The article deals with the problem of comorbidity of acute myocardial infarction (AMI), and disorders of the affective spectrum. Here is a review of recent major studies about the effect of depression to AMI, the mechanisms of the relationship of depression and AMI and influence of associated depressive disorders to the clinical course and prognosis of patients with AMI.

1.	Boitsov S.A., Dovgalevsky P.Ya., Gridnev V.I., Oshchepkova E.V., Dmitriev V.A. A Comparative analysis of Russian and foreign registers of acute coronary syndrome // Cardiological Bulletin. 2010. № 1. P. 82-86.
2.	Population morbidity of Russia in 2007. Statistical materials. M., 2008. P. 38.
3.	Cardiology: national guidelines / Ed. Yu.N. Belenkov, R.G. Oganov. M.: GEOTAR-Media, 2007. P. 43-39.
4.	The Moscow Declaration, adopted on the results of the First Global Ministerial Conference on Healthy Lifestyle and Noninfectious Diseases (28-29 April, 2011) [electronic resource], - Access mode. Http://www.minzdravsoc.ru/ health/zozh/71/ (date of appeal 30.04. 2011).
5.	Oganov R.G., Maslennikova G.Ya. The epidemic of cardiovascular diseases can be stopped by strengthening the prevention//Preventive Medicine. 2009. Vol. 12, № 6. P. 3-7.
6.	Oganov R.G., Kalinina A.M., Kontsevaya A.V. The economic damage of cardiovascular diseases in the Russian Federation // Cardiovascular Therapy and Prevention. 2011. №4. P. 4-9.
7.	Oganov R.G., Pogosova G.V., Koltunov I.E., Romasenko L.V., Deev A.D., Yufereva Yu.M. Depressive symptomatology worsens the prognosis of cardiovascular diseases and reduces the life expectancy of patients with hypertension and coronary heart disease // Cardiology. 2011. №.2. P.59-66.
8.	Oganov R.G., Pogosova G.V., Shal'nova S.A., Deev A.D. Depressive disorders in general practice according to study of COMPASS: view of the cardiologist // Cardiology. 2005. №8. P. 38-44.
9.	Oshchepkova E.V. Population mortality from cardiovascular diseases in the Russian Federation in 2001- 2006 and the ways to reduce it // Cardiology - 2009. № 2. P. 67-72.
10.	Pogosova G.V., Aivazyan T.A., Zaitsev V.P. The effectiveness of psychological rehabilitation of patients after coronary artery bypass operation //Cardiology. 1999. № 7. P 34-37.
11.	Pogosova G.V. Current approaches to the diagnosis and treatment of depressive spectrum disorders in general practice. Manual for physicians. Ed. R.G. Oganov and V.N. Krasnov // Cardiovascular Therapy and Prevention. 2007.№1. P 4-24.
12.	The third universal definition of myocardial infarction // Russian Journal of Cardiology. 2013. №2(100). P. 45.
13.	Chazov E.I., Oganov R.G., Pogosova G.V., Deev A.D., Shal'nova S.A., Koltunov I.E., Romasenko L.V. Depressive symptomatology worsens the prognosis of patients with hypertension and coronary heart disease: first results of the prospective stage in the Russian multicenter study COORDINATA // Cardiology. 2007. № 10. P. 24-30.
15.	Anda R., Williamson D., Jones D., Macera C., Eaker E., Classman A., Marks J. Depressed affect, hopelessness, and risk of ischemic heart disease in a cohort of US adults // Epidemiology. 1993. Vol. 4. P. 285-294.
16.	Bertuccio P., Levi F., Lucchini F., Chatenoud L., Bosetti C., Negri E., Vecchia C. Coronary heart disease and cerebrovascular disease mortality in young adults: recent trends in Europe // European Journal of Cardiovascular Prevention & Rehabilitation. 2011.Vol. 18. P. 627-634.
17.	Broadley A.J.M., Korszun A., Jones C.J.H., Frenneaux M. P. Arterial endothelial function is impaired in treated depression // Heart. 2002. Vol. 88. P. 521-535.
18.	Bush D.E., Ztegelstein R.C., Patel U.V.,Thombs B.D., Ford D.E., Fauerbach J.A., McCann U.D., Stewart K.J., Tsilidis K.K., Patel A.L., Feuerstein C.J., Bass E.B. Post-myocardial infarction depression // Evidence Report/Technology Assessment. 2005. Vol. 1. P. 23-39.
19.	Carney R.M., Blumenthal J.A., Stein P.K., Lana Watkins L., Catellier D., Berkman L.F., Czajkowski S.M., O'Connor C., Stone P.H., Freedland K.E., Depression, heart rate variability, and acute myocardial infarction // Circulation. 2001. Vol. 104. P. 2024-2028.
20.	Carney R.M., Freedland K.E., Miller G.E., Jaffe A.S. Depression as a risk factor for cardiac mortality and morbidity. A review of potential mechanism // J. Psychosom. Res. 2002. Vol. 53. P. 897-902.
21.	Curtis B.M. Autonomic tone as a cardiovascular risk factor: the dangers of chronic fight or flight // Mayo Clin. Proc. 2002. Vol. 77. P. 45-54.
 22.	Dimsdale J.E. What does heart disease have to do with anxiety? // J. Am. Coll. Cardiol. 2010. Vol. 56. P. 47-48.
23.	Duivis H.E., Kupper N., Penninx B.W., Na B., de Jonge P., Whooley M.A. Depressive symptoms and white blood cell count in coronary heart disease patients: Prospective findings from the Heart and Soul Study // Psychoneuroendocrinology. 2012. Vol. 18. P. 234-246.
24.	Eaker E.D., Sullivan L.M., Kelly-Hayes M., D'Agostino R.B.Sr., Benjamin E.J. Tension and anxiety and the prediction of the 10-year incidence of coronary heart disease, atrial fibrillation, and total mortality: The Framingham Offspring Study // Psychosom. Med. 2005. Vol. 67. P. 692-710.
25.	Gruppo Italiano per lo Studio della Soprawivenza nell'infarto Miocardico. GISSI-3: effects oftisinopril and transdermal glyceryl trinitrate singly and together on 6-week mortality and ventricular firnction after acute myocardial infarction // Lancet. 1994. Vol. 343, № 8906. P. 1115-1122.
26.	Guck T.P., Kavan M.G., Elsasser G.N., Barone E.J. Assessment and treatment of depression following myocardial infarction // Am. Fam. Physician. 2001. Vol. 64. P.641-648.
27.	Hansson G.K. Inflammation, atherosclerosis, and coronary artery disease // N. Engl. J. Med. 2005. Vol. 352. P. 1685-1695.
28.	Janszky I., Ahnve S., Lundberg I., Hemmingsson T. Early-onset depression, anxiety and risk of subsequent coronary heart disease. 37-year follow-up of 49,321 young Swedish men //J. Am. Coll. Cardiol. 2010. Vol. 56. P. 31-37.
29.	JoyntK.E., WhellanDJ., O'ConnorC.M. Depression and cardiovascular disease: mechanisms of interaction // Biol. Psychiatry. 2003. Vol. 54. P. 248-261.
30.	Kawachi I., Colditz G.A., Ascherio A., Rimm E.B., Giovannucci E., Stampfer M.J., Willett W.C. Prospective study of phobic anxiety and risk of coronary heart disease in men // Circulation. 1994. Vol. 89. P. 1992-1997.
31.	Laghrissi-Thode F., Wagner W.R., Pollock B.G. Johnson P.C., Finkel M.S. Elevated platelet factor 4 and beta- thromboglobulin plasma levels in depressed patients with ischemic heart disease // Biol. Psychiatry. 1997. Vol. 42.	- P. 290-295.
32.	RitsingerV., Malmberg K., MartenssonA., Ryden L., Wedel H., Norhammar A. Intensified insulin-based glycaemic control after myocardial infarction: mortality during 20 year follow-up of the randomised Diabetes Mellitus Insulin Glucose Infusion in Acute Myocardial Infarction (DIGAMI 1) trial // Lancet Diabetes Endocrinol. 2014. Vol. 2, № 8. P. 627-633.
33.	ISIS-4: a randomised factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulphate in 58,050 patients with suspected acute myocardial infarction. ISIS-4 (Fourth International Study of Infarct Survival) Collaborative Group // Lancet. 1995. Vol. 345, № 8951. P. 669-685.
34.	Lane D., Carrol D., Lip G.Y. Psychology in coronary care // Q. J. Med. 1999. Vol. 92. P. 425-431.
35.	Lesperance F., Frasure-Smith N., Theroux P., Irwin M. The association between major depression and levels of soluble intercellular adhesion molecule 1, interleukin-6, and C-reactive protein in patients with recent acute coronary syndromes//Am. J. Psychiatry. 2004. Vol. 161. P.271-277.
36.	Martens E.J., de Jonge P., Na B.,Cohen B.E., Lett H., Whooley M.A. Scared to death? Generalized anxiety disorder and cardiovascular events in patients with stable coronary heart disease: the Heart and Soul Study //Arch. Gen. Psychiatry.2010. Vol. 67. P. 750-758.
37.	Marchesi C., Ossola P., Scagnelli F., Paglia F., Aprile S., Monici A., Tonna M., Conte G., Masini F., De Panfilis C., Ardissino D. Type D personality in never-depressed patients and the development of major and minor depression after acute coronary syndrome // J. Affect. Disord. 2014. Vol. 155. P. 194-199.
38.	Moser D.K., McKinley S., Riegel B., Doering L.V., Meischke H., Pelter M., Davidson P., Baker H., Dracup K. Relationship of persistent symptoms of anxiety to morbidity and mortality outcomes in patients with coronary heart disease//Pychosom. Med. 2011. Vol. 73. P. 803-809.
39.	Otte C., Neylan T.C., Pipkin S.S., Browner W.S., Whooley M.A. Depressive symptoms and 24-hour urinary norepinephrine excretion levels in patients with coronary disease: findings from the Heart and Soul Study //Am. J. Psychiatiy. 2005. Vol. 162. P. 2139- 2145.
40.	Pajak A., Jankowski P., Kotseva K., Heidrich J., de Smedt D., De Bacquer D. Depression, anxiety, and risk factor control in patients after hospitalization for coronary heart disease: the EUROASPIRE III Study // Eur. J. Prev. Cardiol. 2012. Vol. 6. P. 134-152.
41.	Player M.S., Peterson L.E. Anxiety disorders, hypertension, and cardiovascular risk: a review// Psychiatry Med. 2011. Vol. 41. P. 365-377.
42.	Roest A.M., Martens E.J., de Jone P., Denollet J. Anxiety and risk of incident coronary heart disease. A meta- analysis//J. Am.Coll.Cardiol. 2010. Vol.56. P.38-49.
43.	Scherrer J.F., Chrusciel T., Angelique Zeringue A., Garfield L.D., Hauptman P.J., Lustman P.J., Freedland K.E., Carney R.M., Bucholz K.K., Owen R., True W.R. Anxiety Disorders Increase Risk for Incident Myocardial Infarction in Depressed and Nondepressed Veterans Administration Patients // Am. Heart J. 2010. Vol. 159. P. 772-779.
 44.	Severus W. Е., Liftman А. В., Stoll A. L. Omega-3 fatty acids, homocysteine, and the increased risk of cardiovascular mortality in major depressive disorder // Harv. Rev. Psychiatiy. 2001. Vol. 9. P. 280-283.
45.	Sorensen C., Brandes A., Thrane J., Thrane J., Friis- Hasche E., Haghfelt T., Bech P. Psychosocial predictors of depression in patients with acute coronary syndrome //Acta Psychiatr. Scand. 2005. Vol. Ill, № 2. P. 116-124.
46.	Taylor C.B., Conrad A., Wilhelm F.H., Neri E., DeLorenzo A., Kramer M.A., Giese-Davis J., Roth W.T., Oka R., Cooke J.P., KraemerH., Spiegel D. Psychophysiological and cortisol responses to psychological stress in depressed and nondepressed older men and women with elevated cardiovascular disease risk // Psychosom. Med. 2006. Vol. 68. P. 538-546.
47.	Wittstein I.S. Depression, anxiety, and platelet reactivity in patients with coronary heart disease // Eur. Heart J. 2010. Vol. 31. P. 1573-1582.
48.	Yang E.H., Lerman S., Lennon R.J., Simari R.D., Lerman L.O., Lerman A. Relation of depression to coronary endothelial function // Am. J. Cardiol. 2007. Vol. 99. P. 1134-1136.
49.	Yusuf S., Hawken S., Ounpu S., Dans T.r Avezum A., Lanas F., McQueen M., Budaj A., Pais P., Varigos J., Lisheng L. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART Study): case-control study//Lancet. 2004. Vol. 364, № 9438. P. 937-952.
50.	Ziegelstein R.C., Fauerbach J.A., Stevens S.S., Romanelli J., Richter D.P., Bush D.E. Patients with depression are less likely to follow recommendations to reduce cardiac risk during recovery from a myocardial infarction // Arch. Intern Med. 2000. Vol. 60. P. 1818-1823.

