Сибирское медицинское обозрение. 2018. № 5 View full textКоличество просмотров : 7730
Averyanov A.B., Cherkashina I.I., Nikulina S.Y.
THE ROLE OF SINGLE NUCLEOTIDE POLYMORPHISMS OF SOCS5 AND EGFR GENES IN THE DEVELOPMENT OF ALLERGIC BRONCHIAL ASTHMA
Averyanov AB, Cherkashina II, NikulinaSYu. Th e role of single nucleotide polymorphisms of SOCS5 and EGFR genes in the development of allergic bronchial asthma. Siberian Medical Review.2018;(5):5-10. DOI: 10.20333/2500136-2018-5-5-10. DOI 10.20333/2500136-2018-5-5-10
Averyanov Anatoliy B graduate student; Professor V. F. Voino-Yasenetsky Krasnoyarsk State Medical University; Averyanov_a007@mail.ru
Cherkashina Irina Ivanovna Dr.Med.Sc., Associate Professor of Department of Internal Diseases №1; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; email@example.com
Nikulina Svetlana Yurievna Dr.Med.Sc., Professor, Head of Department of Internal Diseases №1, Vice Rector for Academic Affairs; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; firstname.lastname@example.org
Th is article is a scientifi c review of the literature data for the past 20 years concerning cytokine signal suppressor (SOCS5) gene and epidermal growth factor receptor gene (EGFR), based on OMIM, PubMed, and NCBI databases. SOCS5 and EGFR genes action mechanisms, the structure and functioning of the encoded data by protein genes are considered. Th e results of the published studies, confi rming the role of SOCS5 and EGFR genes in the development of pathology of lungs and other organs are presented. These genes association with the development of allergic bronchial asthma is shown by several case of studies.
Keywords: gene, SNP, multifactorial disease, bronchial asthma, SOCS5, EGFR
Karetnikova V.N., Polikutina O.M., Slepynina Y.S., Katsyuba M.V., Bazdyrev E.D., Barbarash O.L.
CORRELATION OF INFLAMMATION MARKERS AND THE LEVEL OF DIFFUSIONAL CAPACITY OF LUNGS IN PATIENTS WITH MYOCARDIAL INFARCTION
Karetnikova VN, Polikutina OM, Slepynina YS, Katsyuba MV, Barbarash OL. Correlation of infl ammation markers and the level of diffusional capacity of lungs in patients with myocardial infarction. Siberian Medical Review.2018 (5):11-16. DOI: 10.20333/2500136-2018-5-11-16. DOI 10.20333/2500136-2018-5-11-16
Karetnikova Victoria Nicolaevna Dr. Med. Sci., Head of laboratory of blood circulation pathology; Federal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular Diseases; email@example.com
Polikutina Olga Mikhailovna Cand.Med.Sc, Head of Laboratory of Ultrasonic and Electrophysiological Methods; Research Institute for Complex Issues of Cardiovascular Diseases; mailto:firstname.lastname@example.org
Slepynina Yulia Sergeevna Research Scientist of Laboratory of Ultrasonic and Electrophysiological Methods; Research Institute for Complex Issues of Cardiovascular Diseases; mailto:email@example.com
Katsyuba Maya V post-graduate student; Scientific Institution Research Institute for Complex Issues of Cardiovascular Diseases; firstname.lastname@example.org
Bazdyrev Evgeny Dmitrievich Cand.Med.Sc., senior research associate of the laboratory of pathophysiology of multifocal atherosclerosis; Federal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular Diseases; email@example.com
Barbarash O. L. Dr. Med. Sci., Professor; Kemerovo State Medical University; Scientific Research Institute of Complex Problems of Cardiovascular Diseases; firstname.lastname@example.org
Th e aim of the research. Assessment of correlation between the concentration of infl ammation markers, as well as N-terminal fragment of natriuretic peptide (NT-proBNP) and diff usion capacity of lungs (DLCO) in patients with myocardial infarction (MI). Material and methods. Th e study includes 107 patients with myocardial infarction, 88 of whom (82.2 %) are men. All patients had I grade of cardiac insuffi ciency by Killip, Q-forming MI developed in 93 (86.9 %) people. Coronarangiography was done in all patients (100%), percutaneous coronary intervention in 100 (93.4 %) people. Diff usivity of the lungs and the level of infl ammation markers, as well as NT-proBNP in the blood serum were examined in all the patients on the 10-14th day. Results. Depending on the level of DLCO, two groups have been formed: Group 1 – 59 (55.1 %) patients with normal DLCO, Group 2 – 48 (44.9 %) patients with a decreased DLCO data. In the group with the decreased DLCO, the level of C-reactive protein (CRP) was signifi cantly higher – 2.6 (1.9, 4.6) vs. 3.8 (3.3, 8.2), p <0.001. According to linear regression analysis, a signifi cant correlation of CRP and DLCO levels in patients with MI has been revealed. As a result of multiple linear regression analysis, it was revealed that the level of serum CRP concentration is able to explain 11 % of diff usion capacity of lungs in patients with MI. Nonlinear interconnection between concentration of tumor necrosis factor α (TNF-α) and DLCO level was noted. Conclusion. Th e association of CRP as universal infl ammation marker with violation of ACM conductivity has been revealed, which confi rms the involvement of infl ammation in the development of diff usion disorders in patients with MI. Th e obtained quadratic model confi rms the inconsistent data on the infl uence of TNF-α level on ACM conductivity
Keywords: myocardial infarction, lung diff usion, infl ammation, alveolar capillary membrane, C-reactive protein, tumor necrosis factor-α.
