Abstract. This review shows the properties and using of chitosan, contemporary approaches to its use in ophthalmology.

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Abstract. The article describes the current understanding of the factors of prognosis of tumor the bladder cancer. Has been done
the review of recent major studies dedicated to the prognostic significance of clinical, morphological and molecular factors, the
nature of the treatment, as well as the possibility of using integrated systems to assess the likelihood of recurrence and disease
progression.

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Abstract. It was conducted the analysis of published data about the use of contemporary organizational technologies to prevent
hypertension. There were reviewed the basic principles and stages of diagnosis of this pathology, risk groups of developing the
hypertension, features of the organization of preventive programs, the basic principles of the blood pressure self-control system
in organizations and public places.

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18. Gurov A.N. Organization and carrying out additional prophylactic medical examination of working citizens // Compulsory Medical Insurance in the Russian Federation. 2012. № 1. P.20-27.
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Abstract. The review describes the presentation of different authors on the reason of the convulsive syndrome in alcohol addiction.
Growth of the number of cases of alcoholic psychosis and alcohol withdrawal with convulsions makes thinking about the tactics of
these patients treatment and careful assessment of neurophysiological parameters in this group of patients.

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The aim of the research. To assess the influence of gene polymorphism CYP1B1 Leu432Val to the level of bone mineral density
in women of Russian ethnic group living in the Kemerovo Region.
Materials and methods. There were studied the bone mineral density, polymorphism CYP1V1 Leu432Val, as well as the
concentration of malondialdehyde in blood plasma.
Results. The individuals with polymorphic variant Val / Val gene CYP1V1 level lumbar spine BMD was lower compared to
individuals with genotypes Leu / Val and Leu / Leu (p = 0.02).
Conclusion. The obtained data can be used in a complex prediction of osteoporotic changes and stratification of patients for bone
densitometry.

1. Glebova L.A., Kos’kina E.V., Bachina A.V., Chukhrov Yu.S. Assessment of risk to human health in the industrial centers of Kuzbass // Sanitary Doctor. 2013. № 7. P. 61-63.
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5. Os’kina N.A., Boyarskikh U.A., Lazarev A.F., Petrova V.D., Ganov D.I., Lifshits G.I., Filipenko M.L. The study of association SNP rs1056836 gene CYP1B1 replacement with risk of developing the prostate cancer // Vestnik NSU. Series: Biology, Clinical Medicine. 2010. Vol. 8, № 3. P. 27-31.
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7. Davis S., Zhang Y., Zheng T., Rothman N., Lan Q., Zahm S.H., Chanock S.J., Baris D., De Roos A.J., Gold L.S., Brown E.E., Severson R., Milliken K. Associations of common variants in genes involved in metabolism and response to exogenous chemicals with risk of multiple myeloma // Cancer Epidemiol. 2009. Vol. 33. P. 276-280.
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The aim of the research. To determine the change of the level of circulating endothelial progenitor cells (EPC) in patients with
hypertensive disease (HD) II-III stage, compared to healthy volunteers.
Materials and methods. The study involved 20 patients with essential hypertension stage II-III and 10 healthy volunteers aged
40 to 70 years old. The lymphocyte fractions obtained from venous blood samples, was carried out immunocytochemistry by method
of combined staining (2 antigens coexpression analysis, immunofluorescence variant), confocal microscopy of preparations was
carried out using a microscope Olympus FV10i (Olympus, Japan). The cells were counted in 10 fields of view with magnification
600-6000 (due to optical and digital zoom). EPC were identified as CD31 + CD133+ - cells.
Results. It is found that the relative amount of EPC is increased in patients with stage III of HD compared to healthy volunteers (p
= 0.01). It is also found that the relative number of cells expressing CD31, statistically significantly higher in patients with stage III
of HD compared to healthy volunteers (p = 0.005).
Conclusion. In patients with hypertensive disease in comparison with a group of healthy volunteers is increased the level of EPC
in the peripheral blood.

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// International Journal of Cardiology. 2013. Vol. 167, №5. P. 1688-1695.
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The aim of the research. To study the expression of CD38 and CD157 molecules in microglial and astroglial cells in the olfactory bulbs.
Materials and methods. Modeling of AD was performed with intrahippocampal administration of beta-amyloid in CA1 zone of
rat brain. Expression of the markers was studied with indirect immunohistochemistry.
Results. We found elevated expression of CD38 and CD157 in microglial and astroglial cells suggesting the role of NAD+-
converting enzymes in the progression of neuroinflammation and neurodegeneration.
Conclusion. The new data about the features of CD157 and CD38 expression in astrocytes of neurogenic niches complete the
understanding of the mechanisms of neurodegeneration in the reactive gliosis.