In the treatment of patients with acute ST segment elevation myocardial infarction (STEMI) the priority is primary percutaneous coronary intervention (pPCl) during the first 12 hours from the beginning of the disease. However pPCI efficiency outgoes other treatment strategies only when the patient admitted to the angiolaboratory in 60-120 minutes from the first medical contact. If there is a time delay before entering the patient the priority may be given to pharmaco-invasive strategy (FIS) of the treatment. The article presents an analytical review of studies that compare pPCI and FIS.

1.	 Ganiukov V.I. The evidence base for the priority role of primary percutaneous coronary intervention for revascularization of patients with ST segment elevation myocardial infarction // Complex Problems of Cardio - Vascular Diseases. 2013. № 1. P. 22-33.
2.	Garganeeva A.A., Okrugin P.A., Borel' K.N., Efimova E.	V. Pre-hospital mortality from acute myocardial infarction, and possible ways of its reducing // Complex Problems of Cardio - Vascular Diseases. 2012. №2. P. 28-34.
3.	Markov V.A., Vyshlov E.V., Sevastyanov D.R., Fily- ushkina V.Yu., Dem'yanov R.V., Maksimov I.V., Antipov R.I., Krylov A.L., Varvarenko V.I., Gol'tsov R.G., Markov V.V., Danilenko A.M., Karpov R.R. Comparative effectiveness of pharmacoinvasive myocardial reperfusion strategy and primary angioplasty in patients with acute ST segment elevation myocardial infarction//Cardiology. 2013. №10. P. 10-15
4.	Sulimov V.A. Thrombolysis or primary percutaneous coronary intervention at acute ST segment elevation myocardial infarction ? Research STREAM (Strategic Reperfusion Early after Myocardial Infarction) // Rational Pharmacotherapy in Cardiology. 2013. №. 9. P. 640-649.
5.	Aissaoui N., Simon T., Puymirat E., Lucke V., Bouabdallaoui N., Lognone T., Cohen S., Ashrafpoor G., Roul G., Jouve B., Levy G., Charpentier S., Grollier G., Eerricres J., Danchin N. Acute myocardial infarction in women. Initial characteristics, management and early outcome. The FAST- MI registry // Ann. Cardiol. Angeiol. (Paris). 2013. Vol. 62, №4. P. 221-226.
6.	Andersen H.R., Nielsen T.T., Rasmussen K. A comparison of coronary angioplasty with fibrinolytic therapy in acute myocardial infarction // N. Engl. J. Med. 2003. Vol. 349. P. 733-742.
7.	Antman E.M., Braunwald E. ST elevation myocardial infarction: Pathology, Pathophysiology and clinical Features in braunwald's Heart disease - A textbook of cardiovascular Medicine/8th Edition, Published by Elsevier. 2008. P. 1210.
8.	Antman E.M., Anbe D.T., Armstrong P.W., Bates E.R., Green L.A., Hand M., Hochman J.S., Krumholz H.M., KushnerF.G., Lamas G.A., MullanyCJ., OrnatoJ.P., Pearle D.L., Sloan M.A., Smith S.C., Smith S.C., Jacobs A.K., AdamsC.D., AndersonJ.L.,BullerC.E., CreagerM.A., Ettinger S.M., HalperinJ.L., HuntS.A., KrumholzH.M., KushnerF.G., Lytle B.W., NishimuraR., Page R.L., Riegel B., Tarkington L.G., Yancy C.W. Focused update of the ACC/AHA 2004 guidelines for the management of patients with ST-elevation myocardial infarction. A report of the American College of Cardiology/ American Heart Association Task Force on practice guidelines // Circulation. 2008. Vol. 117. P. 296-329.
9.	Armstrong P.W., Boden W.E. Reperfusion paradox in ST-segment elevation myocardial infarction // Ann. Intern. Med. 2011. Vol. 155. P. 389-391.
10.	ArmstrongP.W., GershlickA.H., Goldstein P., Wilcox R., Danays T., Bluhmki E., Frans Van de Werf. The Strategic Reperfusion Early After Myocardial Infarction (STREAM) study //Am. Heart J. 2010. Vol. 160, №1. P. 30-35.
11.	Armstrong P.W., GershlickA.H., GoldsteinP., Wilcox R.	, Danays T., Lambert Y., Sulimov V., Ortiz F.R., Ostojic M., Welsh R.C., Carvalho A.C., Nanas J., Arntz H., Halvorsen S., Huber K., Grajek S., Fresco C., Bluhmki E., Regelin A., Vandenberghe K., Bogaerts K. and Frans Van de Werf. Fibrinolysis or Primary PCI in ST-Segment Elevation // N. Engl. J.	Med. 2013. Vol. 368. P. 1379-1387.
12.	Armstrong P.W., WEST Steering Committee. A comparison of pharmacologic therapy with/without timely coronary intervention vs primary percutaneous intervention early after ST-elevation myocardial infarction: the WEST (Which Early ST-elevation myocardial infarction Therapy) study// Eur. Heart J. 2006. Vol. 27. P. 1530-1538.
13.	Armstrong P.W., Westerhout C.M., Van de Werf F., Califf R.M., Welsh R.C., Wilcox R.G., Bakal J.A. Refining clinical trial composite outcomes: an application to the Assessment of the Safety and Efficacy of a New Thrombolytic-3 (ASSENT-3) trial//Am. Heart J. 2011. Vol. 161. P.848-854.
14.	Armstrong P.W., McDonald W., Ful Y., Zeymer U., Wagner G., Goodman S.G., Ross A., Granger C.B., Van de Werf F.	Assessment of the Safety and Efficacy of a New Treatment Strategy with Percutaneous Coronary Intervention (ASSENT-4 PCI) investigators. Primary versus tenecteplase-facilitated percutaneous coronary intervention in patients with ST- segment elevation acute myocardial infarction (ASSENT - PCI): randomised trial // Lancet. 2006. Vol. 367. P. 569-578.
15.	Boehmer E., Hoffmann P., Abdelnoor M., Amesen H., Halvorsen S. Efficacy and Safety of Immediate Angioplasty Versus Ischemia-Guided Management After Thrombolysis in Acute Myocardial Infarction in Areas With Very Long Transfer Distances. Results of the NORDISTEMI (NORwegian study on District treatment of ST Elevation Myocardial Infarction) //J. Am. Coll. Cardiol. 2010. Vol. 55. P. 102-110.
16.	Bonnefoy E., Lapostolle F., Leizorovicz A., Steg G., McFadden EP., Dubien PY., Caftan S., Boullenger E., Machecourt J., Lacroute J., Cassagnes J., Dissait F., Touboul P. Primary angioplasty versus prehospital fibrinolysis in acute myocardial infarction: a randomised study // Lancet. 2003. Vol. 360. P. 825-829.
17.	Cho J.S., Her S., Baek J.Y., Cho J.S., Park M., Kim H.D., Jeong M.H., Ahn Yk., Chae S.C., Hur S.H., Hong T.J., KimYJ., Seongl.W., ChaeJ.K., RhewJ.Y., Chael.H., ChoM.C., BaeJ.H., RhaS.W., KimCJ., ChoiD., Jang Y.S., Yoon J., Chung W.S., ChoJ.G., SeungK.B., Park S.J. Molecular Weight Heparin for ST-segment Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention with Glycoprotein Ilb/IIIa Inhibitor // J. Korean Med. Sci. 2010 - Vol. 25. P. 1601-1608.
18.	Collen D., Van de Werf F. Coronary thrombolysis with recombinant staphylokinase in patients with evolving myocardial infarction // Circulation. 1993. Vol. 87. P. 1850-1853.
19.	Collins R., Baigent C., Sleight P.r Peto R. Indications for fibrinolytic therapy in suspected acute myocardial infarction: collaborative overview of early mortality and major morbidity results from all randomized trials of more than 1000 patients. Fibrinolytic Therapy Trialists' (FTT) Collaborative Group // Lancet. 1994. Vol. 343. P. 311-322.
20.	Di Mario C., Dudek D., Piscione F., Dudek D., Piscione F., Mielecki W., Savonitto S., Murena E., Dimopoulos K.	, Manari A., Gaspardone A., Ochala A., ZmudkaK., Bolognese L.	, Steg P.G., Flather M. Immediate angioplasty versus standard therapy with rescue angioplasty after thrombolysis in the Combined Abciximab REteplase Stent Study in Acute Myocardial Infarction (CARESS-in-AMI): an open, prospective, randomised, multicentre trial//Lancet. 2008. Vol. 371. P.559-568.
21.	Eagle K.A., Nallamothu B.K., Mehta R.H., Granger C.B., StegP.G., Van de Werf F., JoseLopez-Sendon, Goodman S.G., Quill A., Fox K. Trends in acute reperfusion therapy for ST-segment elevation myocardial infarction from 1999 to 2006: we are getting better but we have got a long way to go // Eur. Heart J. 2008. Vol. 29. P. 609-617.
22.	El Guindy A.M. STREAM and FAST-MI - Pharmacoinvasive therapy: A continued role for fibrinolysis in the primary PCI era // Glob. Cardiol. Sci Pract. 2014. Vol. 2014, № 2. P. 56-60.
23.	Eric R., Bates E.R. Reperfusion therapy reduces the risk of myocardial rupture complicating ST-elevation myocardial infarction // J. Am. Heart Assoc. 2014. Vol. 3, № 5. P. 1-3.
24.	Falk E., Shah P.K., Fuster V. Coronary plague disruption//Circulation. 1995. Vol.92. P.657-671.
25.	Fernandez-Aviles F., Alonso J.J., Castro-Beiras A., Vazguez N., Blanco J., Alonso-Briales J., Lopez-Mesa J., Femandez-Vazguez F., Calvo I., Martinez-Elbal L., MD, Roman J., Ramos B. Routine invasive strategy within 24 hours of thrombolysis versus ischaemia-guided conservative approach for acute myocardial infarction with ST-segment elevation (GRACIA -1) //Lancet. 2004. Vol.364. P. 1045-1053.
26.	Fernandez-Aviles F., Alonso J.J., Blanco J., Alonso- Briales J., Lopez-Mesa J., Fernandez-Vazguez F., Moreu J., Hernandez R., Castro-Beiras A., Gabriel R., Gibson C.	M., Sanchez P.L. Primary angioplasty vs. Early routine postfibrinolysis angioplasty for AM I with ST-segment elevation: the GRACIA-2 non-inferiority, randomized, controlled trial // Eur. Heart J. 2007. Vol. 28. P. 949-960.
27.	Fernandez-AvilesF., AbrahamJ.M., GibsonC.M., Pena G., Sanz R., AlMahameed A., Murphy S.A., Blanco J., Alonso- Briales J., Lopez-MesaJ., Gimeno F., Sanchez P.L. Association of angiographic perfusion score following percutaneous coronary intervention for ST-elevation myocardial infarction with left ventricular remodeling at 6 weeks in GRACIA-2 // Eur. Heart J. 2007. Vol. 28. P. 949-960.
28.	FiguerasJ., BarrabesJ.A. SerraV., CortadellasJ., Lidon R.	, Carrizo A., Garcia-Dorado. Hospital Outcome of Moderate to Severe Pericardial Effusion Complicating ST-Elevation Acute Myocardial Infarction // Circulation. 2010. Vol. 122. P. 1902-1909.
29.	Fitchett D., Borgundvaag B., Cantor W., Ducas J., HeffernanM., Cohen E.A., Morrison L.J., Langer A., DzavikV., Mehta S.R., Lazzam C., Schwartz B., Casanova A., Goodman S. G., Warren J. Routine Early Angioplasty after Fibrinolysis for Acute Myocardial Infarction // N. Engl. J. Med. 2009. Vol. 360. P. 2705-2718.