Kochergina A.M., Leonova V.O., Kashtalap V.V.
ASSESSMENT OF RISK OF BLEEDING IN MYOCARDIAL INFARCTION WITH ST SEGMENT ELEVATION
Kochergina AM, Leonova VO, Kashtalap VV. Assessment of risk of bleeding in myocardial infarction with ST segment elevation. Siberian Medical Review. 2018;(5):17-24. DOI: 10.20333/2500136-2018-5-17-24. DOI 10.20333/2500136-2018-5-17-24
Kochergina Anastasija M Cand.Med.Sci.; Research Institute for Complex Issues of Cardiovascular Diseases; email@example.com
Leonova Valerija O Student; Kemerovo State Medical University; firstname.lastname@example.org
Kashtalap Vasiliy Vasilevich Dr. Med. Sc., Associate Professor of the Cardiology Department; Head of laborafoiy pathophysiology multifocal atherosclerosis; Kemerovo State Medical Academy; Research Institute for Complex Issues of Cardiovascular Diseases; email@example.com
The aim of the research. Assessment of bleeding frequency in diff erent age groups. Search and development of eff ective tools for such complications forecasting. Material and methods. 492 patients, hospitalized with STEMI to Kemerovo Cardiovascular Clinical Hospital, were included into the present singlecenter register observatory investigation. Two groups, based on hemorrhagic complications, were formed. Th e bleeding frequency in patients of this sampling is estimated. All major predictors of hemorrhagic complications are calculated. The model of “2STEPS” scale is constructed, its validity is estimated. Results. The bleeding frequency was 42 (8.53 %) cases (21 case – puncture hematomas, 11 –pulsating hematomas, 10 – gastrointestinal bleeding). The frequency of “heavy” bleeding in patients of diff erent age groups was identical. Hemorrhagic complication predictors: female gender and signs of acute heart failure are revealed. A prognostic model of bleeding risk assessment scale in patients with STEMI was created. Th e validity of the developed scale has been tested in comparison with the existing ACTION and REACH scales, moreover, high predictive level has been obtained. Conclusion. Th e developed 2STEPS scale is an eff ective, accurate and easy-to-use tool for predicting bleeding in STEMI, which makes possible to use it widely in clinical practice.
Keywords: myocardial infarction with ST segment elevation, bleeding, hemorrhagic complications, risk scales, bleeding frequency assessment, myocardial infarction.
Lytkina V.A., Kuzhel D.A., Matyushin G.V.
ANATOMO-FUNCTIONAL CORRELATION OF HEART VENTRICLE CONDITIONS IN IDIOPATHIC BLOCKADE OF LEGS OF A BUNCH OF GIS
Lytkina VS, Kuzhel DA, Matyushin GV.Anatomo-functional correlation of heart ventricle conditions in idiopathic blockade of legs of a bunch of Gis. Siberian Medical Review.2018;(5):25-30. DOI: 10.20333/2500136-2018-5-25-30. DOI 10.20333/2500136-2018-5-25-30
Lytkina V. A. ; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; firstname.lastname@example.org
Kuzhel D. A. ; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; email@example.com
Matyushin Gennady Vasilievich Doctor of Medical Sciences, Professor, Head of the Department of Cardiology and Functional Diagnostics; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; firstname.lastname@example.org
The aim of the research is to study the functional state of the left and right ventricles in patients with complete blockade of the right and left legs of the bunch of Gis with idiopathic lesion of the conduction system of the heart. Material and methods. 72 patients with idiopathic blockade of the left (LBBB) and right (RBBB) leg of a bunch of Gis were examined. All patients underwent routine echocardiography with determination of basic parameters of hemodynamics, as well as indices of myocardium strain, left ventricular (LV) twist, as well as anatomic and functional parameters of the right ventricle (RV). Results. In idiopathic LBBB group, compared to the group with RBBB, the global longitudinal strain parameters (-12.7 ± 5.4 % and -19.3 ± 3.1 %, p = 0.0001), circular strain on the basal (-7.4 ± 3.2 % and -19.3 ± 4.5 %, p = 0.0011) and at the apical levels (-5.0 ± 3.0 % and -20.2 ± 6.7 %, p = 0.0003), as well as the resulting LV twist (6.7 ± 3.6º and 12.5 ± 6.9º, p = 0.0001) are less. When assessing the anatomic and functional parameters of RV in LBBB group, compared to RBBB, there was a larger size of outfl ow tract (26.8 ± 3.7 mm and 21.9 ± 2.7 mm, p = 0.0001, respectively), the thickness of the free RV wall (6,7 ± 0,9 mm and 5,8 ± 0,7 mm, р = 0,0013), smaller values of systolic displacement of tricuspid valve ring (22.9 ± 4.9 mm and 26.0 ± 5, 6 mm, p = 0.0214) and peak basal КМ segment velocity (12.9 ± 2.7 cm / sec and 15.0 ± 4.0 cm / sec, p = 0.0391). Conclusion. Violation of intraventricular conduction along the left leg of a bunch of Gis is accompanied by a decrease in myocardium strain properties and LV twist parameter. Th e result of LV dysfunction is the changes in RV work, connected with the compensatory increase in the load
Keywords: echocardiography, myocardial strain, left ventricular function, right ventricle function, blockade of a leg of bunch of Gis, longitudinal strain, circumferential strain, torsion
Shevchenko E.V., Nagorskaya I.A., Sazonova O.B., Usachev D.Y., Lukshin V.A., Lapteva K.N.