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2. Akther S., Korshnova N., Zhong J., Liang M., Cherepanov S. M., Lopatina O., Komleva Y. K., Salmina A. B., Nishimura T., Fakhrul A. A., Hirai H., Kato I., Yamamoto Y.,Takasawa S., Okamoto H., Higashida H. CD38 in the nucleus accumbens and oxytocin are related to paternal behavior in mice // Mol. Brain. 2013. 6:41. doi: 10.1186/1756-6606-6-41.
3. Blacher E., Dadali T., Bespalko A., Haupenthal V. J., Grimm M. O, Hartmann T., Lund F. E., Stein R., Levy A. Alzheimer’s disease pathology is attenuated in a CD38-deficient mouse model // Ann. Neurol. 2015. Vol. 78. P. 88-103.
4. Braak H., Del Tredici K., Rüb U., de Vos R. A., Jansen Steur E. N., Braak E. Staging of brain pathology related to sporadic Parkinson’s disease // Neurobiol. Aging. 2003. Vol. 24. P. 197-211.
5. Choe C.U., Lardong K., Gelderblom M., Ludewig P., Leypoldt F., Koch-Nolte F., Gerloff C., Magnus T. CD38 exacerbates focal cytokine production, postischemic inflammation and brain injury after focal cerebral ischemia // PLoS One. 2011. Vol. 6. e19046.
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9. Lavagno L., Ferrero E., Ortolan E., Malavasi F., Funaro A. CD157 is part of a supramolecular complex with CD11b/CD18 on the human neutrophil cell surface // J. Biol. Regul. Homeost. Agents. 2007. Vol.21. P. 5-11.
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13. Malavasi F., Deaglio S., Ferrero E., Funaro A., Sancho J., Ausiello C. M., Ortolan E., Vaisitti T., Zubiaur M., Fedele G., Aydin S., Tibaldi E. V., Durelli I., Lusso R., Cozno F., Horenstein A. L. CD38 and CD157 as receptors of the immune system: a bridge between innate and adaptive immunity // Mol. Med. 2006. Vol. 12. P. 334-341.
14. Salmina A. B., Okuneva O. S., Malinovskaya N. A., Taranushenko T. E., Morgun A. V., Mantorova N. S., Mikhutkina S. V. NAD+-dependent mechanisms of disturbances of viability of brain cells during acute period of hypoxicischemic perinatal injury // Neurochem. J. 2008. Vol. 2-3. P. 215-221.
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The aim of the research. We have studied the development of neurological deficits in rats subjected to perinatal hypoxia or early
life stress.
Materials and methods. The study was conducted in Wistar rats of both sexes at the age of 1-120 days with the experimental
models of early life stress and perinatal hypoxia. We assessed neurological dysfunction using the Neurological Severity Scores
(NSS), cognitive deficit in the «Morris water maze». Statistical analysis was done with the T-test.
Results. We found significant changes in the physical development in both the experimental groups associated with neurological
dysfunction at postnatal day 7 after hypoxia or postnatal day 14 during early life stress. Further progression of cognitive dysfunction
was evident in hypoxic or stressed rats up to 42 day of postnatal development.
Conclusion. Early manifestations of neurological deficits, alterations of physical development and cognitive function are the
characteristics of the perinatal hypoxia action whereas postponed development of neurological dysfunction marks the early life
stress effects on brain development.

1. Salmina A.B., Komleva Yu.K., Kuvacheva N.V., Lopatina O.L., Inzhutova A.I., Yauzina N.A., Morozova G.A., Malinovskaya N.A., Pozhilenkova E.A., Morgun A.V., Taranushenko T.E., Petrova M.M. Molecular mechanisms of brain development alterations in pre- and neonatal periods // Voprosy Sovremennoy Pediatrii. 2012. Т. 11, № 6. С. 15-20.
2. Chen J., Sanberg P.R., Li Y., Wang L., Lu M., Willing A.E., Sanchez-Ramos J., Chopp M. Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in rats // Stroke. 2001. Vol. 32, № 11. P. 2682-2688.
3. Clancy B., Finlay B.L., Darlington R.B., Anand K.J. Extrapolating brain development from experimental species to humans // Neurotoxicology. 2007. Vol. 28, № 5. P. 931-937.
4. Dickey E.J., Long S.N., Hunt R.W. Hypoxic ischemic encephalopathy – what can we learn from humans? // J. Vet. Intern. Med. 2011. Vol. 25, № 6. P. 1231-1240.
5. Garrido P. Aging and stress: past hypotheses, present approaches and perspectives // Aging Dis. 2011. Vol. 2, № 1. P. 80-99.
6. Korosi A., Naninck E.F., Oomen C.A., Schouten M., Krugers H., Fitzsimons C., Lucassen P.J. Early-life stress mediated modulation of adult neurogenesis and behavior // Behav. Brain Res. 2012. Vol. 227, № 2. P. 400-409.
7. Marmendal M., Roman E., Eriksson C.J., Nylander I., Fahlke C. Maternal separation alters maternal care, but has minor effects on behavior and brain opioid peptides in adult offspring // Dev. Psychobiol. 2004. Vol. 45, № 3. P. 140-152.
8. Tu Y.F., Tsai Y.S., Wang L.W., Wu H.C., Huang C.C., Ho C.J. Overweight worsens apoptosis, neuroinflammation and blood-brain barrier damage after hypoxic ischemia in neonatal brain through JNK hyperactivation // J. Neuroinflam. 2011. Vol. 8, № 40. P. 1-15.
9. Uhelski M.L., Fuchs P.N. Maternal separation stress leads to enhanced emotional responses to noxious stimuli in adult rats // Behav. Brain Res. 2010. Vol. 212, № 2. P. 208-212.
10. Yoneoka Y, Satoh M., Akiyama K., Sano K., Fujii Y., Tanaka R. An experimental study of radiation-induced cognitive dysfunction in an adult rat model // Br. J. Radiol. 1999. Vol. 72, № 864. P. 1196-1201.
11. Zhang Q., Ding Y., Yao Y., Yu Y., Yang L., Cui H. Creating rat model for hypoxic brain damage in neonates by oxygen deprivation // PLoS One. 2013. Vol. 8, № 12. P. e83589.