30.	Frederick G., Kushner F.G., Hand M., Smith S.C., King S.B., Anderson J.L., AntmanE.M., Bailey S.R., Bates E.R., Blankenship J.C., Casey D.E., Green L.A., Casey D.E., Green L.	A., Hochman J.S., Jacobs A.K., Krumholz H.M., Morrison D.A., Ornato J.P., Pearie D.L., Peterson E.D., Sloan M.A., Whitlow P.L., Williams D.O. 2009 Focused updates: АСС/ AHA Guidelines for the management of patients with ST- Elevation myocardial infarction (updating the 2004 Guideline and 2007 Focused Update) and ЛСС/Л1IA/SCAI guidelines on percutaneous coronary intervention (Updating the 2005 Guideline and 2007 Focused Update). A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines // J. Am. Coll. Cardiol. 2009.-Vol. 54.-P.2205-2241.
31.	Gershlick A.H., Banning A.P., Myat A., Verheugt F.W., Gersh B.J. Reperfusion therapy for STEMI: is there still a role for thrombolysis in the era of primary percutaneous coronary intervention? // Lancet. 2013. Vol. 382. P. 624-632.
32.	Gibson C.M., Ryan K.A., KelleyM., Michael C., Rizzo M.	J., Mesley R., Murphy S., Swanson J., Marble S.J., Dodge J.T., Giugliano R.P., Cannon C.P., Antman E.M. Methodologic drift in the assessment of TIMI grade 3 flow and its implications with respect to the reporting of angiographic trial results. The TIMI Study Group // J. Am. Heart. 1999. Vol. 137. P.1179-1184.
33.	Gibson C.M., Cannon C.P., Daley W.L., Dodge Jr J.T., Alexander B., Marble S.J., McCabe C.H., Raymond L., Fortin T., Poole W.K., Braunwald E. TIMI frame count: a guantitative method of assessing coronary artery flow // Circulation. 1996. Vol. 93. P. 879-888.
34.	Gibson C.M., Cannon C.P., Murphy S.A., Gibson C.M., Cannon C.P., Murphy S.A., Marble SJ., Barron H.V., Braunwald E. Relationship of the TIMI myocardial perfusion grades, flow grades, frame count, and percutaneous coronary intervention to long-term outcomes after thrombolytic administration in acute myocardial infarction// Circulation. 2002. Vol. 105. P. 1909-1913.
 35.	Gibson С.М., Murphy S.A., Rizzo M.J., Gibson C.	M., RyanK.A., Marble S.J., McCabeC.H., CannonC.P., Van de Werf F., Braunwald E. Relationship between TIMI frame count and clinical outcomes after thrombolytic administration. Thrombolysis In Myocardial Infarction (TIMI) Study Group //Circulation. 1999. Vol. 99. P. 1945-1950.
36.	Gibson C.M., Pride Y.B., Frederick P.D., Charles V., Pollack Jr., Canto J.G., Tiefenbrunn A.J., Weaver W.D., Lambrew C.T., French W.J., Peterson E.D., Rogers W.J. Trends in reperfusion strategies, door-to-needle and door-to- balloon times, and in-hospital mortality among patients with ST-segment elevation myocardial infarction enrolled in the National Registry of Myocardial Infarction from 1990 to 2006 //Am. HeartJ. 2008. Vol. 156. P. 1035-1044.
37.	Gibson C.M. Primary angioplasty compared with thrombolysis: new issues in the era of glycoprotein Ilb/IIIa inhibition and intracoronary stenting // Ann. Intern. Med. 1999. Vol. 130. P. 841-847.
38.	Grajek S., Araszkiewicz A., Lesiak M., Grygier M., Pyda M., Skorupski W., Mitkowski P., Baszko A. Primary percutaneous angioplasty, thrombolysis and conservative treatment in low-risk patients with ST-elevation myocardial infarction: effects on short- and long-term mortality // Kardiol. Pol. 2012. Vol. 70. P. 1-5.
39.	Harper R.W., Lefkovits J. Prehospital thrombolysi s followed by early angiography and percutaneous coronary intervention where appropriate - an underused strategy for the management of STEMI // Med. J. Aust. 2010. Vol. 193, № 4. P. 234-237.
40.	Kaul S., Diamond G.A., Weintraub W.S. Trials and tribulations of non-inferiority: the ximelagatran experience //J. Am. Coll. Cardiol. 2005. Vol. 46. P. 1986-1995.
41.	Kristensen S.D., Laut K.G., Fajadet J., Kaifoszova Z., Kala P., Di Mario C., Wijns W. European Association for Percutaneous Cardiovascular Interventions // Eur. Heart J. 2014. Vol. 35. P. 2697.
42.	Larson D.M., Duval S., SharkeyS.W., Garberich R.F., MadisonJ.D., StokmanPJ., Dirks T.G., WestinR.K., Harris J.L., Henry T.D. Safety and efficacy of a pharmacoinvasive reperfusion strategy in rural ST elevation myocardial infarction patients with expected delays due to long-distance transfers // Eur. Heart J. 2012. Vol. 33. P. 1232-1240.
43.	Le May M.R., Wells G.A., Labinaz M., Davies R.F., Turek M., Leddy D., Maloney J., McKibbin T, Quinn B., Beanlands R.S., Glover C., Marquis J., O'Brien E.R., Williams W.L., Higginson L.A. Combined angioplasty and pharmacological intervention versus thrombolysis alone in acute myocardial infarction (CAPITAL AMI study) //J. Am. Coll. Cardiol. 2005. Vol. 46. P. 417-424.
44.	O'Gara P.T., Kushner F.G., Ascheim D.D., Casey D. E., Chung M.K., de Lemos J.A., Ettinger S.M., Fang J.C., Fesmire F.M., Franklin B.A., Granger C.B., Krumholz H.M., Linderbaum J.A., Morrow D.A., Newby L.K., Ornato JP O.N., Pharm D., Radford M.J., Tamis-Holland J.E., Tommaso C.L., Tracy C.M., Woo J., Zhao D.X. 2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction: a report of the American College of Cardiology Foundation/ American Heart Association Task Force on Practice Guidelines //J. Am. Coll. Cardiol. 2013. Vol. 6. P. 140-178.
45.	Ohman E.M., Califf R.M., Topol E.J., Candela R., Abbottsmith C., Ellis S., Sigmon K.N., Kereiakes D., George B., Stack R. Conseguences of reocclusion after successful reperfusion therapy in acute myocardial infarction. TAMI Study Group // Circulation. 1990. Vol. 82. P. 781-791.
46.	RenillaA.,BarreiroM.,DiazE.,RozadoJ.,BarrialesV., Moris C. Minerva Impact of reperfusion strategy on outcomes in very elderly patients with acute myocardial infarction //Cardioangiol.- 2014. Vol.62. P.473-479.
47.	Rezkalla S.H., Kloner R.A. No-reflow phenomenon //Circulation.2002. Vol. 105. P.656.
48.	Roe M.T., Harrington R.A., Prosper D.M., Pieper K.S., Bhatt D.L., Lincoff A.M., Simoons M.L., Akkerhuis M., Ohman E.M., Kitt M.M., Vahanian A., Ruzyllo W., Karsch K., Califf R.M., Topol E.J. Clinical and therapeutic profile of patients presenting with acute coronary syndromes who do not have significant coronary artery disease. The Platelet glycoprotein Ilb/IIIa in Unstable angina: Receptor Suppression Using Integrilin Therapy (PURSUIT) trial Investigators //Circulation. 2000. Vol. 102. P. 1101-1106.
49.	Sanchez P.L., Gimeno F., Ancillo P., Sanz J J., Alonso- Briales J.H., BosaF., Santos I.,SanchisJ., Bethencourt A., Lopez- MessaJ., de Prado A.P., Alonso JJ., SanRomanJA, Femandez- Aviles F. Role of the paclitaxel-eluting stent and tirofibanin patients with ST-elevation myocardial infarction undergoing post fibrinolysis angioplasty: the GRACIA-3 randomized clinical trial // Circ. Cardiovasc. Interv. 2010. Vol. 3. P. 297-307.
50.	Sloth A.D., Schmidt M.R., Munk K., Kharbanda R.K., Redington A.N., Schmidt M., Pedersen L., Sorensen H.T., Botker H.E. CONDI Investigators. Improved long-term clinical outcomes in patients with ST-elevation myocardial infarction undergoing remote ischaemic conditioning as an adjunct to primary percutaneous coronary intervention // Eur. Heart J. 2014. Vol. 35. P.75-168-175.
51.	Steg P.G., Bonnefoy E., Chabaud S., Lapostolle F., Dubien P., Cristofini P., Leizorovicz A., Touboul P. Impact of Time to Treatment on Mortality After Prehospital Fibrinolysis or Primary Angioplasty: data from the CAPTIM randomized clinical trial//Circulation. 2003. Vol. 108. P.2851-2856.
52.	Steg P.G., James S.K., AtarD., BadanoL.P., Lundqvist C.	B., Borger M.A., Mario C.D., KennethDickstein, Ducrocq G.	, Fernandez-Aviles F., Gershlick A.H., Giannuzzi P., Halvorsen S., Huber K., Juni P., Kastrati A., Knuuti J., LenzenMJ., MahaffeyK.W., ValgimigliM., Hof A., Widimsky P., Zahger D., Bax J.J., Baumgartner H., Ceconi C., Dean V., Deaton C., Fagard R., Funck-Brentano C., Hasdai D., Hoes A., Kirchhof P., Knuuti J., Kolh P., McDonagh T., Moulin C., Popescu B.A., Reiner Z., Sechtem U., Simes P.A., Tendera M., Torbicki A., Vahanian A., Windecker S.,, Hasdai D., Astin F., Astrom-Olsson K., Budaj A., Clemmensen P., Collet J., Fox K.A., Fuat A., Gustiene 0., Hamm C.W., Kala P., Lancellotti P., Maggioni A.P., Merkely B., Neumann F., PiepoliM.F., Van de Werf F., Verheugt F., Wallentin L. ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force on the management of ST-segment elevation acute myocardial infarction of the European Society of Cardiology (ESC) // Eur. Heart J. 2012. Vol. 33. P. 2569-619.
53.	Stewart R.E., O'Neill W.W. Direct angioplasty for acute myocardial infarction // Current Opinion Cardio. 1995. Vol. 10, №52. P.367-371.
54.	Stone G.W., Brodie B.R., Griffin J.J., Morice M.C., Constantini C., St. Goar F.G., Overlie P.A., Popma J.J., McDonnell J.A., Jones D„ O'Neil W.W., Grines C.L. Prospective, multicenter study of the safety and feasibility of primary stenting in acute myocardial infarction: in-hospital and 30-day results of the PAMI stent pilot trial. Primary Angioplasty in Myocardial Infarction Stent Pilot Trial Investigators //J. Am. Coll. Cardiol. 1998. Vol. 31. P. 23-30.
55.	Thiele H., Eitel I., Meinberg C., Desch S., Leuschner A., Pfeiffer D., Hartmann A., Lotze U., Strauss W., Schuler G. Randomized comparison of pre-hospital-initiated facilitated percutaneous coronary intervention versus primary percutaneous coronary intervention in acute myocardial infarction very early after symptom onset: the LIPSIA-STEMI trial (Leipzig immediate prehospital facilitated angioplasty in ST-segment myocardial infarction) //JACC Cardiovasc Interv. 2011. Vol. 4. P. 605-614.
56.	Thygesen K., Alpert J.S., Jaffe A.S., Simoons M.L., Chaitman B.R., White H.D. Third universal definition of myocardial infarction // Eur. Heart Journal. 2012. Vol. 33. P. 2551-2567.
57.	Vasile V.C., Babuin L., Ting H.H. Aborted myocardial infarction: is it real in the troponin era? // Am. Heart J. 2009. Vol. 157, № 4. P. 636-641.
58.	Van de Werf F. The history of coronary reperfusion // Eur. Heart J. 2014. Vol. 35, № 37. P. 2510.
59.	Van de Werf F.J., Topol E.J., Sobel B.E. The impact of fibrinolytic therapy for ST-segment-elevation acute myocardial infarction // J. Thromb. Haemost. 2009. Vol. 7. P. 14-20.
60.	Wsek W., Stec S., Maciejewski P., Klosiewicz Wqsek B., Bednarz B., Budaj A. Participation in thrombolytic trials delays reperfusion therapy in acute myocardial infarction // Kardiol. Pol. 2012. Vol.70, №8. P. 775-780.