NEUROFUNCTIONAL STATE OF THE BRAIN IN CHILDREN WITH CHRONIC CEREBRAL ISCHEMIA
Shevchenko EV, Nagorskaya IA, Sazonova OB, Usachev DYu, Lukshin VA, Lapteva KN. Neurofunctional state of the brain in children with chronic cerebral ischemia. Siberian Medical Review.2018;(5):31-40. DOI: 10.20333/2500136-2018-5-31-40. DOI 10.20333/2500136-2018-5-31-40
Shevchenko Elena V Cand.Med.Sci.; N. N. Burdenko National Scientific and Practical Center of Neurosurgery; email@example.com
Nagorskaya Irina A Cand.Med.Sci.; N. N. Burdenko National Scientific and Practical Center of Neurosurgery; firstname.lastname@example.org
Sazonova Ol’ga B Cand.Med.Sci.; N. N. Burdenko National Scientifi c and Practical Center of Neurosurgery; OSazonova@nsi.ru
Usachev Dmitriy Yu Dr.Med.Sci., Professor; N. N. Burdenko National Scientific and Practical Center of Neurosurgery; DOusachev@nsi.ru
Lukshin Vasiliy A Cand.Med.Sci.; N. N. Burdenko National Scientifi c and Practical Center of Neurosurgery; email@example.com
Lapteva Kristina N junior researcher; N. N. Burdenko National Scientific and Practical Center of Neurosurgery; firstname.lastname@example.org
Th e aim of the research is to assess the neurofunctional state of the brain by means of electroencephalography and neuropsychological examination of children with chronic cerebral ischemia caused by intra- and extracranial pathology of the main arteries with cerebral circulation disturbance of ischemic type in anamnesis. Material and methods. 31 children with chronic cerebral ischemia, caused by the pathology of the main arteries of the brain got surgical treatment in Scientific Research Institute of Neurosurgery aft er academician N.N. Burdenko for the period from 2012 to 2017. Th e age of children varied from 2 to 18 years. All the patients underwent comprehensive clinical and instrumental examination aimed at clarifying the leading pathogenetic mechanism of the disease. Special attention was paid to the examinations, clarifying the structural and functional features of the pathology of the cerebral vascular system (USDG, TKDG, spiral CT angiography, MRA, brain perfusion examination, examination of brain blood fl ow with functional tests). In order to assess functional state of the brain, in addition to standard neurologic examination, EEG and neuropsychological examination were done. As far as, the last two kinds of examinations in children with vascular pathology were not practically carried out in other institutions, we decided to share the details of the results in this article. Results. Assessing neurofunctional state of the brain of children with chronic cerebral ischemia, the children were divided into two groups. Comparison of EEG-examination data and neuropsychological diagnostics was performed. In the group of children with intracranial pathology of the main vessels, more severely expressed pathological changes are revealed, which is manifested both in the nature of changes in the electroencephalogram and in neuropsychological diagnostics. Conclusion. By comparing the data of these two methods against the background of diff use pathological changes, it was possible to single out the specifi city of the brain in children with extra- and intracranial pathology of the main vessels in the neurofunctional state.
Keywords: chronic cerebral ischemia, neuropsychological examination of children, electroencephalogram, extra- and intracranial pathology of the main arteries of the brain, reconstructive surgery, revascularization surgery.
Dochkina E.S., Ustinova A.V., Taranushenko T.E.