The aim of the research. To study of enzymatic and chemiluminescent activity of blood neutrophils in patients with severe and moderate course of community-acquired pneumonia.
Materials and methods. The study involved 48 patients with moderate severity of pneumonia and 40 patients with severe degree on the 1st day of hospitalization. Lyutsigenin- and luminol-dependent chemiluminescence of neutrophils was studed. Using bioluminescent method were studied the activity levels of NAD (P) -dependent dehydrogenases in neutrophils. Results. The level of "respiratory burst" in neutrophilic granulocytes was increased in patients with pneumonia. Only in patients with severe pneumonia in the cells was increased the intensity of the terminal reactions of anaerobic glycolysis and the tricarboxylic acids cycle.
Conclusion. The violations of the metabolic mechanisms that determine the intensity of the "respiratory burst" of neutrophils in patients with varying severity of community-acquired pneumonia, determine the need for a pathogenetically substantiated therapy aimed at restoring of the basic metabolic processes of phagocytes and their function.

1.	Vladimirov Yu.A., Proskurina E.V. Free radicals and cellular chemiluminescence // Advances of Biological Chemistry. 2009. Vol. 49. P. 341-388.
2.	Dvoretskiy L.I. Community-acquired pneumonia: diagnosis and antibacterial therapy // Consilium Medicum. 2008. № 3. P. 25-30.
3.	Kurtasova L.M., Zukov R.A., Shkapova E.A. Change of functional and metabolic activity of neutrophils of periphery blood in patients with renal cell carcinoma // Vestnik of RAMS. 2014. № 11-12. P.104-110.
4.	Savchenko A.A. Determination of the activity NAD (P) -dependent dehydrogenases in neutrophil granulocytes by the bioluminescent method // Bulletin of Experimental Biology and Medicine. 2015. Vol. 159, № 5. P. 656-660.
5.	Savchenko A.A., Zdzitovetsky D.E., Borisov A.G., Luzan N.A. Chemiluminescent and enzymatic activity of neutrophil granulocytes in patients with widespread purulent peritonitis depending on the outcome of the disease // Bulletin of RAMS. 2014. № 5-6. P. 23-28.
6.	Sinopal'nikov A.I., Kozlov R.S. Community-acquired infections of the respiratory tract: Manual for Physicians . M .: Premier MT, Our City, 2007. 353 p.
7.	Soodaeva S.K. Free radical mechanisms of damage in diseases of the respiratory system // Pulmonology. 2012. № 1. P. 5-10.
8.	Chirkin A.A., Danchenko E.O. Biochemistry. Moscow: Medical literature. 2010. 608 p.
9.	Chuchalin A.G., Sinopal'nikov A.I., Kozlov R.S., Tyurin I.E., Rachina S.A. Community-acquired pneumonia in adults: recommendations for diagnosis, treatment and prevention. Manual for Physicians. M., 2010. 54 p.
10.	Yarilin A,A, Immunology. Moscow: GEOTAR-Media, 2010. 752 p.
11.	American Thoracic Society, Infectious Diseases Society of America. Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia // Am. J. Respir. Crit. Care Med. 2005. Vol. 171, № 4. P. 388-416.
12.	Bao Y., Ledderose C., Seier T. et al. Mitochondria regulate neutrophil activation by generating ATP for autocrine purinergic signaling // J. Biol. Chem. 2014. Vol. 289, № 39. P. 26794-26803.
13.	Chroneou A., Zias N., Beamis J.F., Craven D.E. Healthcare-associated pneumonia: principles and emerging concepts on management // Expert Opin. Pharmacother. 2007. Vol. 8, № 8. P. 3117-3131.
14.	Dinauer M.C. Disorders of neutrophil function: an over-view // Methods Mol. Biol. 2014. Vol. 1124. P. 501-515.
15.	Genestet C., Le Gouellec A., Chaker H. Scavenging of reactive oxygen species by tryptophan metabolites helps Pseudomonas aeruginosa escape neutrophil killing // Free Radic. Biol Med. 2014. Vol. 73. P. 400-410.
16.	Kotzamanis K., Angulo A. Ghazal1 P. Infection homeostasis: implications for therapeutic and immune programming of metabolism in controlling infection // Med. Microbiol. Immunol. 2015.-Vol. 204, № 3. P. 395-407.
17.	Liu G., Yang H., Chen X. Modulation of neutrophil development and homeostasis // Curr. Mol. Med. 2013. Vol. 13, № 8. P. 1270-1283.
18.	Liu X., Yang Z., Chen Z. Effects of the suppression of lactate dehydrogenase A on the growth and invasion of human gastric cancer cells // Oncol. Rep. 2015. Vol. 33, № 1. P. 157-162.
19.	Nagasaki H., Nakashima A., Kaneko Y.S. et al. Aripiprazole increases NADPH level in PC12 cells: the role of NADPH oxidase // J. Neural. Transm. 2014. Vol. 121, № 1. P. 91-103.
20.	Pliyev B.K., Ivanova A.V., Savchenko V.G. Extracellular NAD( +) inhibits human neutrophil apoptosis // Apoptosis. 2014. Vol. 19, № 4. P. 581-593.