This review deals with the etiology, pathogenesis and prevalence of cognitive impairment in patients undergoing coronary bypass surgery. The importance of early diagnosis and early treatment of cognitive disorders in patients after coronary artery bypass grafting is emphasized.

1.	Buziashvili Yu.L, Ambat'ello S.G., Aleksakhina Yu.A., Pashchenkov M. V. Influence of artificial circulation to the state of cognitive functions in patients with ischemic heart disease // Journal of Neurology and Psychiatry named after S.S. Korsakov.2005. № 1. P. 30-35.
2005.	Bokeria L.A., Golukhova E.Z., Polunin A.G., Breskina N.Yu. Methods for assessing the neurological outcomes in cardiac surgery // Thoracic and Cardiovascular Surgery. №2. P.8-14.
2.	Damulin I.V. Cognitive impairment in vascular diseases of the brain: some aspects of diagnosis and therapy // Farmateka: Medical Journal. Guidelines and recommendations for families and therapists. 2011. № 19. P.20-28.
2006.	Damulin I.V. Cognitive impairment of vascular origin: clinical and therapeutic aspects // Difficult Patient. №7. P. 34-36.
3.	Eremina O.V., Petrova M.M., Schnaider N.A. The urgency of the problem of cognitive dysfunction in patients with arterial hypertension // Siberian Medical Review. 2006 - Vol. 41, №4. P. 3-10.
4.	Eremina O.V., Petrova M.M., Prokopenko S.V., Isaeva N.V., Kaskaeva D.S. Cognitive impairment in patients with ischemic heart disease // Bulletin of Siberian Medicine. 2014. Vol. 13,№4. P.48-56.
5.	Zakharov V.V. All-Russian program of researching the epidemiology and treatment of cognitive disorders in old age ("Prometheus") // Journal of Neurology. 2006. Vol. 11, № 3. P. 27-32.
6.	Zakharov V.V. Using Pronoran in the treatment of non- demetia cognitive impairment // Journal of Neurology. 2008. № 2. P. 38-42.
7.	Zakharov V.V., Savushkina I.Yu. Diagnosis and treatment of cognitive impairment in dyscirculatory encephalopathy //Russian Medical Journal. 2011. Vol. 19, №2. P. 108-112.
8.	Levin O.S., Dudarova M.A., Usoltseva N.I. Diagnosis and treatment of post-stroke cognitive impairment // Consilium Medicum. 2010. Vol. 12, № 2. P. 126-133.
9.	Malinovsky N.N., Belyaev A.A., Khomskaya E.D. Neuropsychological analysis of mental functions of patients undergoing coronary artery bypass surgery // Surgery. 2000. №7. P. 3-10.
10.	Mil'chakova A.E., Popov G.R., Bykov A.V., GechtA.B. Clinical and pharmacoeconomic analysis of using Piribedil (Pronoran) in the treatment of Parkinson's disease // Journal of Neurology and Psychiatry named after S.S. Korsakov. 2008. № 4. P. 49-55.
13.	Ostroumova O.D., Desnitskaya I.V. Effect of Rosu- vastatin on cognitive functions // Consilium medicum.2007.	- № 1 (2). P.61-63
14.	Parfenov V.A., Starchina Yu.A. Cognitive disorders in cerebrovascular diseases: diagnosis and treatment // Russian Medical Journal. 2008. № 12. P. 1650-1652.
15.	Petrova M.M., Eremina O.V., Kaskaeva D.S. Clinic and diagnosis of cognitive impairment in patients with arterial hypertension // Problems of Women's Health. 2010. Vol. 5, № 3. P. 28-32.
16.	PetrovaM.M., Prokopenko S.V., EreminaO.V., Smertina E.G., Gankin M.I., Fursov A.A., Alekseevich G.Yu., Mozheyko E.Yu., Kuznetsova O.O. The use of Citicoline after coronary bypass surgery// Doctor. 2014. № 8. P. 75-78.
17.	Petrova M.M., Schnaider N.A., Eremina O.V. Characteristics of cognitive disorders in hypertensive patients. Cardiovascular therapy and prevention. 2008. Vol. 7, № 2. P. 36-39.
18.	Tribuntseva L.V., Burlachuk V.T., Alekhina O.D., Popova A.A., Gandalyan E.V. Possibilities of correction at mild cognitive disorders in patients of elderly and senile age in general practice // Mental disorders in general medicine. 2010. №2. P.49-52.
19.	Prokopenko S.V., Chernykh T.V., Mozheyko E.Yu, Koryagina T.D., Kaskaeva D.S. Evaluation of cognitive impairment and efficiency of its correction with the use of computer programs in acute ischemic stroke // Siberian Medical Review. 2012. №2. P.59-62.
20.	Chernykh T.V., Prokopenko S.V., Mozheyko E.Yu. The effectiveness of the cognitive disorders correction using computer incentive programs in patients with acute ischemic stroke, depending on the localization of the lesion // Bulletin of the New Medical Technologies. 2012. Vol. 19, №4. P.98-101.
21.	Shal'novaS.A. ConradiA.O., KarpovYu.A., Kontsevaya A.V., DeevA.D., Kapustina A.V., Khudyakov M.B., Shlyakhto E.V., Boitsov S.A. Analysis of mortality from cardiovascular diseases in 12 regions of the Russian Federation participating in the study "Epidemiology of cardiovascular diseases in various regions of Russia" // Russian Journal of Cardiology. 2012.	- №5(97). P. 6-11.
22.	Schnaider N.A. Neurological complications of general anesthesia. Krasnoyarsk: Medica, 2009. P. 108.23.	AgaA., Gates Р.С., FoxA.J. Side of brain infarction and long-term risk of sudden death in patients with symptomatic carotid disease//Stroke.2003. Vol. 34. P. 2871-2875.
24.	Bavaria J.E., Woo Y.J., Hall R.A. Circulatory management with retrograde cerebral perfusion for acute type A aortic dissection // Circulation. 1996. Vol. 94, №9. P. 173-176.
25.	Boden W.E., Taggart D.P. Diabetes with coronary disease—a moving target amid evolving therapies ? // N. Engl. J. Med. 2009. Vol. 360.P. 2570-2572.
26.	Bokesch P.M., Kapural M., Drummond J. Neuropro- tective, anesthetic, and cardiovascular effects of the NMDA antagonist, CNS 5161 A, in isoflurane-anesthetized lambs //Anesthesiology. 2000. Vol. 93. P. 202-208.
27.	Bokeriia L. A., Golukhova E. Z., Polunina A. G. Neural correlates of cognitive dysfunction after cardiac surgery // Brain Res. Brain Re.s Rev. 2005. Vol. 50. P. 266-274.
28.	Capewell S. Proportion of the decline in cardiovascular mortality disease due to prevention versus treatment: public health versus clinical care // Ann. Rev. Public Health. 2011.	- Vol.32. P.5-22
29.	Cork R.C., Heaton J.F., Campbell C.E. Is there implicit memory after propofol sedation? // Brit. J. of Anaesthesia. 1996. Vol. 76. P. 492-498.
30.	ChaitmanB. R., HardisonR. M., Adler D. The bypass angioplasty revascularization investigation 2 diabetes randomized trial of different treatment strategies in type 2 diabetes mellitus with stable ischemic heart disease: impact of treatment strategy on cardiac mortality and myocardial infarction//Circulation. 2009. Vol. 120. P.2529-2540.
31.	Evered L., Scott D.A., Silbert B., Maruff P. Postoperative cognitive dysfunction is independent of type of surgery and anesthetic // Anesth. Analg. 2011. Vol. 112. P.1179-1185.
32.	Fong H.K., Sands L.P.,Leung J.M. The Role of Postoperative Analgesia in Delirium and Cognitive Decline in Elderly Patients: A Systematic Review // Anesth. Analg. 2006.	- Vol. 102. P. 1255-1266.
33.	Fontes M.T., Swift R.C., Phillips-Bute B., Podgoreanu M.V., Stafford- Smith M., Newman M.F., Mathew J.P. Neurologic Outcome Research Group of the Duke Heart Center. Predictors of cognitive recovery after cardiac surgery //Anesth.Analg. 2013. Vol. 116. P.435-442.
34.	Goto T., Baba T., Honma K. Magnetic resonance imaging findings and postoperative neurologic dysfunction in elderly patients undergoing coronary artery bypass grafting // Ann. Thorac. Surg. 2001. Vol. 72. P. 137-142.
35.	Gersh B.J., Frue R.L. Methods of coronary revascularization - things may not be as they seem // N. Engl. J. Med.2005. Vol. 352. P. 2235-2237.
36.	Guaragna J.C., FacchiL. M., Baiao C.G. Preditores de mediastiniteemcirurgiacardiaca // Rev. Bras. Cir. Cardio- vasc. 2004. Vol. 19.P. 165-170.
37.	Hudetz J.A., Gandhi S.D., Iqbal Z., Patterson K.M., Pagel P.S. Elevated postoperative inflammatory biomarkers are associated with short- and medium-term cognitive dysfunction after coronary artery surgery //J. Anesth. 2011. Vol. 25. P.1-9.
38.	Jensen B.O., Hughes P., Rasmussen L.S., Pedersen P.U., Steinbriichel D.A. Cognitive outcomes in elderly high-risk patients after off-pump versus conventional coronary artery bypass grafting: a randomized trial // Circulation. 2006. Vol. 113. P.2790-2795.
39.	Johnson T., Monk T., Rasmussen L.S. ISPOCD2 Investigators. Postoperative cognitive dysfunction in middle- aged patients//Anesthesiology. 2002.Vol. 96, № 6. P. 1351-1357.
40.	Kellermann K., Jungwirth B. Avoiding stroke during cardiac surgery // Semin. Cardiothorac.Vasc.Anesth. 2010. Vol. 14. P. 95-101.
41.	Khann G.M., GregaMA, Borowicz Jr L.M. Stroke and encephalopathy after cardiac surgery: An update // Stroke. 2006. Vol. 37. P. 562-571.
42.	Krenk L., Rasmussen L.S., Kehlet H. New insights into the pathophysiology of postoperative cognitive dysfunction //ActaAnaesthesiol.Scand. 2010. Vol.54. P.951-956.
43.	Laskowitz D.T., Grocott H.P., Serum markers of cerebral ischemia // J. Stroke Cerebrovasc. Dis. 1998. Vol. 7. P. 234-241.
44.	Lum H., Roebuck K. A. Oxidant stress and endothelial cell dysfunction // Am. J. Physiol. Cell. Physiol. 2001. P.719-741.
 45.	LedurP., Almeida L., PellandaL. C. Preditoresdeinfecfao no pos-operatorio de cirurgia de revascularizafaomiocardica // Rev. Bras. Cir. Cardiovasc.2011. Vol. 2. P. 190-196.
46.	Maekawa K., Goto T., Baba T., Yoshitake A., Morishita S., Koshiji T. Abnormalities in the brain before elective cardiac surgery detected by diffusion-weighted magnetic resonance imaging// Ann. Thorac. Surg. 2008. Vol.86. P. 1563-1569.
47.	McBride W.T., Armstrong M.A., Crockard A.D. Cytokine balance and immunosuppressive changes at cardiac surgery: contrasting response between patients and isolated СРВ circuits //Br.J.Anaesth. 1995. Vol. 75. P.724-733.
48.	Match W.A., RynerL.N., KozlowskiP. Cerebral hypoxia during cardiopulmonary bypass: a magnetic resonance imaging //Ann. Thorac. Surg. 1997. Vol. 64. P. 695-701.
49.	Millar K., Asbury A.J., Murray G.D. Pre-existing cognitive impairment as a factor influencing outcome after cardiac surgery // Br. J. Anaesthesia. 2001. Vol. 86, № 1. P. 63-67.
50.	Molle J., Cluitmans T.P., Rasmussen L.S. Long-term postoperative cognitive dysfunction in the elderly: ISPOCDI study//Lancet. 1998. №4. P.235-239.
51.	Mozheyko E.Y., Prokopenko S.V., Petrova M.M., Koryagina T.D., Kaskaeva D.S., Chernykh T.V., Shvetzova
I.	N., Bezdenezhnih A.F. Correction of post- stroke cognitive impairments using computer programs // Journal of the Neurological Sciences. 2013.Vol. 325. № 1-2. P. 148-153.
52.	Mullges W., Berg D. Early natural course of transient encephalopathy after coronary artery bypass grafting //Crit. CareMed. 2000. Vol. 28. P. 1808-1811.
53.	NewmanM.F., KirchnerJ.L., Phillips-Bute B. Longitudinal assessment of neurocognitive function after coronary-artery bypass surgery // NEJM. 2001.Vol. 6. P. 395-402.
54.	Newman M.F., Mathew J.P., Grocott H.P. Central nervous system injury associated with cardiac surgery //Lancet. 2006. Vol.368. P.694-703.
55.	Newman S.P. Analysis and interpretation of neuropsy- chologic tests in cardiac surgery // Ann. Thorac. Surg. 1995. Vol. 59. P.1351-1355.
56.	Nunn J., Hodges H. Cognitive deficits induced by global cerebral ischaemia: Relationship to brain damage and reversal by transplants // Behav. Brain Res. 1994. Vol. 65. P. 1-31.
57.	Roger V.L., Go A.S., Lloyd-Jones D.M. Heart Disease and Stroke Statistics 2012 Update: A Report From the American Heart Association Circulation 2012,125: e2-e220: originally published online December 15, 2011 http://circ.ahajournals. org/content/125/1 /e2.
58.	Rudolph J.L., SchreiberK.A., Culley D.J., McGlinchey R.E., Crosby G., Levisky S., Marcantonio E.R. Measurement of post-operative cognitive dysfunction after cardiac surgery: a systemic review //ActaAnaesthesiol. Scand. 2010. Vol. 54. P. 663-677.
59.	Sa M.P., Soares E.F., Santos C.A. Risk factors for mediastinitis after coronary artery bypass grafting surgery. // Rev. Bras.Cir.Cardiovasc.- 2011.-Vol. 26. P. 27-35.
60.	Seines O.A., Royall R.M., GregaM.A. Cognitive changes 5 years after coronary artery bypass grafting: Is there evidence of late decline? // Arch. Neurol. 2001. Vol. 58. P. 598-604.

Therapy, that restricted the movement, or CI therapy - is a new approach to rehabilitation. This complex of neurorehabilitation effective manipulations includes CI therapy for upper limb, CI therapy for the lower limb, children's CI and CI therapy at aphasia. The intervention is based on the concept of “learned non-use" - the mechanism that is started by a violent activation of impaired function. CI therapy promotes the development of the brain plasticity that correlates with its therapeutic effect.