ANALYSIS OF PERINATAL PERIOD AND DAMAGE OF CNS IN CHILDREN WITH CP
Dochkina ES, Ustinova AV, Taranushenko TE. Analysis of perinatal period and damage of CNS in children with CP. Siberian Medical Review. 2018;(5):41-47. DOI: 10.20333/2500136-2018-5-41-47. DOI 10.20333/2500136-2018-5-41-47
Dochkina Elena S. ; Profmed Ltd. Clinic Elife; email@example.com
Ustinova Alena V. ; Krasnoyarsk Regional Children`s Hospital; firstname.lastname@example.org
Taranushenko Tatyana Evgenyevna Dr.Med.Sc, Professor, Head of the Department of Pediatrics; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; email@example.com
The aim of the research is to analyze the course of intranatal and early neonatal periods in children with CP combined with perinatal CNS damage. Material and methods. The article presents data of anamnesis with the features of early neonatal and intranatal periods course in 81 children with CP: 50 children with hypoxic-ischemic damage of CNS (HID CNS) and 31 children with hypoxic-hemorrhagic damage of CNS (HHD CNS), including neurosonography data assessment. Results. Th e anamnesis of children with CP was studied, boys accounted 59.3 %, girls – 40.7 %, and the total number of premature infants was 87.7 %. It was found out that children suff ering from CP were born predominantly by cesarean section –79%. Severe degree of asphyxia at 1 minute was registered in most newborns (60.5 %), infants with average degree of asphyxia accounted 34.6 %. Most of the children (97.5 %) underwent mechanical ventilation. In the group with HHD CNS in 16,1 % a prolonged ventilation was performed (for more than 20 days), in the group with HID CNS no cases were recorded. Conclusion. Taking into consideration high percentage of premature infants’ birth, it is necessary to improve obstetric and gynecological control of pregnant women and to diagnose fetal pathology, to improve the methods of resuscitation of newborns with asphyxia. Timely neurosonography in the early neonatal period provides opportunities for early diagnosis and further prognosis with the identifi cation of risk groups for CP.
Keywords: cerebral palsy, perinatal damage of CNS, hypoxic-ischemic damage of CNS, hypoxic-hemorrhagic damage of CNS, early neonatal period, intranatal period, neurosonography
Smolnikova M.V., Barilo A.A., Smirnova S.V.
POLYMORPHISM OF CYTOKINE GENES (IL17A AND IL17F) IN PSORIASIS AND PSORIATIC ARTHRITIS
Smolnikova MV, Barilo AA, Smirnova SV. Polymorphism of cytokine genes (IL17A and IL17F) in psoriasis and psoriatic arthritis. Siberian Medical Review.2018;(5):48-53. DOI: 10.20333/2500136-2018-5-48-53. DOI 10.20333/2500136-2018-5-48-53
Smolnikova M. V. ; Scientific Research Institute for Medical Problems of the North of Siberian Division of Russian Academy of Medical Sciences; firstname.lastname@example.org
Barilo Anna A Cand.Med.Sci.; Scientifi c Research Institute of Medical Problems of the North FRC KSC SB RAS; email@example.com
Smirnova S. V. ; Federal Budget State Medical Research Institute for Northern Problems, Siberian Division of Russian Academy of Medical Sciences, Krasnoyarsk; firstname.lastname@example.org
The aim of the research is to study the frequency of distribution of allelic variants of polymorphisms of cytokine genes IL17A (rs2275913), IL17F (rs763780) in psoriasis and psoriatic arthritis in Caucasians of Krasnoyarsk city in order to identify psoriatic disease progression markers. Material and methods. 176 patients with vulgar psoriasis in Caucasians, living in Krasnoyarsk, aged 18 to 66, were examined. Patient groups were formed in the following way: psoriasis (n = 77), psoriatic arthritis (n = 99). Th e check group consisted of 102 practically healthy volunteers. Venous blood served as a material for the study. DNA isolation was performed using a standard sorbent method. Th e allelic variants of cytokine genes IL17A (rs2275913), IL17F (rs763780) were determined by restriction analysis of amplifi cation products (RFLP analysis) of specific genome parts. Diff erences in the frequency of genotypes in patients and check groups were carried out using Pearson χ2 criterion. The correlation of the disease with genotypes was assessed by calculating the chances ratio and the confi dence interval. Results. Based on the conducted studies, it was found out that in psoriasis the frequency of genotypes AG and GG of polymorphism IL17A (rs2275913) statistically is signifi cantly higher in comparison with psoriatic arthritis. Genotypes AG and GG of polymorphic variant rs763780 of IL17F gene statistically are signifi cantly more frequent in patients with psoriatic arthritis in comparison to check ones. Conclusion. Th e result of the study has shown that in patients with psoriasis the frequency of genotypes AG and GG of polymorphism rs2275913 of IL17A gene statistically is signifi cantly higher in comparison with psoriatic arthritis, which indicates its correlation with the risk of psoriasis. In addition, genotypes AG and GG IL17F (rs763780) are more common in patients with psoriatic arthritis, being genetic markers of disease developing risk. Th e obtained findings confirm that Th 17-lymphocytes and polymorphism of IL17A / F genes play an important role in the pathogenesis of psoriasis and psoriatic arthritis.