Aim of the research. To identify the features of the body composition of men and women with sustained, accelerated version of normal and aging
Materials and methods. The study involved 703 women and 665 men of the first and second periods of mature age. Evaluation of biological age by A.G. Gorelkin and B.B. Pinkhasov and body composition analysis by bioimpedance measuring. Results. People with accelerated aging are characterized by increased fat mass, increase in proportion to the speed of the aging factor. Slow aging is associated with high values of lean mass, the water component and phase angle.
Conclusion. Identified aging rate due to the parameters of body composition allows the last to recognize the markers of human health.

1.	Banerzhi A. Medical statistics in plain language: transl. from English. M .: Practical Medicine, 2007. 288 p.
2.	Golubeva E.Yu., Danilova R.I. Pace of aging of the elderly in the European North of Russia // Clinical Gerontoloy. 2012. №7-8. P. 31-35.
3.	Deev A.I. How to determine the pace of human aging? // Clinical Gerontology. 2008. № 9. P. 87.
4.	Kishkun A.A. Biological age and aging: the possibility of determining and the path of correction. M .: GEOTAR-Media, 2008. 976 p.
5.	Kobileva N.G. Ethnic and constitutional features acne in young men Republic of Khakassia // Siberian Medical Review. 2009. № 2. P. 48-51.
6.	Krut'ko V.N., Slavin M.B., Smirnova T.M. Mathematical Foundations of Gerontology. M.: IRDA, 2002. 384 p.
7.	Pat. number 238774 Russian Federation. The method for determining the biological age of the person and the rate of aging / A.G. Gorelkin, B.B. Pinkhassov. № 2008130456/1; publ. 27.04.2010, Bull. № 12. 2 p.
8.	Peshkov M.V., Sharaykina E.P. Gender-specific indicators based on the bioimpedance measuring the body mass index of students // Siberian Medical Review. 2014. № 6. P. 52-57.
9.	Pozdnyakova N.M., Proshchaev K.I., Ilnitsky A.N. Modern views on the possibility of assessment of biological age in clinical practice // Basic Research. 2011. № 2. P. 17-22.
10. Box G. E. P., Cox D. R. An analysis of transformation // J. Royal Statistical Sosiety: Series B (Statistical Methodology). 1964. Vol. 26, № 2. P. 211-246.

The aim of the research. To study the morbidity of febrile seizures (FS) in children of Zabaikalsk Territory from 200 to 2013. Materials and methods. Has been done the retrospective analysis of the register data of patients with epilepsy and convulsions of children age (FS and isolated seizure) of Zabaikalsk Regional Antiepileptic Center (ZRAC) for period 2004-2013.
Results. FS morbidity in Zabaikalsk Territory increased from 0,08 (26 cases in 2004) to 0,95 (277 cases in 2013) per 1000 children population from the opening of ZRAC. The frequency of FS cases in the register structure of children with epilepsy and convulsions increased from 5,69% in 2004 to 17,7% in 2013. FS were prevailed in children from 1 year 1 month up to 3 years old. The ratio of frequency FS cases among boys and girls varies from 1,2:1 to 1,4 : 1 without statistically significant ratio. Morbidity of FS significantly didn't differ among children living in Chita and in the regions of Zabaikalsk Territory.
Conclusion. FS morbidity in Zabaikalsk Territory in the period 2004-2013 varied from 0,08 (26 cases in 2004) to 0,95 (277 cases in 2013) per 1000 children. Gender and geographical differences of the FS morbidity indicators in the studied population were not founded.