1.	Belova A.N., Prokopenko S.V., Bulyubash I.D., Grigoryeva V.N., Mozheyko E.Yu. Neurorehabilitation. M., 2010. 1228 p.
2.	Ondar V.S., Lyapin A.V., Prokopenko S.V., Abros'kina M.V., Zhivayev V.P., Prokopenko V.S. Diagnostics of pace asymmetry in central hemiparesis syndrome by induction analyzers of walking parameters // Siberian Medical Review. 2010. № 3. P. 37-40.
3.	Prokopenko S.V., Mozheyko E.Yu. Alekseevich G.V. The possibility of restoring the advanced hand activity using the sensorial glove in patients with stroke // Siberian Medical Review. 2014. № 2. P. 72-77.
4.	Chernikov L.A. Neurorehabilitation: current state and prospects of development // RMJ. 2005. № 22. P. 1453-1456.
5.	Bhogal S.K., Teasell R., Speechley M. Intensity of aphasia therapy, impact on recovery // Stroke. 2003. Vol. 34. P. 987-993.
6.	Candia V., Schafer T., Taub E., Rau H., Aitenmiiller E., Rockstroh B., Elbert T. Sensory motor retuning: A behavioral treatment for focal hand dystonia of pianists and guitarists // Archives of Physical Medicine and Rehabilitation. 2002. Vol. 83. P.1342-1348.
7.	Candia V., Elbert T., AltenmullerE., RauH., SchaferT., Taub E. Constraint-induced movement therapy for focal hand dystonia in musicians//Lancet. 1999. Vol. 353. P.42.
8.	Draganski B., Gaser C., BuschV., Schuierer G., Bogdahn U.	, May A. Changes in grey matter induced by training //Nature. 2004. Vol.427. P.311-312.
9.	Gauthier L.V., Taub E., Perkins C., Ortmann M., Mark V.	W., Uswatte G. Remodeling the brain: Plastic structural brain changes produced by different motor therapies after stroke 11 Stroke. 2008. Vol. 39. P. 1520-1525.
10.	Gordon AML, Charles J., Wolf SL. Efficacy of constraint- induced movement therapy on involved upper-extremity use in children with hemiplegic cerebral palsy is not age-dependent // Pediatrics. 2006. Vol. 117, № 3. P. 63-73.
11.	Liepert J., Bauder H., Wolfgang H.R., Miltner W.H., Taub E., Weiller C. Treatment - induced cortical reorganization after stroke in humans // Stroke. 2000. Vol. 31. P. 1210-1216.
12.	Mark V., Taub E., Uswatte G., Cutter G., Morris D., Mc-Kay S., Bowman M., Haddad M., Rickards T., Sterling C. Randomized Controlled Trial of Cl Therapy for Progressive MS: Increased Real-World Function and Neuroplasticity on MRI (S23.007) [Electronic resource], - Neurology. 2014. Vol. 82, № 10. URL: http://www.neurology.org/content/82/10_ Supplement/S23.007/ [ Дата обращения 12.11.2014].
13.	MarkV. W., Taub E., Uswatte G., BashirK., CutterG.R., Bryson C.C., Bishop-McKay S., Bowman M.N. Constraint- Induced Movement Therapy for the Lower Extremities in Multiple Sclerosis: Case Series With 4-Year Follow-Up // Archives of Physical Medicine and Rehabilitation. 2013. Vol. 94, №4. P. 753-760.
14.	Murray L.L. Attention and aphasia: theory, research and clinical implications // Aphasiology. 1999. Vol. 13. P.91-111.
15.	Pulvermuller F., Neininger B., Elbert T., Mohr B., Rockstroh B., Koebbel P., Taub E. Constraint-induced therapy of chronic aphasia after stroke // Stroke. 2001. Vol. 32. P. 1621-1626.
16.	Shaw S.E., Morris D.M., Uswatte G., McKay S., Meythaler J.M., Taub E. Constraint-induced movement therapy for recovery of upper-limb function following traumatic brain injury//Journal of Rehabilitation Research & Developmen. 2005. Vol. 42. P. 769-778.
17.	Taub E., Uswatte G., King D., Morris D., Crago J.E., Chatterjee A. A placebo controlled trial of Constraint- Induced Movement therapy for upper extremity after stroke //Stroke. 2006. Vol.37. P. 1045-1049.
18.	Taub E., RameyS., DeLucaS., Echols K. Efficacy of Constraint-Induced (Cl) Movement therapy for children with cerebral palsy with asymmetric motor impairment // Pediatrics. 2004. Vol. 113. P. 305-312.
19.	Taub E. Harnessing brain plasticity through behavioral technigues to produce new treatments in neurorehabilitation //AmericanPsychologist. 2004. Vol.59(8). P.692-704.
20.	Taub E., Uswatte G., Mark V.W., Morris D.M., Barman J., Bowman M.H., Bryson C., Delgado A., Bishop-McKay S. Method for enhancing real-world use of a more-affected arm in chronic stroke: transfer package of Cl therapy // Stroke. 2013. Vol. 44. P.1383-1388.
21.	Taub E., Griffin A., Nick J., Gammons K., Uswatte G., Law C.R. Pediatric Cl therapy for stroke-induced hemiparesis in young children // Developmental Neurorehabilitation. 2007.	- Vol 10, №1. P. 3-18.
22.	Taub E. The Behavior-Analytic Origins of Constraint- Induced Movement Therapy: An Example of Behavioral Neurorehabilitation // The Behavior Analyst. 2012. Vol. 35. P. 155-178.
23.	Taub E., Uswatte G., Markn V.W. The functional significance of cortical reorganization and the parallel development of Cl therapy // Frontiers in Human Neuroscience. 2014. Vol. 8. P. 396.
24.	Taub E., Griffin A., Uswatte G„ Gammons K., Nick J., Law C.R. Treatment of congenital hemiparesis with pediatric constraint-induced movement therapy // Journal of Child Neurology. 2011. Vol. 26. P. 1163-1173.
25.	Taub E., Uswatte G., Pidikiti R. Constraint-induced movement therapy: A New Family of Techniques with Broad Application to Physical Rehabilitation - A Clinical Review // Journal of Rehabilitation Research & Development. 1999. Vol. 36, № 3. P.237-251.
26.	UAB. Department of Psychology [Electronic resource]. URL: http://www.uab.edu/citherapy/ [Дата обращения 28.10.2014].

The aim of the research. To study the guantitative and gualitative structural changes of neuro-glial populations of the motor nuclei of the spinal cord of young animals following tobacco smoke exposure (passive smoking).
Materials and methods. The object of the study the neuro-glial population of the motor nuclei at the spinal cord in young rats. Were used histological and immunohistochemical methods of research, statistical analysis of data.
Results. It was noted a decrease in the number of normally functioning neurons, the appearance of cells in the state of degradation, braking process of neurogenesis.
Conclusion. There were revealed morphological and immunohistochemical changes in the spinal cord of rats, indicating the inclusion of compensatory and adaptive processes after the exogenous impact.

1.	Blagova N.V. Quantitative analysis of the population of motor neurons of the spinal cord involved in the formation of the sciatic nerve // Morphology. 2010. №4. P.33.
2.	Bonitenko E.Yu., Grebenyuk A.N., Basharin V.A. Evaluation of neurological status in acute alcohol intoxication in experiment // Bulletin of Experimental Biology and Medicine. 2010. № 3. P. 300-303.
3.	GladkovichN.G.,NaumovaL.N.,VorobyovA.D. Quantitative morphological characteristics of neurons in the anterior horns of the spinal cord in kitten // Journal of Evolutionary Biochemistry and Physiology. 1992. №2. P.254-261.
4.	Zhivolupov S.A., Samartsev I.N., Syroezhkin F.A. Current concept of neuroplasticity (theoretical aspects and practical significance) //Journal of N eurology and Psychiatry named after S.S. Korsakov. 2013. № 10. P. 102-108.
5.	Zhukov I.N., Kashevskaya O.P., Hodzhagel'diev T. Experimental model of craving for tobacco and the selection of funds for its pharmacocorrection // Problems of Narcology. 1989. №3. P. 11-14.
6.	Zapadnyuk I.P., ZapadnyukV.I., Zakharia E.A. Laboratory animals. Breeding, maintenance, use in the experiment. Kiev: Naukova Dumka, 1983. 383 p.
7.	Kalimulina L.B. On the question of «dark» and «light» cells // Morphology. 2002. № 4. P. 75-79.
8.	Malinovskaya N.A., Salmina A.B., Prokopenko S.V., Komleva Yu.K., Morozova G.A., Panina Yu.A., Gasymly E.D. Neuron-astroglial interactions in cells of the midbrain at experimental Parkinson's disease // Siberian Medical Review. 2014. №6. P.5-10.
9.	Malinovskaya N. A., Prokopenko S. V., Komleva Yu. K., Panina Yu. A., Pozhilenkova E. A., Ryabokon R. V., Salmina A. B.	Molecular markers of glial cells activation in neuroinflammation: new opportunities for pharmacotherapy of neurodegeneration // Siberian Medical Review. 2014. № 5. P. 5-15.
10.	Morgun A.V., Kuvacheva N.V., Khilazheva E.D., Salmina A.B. Research of the metabolic conjugation and intercellular interactions on the model of neurovascular unit in vitro // Siberian Medical Review. 2015. № 1. P. 28-32.
11.	Elmore S. Apoptosis: a review of programmed cell death // Toxicol. Pathology. 2007. Vol. 35, № 4. P. 495-516.
12.	Kawakami Y., Yoshida K., Yang J. H. Impaired neuro- genesis in embryonic spinal cord of Phgdh knockout mice, a serine deficiency disorder model// Neurosci. Res. 2009. Vol. 63, №3. P. 184-193.
13.	Zhang G., Vidal Pizzarol., Swain G. P. Neurogenesis in the lamprey central nervous system following spinal cord transection //J. Comp. Neurol. 2014. Vol. 522, № 6. P. 1316-1332.

The aim of the research. To evaluate the degree of postural disorders in patients with sensory forms of polyneuropathy on the example of diabetic (DPN) and chronic inflammatory demyelinating polyneuropathy (CIDP).
Materials and methods. The study included 21 persons with sensor variant CIDP (group 1) and 18 persons (group 2) with DPN on the base of University Hospital of KrasSMU named after Prof. V.F. Voino-Yasenetsky. Ingroup 1 the age of the patients from 13 to 74 years old, median of age - 27.5 years old. In group 2 the age of the patients ranged from 35 to 76 years, median of age - 60.5 years. Methods of diagnosis: clinical neurological, neurophysiological.
Results. As a result of the stabilometric study the disorders of postural functions in patients with CIDP and DPN appear as light retropul- sion, more pronounced in the phase of closed eyes (CE); general instability of the main stand in the form of increasing the area ofstatoki- nesiogram more pronounced in the phase of CE and in the case of DPN - and even acceleration of the center of gravity in the CE phase. Conclusion. The method of the computer stabilometry allows objectively evaluate the presence and severity of postural disorders in patients with sensory forms of chronic polyneuropathy.

1.	Babskiy E.B., Gurfinkel V.S., Romel E.L. A new way of studying the stability of a person standing. // Physiological Journal of the USSR. 1955. Vol. 12, № 3. P. 423-426.
2.	Diagnosis of diabetic neuropathy // Ed. N.A. Schnayder, M.M. Petrova. M.: Publishing Medica, 2014. 288 p.
3.	PopovaT.E., SchnayderN.A., PetrovaM.M., Goncharova S.I.,	Gazenkampf K.A., Nikolaeva T.Ya. Dynamics of vibrating sensivity changes according to computer pallesthesiometry at acquisition and genetically determined forms of polyneuropathy, class myelinopathy // Siberian Medical Review. 2014. № 4. P. 69-74.
4.	PopovaT.E., SchnayderN.A., PetrovaM.M., Kantimirova E.A., Gazenkampf K.A., Dyuzhakov S.K., Nikolaeva T. Ya. Computer pallesthesiometry as a perspective method for the diagnosis of sensory form of chronic inflammatory demyelinating polyneuropathy // Siberian Medical Review. 2014. № 5. P. 79-85.
5.	PopovaN.F., ShagaevA.S.,DeminaT.L.,BoikoA.N.The research of dynamic stabilometry as monitoring of motor and coordinatory disorders during rehabilitation in patients with multiple sclerosis // Journal of Neurology and Psychiatry. 2009.- № 1. P. 35-39.
6.	Skvortsov D.V. Stabilometric research. M.: Mask, 2010.	- 176 p.
7.	Sliva S.S. Biological feedback on the base of the methods and means of computer stabilography. Biocontrol-4: Theory and Practice. Novosibirsk: CERIS, 2002. P. 292-299.
8.	Usachev V.I., Dotsenko V.I., Kononov A.F., Artyomov V.G. The new methodology of stabilometric diagnostic at dysfunction of body equilibrium // Bulletin of Otorhinolaryngology. 2009. № 3. P. 19-22.
9.	Edouard P., Gasq D., Calmels P., Degache F. Sensorimotor control deficiency in recurrent anterior shoulder instability assessed with a stabilometric force platform. //Journal of Shoulder and Elbow Surgery. 2014. Vol. 23, № 3. P. 355-360.
10.	Gandevia S.C. Proprioception, tensegrity, and motor control//J.mot. behav.2014. Vol. 46, №3. P.199-201.
11.	Nardone A., Galante M., Pareyson D., Schieppati M. Balance control in Sensory Neuron Disease. // Clinical Neurophysiology.2007. Vol. 118. P.538-550.
12.	Nardone A., TarantolaJ., Miscio G., Pisano F., Schenone A., Schieppati M. Loss of large-diameter spindle afferent fibres is not detrimental to the control of body sway during upright stance: evidence from neuropathy // Exp. Brain Res. 2000. Vol. 135. P. 155-162.
13.	Nardone A., Schieppati M. Group II spindle fibres and afferent control of stance. Clues from diabetic neuropathy // Clin. Neurophysiol. 2004. Vol. 115. P. 779-789.
14.	Schieppati M., Nardone A. Group II spindle afferent fibers in humans: their possible role in the reflex control of stance. // Prog. Brain Res. 1999. Vol. 123. P. 461-472.
15.	Scoppaa F., Capra R., Gallamini M., Shiffer R. Clinical stabilometry standardization. Basic definitions - Acquisition interval - Sampling frequency // J. Gait and Posture. 2013.-Vol. 37, №2.-P.290-292.