Keywords: psoriasis, psoriatic arthritis, cytokines, IL17A, IL17F, gene polymorphism
Byvaltsev V.A., Kalinin A.A., ., Irintseev A.A.
DIFFERENTIATED SURGICAL TACTICS IN DEGENERATIVE DISEASES OF LUMBAR SPINE DEPARTMENT WITH THE USE OF PUNCTIONAL METHODS
Byvaltsev VA, Kalinin AA, Okoneshnikova AK, Irintseev AA. Diff erentiated surgical tactics in degenerative diseases of lumbar spine department with the use of functional methods. Siberian Medical Review.2018;(5):54-65. DOI: 10.20333/2500136-2018-5-54-65. DOI 10.20333/2500136-2018-5-54-65
Byvaltsev Vadim Anatolyevich Professor, Head of the Neurosurgery Course of the Irkutsk State Medical University, the Chief Neurosurgeon of the Health Department of «Russian Railways», Leading Researcher at the Laboratory of boron-neutron capture therapy, Institute of Nuclear Physics SB RAS, Professor of the Department of Traumatology, Orthopaedics and Neurosurgery, Irkutsk State Academy of Postgraduate Education, Leading Researcher of the Irkutsk Scientific Center of Traumatology and Surgery.; Irkutsk State Medical University; Department of «Russian Railways»; Irkutsk State Academy of Postgraduate Education; email@example.com
Kalinin Andrey A Cand.Med.Sci.; Irkutsk State Medical University; firstname.lastname@example.org
; ; email@example.com
Irintseev Ayur A clinical resident; Irkutsk State Medical University; firstname.lastname@example.org
Th e aim of the research is to analyze the results of diff erentiated surgical treatment of patients with degenerative diseases of lumbar spine with the use of puncture techniques. Material and methods. The study included 841 patients who, aft er conducting puncture provocative techniques, were implemented with a diff erentiated surgical approach: in isolated discogenic pain syndrome (n = 215), puncture posterolateral laser nucleoplasty was performed; in isolated facet syndrome (n = 247) laser denervation of facet joint took place; in verifi cation of combined clinical symptomatology (n = 379), a simultaneous operative intervention on intervertebral disc and facet joint was performed. To assess the result of surgical treatment, the level of pain by visual analogue scale (VAS) in the lumbar and lower extremities and the functional status according to ODI were studied, the remote satisfaction with the operation on Macnab scale and the development of perioperative complications were analyzed. Results. A signifi cant decrease in the severity of pain syndrome in lumbar spine and lower limbs was found, respectively: in I group from 61 mm (59; 72) to 16 mm (13; 17) (p = 0.001) and from 72 mm (65.84) to 17 mm (13; 20) (p = 0.003); in II group from 74 mm (63; 85) to 15 mm (12; 17) (p = 0.005) and from 62 mm (57; 69) to 16 mm (13 (P = 0.002), and from 76 mm (67, 89) to 14 mm (12; 17); and in III group, from 73 mm (64; 80) to 15.5 mm; 17) (p = 0.005); positive dynamics of functional status: in I group from 82 (76, 86) to 16 (12; 18) (p = 0.007), in II group from 72 (68; 76) to 16 (14; 18) (p = 0.003) , in III group from 82 (80, 84) to 14 (12; 18) (p = 0.004); by Macnab subjective evaluation scale, in 18 months, there were predominantly excellent and good results in group I 107 (49.76 %) and 88 (40.93 %), respectively, in group II–111 (44.93 %) and 94 (38, 05 %) of cases, respectively, in group III–169 (44.59 %) and 133 (35.09 %) cases, respectively. Conclusion. Diff erential surgical tactics, that have been chosen, according to VAS, allowed achieving in the early and distant postoperative periods a minimal level of pain syndrome in the lumbar and lower extremities, good functional status according to ODI and high degree of patient’s satisfaction with the operation performed without any perioperative complications.
Keywords: intervertebral disc, facet joint, protrusion of intervertebral disc, spondyloarthrosis, laser nucleoplasty, laser denervation
Kutikhin A.G., Antonova L.V., Sevostyanova V.V., Ponasenko A.V., Barbarash L.S.