1. Martynova G.P., Schnayder N.A., Stroganova M.A. Epidemiology of febrile seizures in the pediatric population of the city of Krasnoyarsk // Epilepsy and paroxysmal states. 2014 - Vol.6, № 2. P. 6-10.
2. Marueva N.A., Schnayder N.A., Shulmin A.V., Shirshov Yu.A., Goltvanitsa G.A., Kulinich T.S. The epidemiology of epilepsy and seizures in the pediatric population of Zabaikalsk Territory // Zabaikalsk Medical Bulletin. 2015. №2. P.119-128.
3.Distribution of the population of Zabaikalsk Territory by age and gender. Statistical Digest. Chita: Zabaykalkray-stat, 2014 - 57p.
4.Stroganova M.A., Schnayder N.A., Martynova G.P., Dyuzhakova A.V. Epidemiology of febrile seizures in children (review) // In the World of Scientific Discoveries. 2014. №8 (56). P. 216-230.
5.Sergeyeva K.M. Age periods of childhood. Pediatrics: ed. SPb. 2007. 544 p.
6.Schnayder N.A., Shapovalova E.A., Dmitrenko D.V., Sadykova A.V., Shapovalova L.P. Epidemiology of children epilepsy // Siberian Medical Review. 2012. № 2. P. 44-50.
7.Shnayder N.A., Dmitrenko D.V., Sadykova A.V., Sharavii L.K., Shulmin A.V., Shapovalova E.A., Pilyugina M.S., Darsavelidze O.K. Epidemijlogical studies on epilepsy in Siberia // Medical and Health Science Journal. 2011. Vol. 6. P. 35-42.

The aim of the research. To develop and validate the system of medical care that allowed to decrees the frequency of post¬operative complications and letality among patients with spread peritonitis.
Materials and methods. The research base was choosen the surgical department of BUZ Altai Republic "Respublican Hospital". It was examined 2585 medical cases of patients with peritonotis of different etiology, severity and prevalence, 628 (24,2 ±0,017%.) of them had spread form of peritonitis.
The results. For achieving the main goal, there were studed the results of the patients treatment with failure of the small intestine anastomosis - 44 patients (81,5±5,4%), that were distributed into the groups. In the first group the sourse of the peritoitis was removed (anastomosis was resected), abdomen was sanitized and sewed tightly, in the seconsd group the abdomen wall wasn't sewed and there were superimposed the laparostomy.
Conclusion. The developed and investigated method of obstructive resection of intestine with laparostome and programmed sanitasing of abandom in patients with spread peritonitis helped to dicrees the letality from 56,0±9,9% to 21,0±9,3% and frequency of post-operative complications from 68,0±9,3% to 37,0±11,2%.

1.	Aliyeva E.A., Isaev N.B., Gasanov F.D. Ways to increase the efficiency of post-operative rehabilitation of the abdominal cavity with diffuse purulent peritonitis (experimental-clinical research) // Annals of Surgery. 2008. №5. P. 57-59.
2.	Babadjanov B.D., Teshaev O.R., Beketov G.I. New approaches to treatment of postoperative peritonitis // Journal of Surgery. 2002. № 4. P. 25-28.
3.	Buzunov A.F. Laparostomy. Treatment of surgical diseases of the abdomen through open treatment of the abdominal cavity. M.: Practical Medicine, 2008. 202 p.
4.	Savelyev V.S., Filimonov M.I., Podachin P.V., Chubchenko S.V. Errors in the choice of tactics of surgical treatment of widespread peritonitis // Annals of Surgery. 2008. № 1. P. 26-33.
5.	Agalar F., Eroglu E., Bulbul M., Agalar C., Tahran O.R., Sari M. Staged Abdominal repair for treatment of moderate to severe secondary peritonitis // World J. Surg. 2005. Vol. 29, № 1. P.240-244.
6.	Mulier S., Penninckx F., Verwaest С., Filez L., Aerts R., Fieuws S., Lauwers P. Factors affecting mortality in generalized postoperative peritonitis: multivariate analysis
in 96 patients // World J. Surg. 2003. Vol.27, №4. P.379-384.

The aim of the research. To identify the features of nutritional support in patients at the operational oncology on the regional level. Materials and methods. It was conducted the retrospective pharmacoepidemiological analysis of the nutritional support in operational oncology on the basis of medical data records of 1,500 patients.
Results. There were revealed the leading nosologies of nutritional deficiency and pathology types of trophological status. There were identified unsolved problems at the nutritional support to the surgical oncology patients.
Conclusion. To optimize the nutritional support it is nesessary some organizational and methodical measures aimed at improving of this type of medical care.