The aim of the research. To study the effect ofchitosan compound to the elimination of nickel, cobalt and chromium from leather of laboratory animals through the use of apparatus IR - radiation and ultrasound.
Materials and methods. The study was conducted on laboratory rats breed “Wistar", total 96 animals.
Results. By atomic-sorption chromatography method was confirmed the high sorption activity of 1% water-soluble chitosan with regard of compounds of nickel, cobalt and chromium. Sorption activity increased with the use ofphonophoresis and photophoresis. Conclusion. Application phonophoresis and photophoresis 1 % solution of water-soluble chitosan in experimental allergic dermatitis accelerates elimination of compounds nickel, cobalt and chromium from leather.

1.	Albegova Zh.K., Brin V.B., Gagloyeva E.M. Influence of enterosorbents on hemodynamic indicators and free-radical processes in rats at the modeling of chronic intoxication by nickel chloride // Bulletin of New Medical Technologies. 2010. 2010. Vol. 17, № 3. P. 91-93.
2.	Geinits A.V., MoskvinaS.V. Laser therapy in cosmetology and dermatology. M.: Triada, 2010. P. 63-130.
3.	ZemlyakovaS.S., IvanovO.L., L'vov A.N. Allergic contact dermatitis and associated allergodermatoses: modem concepts of the etiology, pathogenesis and diagnosis // Russian Journal of Skin and Venereal Diseases. 2010. №4. P.47-51.
4.	Izmerova N.I., Chikin V.V. The problem of allergic dermatoses in different regions of the world // Russian Journal of Skin and Venereal Diseases. 2009. №6. P. 14-17.
5.	Ukhanova O.P., Shishalova T.N., Kopylova A.V. Pathomorphological changes in the skin in patients with allergic contact dermatitis when exposed of low-molecular allergens (haptens) // Medical Bulletin of the North Caucasus. 2012. Vol.26,№2. P.71-73.
6.	Jen-You Wang and Yun-Peng Chao. Immobilization of Cells with Surface-Displayed Chitin-Binding Domain //Appl.Envir.Microbiol. 2006. Vol.72, - P.927-931.

The aim oT the research. To set the carrier frequency of polymorphic alleles variants at genes of clotting factors in adolescents in Barnaul.
Materials and methods. Material was the DNA samples of 1306 adolescents (580 boys and 726 girls) aged 15-16 years old. The analysis was based on the polymerase chain reaction in real time (Real-Time PCR) using competing TagMan probes.
Results. It was found that the frequency of the minor allele A 20210 of the gene FII and allele C1565 GRIIIa were higher in girls. Conclusion. The population of adolescents is characterized by high heterozygosity on polymorphic variants of three genes of clotting factors: G (-455) A gene FGB, G226A gene FXIII and 4G (-675) 5G PAI-1 gene. The highly informative marker of gene diversity of polymorphic gene variants of clotting factors is a gene of inhibitor plasminogen activator (PAI-1).

1.	Kosyankova T.V., Puzyrev K.V. Polymorphism of genes of nitric oxide synthase: a study in the Siberian populations and in patients with cardiovascular disease // Bulletin SB RAMS. 2003. №1. P.6-11.
2.	Momoth A.P., Strozenko L.A., Tsyvkina L.P., Roitman E.V., Klimenko O.V., Serdyuk G.V. Primary thromboprophylaxis in children of Altai Region on the basis of the identification and modification of permanent and temporary thrombogenic risk factors:
guidelines. Barnaul: Publishing house ASMU, 2013. P. 83.
3.	Momoth A.P., Roitman E.V., Elykomov V.A. Minutes conducting of All-Russian register" Genetic risk factors for thrombosis among residents living in the territory of the Russian Federation, the clinical phenotyping and thromboprophylaxis of
thromboembolic complications in ontogenesis" // Thrombosis, Hemostasis and Rheology. 2010. № 3. P. 30-78.
4.	Strozenko L.A., Momoth A.P. Lobanov Yu.F., Taranenko I. A., Serdyuk G.V. Thrombogenic risk factors and health status of adolescents in Barnaul // Health and Education in Siberia. 2012. № 2. [Electronic Resource]. Mode of access: http: // ngmu.ru. / cozo / mos.
5.	Kenet G., Lutkhoff L.K., Albisetti M., Bernard T., Brandao M., Chabrier S., Chan A., deVeber G., Fiedler B., Fullerton H.S., Goldenberg N.A. Impact of thrombophilia on risk of arterial ischemic stroke or cerebral sinonenosus thrombosis in neonates and
children: a systematic review and meta-analysis of observational studies // Circulation. 2010. Vol. 121, № 16. P. 1838-1847.
6.	Nowak-Gottl U., Kurnik K., Krumpel A. Thrombophilia in the young // Haemostaseologie. 2008. Vol. 28, № 1. P. 16-20.
7.	Young G., Albisetti M., Bonduel M., Brandao L., Chan A., Friedrichs F., Neil A. Goldenberg N. A., Grabowski E., Heller C., Nowak-Gottl U. Impact of inherited thrombophilia on venous thromboembolism in children: a systematic review and meta-analysis of observational studies // Circulation. 2008. Vol. 118,№13.- P.1373-1382.

The aim of the research. To study the frequency of virulent genotypes of Helicobacter pylori (HP) in children with chronic gastroduodenal pathology and assess their impact on the severity of the inflammatory process.
Materials and methods. The study involved 230 children aged 8-17years old with chronic gastroduodenal pathology.
Results. It was determined wide heterogeneity of Helicobacter pylori genome among the surveyed children.
Conclusion. Virulent strains of Helicobacter pylori with the genotype cagA + vacAslml are specific to children with distinctive changes in the duodenal mucosa.

1.	BaryshnikovN.V., SuvorovA.N., Tkachenko E.I., Uspen- skiy Yu.P. The role of the genetic characteristics of Helicobacter pylori in the pathogenesis of diseases of the digestive system: from theory to practice // Experimental and Clinical Gastroenterology. 2009. № 1. P. 12-19.
2.	Kornienko E.A., Parolova N.I. The problem of diagnosis and treatment of Helicobacter pylori infection in children according to the recommendations of the International Consensus Maastricht-IV//Bulletin of Practitioner. 2012. Spec. Issue. 1. P. 34-39.
3.	Leontyeva N.I., Shcherbakov I.T., Gracheva N.M., Khrennikov B.N., Shcherbakova E.G. The impact of different forms of pyloric helicobacter on morphological changes in the gastric mucosa // Medical Almanac. — 2011. — № 2 (15). — P.61-64.
4.	Makarenko E.V., Voropaeva A.V., Matveenko M.E. Effect of Helicobacter pylori genotypes in the morphological parameters of the gastric mucosa in patients with duodenal ulcer and chronic gastritis // Bulletin of VSMU. 2009. Vol.8, № 2. P. 88-96.
5.	Ursova N.I. Helicobacter pylori infection in children: the problem, the analysis of data // The Attending Physician. 2009. № 6. P. 43-46.
6.	Shadrin O.G., Zaitseva N.E., Garynycheva T.A. Helicobacter pylori in children: current approaches to diagnosis and ways to optimize therapy // Contemporary Pediatrics. 2014. Vol. 5, №61. P.119-127.
7.	Shcherbakov P.L. Features helikobacteriosis in children of Russia // Experimental and Clinical Gastroenterology. 2008. №8. P.46-52
8.	Argent R.H., Thomas R.J., Letley D.P., Rittig M.G., Hardie K.R., Atherton J.C. Functional association between the Helicobacter pylori virulence factors VacA and CagA // J. Med. Microbiol. 2008. Vol. 57, Pt. 2. P. 145-150.
9.	Backert S., Clyne M. Pathogenesis of Helicobacter pylori infection// Helicobacter. 2011. Vol.l6,suppl. 1. P. 19-25.
10.	Hunt R.H., Xiao S.D., Megraud F., Leon-Barua R., Bazzoli F., van der Merwe S., Vaz Coelho L.G., Fock M., Fedail S., Cohen H., Malfertheiner P., Vakil N., HamidS., GohK.L., Wong B.C., KrabshuisJ., Le MairA. Helicobacter pylori in developing countries. World Gastroenterology Organisation Global Guideline //J. Gastrointestin. liver Dis. 2011. Vol. 20, № 3. P. 299-304.
11.	Matteo M.J., Armitano R.I., Romeo M., Wonaga A., Olmos M., Catalano M. Helicobacter pylori bab genes during chronic colonization // Int.J. Mol. Epidemiol. Genet. — 2011. — Vol.2,№3. P.286-291.
12.	Shiota S., Watada M., Matsunari O., Iwatani S., Suzuki R., Yamaoka Y. Helicobacter pylori iceA, clinical outcomes, and correlation with cagA: a meta-analysis //PLoS One. 2012. Vol. 7, № 1. e30354.
13.	Talebi Bezmin Abadi A., Taghvaei T., Mohabbati Mo- barez A., Vaira G., Vaira D. High correlation of babA2-positive strains of Helicobatcter pylori with the presence of gastric cancer // Intern. Emerg. Med. 2013. Vol. 8, № 6. P. 497-501.

The aim of the research. To improve the effectiveness of secondary prevention and rehabilitation of patients after myocardial infarction at the outpatient stage.
Materials and methods. 164 patients with myocardial infarction were divided into 3 groups: inpatient and outpatient rehabilitation on the base therapy, and without rehabilitation. The study results are processed using statistical software packages «Excel 8.0 module StatPlus», «SPSS Statistics 17.0» company «IBM» USA. Use non-linear transformation scales with maximizing the average value of the correlation coefficient (MAC). The reliability of values, do not differ from the normal (for normal distribution «of Gauss function») was determined by Student>s t-test.
Results. Rehabilitation of basic therapy reduces the number of hospital readmissions.
Conclusion. Outpatient rehabilitation can be an alternative to inpatient rehabilitation therapy and is egually effective in different types of myocardial revascularization.

1.	Aronov D.M. Primary and secondary prevention of cardiovascular diseases - interpolation to the Russian // Heart. 2002. Vol. 1, № 3 (3). P. 109-112.
2.	Kuimov A.D., Yacobson G.S. Myocardial infarction: clinical and pathophysiological aspects. Novosibirsk: publishing NSU1992. 221 p.
3.	Nikolaeva L.F., Aronov D.M. Rehabilitation of patients with coronary heart disease. M.: Medicine, 1988. 288 p.
4.	Oganov R.G. Prevention of cardiovascular diseases the possibility of practical health // Cardiovascular Therapy and Prevention. 2002. № 1. P.5-9.
5.	Maron D.J., Spertus J.A., Mancini G.B.J., Hartigan P.M., Sedlis S.P., Bates E.R., Kostuk W.J., Dada M., Berman D.S., ShawLJ., Chaitman B.R,. Teo K.K., O'Rourke R.A., Weintraub W.S., Boden W.E.; COURAGE Trial Research Group. Impact of an initial strategy of medical therapy without percutaneous coronary intervention in high-risk patients from the Clinical Outcomes Utilizing Revascularization and Aggressive druG Evaluation (COURAGE) trial // Am. J. Cardiol. 2009. Vol. 104. P. 1055.

The aim oT the research. To determine the significance of ultrasound examination in differential diagnosis of jaundice syndrome. Materials and methods. Was achieved ultrasound of398 patients with pathology ofbiliopancreaticduodenal area complicated by
syndrome of jaundice.
Results. There were revealed ultrasound signs that allow to differentiate the etiology of biliary hypertension. Was set the frequency of false-positive and false-negative results, and the sensitivity of ultrasound at a syndrome of jaundice.
Conclusion. Ultrasound examination is not critical in the differential diagnosis of pathology biliopancreaticduodenal area syndrome, complicated by jaundice and is the additional method of diagnosis.