IN SILICO ANALYSIS OF HUMAN VEGF, bFGF, SDF-1α AFFINITY TO RELEVANT HUMAN / OVINE RECEPTORS
Kutikhin AG, Antonova LV, Sevostyanova VV, Ponasenko AV, Barbarash LS. In Silico analysis of human VEGF, bFGF, SDF-1α affi nity to relevant human / ovine receptors. Siberian Medical Review.2018;(5):66-76. DOI: 10.20333/2500136-2018-5-66-76. DOI 10.20333/2500136-2018-5-66-76
Kutikhin Anton Gennadievich Researcher Laboratory Genomic Medicine, Department of Experimental and Clinical Cardiology; Federal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular Diseases; email@example.com
Antonova Larisa V. ; Research Institute for Complex Issues of Cardiovascular Diseases; firstname.lastname@example.org
Sevostyanova Victoria V. ; Research Institute for Complex Issues of Cardiovascular Diseases; email@example.com
Ponasenko Anastasiya Valerievna Cand.Med.Sci., Head of the Laboratory of Genomic Medicine, Department of Experimental and Clinical Cardiology; Federal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular Diseases; firstname.lastname@example.org
Barbarash Leonid S. ; Research Institute for Complex Issues of Cardiovascular Disease; email@example.com
Th e aim of the research. Comparison of affi nity of human bioactive factors (VEGF, bFGF / FGF-2 and SDF-1α) to the corresponding human and ovine receptors (VEGFR2, FGFR1, FGFR2, CXCR4). Material and methods. PDB numbers of tertiary structures of the mentioned proteins, as well as UniProtKB-numbers of their amino acid sequences, were determined from the RCSB PDB, PDBe and PDBj databases. Further, by aligning and comparing the amino acid sequences in Geneious program, the homology of primary and secondary structure of human and ovine proteins were analyzed. Since the tertiary structure of the analyzed proteins was experimentally decoded only for humans, homologous modeling of tertiary structure of corresponding ovine proteins was performed in SwissModel program. Molecular docking analysis was carried out in PatchDock program in order to evaluate ligand affi nity to the receptor and in ZDOCK program to construct 3D models of ligand-receptor interactions. Results. Primary and secondary structure of the analyzed human and ovine proteins was identical for more than 90 %, that made it possible to suggest similar affi nity of bioactive factors to relevant receptors. The percentage of diff erences between the conditional indices of the affi nity of human bioactive factors and ovine receptors in comparison with relevant conditional indices of affi nity for human receptors was only slightly higher than the combined percentage of interspecifi c diff erences in primary structure of these proteins. 3D modeling of interactions of diff erent variants of bioactive factors with their receptors has shown that the variant of deciphering the tertiary structure of bioactive factor (PDB-number) practically does not aff ect their interaction with receptors within a single biological species. Conclusion. Affi nity of human bioactive factors (VEGF, bFGF, SDF-1α) to the corresponding ovine and human receptors (VEGFR2, FGFR1, FGFR2, CXCR4) differs insignificantly
Keywords: vascular grafts, ovine model, VEGF, bFGF, SDF-1α, in silico analysis, molecular docking analysis, affi nity
Khodakova O.V., Evstafieva J.V.
OBSERVANCE OF RULES OF PROVIDING PAID MEDICAL SERVICES (BY THE RESULTS OF SOCIOLOGICAL EVALUATIONS)
Khodakova OV, Evstafi eva JV. Observance of rules of providing paid medical services (by the results of sociological evaluations). Siberian Medical Review. 2018;(5):77-85. DOI: 10.20333/2500136-2018-5-77-85. DOI 10.20333/2500136-2018-5-77-85
Khodakova Olga V Dr.Med.Sci., Assistant Professor; Chita State Medical Academy; firstname.lastname@example.org
Evstafieva Julia V graduate student; Chita State Medical Academy; email@example.com
The aim of the research. Assessment of compliance with the requirements of regulatory legal acts in terms of providing paid medical services in state and non-state medical organizations. Material and methods. To assess the implementation of the rules for providing paid medical services, a sociological survey was conducted among 220 health workers, 20 experts in the fi eld of healthcare organization and 350 consumers of paid medical services. Using calculating the relative risk procedure, the influence of professional and social characteristics of health workers on observation of rules of providing paid medical services has been studied. Results. Along with annual growth in the volume of medical services provided on onerous basis, violations of consumer rights are being registered, the main cause of which is non-observation of paid medical services with the requirements of legislation of the Russian Federation in the fi eld of private healthcare sphere by providers. According to the results of sociological survey, the main violations of the requirements of regulatory legal acts in the sphere of providing paid medical services were revealed, among them: non-observance of the procedure for providing information to consumers on a fee-for-service basis, lack of keeping primary medical documentation and statistical accounting forms, violation of the procedure for making contract for providing paid medical services, etc. Conclusion. The conducted study allowed to determine the most common violations of the procedure for providing paid medical services, as well as to identify certain professional and social characteristics that are the risk factors for violating the rules for proving paid medical services and, as a consequence, leading to violation of consumers’ rights for services on onerous basis
Keywords: paid medical services, consumers of paid medical services, private health system, health experts, relative risks, patient information
Fomicheva M.L., Bortsov V.A., Khikhlich O.S.