1.	Leiderman I.N., Snegovoy A.V., Khlynov I.B., Chikunova M.V., Lisovskaya T.V. Basic principles and techniques of clinical nutrition in oncology: a guide for doctors. M., 2006. 36 p.
2.	Makeyeva T.K., Galkin A.A. Trophological status of patients with gastric cancer // Bulletin of Saint - Petersburg University. 2008. №1 (ser.1). P. 105-117.
3.	Mal'kov O.A., Moroz V.V., Dolgikh V.T. Nutritional support in surgical oncology // General Reanimatology. 2008. № 2. P.94-97.
4.	Obukhova O.A., Kishin Sh.R., Sviridova S.P. Strategy of perioperative nutritional support in surgical patients // Consilium - medicum. 2010. Vol.12. P. 97-103.
5.	Parenteral and enteral nutrition: national leadership / M.Sh. Khubutiy, T.S. Popova, A.I. Saltanov. M .: GEOTAR-Media, 2014. - 800 p.
6.	Pasechnik I.N., Gubaidullin R.R., Borisov A.Yu. Fundamentals of nutritional support of patients in the critical states. M .: Colisey, 2012. 160 p.
7.	Popova T.S., Shestopalov A.E., Protsenko D.N. The practice of nutritional support in the intensive care departments of the Russian Federation // Journal of Anesthesiology and Intensive Care. 2011. Vol. 8, №5. P. 7-10.
8.	Pugaev A.V., Achkasov E.E. Assessment of nutritional status and identifying of the need for nutritional support: a tutorial. M .: Profile, 2007. 103 p.
9.	Snegovoy A.V., Leiderman I.N., Saltanov A.I., Sel'chuk V.Yu. Basic principles and techniques of clinical nutrition in oncology: a guide for doctors. M., 2009. 38 p.
10.	Santarpia L., Contaldo F., Pasanisi F. Nutritional screening and early treatment of malnutrition in cancer patients // J. Cachexia Sarcopenia Muscle. 2011. Vol. 2. P. 27-35.

The aim of the research. To study the clinical and laboratory CUP manifestations on the background of the treatment with ozonetherapy using quantificational scales SOS-HP and SPS.
Materials and methods. The study included 306 patients with CUP aged 22 to 35 years old, the age group of men of the first period of mature age and living in Krasnoyarsk.
Results. After complex treatment of CUP with general and local ozonetherapy has been achieved symptomatic improvement, to reduce the intensity of pain, to reduce dysuric disorders, to improve sexual function and quality of men's life. In addition, the patients marked the increase of blood flow in arteries and veins of the prostate, reducing the size of the organ and its volume, improved reproductive and hormonal status, complete elimination of STIs.
Conclusion. Using general and local ozonetherapy in the complex treatment of CUP can achieve significant clinical and instrumental improvements.

1.	Apolikhin O. I. Sivkov A.V., Believ D. A., T. V. Solntseva, V. A. Komarova Analysis uronefrologicheskoy morbidity in the Russian Federation according to official statistics // Exper. clin. urology. 2010. № 1. P. 4-11.
2.	Vinnik Yu. Yu., Prohorenkov V.I., Nikolaev V.G. Monitoring the effectiveness of treatment of chronic prostatitis using laser doppler flowmetry // Sib. med. review. 2009. № 5. P. 58-61.
3.	Loran O.B., Segal A.S. The system total symptom scores in chronic prostatitis (SOS - CP) // Urology. 2001. № 5. P. 16-19.
4.	Molochkov V.A., Ilyin I.I. Chronic prostatitis urethrogenic. Moscow: Medicine, 2004. 288 p.
5.The overall sexual pathology: a guide for doctors / G.S. Vasilchenko, I.L. Botneva, Yu. Yu. Vinnik [et al.] / Ed. G.S. Vasilchenko. M.: Medicine, 2005. 512 p.
6.Prostatitis / ed. P.A. Scheplev. M.: MEDpress-inform, 2007. 232 p.
7.Segal A. S. Diseases of the reproductive system of men. M.: Icarus, 2010. 324 p.

The aim of the research. To identify the features of osteoporosis in COPD.
Materials and methods. The study involved 79 women suffering from postmenopausal osteoporosis, mean age was 66,9 ± 1,7 years. All of the women not using oral glucocorticoid therapy.
Results. When comparing patients with COPD of FEV1 values, bone mineral density (BMD) of the forearm (spoke-bone), T-test of the arm were significantly higher in patients with asthma and in women without pulmonary disease (p<0,05). Cases of fractures were more common in patients with COPD (p<0,05). There were no significant differences in rates of osteoporosis in patients with asthma and without lung disease.
Conclusion. The received data indicate more severe course of the osteoporosis in patients with COPD.

