Сибирское медицинское обозрение. 2018. № 4 View full textКоличество просмотров : 2960
Chuyanova A.A., Ponasenko A.V.
ASSOCIATION OF SELECTIN GENES POLYMORPHISMS AND ENDOTELIN-1 WITH THE DEVELOPMENT OF PULMONARY EMBOLISM
Chuyanova AA, Ponasenko AV. Association of selectin genes polymorphisms and endotelin-1 with the development of pulmonary embolism. Siberian Medical Review.2018;(4):5-12. DOI: 10.20333/2500136-2018-4-5-12. DOI 10.20333/2500136-2018-4-5-12
Chuyanova Anna A Junior Researcher, Cand. Biol. Sci.; Research Institute for Complex Issues of Cardiovascular Diseases; firstname.lastname@example.org
Ponasenko Anastasiya Valerievna Cand.Med.Sci., Head of the Laboratory of Genomic Medicine, Department of Experimental and Clinical Cardiology; Federal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular Diseases; email@example.com
The article reviews the literature on fundamental and clinical studies devoted to the problems of molecular mechanisms of endothelial dysfunction formation of pulmonary embolism (PE). Despite the sufficient scientific justification of the role of discoordination of endothelial cell functions in the development of thrombotic processes, only some aspects of molecular genetic mechanisms of its realization have been studied. The main attention is paid to the less studied predictors of PE among the biologically active substances that are involved in the process of maintaining vascular homeostasis. Candidate molecular genetic markers of genes E- and P-selectin, Endothelin-1, with scientific substantiation for their use as prognostic factors while treating patients with PE, are revealed.
Keywords: venous thromboembolism, pulmonary embolism, endothelial dysfunction, cell adhesion molecules, selectins, endothelin-1, single nucleotide polymorphisms.
Chulkov V.S., Gavrilova E.S., Chulkov V.S., Minina E.E.
REPRODUCTIVE HEALTH AND CARDIOMETABOLIC RISK
Chulkov VS, Gavrilova ES, Chulkov VS, Minina EE. Reproductive health and cardiometabolic risk. Siberian Medical Review. 2018;(4):13-21. DOI: 10.20333/2500136-2018-4-13-21. DOI 10.20333/2500136-2018-4-13-21
Chulkov Vasilii S Dr.Med.Sci., Associate Professor; South Ural State Medical University; firstname.lastname@example.org
Gavrilova Elena Sergeevna ; South Ural State Medical University; г. Челябинск, ул. Воровского, 64; тел.: +7(968)1124711; e-mail: email@example.com
Chulkov Vladislav S Assistant; Assistant, South Ural State Medical University; firstname.lastname@example.org
Minina Elena E Cand.Med.Sci., Assistant; South Ural State Medical University; email@example.com
The article contains a review of the research works, studying the influence of macro- and micronutrients on the state of reproductive health and their potential impact on subsequent cardiometabolic risk, starting from prenatal development. Unique actions, biological effects and synergism or antagonism of macro- and micronutrients determine their correlation with other regulators of reproductive function of the whole organism. It is significant to compensate the deficit of macro- and micronutrients, which are important preventive and curative options in the framework of modern strategies, aimed at improving the reproductive health. One of the promising areas, that allow to solve the problem of public health, is the enrichment of food with vitamins and microelements
Keywords: reproductive health, cardiometabolic risk, folic acid, magnesium deficiency, myo-inositol, vitamin D, abnormalities.
Uspenskaya Y.A., Komleva Y.K., Gorina Y.V., Pozhilenkova E.A., Belova O.A., Salmina A.B.