READINESS OF SCHOOL TEACHERS TO PARTICIPATE IN THE PROCESS OF FORMING HEALTHY LIFESTYLE OF THE POPULATION
Fomicheva ML, Bortsov VA, Khikhlich OS.Readiness of school teachers to participate in the process of forming healthy lifestyle of the population. Siberian Medical Review.2018;(5):86-90. DOI: 10.20333/2500136-2018-5- 86-90. DOI 10.20333/2500136-2018-5-86-90
Fomicheva Marina L. Cand. Med. Sci.; Novosibirsk state medical university; Regional center for medical prevention; firstname.lastname@example.org
Bortsov V. A. D.Med.Sc.; Novosibirsk State Medical University; Novosibirsk city consultative-diagnostic polyclinic № 27; email@example.com
Khikhlich Oksana S doctor; Regional center of medical prevention; firstname.lastname@example.org
The aim of the research. Assessment of teachers’ competence in the development of healthy lifestyle of the population. Material and methods. In order to study additional opportunities aimed at forming healthy lifestyle, a sociological survey of school teachers was conducted to determine their willingness to participate in the process of forming healthy lifestyle of the population. Results. Th e majority of respondents (64.6 ± 4.2 %) consider it necessary and appropriate to conduct work with population, aimed at formation of healthy lifestyle; 23.8 ± 3.7 % partially share this viewpoint and only 2.1 ± 1.3% of the respondents do not consider it necessary and appropriate to conduct primary medical prevention among population. Most teachers consider it advisable to receive training on healthy lifestyle issues. Th e most convenient forms of improving their competence in matters of healthy lifestyles the surveyed teachers consider: training in regional centers of medical prevention or health centers. Most of the interviewed teachers believe that greatest part of population has the need to obtain information on healthy lifestyle issues. Taking into consideration the level of population’s informatization, the respondents noted the advisability of providing people with information materials on healthy lifestyle on the Internet. Conclusion. As a result of the conducted sociological research it is found out that teachers consider it advisable to carry out preventive work with population, they are ready to become competent in matters of healthy lifestyle and to participate in creating information materials on healthy lifestyle issues.
Keywords: teachers, healthy lifestyle, primary medical prevention, population, readiness, Internet, information materials
BLAND-WHITE-GARLAND SYNDROME IN A 15-YEAR-OLD GIRL. CLINICAL CASE
Tolstikova TV, Barakin AO, Bregel LV, Gvak GV, Podkamennyj VA, Medvedev VN, Efanov ES, Medvedev AV. Bland-White-Garland syndrome in a 15-year-old girl. Clinical case. Siberian Medical Review. 2018;(5):91-94. DOI: 10.20333/2500136-2018-5-91-94. DOI 10.20333/2500136-2018-5-91-94
A clinical case of congenital heart disease – an abnormal origin of the left coronary artery from the pulmonary artery (Bland-White-Garland syndrome), is revealed for the fi rst time in a 15- year-old girl. This congenital heart disease in natural course and without surgical correction is characterized by high mortality (up to 90 % of cases) in the fi rst year of life, being connected with the development of extensive myocardial infarction, or multiple heart attacks, but when a network of intercoronary anastomoses develops, it cannot appear clinically for a long time. Classic signs of this patient’s disease were revealed during echocardiography, being confi rmed by coronary angiography, which allowed timely surgical intervention.
Keywords: congenital heart disease, coronary arteries, Bland-White-Garland syndrome, abnormal left coronary artery origin, echocardiography, children.
COMPLEXITY OF DIAGNOSING INFECTIOUS ENDOCARDITIS IN FALSE-NEGATIVE RESULTS OF TRANSTHORACIC ECHOCARDIOGRAPHY
Surgutskaya MS, Osipova IV, Antropovа ON, Borisova LV, Bulovitskaya AV. Complexity of diagnosing infectious endocarditis in falsed-negative results of transthoracic echocardiography. Siberian Medical Review. 2018;(5):95-98. DOI: 10.20333/2500136-2018-5-95-98. DOI 10.20333/2500136-2018-5-95-98
Th e possibilities of diagnosing infectious endocarditis signifi cantly expanded aft er the creation of standardized clinical diagnostic criteria and after the development of visualization technologies, such as echocardiography. However, the sensitivity of transthoracic echocardiography is only 40-60%, while transesophageal echocardiography is 90-100%. Th is article describes a clinical case of complexity of diagnosing infectious endocarditis with false-negative results of primary transthoracic echocardiography.
Keywords: primary infectious endocarditis, criteria for diagnosing infectious endocarditis, vegetation in infectious endocarditis, transthoracic echocardiography, transesophageal echocardiography, false-negative results of echocardiography.