1.	Avdeev S. System effects in patients with COPD // Doctor. 2006. № 12. P.3-8.
2.	Dvoretskiy L.I., Chistyakova E.M. Osteoporosis in patients with COPD: comorbidity or systemic manifestation? // Consilium Medicum. 2007. Vol.9, №12. P. 42-48.
3.	Zhestkov A.V., Kosarev V.V., Babanov S.A., Glazitov A.V. Epidemiology and risk factors for chronic obstructive pulmonary disease in a large industrial center of the Middle Volga region // Disease Prevention and Health Promotion. 2009. №1. P.42-44.
4.	Klyachkina I.L. Mucolytic drugs in productive cough in patients with chronic obstructive pulmonary disease // Consilium Medicum. 2007. Vol. 9, № 3. P.58-62.
5.	Osteoporosis. Diagnosis, prevention and treatment. Clinical guidelines of the Russian Association on Osteoporosis / Ed. L.I. Benevolenskaya and O.M. Lesnyak. M .: GEOTAR -Media, 2005. 171 p.
6.	Rozhinskaya L.Ya. The concept of bone quality: the impact of antiresorptive agents (Miacalcic) on bone strength // Russian Medical Journal. 2004. № 9. P. 557-631.
7.	The Russian Respiratory Society. Federal clinical guidelines for the diagnostics and treatment of chronic obstructive pulmonary disease. 2014. 41 p.
8.	Toroptsova N.V., Mikhailov E.E., Benevolenskaya L.I. The problem of osteoporosis in the modern world // RMJ. 2005. Vol. 13, № 24 (248). P. 1582-1585.
9.	Chuchalin A.G. Chronic obstructive pulmonary disease and related diseases // Health Protection of Ukraine. 2010. № 2 (231). P. 26-27.
10.	Barnes P.J., Celli B.R. Systemic manifestation and comorbidities of COPD // Eur. Respir. J. 2009. Vol. 33. P. 1165-1185.
11.	Buist A.S., McBurnie M.A., Vollmer W.M., Gillespie S., Burney P., Mannino D.M., Menezes A. M.B., Sullivan S.D., Lee T.A., Weiss K.B., Jensen R.L., Marks G.B., Gulsvik A., Nizankowska-Mogilnicka E. ОП behalf of the BOLD Collaborative Research Group. International variation in the prevalence of COPD (the BOLD Study): a population-based prevalence study// Lancet. 2007. Vol. 370. P. 741-750.
12.	Garcia-Rio F., Miravitlles M., Soriano J.B., Munoz L., Duran-Tauleria E., Sanchez G., Sobradillo V., Ancochea J. EPI-SCAN Steering Committee: Systemic inflammation in chronic obstructive pulmonary disease: a population-based study// Respiratory Research. 2010. Vol.11. P. 63-65.
13.	Hurst J.R., Perera W.R., Wilkinson T.M., Donaldson G.C., Wedzicha J.A. Systemic and upper and lower airway inflammation at exacerbation of chronic obstructive pulmonary disease // Am. J. Respir. Crit. Care Med. 2006. Vol.173. P. 71-78.
14.	National Osteoporosis Foundation. Osteoporosis: review of the evidence for prevention, diagnosis and treatment, and cost-effectiveness analysis. // Osteoporosis Int. 1998. Vol.8, № 4. P. 51-58.

This article presents a clinical case of a severe form of influenza B, complicated by infection-toxic shock, acute myocarditis and pericarditis. This example proves the need for increased alertness vigilance in the interpretation of the clinical symptoms of the disease in conjunction with instrumental methods.

1.	Flu (seasonal, avian, pandemic) and other ARVI / Ed. V.P. Malyi, M.A. Andreychin - M.: GЕOTAR - Media, 2012. 320 p.
2.	Flu: epidemiology, diagnosis, treatment, prevention / Ed. by Acad. RAMS O.I. Kiselev, Dr.Med.Sc. L.M. Tsybalova, Acad. RAMS V.I. Pokrovskiy. M .: OOO «Publishing House «Medical News Agency», 2012. 496 p.
3.	Dondurei E.A., Osidak L.V., Golovacheva E.G.,Sukhovetskaya V.F. Influenza with gastrointestinal symptoms: causes of development, principles of therapy // Epidemiology and Infectious Diseases. 2013. №2. P. 61-67.
4.	Orlov V.N. Guide on electrocardiography. M .: Medical Information Agency, 2014. 526 p.
5.	Sergeyeva I.V., Kamzalakova N.I., Tikhonova E.P., Bulygin G.V. Immunological aspects of acute respiratory viral infections and flu // Siberian Medical Review. 2012. №6. P. 4-8.
6.	Yushchuk N.D., Bokova N.O., Dudina K.R., Znoiko O.O., Karetkina G.N., Balmasova I.P., Kelly E.I., Malyshev N.A. Features of severe influenza A (H1N1) pdm09 with different outcomes // Attending Physician. 2014. №11. P. 45-48.

The article presents a case of hypersensitive pneumonitis in young 21-year-old patient. Currently there are no accurate data on the prevalence of this pathology. The complexity of the diagnosis of hypersensitive pneumonitis is explained by the low awareness of the doctors about this disease and the need for special high-tech methods of examination.

