroscience. 2009;10(5):333-44. DOI:10.1038/nrn2620. 14. Smith CE, Tucker KL, Lai C-Q, Parnell LD, Lee Y-C, Ordovas JM. Apolipoprotein A5 and lipoprotein lipase interact to modulate anthropometric measures in Hispanics of Caribbean origin. Obesity (Silver Spring). 2010;18(2):327-32. DOI:10.1038/ oby.2009.216. 15 Kokh NV, Lifshits GI, Voronina EN. Approaches to the lipid metabolism genes polymorphism analysis in screening for atherosclerosis risk factors. Russian Journal of Cardiology. 2014;10(114):53-7. DOI:10.15829/1560-4071-2014-10-53-057. (In Russian). 16. Gong M, Long J, Liu Q, Deng HC. Association of the ADIPOQ rs17360539 and rs266729 polymorphisms with type 2 diabetes: A meta-analysis. Molecular and Cellular endocrinology. 2010;325(1):78-83. DOI:10.1016/j.mce.2010.05.007. 17. Neeha VS, Kinth P. Nutrigenomics research: a review. Journal of Food Science and Technology. 2013;50(3):415-28. DOI:10.1007/s13197-012-0775-z. Comments Warning: mysqli_query(): (42S02/1146): Table 'site57.sys_comment' doesn't exist in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 10 Table 'site57.sys_comment' doesn't exist Warning: mysqli_query(): (42S02/1146): Table 'site57.sys_comment' doesn't exist in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 53 Table 'site57.sys_comment' doesn't exist Warning: mysqli_num_rows() expects parameter 1 to be mysqli_result, bool given in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 33 Table 'site57.sys_comment' doesn't exist Warning: mysqli_fetch_assoc() expects parameter 1 to be mysqli_result, bool given in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 39 Table 'site57.sys_comment' doesn't exist Visits: 11390 Kondrikova N.V., Pomeshkina S.A., Barbarash O.L. PATIENT AFTER CORONARY ARTERY BYPASS GRAFTING. FOCUS FOR RECOVERY OF LABOUR ABILITY Pages: 109-114 Kondrikova NV, Pomeshkina SA, Barbarash OL. Patient after coronary artery bypass grafting. Focus for recovery of labour ability. Siberian Medical
Review. 2017; (5): 109-114. DOI 10.20333/2500136-2017-5-109-114 Authors Kondrikova Natalia V. ; Research Institute for Complex Issues of Cardiovascular Diseases; NKondrik@yandex.ru Pomeshkina S. A. ; Research Institute for Complex Issues of Cardiovascular Diseases; swetlana.sap2@mail.ru Barbarash O. L. Dr. Med. Sci., Professor; Kemerovo State Medical University; Scientific Research Institute of Complex Problems of Cardiovascular Diseases; olb61@mail.ru Annotation The article provides an overview of the main causes leading to a low return of patients who underwent CABG to their professional activities. As well as a review of activities, changes in the regulatory base that occurred between 2009 and 2015, aimed at improving the rehabilitation of patients, after coronary artery bypass grafting. Keywords: coronary artery bypass grafting, labour ability, disability, rehabilitation Reference List: 1. Barbarash OL. Do patients need rehabilitation after a coronary bypass surgery? (interview). RMJ. 2016;(19):1254- 1256. (In Russian) 2. Pomeshkina SA, Kondrikova NV, Barbarash OL. Labour ability assessment of patients undergone by coronary artery bypass grafting. Complex Issues of Cardiovascular Diseases. 2014;(1):26-30. DOI: 10.17802/2306-1278-2014-1-26-30. (In Russian) 3. The Statement of the SIF of the RF dated 09.01.2000 N 02-18 / 10-5766 “Approximate timing of temporary disability in common diseases and injuries - Guidelines for managers of health care institutions and physicians, expert physicians of the Social Insurance Fund of the Russian Federation - approved on 08.18.2000, by the Ministry of Healthcare of the Russian Federation on 21.08.2000 N 2510 / 9362-34, by the SIF on 21.08.2000 N 02-08 / 10-1977P. Available from: http:// www.consultant.ru/document/cons_doc_LAW_56793/. (cited 2016 Nov 28). (In Russian) 4. The Order of the Ministry of Healthcare and Social Development of the Russian Federation issued on 06.29.2011 N 624n (ed. on 02.07.2014) “On approval of the procedure for issuing sick leave” (Registered in the Ministry of Justice of the Russian Federation on 07.07.2011 N 21286). Available from: http://www.consultant.ru/document/cons_doc_LAW_116333/ (cited 2016 Nov 28). (In Russian) 5. Barbarash OL, Samorodskaya IV, Efros LA, Pomeshkina SA, Kondrikova NV, Boitsov SA. Problems of Determination of Degree of Disability After Coronary Artery Bypass Surgery. Kardiologiia. 2016;(6):96-101.DOI: 10.18565/cardio.2016.6.96-101. (In Russian) 6. Pomeshkina SA, Kondrikova NV, Krupyanko EV, Kagan ES, Barbarash OL. Analysis of Approaches to Assessment of Persistent Loss of Capacity to Work in Patients Who Had Undergone Coronary Bypass Surgery. Kardiologiia. 