1.	Cameron I., ChadwickC., Phillips J., Johnson A. Management of acute cholecystitis in UK hospitals: time for a change //Am. Med.J. 2004. Vol. 80. P. 292-294.
2.	MiyazakiM., TakadaT., MiyakawaS., TsukadaK., Nagino M., Kondo S., Furuse J., Saito H., Tsuyuguchi T., Chijiiwa K., Kimura F., Yoshitomi H., Nozawa S., Yoshida M., Wada K., Amano H., Miura F. Risk factors for biliary tract and ampullary carcinomas and prophylactic surgery for these factors //J. Hepatobiliary Pancreat. Surg. 2008. Vol. 15, № 1. P. 31-40.
3.	Saifuku Y., Yamagata M., Koike T. Endoscopic ultrasonography can diagnose distal biliary strictures without a mass on computed tomography // World J. Gastroenterol. 2010.	- Vol. 16,№2. P.237-244.
4.	Spier B.J., Johnson E.A., Gopal D.V., Frick T., Einstein M. M., Byrne S., Koscik R. L., Liou J. I., BroxmeyerT., Selvaggi S.	M., Pfau P. R. Predictors of malignancy and recommended follow-up for patients with negative endoscopic ultrasound- guided fine-needle aspiration of suspected pancreatic lesions // Can. J. Gastroenterol. 2009. Vol. 23, № 1. P. 31-40.
5.	Tajiri T., Yoshida H., Mamada Y. Tania N., Yokomuro S., Mizuguchi Y. Diagnosis and initial management of cholangio- carcinoma with obstructive jaundice // World J. Gastroenterol. 2008. Vol. 14, № 19. P. 3000-3005.
6.	Wheeler P.G., Atrey A., Healey A. A cause of cholestatic jaundice // Gut. 2007. Vol. 56, № 2. P. 1346.

The aim of the research. To study the effect of vaccination on the morbidity of tick-borne encephalitis in children at Krasnoyarsk Region. Materials and methods. We used epidemiological and statistical methods. There were determined such statistical quantities as indicators of frequency and structure of the phenomena. Assessment of the dynamics of the processes was carried out along with the standard format of linear graphs using trending reaching the best indicators of the level of approximation. Results. Specific immunoprophylaxis carried out in the framework of regional target programs for vaccineprophylaxis allows to reduce in Krasnoyarsk Region the morbidity of tick-borne encephalitis by 6.4 times in children aged 7-14 years old. In the age group 0-6 years, where vaccinations are carried out only by the parents, the incidence of tick-borne encephalitis is not significantly changed. Conclusion. Immunizing of children against encephalitis that carried out in the framework of regional target programs has reduced the morbidity of tick-borne encephalitis in children aged 7-14 years, from the index 46.1 0/0000 in 2000 to figure 7.2 0/0000 in 2014. Vaccineprophylaxis against tick-borne encephalitis in the Krasnoyarsk Region since 2011 is included in the regional calendar of preventive vaccinations, which will gradually increase the coverage of immunization and stabilize the epidemic situation in the region.

1. State report on the status of public health and health care activities of the Krasnoyarsk Region in 2013. Krasnoyarsk, 2014. 278 p.
2. Dalmatov V.V., Gotwald R.N., Stasenko V.L. Application of mathematical statistics in epidemiological analysis: Omsk. Med. Acad. Omsk, 2002. 80 p.
3. Zlobin V.I. The epidemiological situation and the problems of struggle against tick-borne encephalitis in the Russian Federation // Bulletin of Siberian Medicine. 2006. № 1. P. 16-24.
4. Kon’kova-Reydman A.B., Ter-Bagdasaryan L.V. Modern aspects of the epidemiology of infections transmitted by ixodid ticks // Journal of Epidemiology and Infectious Diseases. 2014. Vol. 19, № 5. P. 26-31.
5. Order of the Ministry of Health of the Russian Federation dd. 03.21.2014 г. № 125n «On approval of the national calendar of preventive vaccinations and preventive vaccination calendar on epidemic indications.»
6. Resolution of the Government of Krasnoyarsk Region dd. 30.09.2013 г. № 516-p «On approval of the state program of the Krasnoyarsk Region « Development of healthcare «for 2014-2016».
7. Prevention of tick-borne viral encephalitis: San.-epid. Rules SP 3.1.3.2352-08. Moscow: Federal Service for Supervision of Consumer Rights Protection and benefits of person, 2008. 16 p.
8. Regional calendar of preventive vaccinations of Krasnoyarsk region: guidelines. Krasnoyarsk, 2011. 18 p. 
9. Scripchenco N.V. Tick-borne encephalitis in children: diagnosis, treatment and prevention // Infectious Diseases. 2010. № 1. P. 5-11.

The aim of the research. To study the frequency and structure of cardiac conduction disorders (CCD) in the populationof Arctic. Materials and methods. There were examined 348 people of both sexes aged 20 years old and older, randomly selected. All participants performed an electrocardiogram and Holter ECG monitoring (HMEKG). Results. The most frequently registered an incomplete right bundle branch block (BPNPG), other blockades were rare. Conclusion. The inhabitants of the Arctic have incomplete BPNPG very often. Other disturbances of cardiac conduction (DCC) have mainly older age groups. In men more often than women was identified sinoatrial block (SAB) and atrioventricular block (AVB).

1. Dzhanashia P.H., Shevchenko N.M., Olishevko S.V. Emergency Cardiology. M.: Publishing BINOM, 2010. 288 p.
2. Kushakovskiy M.S. Cardiac arrhythmias. St. Petersburg.: «Foliant», 2007. 672 p.
3. Lyusov V.A., Kolpakov E.V. Cardiac arrhythmias. Therapeutic and surgical aspects. M.: GEOTAR Media, 2009. 400 p.
4. Orlov V.N. Guide on electrocardiography. M.: Medicine, 1984. 528 p.
5. Shkol’nikova M.A., Shubik Yu.V., Shal’nova V.M., Shkol’nikov V.M., Vaupel’ D. Cardiac arrhythmias in the elderly persons, and their association with the characteristics of health and mortality // Bulletin of Arrhythmology. 2007. Vol. 49. P. 5-13. 6. Evert L.S., Lytkin V.A. Cardiogenic syncope states in children and adolescents: problems of differential diagnosis // Siberian Medical Review. 2010. № 5. P. 88-94.
7. Bansilal S., Aneja A., Mathew V., Reeder G.S., Smars P.A., Lennon R.J., Wiste H.J., Traverse K., Farkouh M.E. Longterm cardiovascular outcomes in patients with angina pectoris presenting with bundle branch block // Am. J. Cardiol. 2011. Vol. 107. P. 1565-1570.
8. Bussink. E., Holst A.G., Jespersen L., Deckers J.W., Jensen G.B., Prescott E. Right bundle branch block: prevalence, risk factors, and outcome in the general population: results from the Copenhagen City Heart Study // Eur. Heart J. 2013. Vol. 34. P. 138-146.
9. Eriksson P., Wilhelmsen L., Rosengren A. Bundlebranch block in middle-aged men: risk of complications and death over 28 years. The Primary Prevention Study in Göteborg, Sweden // Eur. Heart J. 2005. Vol. 26. P. 2300-2306. 
10. Hingorani P., Natekar M., Deshmukh S., Karnad D.R., Kothari S., Narula D., Lokhandwala Y. Morphological abnormalities in baseline ECGs in healthy normal volunteers participating in phase I studies // Indian. J. Med. Res. 2012. Vol. 135. P. 322-330.
11. Prineas R.J., Le A., Soliman E.Z., Zhang Z.M., Howard V.J., Ostchega Y., Howard G. Reasons for Geographic and Racial Differences in Stroke (REGARDS) Investigators. United States national prevalence of electrocardiographic abnormalities in black and white middle-age (45- to 64-Year) and older (≥65-Year) adults (from the Reasons for Geographic and Racial Differences in Stroke Study) // Am. J. Cardiol. 2012. Vol. 109. P. 1223-1228.
12. Tadros R., Ton A.T., Fiset C., Nattel S. Sex Differences in Cardiac Electrophysiology and Clinical Arrhythmias: Epidemiology, Therapeutics, and Mechanisms // Can. J. Cardiol. 2014. Vol. 30. P. 783-792.
13. Thrainsdottir I.S., Hardarson T., Thorgeirsson G., Sigvaldason H., Sigfusson N. The epidemiology of right bundle branch block and its association with cardiovascular morbidity – The Reykjavik Study // Eur. Heart J. 1993. Vol. 14. P. 1590-1596.

The aim of the research. To study demographic and migration processes affecting to the demographic situation in the city of Krasnoyarsk. Materials and methods. Official data of the territorial administration of the Federal State Statistics Service of the Krasnoyarsk Region on the natural movement and migration of the population from 2007 to 2012. Results. Since 2009, the increase in population of Krasnoyarsk is carried out mainly due to migration. Conclusion. The growth of rates of natural increase is mainly due to migration growth that exceeds it more than 5 times. Key words: fertility, migration, natural population growth.

1. Artyukhov I.P., Kapitonov V.F., Novikov O.M. The dynamics of health and social status of small families // Siberian Medical Review. 2007. № 3. P.54-56.
2. Archangel’skiy V.N. Factors of fertility. M.: TEIS, 2006. 399 p.
3. Borisov V.A. The demographic situation in modern Russia. M .: Demos, 2007. 190 p.
4. Vishnevsky A.G. Saving people or depopulation of Russia? – M .: Publishing House of the State University – Higher School of Economics, 2010. 82 p.
5. Guseva E.V., Filippov O.S. «The Birth Certificate» Programm: results and prospects // Obstetrics and Gynecology. 2010. № 1. P. 42-45.
6. Guseva E.V., Filippov O.S. The effectiveness of modern organizational technologies in the prevention and reduction of maternal mortality in the Russian Federation // Russian Bulletin of Obstetrician-gynecologist. 2009. № 3. P. 4-9.
7. Denisov A.P., Babenko A.I., Spinov V.I. Reproductive attitudes of women and implementation of the measures of the national project «Demography» // Health Care of the Russian Federation. 2009. № 5. P. 29-31.
8. Konovalov V.N., Tskhai V.B., Kapitonov V.F. Domracheva M.Ya., Brekhova I.S., Panchenko E.A., Li-Gi-Ru S.Yu. The birth rate and the socio-demographic characteristics of the population of Krasnoyarsk // Bulletin of NSU. Series: biology, clinical medicine. 2013. Vol. 11, № 1.
P.180-185.
9. Li-Gi-Ru S.Yu., Tskhai V.B., Kapitonov V.F. Comparative social portrait, the course and outcome of births in women migrants and women of the city of Krasnoyarsk // In the world of scientific discoveries. 2011. № 4. P. 367-374.
10. Mkrtchyan N.V. Migration as a component of population dynamics of Russian regions: assessment based on the 2010 census // Bulletin of the RAS. 2011. № 5. P. 28-41.
11. Soboleva S.V., Smirnova N.E., Chudaeva O.V. Risks in the formation of the demographic potential of Siberia // Region: Economics and Sociology. 2011. № 4. P. 98-115.
12. Soultanaeva Z.M. Demographic policy at regional level // Problems of social hygiene, health and medical history. 2010. № 5. P. 3-5.
13. The territorial body of the Federal State Statistics Service of the Krasnoyarsk Region [electronic resource]. Access mode : http://krasstat.gks.ru/wps/wcm/connect/rosstat_ts/ krasstat/ru/statistics/population/ Date of handling: 13.03.2013.
14. Toichkin V.P. National demographic policy in matters of population reproduction in the countries of northern Europe // North and market: formation of economic order. 2011. Vol. 2, № 28. P. 111-114.
15. Shakhot’ko L.P., Privalova N.N. Demographic security: the nature, objectives, system of indicators and implementation mechanism // Questions of Statistics. 2001. № 7. P. 16-21.

The aim oT the research. To study prognostic factors of alcohol consumption by students and, on its base, development of measures to prevent the use of alcohol by young people.
Materials and methods. It was conducted a survey of880 students of the First MSMU named after 1. M. Sechenov (282 boys, 598 girls). In order to predict the probability of consumption the alcoholic beverages by students used the method of multiple logistic regression analysis.
Results. Were identified family predictors of alcohol consumption by students, as well as factors associated with learning, a way of life and the health of young people.
Conclusion. These results confirm the need for a comprehensive approach to the prevention of alcohol consumption among students.

1.	Bagulina V.A., Zaitsev A.A. Formation of anti-drug position at students of a technical university // Bulletin of the Russian State University named after I. Kant. 2009. №5. P. 89-93.
2.	Golenkov A.V., Andreeva A.P. Screening for alcohol abuse students in medical school//Drug Addiction. 2010. № 2. P. 71-74.
3.	Golenkov A. V., Andreeva A.P., Bulygina I.E. Freguency- guantitative indicators and motives of alcohol consumption by medical students // Drug Addiction. 2009. № 10. P. 25-29.
4.	Deryusheva M.A., Kokorina N.P., Lopatin A.A. Prevention of psychoactive substance and alcohol dependence among students of secondary specialized schools: guidelines. Tomsk, 2003. 19 p.
5.	Cheverikina E.A. Socio-psychological characteristics of students that are inclined to psychoactive substance dependence // Kazan Pedagogical Magazine. 2012. №5-6.-P.126-132.
6.	Cheverikina E. A. Value orientations of students inclined to psychoactive substance dependence // Kazan Pedagogical Magazine. 2011. №3. P.91-97
7.	El'garova L.V. The role of prevention programs in the system of health care the students // Medicine of Work and Industrial Ecology. 2007. № 10. P. 17-23.
8.	Botvin, G.J., Griffin, K.W. Drug abuse prevention curricula in schools // Handbook of Drug Abuse Prevention: Theory, Science, and Practice. 2003. P. 45-74.
9.	Carvalho K., Sant'AnnaM., CoatesV., OmarH. Medical students: abuse of psychoactive substances and sexuality aspects // Int. J. Adolesc. Med. Health. 2008. Vol. 20, №3. P.321-328.
10.	Johnston L., O'Malley P., Bachman J. Monitoring the Future national survey results on adolescent drug use: Overview of key findings // Bethesda, MD: National Institute on Drug Abuse. 2003. 56 p.
11.	Kenna G., Wood M. The prevalence of alcohol, cigarette and illicit drug use and problems among dentists // J. Am. Dent. Assoc. 2005. Vol. 136, № 9. P. 1023-1032.
12.	Reddy P., Resnicow K., Omardien R., Kambaran N., Prevalence and correlates of substance use among high school students in South Africa and the United States // Am. J. Public Health. 2007. Vol. 97, № 10. P. 1859-1864.
13.	Shah A., Bazargan-Hejazi S., Lindstrom R., Wolf K. Prevalence of at-risk drinking among a national sample of medical students // Subst. Abus. 2009. Vol. 30, № 2. P. 141-149.
14.	Shvangwa P., Joshi D., Lai R. Alcohols and other substance use/abuse among junior doctors and medical students in a teaching institute // JNMA J. Nepal Med. Assoc. 2007. Vol. 46, № 4. P. 215-223.