1.	Avdeev S.N., Avdeeva O.E., Chuchalin A.G. Exogenous allergic alveolitis // Russian Medical Journal. 2007. № 6. P. 20-32.
2.	Babanov S.A., Kosarev V.V. Exogenous allergic alveolitis: problems of diagnostics // Russian Medical Journal. 2013. Vol. 21, № 7. P. 388-392.
3.	Vasilyeva O.S., Chuchalin A.G., Chernyaev A.L., Samsonova M.V., Kulemina E.A. Hypersensitive pneumonitis caused by exposure to metal allergens // Pulmonology. 2008. № 4. P. 116-118.
4.	Demko I.V. Medicinal allergies // Siberian Medical Review. 2013. № 4. P.83-88.
5.. Lev N.S., Kovalevskaya M.N., Sorokina E.V., Lepekha L.N. Difficult patient. Hypersensitive pneumonitis. Clinical observation // Pediatric Practice. 2013. October. P. 4-7.
6.	Lev N.S., Shmelyov E.I., Rozinova N.N. Hypersensitive pneumonitis as a form of diffuse interstitial lung diseases in children // Pediatrics. 2013. № 92 (36). P. 96-101.
7.	Mukhin N.A. Interstitial lung diseases. M Litterra, 2007. 434 p.
8.	Kamangar N. Hypersensitivity Pneumonitis. eMedicine. Eds. Zab Mosenifar, et al. 2013. Medscape.<http://emedicine.medscape.com/ article/299174-overview>.

Here is the clinical case of neglected form of the stomach cancer in a pregnant woman. This pathology in pregnant women is rare and is very difficult to verify the diagnosis, as well as at the doctors obstetricians-gynecologists, so the doctors gastroenterologists. The authors focuse the attention on the development of clinical signs of tumor before pregnancy, errors and complexity of diagnosis.

1.	Dobrodeev A.Yu. Pregnancy and cancer of the gastrointestinal tract // Siberian Journal of Oncology. 2003. №3. P. 37-39.
2.	Protasova A.E., Protasov D.A. The rare combination of cancer and pregnancy // Practical Oncology. 2009. Vol. 10, № 4. P. 220-221.
3.	Shanazarov N.A., Mashkin A.M., Sagandykov Zh.K, Midlenko A.A. Stomach cancer. Epidemiological features at the present stage // Modern problems of science and education. [Electronic Scientific Journal]. 2014. № 4. URL: http://www.science-education.ru/118 (date of appeal 24.05.2015).
4.	Yuxuan Chen, Yao Li, Hong Wang, Junli Lu, Mulan Jin, Zhenyu Zang. Maternal gastric carcinoma with metastasis to the placenta: A case report // Oncology Letters. 2014. № 8. P. 2509-2510.
5. Alpaslan Terzi, Sacit Qoban, Fahrettin Yildiz, §ahin Aksoy, Harun Toy, Ali Uzunkoy Surgical. Treatment of a Gastric Cancer in a Pregnant Woman without Performing Abortion // European Journal of General Medicine. 2010. №7(1). Р. 111-113.

The lecture describes contemporary idea of the surgical treatment of gastric cancer. It provides the basic types and volumes of the currently used methods of ablation and operational capabilities, depending on the incidence of cancer.

1.	Afanasyev S.G., Avgustinovich A.V., Tuzikov S.A., Pak A.V., Volkov M.Yu., Savelyev I.N., Frolova I.G. The results of combined operations for locally advanced gastric cancer // Oncology. Journal named after P.A. Herzen. 2013. № 2. P. 12-15.
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The article is devoted to the problems of readiness the medical community to work in a deliberate use of biopathogens, main biopathogens, their fighting qualities, application conditions, factors affecting biological weapons, complex of the protective measures.

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In this article the authors examined topical issues of methodology of teaching the subject "Economics" in higher medical education. It discussed in details the issue of detention of the discipline and its practical application by the physicians - specialists. Separately are considered the motivational factors in the study by the students the non-core subjects.

1.	Kostenko V.B., Kiyan T.V., Yurieva E.A. Ways to improve the educational process in the course «Economics» in the new FGOS «Modern aspects of the implementation of the FGOS and FGT.» - Krasnoyarsk: KrasSMU, 2013. P.35-37.
2.	Kostenko V.B., Baidasheva E.N., Yurieva E.A. On the question of the organization of distance learning in medical school: the materials of the conference «Modern trends in the development of educational technology in medical education.)) – Krasnoyarsk: KrasSMU, 2015. P.316-319.
Chelnokova O.Yu. The specifics of teaching economics at the mathematical specialties in the high school. Methods of Teaching Economics: experience and problems. Iss. 1. Saratov: Publishing Center «Nauka», 2010. P.15-20.