2013;53(7):62-66. (In Russian) 7. Kondrlkova NV, Simchina YV, Bratchikova VA. Analysis of errrors when referring patients to sociomedical examinatio. Vrach (The Doctor). 2016;(7):2-5. (In Russian) 8. Kondrikova NV, Barbarash OL. Assessment of physicians, awareness about sociomedical examination. Vrach (The Doctor). 2015;(3):83-85. 9. Dymochka MA, Lavrova DI. The Statement of the FSBI “Federal Bureau of Medical and Social Expertise” of the Ministry of Labor and Social Protection “List of examination methods for healthcare institutions for citizens’ referral to medical and social expertise // Moscow. 2012. Available from: http://www.invalidnost.com/publ/sotrudnikam_sluzhby_mseh/perechen_obsledovanij_dlja_mseh_pri_razlichnykh_ zabolevanijakh/3-1-0-484 (cited 2016 Dec 30). (In Russian) 10. The Order of the Ministry of Labor and Social Protection of the Russian Federation issued on December 17, 2015 N 1024n “On the classification and criteria used in medical and social expertise of citizens by federal government agencies for medical and social expertise” (amended and augmented). Available from: http://base. garant.ru/71309914/#ixzz4QizoaVSo (cited 2017 Jan 09). (In Russian) 11. The Government Decree issued on 02.20.2006 N 95 (amended by the RF Government Decree issued on 04.07.2008 N 247, on 12.30.2009 N 1121, on 02.06.2012 N 89, on 04.16.2012 N 318, on 09.04.2012 N 882, on 08.06.2015 N 805, on 10.08.2016 N 77) “Procedures and conditions of getting approved for disability” . Available from: http://www. studfiles.ru/preview/6212897/page:2/. (cited 2016 Dec 28). (In Russian) 12. Windecker S, Kolh Ph, Alfonso F, Collet J-P, Cremer J, Falk V. 2014 ESC/EACTS guidelines on myocardial revascularization. Russian Journal of Cardiology. 2015;2(118):5-81.DOI: 10.15829/1560-4071-2015-02-5-81 13. Bokeria LA, Aronov DM, Barbarash OL, Bubnova MG, Knyazeva TA, Krasnitskiy VB, Lyamina NP, Malikov VE, Novikova NK, Petrunina VE, Arzumanyan MA, Sumin AN, Chumakova GA. Russian clinical guidelines “Coronary artery bypass grafting in patients with coronary artery disease - rehabilitation and secondary prevention”. Moscow. 2016. Available from: http://www.scardio.ru/content/Guidelines/ project/Project_Koronarnoe_shuntirovanie_pacientov_ IBS_19.07.2016.pdf. (cited 2016 Dec 28). (In Russian) 14. Belyakin SA, Yudin VE, Shchegol’kov AM, Shkarupa OF. Problems of the efficiency and quality of medical rehabili¬tation of coronary heart disease patients after coronary bypass surgery and solution. Russian journal of rehabilitation medicine. 2014;1(4):10-18. (In Russian) 15. Pomeshkina SA, Kondrikova NV, Inozemtseva AA, Panycheva EP, Barbarash OL. Effects of a three-stagerehabil- itation program after coronary artery bypass grafting on pa¬tients’ disability. Abstracts of the Russian National Congress. Cardiology 2016: Challenges and Solutions. P. 583. (In Russia) Comments Warning: mysqli_query(): (42S02/1146): Table 'site57.sys_comment' doesn't exist in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 10 Table 'site57.sys_comment' doesn't exist Warning: mysqli_query(): (42S02/1146): Table 'site57.sys_comment' doesn't exist in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 53 Table 'site57.sys_comment' doesn't exist Warning: mysqli_num_rows() expects parameter 1 to be mysqli_result, bool given in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 33 Table 'site57.sys_comment' doesn't exist Warning: mysqli_fetch_assoc() expects parameter 1 to be mysqli_result, bool given in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 39 Table 'site57.sys_comment' doesn't exist Visits: 11375 Shtarik S.Y. REVIEW OF DISSERTATION TOPICS THAT WERE SUBMITTED IN 2016 BY THE COMMITTEE OF DISSERTATION DEFENSE FOR THE DEGREE OF CANDIDATE OF SCIENCE, FOR THE DEGREE OF DOCTOR OF SCIENCE D 208.037.01 IN SPECIALTY 14.01.08 - PEDIATRICS Pages: 115-116 . Authors Shtarik S. Yu. Dr. Med. Sci.,Professor; Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University; shtarik@yandex.ru Comments Warning: mysqli_query(): (42S02/1146): Table 'site57.sys_comment' doesn't exist in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 10 Table 'site57.sys_comment' doesn't exist Warning: mysqli_query(): (42S02/1146): Table 'site57.sys_comment' doesn't exist in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 53 Table 'site57.sys_comment' doesn't exist Warning: mysqli_num_rows() expects parameter 1 to be mysqli_result, bool given in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 33 Table 'site57.sys_comment' doesn't exist Warning: mysqli_fetch_assoc() expects parameter 1 to be mysqli_result, bool given in /home/var/www/mirror/site/smr.krasgmu.ru/sys/phpsys/__db.php on line 39 Table 'site57.sys_comment' doesn't exist Visits: 11367 |
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