The aim of the research. To study the changes in visual acuity and eye refraction in the dynamics of the students of Krasnoyarsk State Medical University
Materials and methods. Within 5 years of training annually were tested visual acuity and refractive errors in 300 students of Medical University.
Results. The most actively strengthening of eye refraction was occurred on the second course. The development of myopia in emmetrops promotes changing the living conditions from rural to urban and higher academic achievement in training. The amplification of eye refractive was observed in myopes more likely than in students with original emmetropia.
Conclusion. The frequency of "students’" myopia is relatively low and amounts 4,33%.

1. Health status assessment of the higher educational institutions students in the city Krasnoyarsk //SiberianMedical Review. 2014. №6. P.61-64.
2.	Bezkorovainaya I.M. Status of visual functions in medical students//Bulletin of Biology and Medicine. 2013. Vol. 1,№ 4. P.108-109.
3.	Gololobov V.T., Khrebtova L.A., Kozina E.V., Kob- ezhikov A.I. The frequency of myopia in Khakassia // Bulletin of Ophthalmology. 2009. №4. P.21-23.
 4.	Zhuravleva E.V. Monitoring of visual functions in higher education //Bulletin of new medical technologies. — 2011 — Vol.18, № 1. P. 161-162.
5.	ZhuravlevaE.V., RyzhakovD.I., PoteminaT.E., Zhuravlev V.A. Dynamics of vision changes in students of Nizhny Novgorod State Medical Academy from different regions during the school year // Medical Almanac. 2009. № 3. P. 130-132.
6.	Kamaev I.A., Pozdeyeva T.V., Dmitrochenkov A.V., Ananyin S.A. fiealth and lifestyle of pupils, students and the conscriptse: the state, problems and solutions. Nizhny Novgorod: Publishing fiouse of the NSMA, 2005. 183 p.
7.	Ostakhova K.V. The freguency of refractive errors in students of medical university // Bulletin of the Bashkir State Medical University. 2014. № 3 (annex). P. 1693-1697.
8.	Pospelov V.I. Classification of myopia in children // New technologies in diagnosis and treatment of eye diseases. Krasnoyarsk: KrasSMA, 1996. P. 29-31.
9.	Soshnikov E.A. Specifics of adaptation the Southeast Asian students to the conditions of the capital metropolis // Bulletin of the Russian Peoples' Friendship University. Series: Ecology and Life Safety. 2011. №4. P 48-51.
10.	Chaudhry R., Ali H. Sheikh N.H. Freguency and underlying factors of myopia among medical students // Biomedica. 2011. Vol.27, № 2. P. 154-160.
11.	MidelfartA., Aamo B., Sjohaug K.A., DystheB.E. Myopia among medical students in Norway // Acta Ophthalmol. 1992. Vol. 70. P.317-322.
12.	Onal S., Toker E., Akingol Z., Arslan G., Ertan S., Turan C., Kaplan O. Refractive Errors of Medical Students in Turkey: One Year Follow-Up of Refraction and Biometry// Optometry & Vision Science. 2007. Vol. 84, № 3. P. 175-180.
13.	Shiny G., Biju В. J. Study on the prevalence and underlying factors of myopia among the students of a medical college in Kerala // Int. J. Med. Res. ffealth Sci. 2014. Vol. 3, № 2. P. 330-337.
14.	Woo W.W., Lim K.A., Yangff, LimX.Y., Live F., Lee Y.S., Saw S.M. Refractive errors in medical students in Singapore // Singapore Medical Journal. 2004. Vol. 45, № 10. P. 470-474.

The purpose of the study. To develop the functional approach to the use of quality management tools in the evaluation of internal audits in the education complex.
Materials and methods. Were used the following methods: design, system analysis, checklist, Ishikawa diagram, Pareto chart, ABC analysis, the tree diagram
Results. Was proposed a functional approach to the use of quality management tools in the processing of the results the internal audits. Conclusion. The considered quality management tools allow objectively evaluate the results of the internal audit and develop the competent management decisions based on facts.

1.	GOST ISO 9001-2011. The quality management system. Requirements. - Enter. 01.01.2013. - M.: «Standartinform», 2012.	- 28 p.
2.	Kravchenko E.V., FarukshinaD.D., Garifullina L.R. Using the tools of quality management Q7 in the learning process //BulletinTISBI. - 2011. - P.2-8.
3.	Sokolovskaya M.V., Zamiralova E.V., Buyankina R.G. Improving the quality management system based on ISO 9000 // Medical education and university science.-2013. - №3. - P.5-10.
4.	Sokolovskaya M.V., Buyankina R.G., Popova O.M., Nikulina S.Yu. Criteria of efficiency of the internal audit in the educational organization // Siberian Medical Review. - 2014. - №6. - С. 95-100

The aim of the research. To provide practical recommendations on the organization of the quality control of medical care in the consultative and diagnostic polyclinic.
Materials and methods. The main parameters of the quality of specialized consultative and diagnostic medical care were assessed byadeguacy, availability, continuity and regularity effectiveness, efficiency, safety, timeliness, ability to meet the expectations and needs.
Results. Conducting internal quality expertise in a consultative and diagnostic polyclinic using quality indicators tells about adequate medical care. The current system of internal control made it possible to determine the quality level of the consultative medicalcare, to identify the causes of poor quality of the consultations and resolve them.
Conclusion. Quality indicators, designed taking into account the medical care, are objective assessment tool.

1.	About quality and safety management of medical activities in the area of volume control, timing and quality in terms of health care in the Krasnoyarsk region and internal control // Guidelines, the Ministry of Health of the Krasnoyarsk Region. Krasnoyarsk, 2011. 184 p.
2.	Government Decree of RF dd. 28.11.2014 № 1273 «On the Program of the governmental guarantees of the free provision of medical care to citizens for 2015 and the planning period of 2016 and 2017» // Law assistance system «Consultant Plus» [Electronicresource], - URL:http://www.consultant.ru(date of appeal: 25.12.2014).
3.	Order FFOMS dated 01.12.2010 N 230 «On approval of the organization and control of the volume, timing, quality and conditions of providing medical care for compulsory health insurance» // Law assistance system «Consultant Plus» (Electronicresource). URL:http://www.consultant.ru(date of appeal: 25.12.2014).
4.	Federal Law dated November 21,2011 № 323-FZ «About the basis of the health care of citizens in the Russian Federation» // Law assistance system «Consultant Plus» [Electronic resource], - URL: http://www.consultant.ru (date of appeal: 25.12.2014).
5.	Federal Law dated November 29, 2010 № 326-FZ «On the Obligatory Medical Insurance in the Russian Federation» // Law assistance system «Consultant Plus» [Electronic resource], - URL: http://www.consultant.ru (date of appeal: 25.12. 2014).

Nowadays there are new trends in the continuing evolution of infectious endocarditis. This applies to the emergence of a new form of the disease - namely, infective endocarditis of transplanted heart. This confirms the long-known postulate: «Infective endocarditis - a consequence of medical progress».

1.	Reznick I.I. Infective endocarditis in a quarter of the century: clinical and morphological evolution, medical tactic. Novosibirsk: Nauka, 2004. 281 p.
2.	Reznik I.I., Idov E.M., Kislyak S.V. Modern infective endocarditis: clinical and morphological evolution, the relationship with antiphospholipid syndrome // Archives of Internal Medicine. 2013. № 1. P.49-59.
3.	Bull D.A., Stahl R.D., McMahan D.L. The high risk heart donor: potential pitfalls// J. Heart LungTransplant. 1995. Vol. 14. P. 424-428.
4.	Counihan P.J., Yelland A., Debelder M.A., Pepper J.R. Infective endocarditis in a heart transplant recipient //J. Heart LungTransplant. 1991. Vol. 10. P.275-279.
5.	Fazia R.B., Mills R.M., Conti C.R., Staples E.D. Aortic valve endocarditis in an acutely rejecting orthotopic heart transplant recipient// Clin. Cardiol. 1996. Vol. 19. P. 672-674.
6.	Galbraith A.J., McCarthy J., Tesar P.J., McGiffw D.C. Cardiac transplantation for prosthetic valve endocarditis in a previously transplanted heart// J. Heart Lung Transplant. 1999.-Vol. 18.-P.805-806.
7.	Hasan A., Hamilton J.R., Au J. Surgical management of infective endocarditis after heart-lung transplantation //J. Heart Lung Transplant. 1993. Vol. 12. P.330-332.
8.	Khoo D.E., Zebro T.J., English ТА Bacterial endocarditis in a transplanted heart // Pathol. Res. Pracl. 1989. Vol. 185. P. 445-447.
9.	Kunst H., Paruchuru P.K., Madden B. Bacterial endocarditis: a rare complication following orthotopic cardiac transplantation // J. Heart Lung Transplant. 2001. Vol.20. P.483-485.
10.	Lpaterson D.L., Domingues E.A., Chang F.Y. Infective endocarditis in solid organ transplant recipients // Clin. Infect Dis. 1998. Vol. 26. P. 89-694.
11.	Rueter F., Hirsch H.H., Kunz E. Late Aspergillus fumigetus endomyocarditis with brain abscess as a lethal complication after heart transplantation // J. Heart Lung Transplant. 2002. Vol. 21.P. 1242-1245.
12.	Spes C.H., Angermann C.E., Mudra H. Infectious endocarditis following orthotopic heart transplantation // Z. Kardiol. 1990. Vol. 79. P. 66-68.
13.	StewartMJ., Huwez F., Richens D. Infective endocarditis of the tricuspid valve in an ortho topic heart transplant recipient //J Heart Lung Transplant. 1996. Vol. 15. P.646-649.
14.	Toporoff B., Rosado L.J., Appleton C.P. Successful treatment of early infective endocarditis and raediastinitis in a heart transplant recipient // J. Heart Lung Transplant. 1994. Vol. 13. P. 546-548.
15.	Uip D.E., Strabelli T.M. Infective endocarditis in 100 patients subjected to heart transplantation// Arq. Bras. Cardiol. 1996. Vol. 66. P. 1-3.

Hemorrhagic fever with renal syndrome (HFRS) - an acute viral, zoonotic natural focal infection. The most active natural foci of HFRS are in the Urals, the Volga Federal Districts and the Russian Far East. The paper presents the case of imported case of primary diagnosis of hemorrhagic fever with renal syndrome. The description of this event is aimed at attracting the attention of the therapeutic profile doctors to the differential diagnosis of renal syndrome, the importance of epidemiological history.

1. Artamonova I.V., Mukhetdinova G.A., Fazlyeva R.M., Boris G.D. Hemorrhagic fever with renal syndrome: does the recovery happen always? // The Practical Medicine. 2014. Vol. 83, №7. P.108-110.
 2.	Afanasyeva V.I., Ivanis V.A., Pereverten' L.Yu., Pecherkina МЛ. The evolution of clinical manifestations of hemorrhagic fever with renal syndrome in the region of the circulation of several serotypes of hantaviruses // Infectious Diseases. 2012. Vol. 10, Annex №1. P. 29.
3.	Valishin D.A., Mamon A.P., Murzabaeva R.T., Mamon M.A., Murgaleeva L.V., Mingazova E.M., Svirina A.S. Clinical and epidemiological peculiarities and prognostic criteria of severe hemorrhagic fever with renal syndrome // Infectious Diseases. 2012. Vol. 10, Annex № 1. P. 77.
4.	Korolevskaya L.B., Ivanova M.V., Shmagel' K.V., Vorobieva N.N. Hemorrhagic fever with renal syndrome: possible role of humoral immunity factors in kidney damage // Infectious Diseases. 2012. Vol. 10, № 2. P. 33-38.
5.	Marunich N.A., Gavrilov A.V., Pavlova I.I., Burdinskaya E.N. Epidemiological characteristics of hemorrhagic fever with renal syndrome in the Amur region // Practical Medicine. 2014.-T. 83, №7. P.115-117.