EXPERIENCE OF NINTEDANIB USE IN THE PATIENT WITH IDIOPATHIC PULMONARY FIBROSIS AND EMPHYISEMA
Kudelya LM, Manakova YL, Khusainova ES. Experience of nintedanib use in the patient with idiopathic pulmonary fi brosis and emphysema. Siberian Medical Review. 2018;(5):99-103. DOI: 10.20333/2500136-2018-5-99-103. DOI 10.20333/2500136-2018-5-99-103
Idiopathic pulmonary fi brosis (IPF) is a progressive fi brotic lung disease, the cause of which is unknown. It is characterized by a progressive decrease of pulmonary function, and by unfavorable prognosis in case of specific treatment absence. Further goes the description of a clinical case of idiopathic pulmonary fi brosis combined with emphysema with a positive clinical and radiological response for the prescribed antifi brotic – nintedanib.
Keywords: interstitial lung diseases, idiopathic pulmonary fi brosis, emphysema, phenotype, clinical case, pirfenidone, nintedanib.
Gordyukova I.Y., Isaeva N.V., Korchagin E.E., Shnyakin P.G., Shul'min A.V., Ippolitova E.V.
STROKE PREVENTION ROOM EXPERIENCE IN KRASNOYARSK REGIONAL CLINICAL HOSPITAL
Gordyukova IYu, Isaeva NV, Korchagin EE, Shnyakin PG, Shulmin AV, Ippolitova EV. Stroke prevention room experience in Krasnoyarsk regional clinical hospital. Siberian Medical Review.2018;(5):104-110. DOI: 10.20333/2500136-2018-5-104-110. DOI 10.20333/2500136-2018-5-104-110
Gordyukova Irina Yu graduate student, Professor; Professor V. F. Voino-Yasenetsky Krasnoyarsk State Medical University; email@example.com
Isaeva Natalia Victorovna Dr.Med.Sc., Associate Professor of the Department of Nervous Diseases, traditional medicine with PE course; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; firstname.lastname@example.org
Korchagin Egor Evgenievich Associate Professor; Professor V. F. Voino-Yasenetsky Krasnoyarsk State Medical University; Regional Clinical Hospital; email@example.com
Shnyakin P. G. ; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; Shnyakinpavel@mail.ru
Shul'min Audrey Vladimirovich Candidate of Medical Sciences, Associate Professor, Head of Department of Public Health and Health Care; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; аndreyshumn@gmail.com
Ippolitova Elena Veniaminovna Head of Department,; Regional Clinical Hospital; firstname.lastname@example.org
The aim of the research. Analysis of the work of stroke prevention room located in consultative and diagnostic clinic of the Regional Clinical Hospital. Material and methods. Th e subject of the study was 149 patients with a stroke who were discharged from the regional vascular center in Krasnoyarsk. Dynamic monitoring of patients for 6 months with clinical and neurological examination, Rankin, Rivermid scales, USA scale of NIHSS National Institute of Health, telephone interview method were used. Th e statistical analysis was carried out using the SPSS package. Results. Aft er being discharged from the hospital, only 73.39 % from total number of patients referred to stroke prevention room. High risk of recurrent stroke was found in 38.26 % of patients, among vascular risk factors hypertension prevailed 97 %, atrium fi brillation – 23.48 %, diabetes –8.72 %, cerebral atherosclerosis – 88.59 %. Hemodynamically signifi cant stenoses were in 11.41 % of patients. Th e advisability of monitoring in stroke prevention rooms in the first three months aft er the stroke was noted, during which, the early specialized dispensary observation, is the most eff ective in developing individual strategies for secondary stroke prevention, including selection of carotid endarterectomy, stenting of carotid arteries. In future, in case of stable patients’ status, regular medical check-up is continued in polyclinic at the place of residence.
Keywords: stroke, prevention, risk factors, regular medical check-up, polyclinic, stroke prevention room
THRICE THE FIRST. ABOUT THE FIRST HEAD OF CHILDREN’S DISEASES DEPARTMENT OF KRASNOYARSK MEDICAL INSTITUTE
Prakhin EI. Trice the fi rst. About the first head of children’s diseases department of Krasnoyarsk medical institute. Siberian Medical Review.2018; (5): 111-116. DOI: 10.20333/2500136-2018-5-111-116. DOI 10.20333/2500136-2018-5-111-116
Prahin E. I. ; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; email@example.com
The article presents information about the fi rst head of Children’s Diseases Department of Krasnoyarsk Medical Institute – Edda (Eda) Abramovna Gornitskaya (Zuckerstein-Gornitskaya). She was one of the famous pediatricians of the country, the fi rst woman to head Children’s Hospital named aft er K.A. Raukhfus, she became the fi rst female professor of pediatrics and the head of the department in Leningrad. In the history of Krasnoyarsk Medical Institute, Edda Abramovna Gornitskaya was the first professor, who headed the department of children’s diseases; she was the organizer of children’s doctors society, she was consulting and organizing the work during the severe years of the Great Patriotic War.
Keywords: Krasnoyarsk Medical Institute, pediatric faculty, children’s diseases department, Great Patriotic War, professor E.А. Gornitskaya, first Leningrad Medical Institute named after academician I.P. Pavlova