CD147 POLYFUNCTIONALITY AND NEW DIAGNOSTIC AND THERAPY OPPORTUNITIES
Uspenskaya YuA, Komleva YuK, Gorina YV, Pozhilenkova EA, Belova OA, Salmina AB. CD 147 polyfunctionality and new diagnostic and therapy opportunities. Siberian Medical Review.2018;(4):22-30. DOI: 10.20333/2500136-2018-4-22-30. DOI 10.20333/2500136-2018-4-22-30
Uspenskaya Yuliya Alexandrovna Dr.Biol.Sc., Researcher at the Research Institute of Molecular Medicine and Patobiochemistry; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; firstname.lastname@example.org
Komleva Yulia Konstantinovna Cand.Med.Sc., Associate Professor, Department of Biochemistry with courses of medical, pharmaceutical and toxicological chemistry; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; email@example.com
Gorina Yana Valeryevna Cand.Pharm.Sc., Associate Professor, Department of Biochemistry with courses of medical, pharmaceutical and toxicological chemistry; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; firstname.lastname@example.org
Pozhilenkova Elena Anatol’evna Cand.Biol.Sc., Associate Professor of the Department of Biological Chemistry with the Course of Medical, Pharmaceutical and Toxicological Chemistry; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; email@example.com
Belova Olga Anatolyevna Assistant of the Department of Traumatology; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; firstname.lastname@example.org
Salmina Alla Borisovna PhD, Dr.Med.Sc., Professor, Head of the Department of Biological Chemistry with the Course of Medical, Pharmaceutical and Toxicological Chemistry; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; email@example.com
The review presents modern ideas concerning the discovery, characterization, molecular structure, features of expression in cells of different nature, biological functions and CD147 regulatory mechanisms in humans in physiological and pathological conditions. The role of CD147 in the regulation of central nervous system cells activity in normal conditions and in neurodegeneration is discussed. The participation of CD147 in the pathology of central nervous system, in the pathogenesis of Alzheimer’s disease, in particular, is considered. The mechanisms, regulating the level of beta-amyloid by CD147 are described. Data on the possibility of CD147 use as a target for pharmacotherapy of central nervous system diseases are presented.
Keywords: CD147, matrix metalloproteinases, signal transduction, central nervous system, neurodegeneration, Alzheimer’s disease, γ-secretase complex.
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DOI: 10.1016/j.yjmcc.2010.05.007 52. Philp NJ, Ochrietor JD, Rudoy C, Muramatsu T, Linser PJ. Loss of MCT1, MCT3, and MCT4 expression in the retinal pigment epithelium and neural retina of the 5A11/basigin-null mouse. Investigative Ophthalmology & Visual Science. 2003;44(3):1305-11 53. Aït-Ali N, Fridlich R, Millet-Puel G, Clérin E, Delalande F, Jaillard C, Blond F, Perrocheau L, Reichman S, Byrne LC, Olivier-Bandini A, Bellalou J, Moyse E, Bouillaud F, Nicol X, Dalkara D, van Dorsselaer A, Sahel JA, Léveillard T. Rod-derived cone viability factor promotes cone survival by stimulating aerobic glycolysis. Cell. 2015;161(4):817-32. DOI: 10.1016/j.cell.2015.03.023 54. Muramatsu T. Basigin (CD147), a multifunctional transmembrane glycoprotein with various binding partners. Journal of Biochemistry. 2016;159(5):481-90. DOI: 10.1093/jb/mvv127 55. Wei M, Li H, Shang Y, Zhou Z, Zhang J. Increased CD147 (EMMPRIN) expression in the rat brain following traumatic brain injury. 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Shurygina I.A., Shurygin M.G.
PERSPECTIVES OF METAL NANOPARTICLES APPLICATION FOR THE PURPOSES OF REGENERATIVE MEDICINE
Shurygina IA, Shurygin MG. Perspectives of metal nanoparticles application for the purposes of regenerative medicine. Siberian Medical Review. 2018;(4):31-37. DOI: 10.20333/2500136-2018-4-31-37. DOI 10.20333/2500136-2018-4-31-37
Shurygina Irina A Dr.Med.Sci., prof. RAS; Irkutsk Scientific Center of Surgery and Traumatology; firstname.lastname@example.org,
Shurygin Mikhail G Dr.Med.Sci.; Irkutsk Scientific Center of Surgery and Traumatology; email@example.com
The review discusses the possibility of application, for the purposes of regenerative medicine, of nanoparticles of metals and their oxides, as well as selenium. It is shown that nanoparticles of silver, gold, platinum, selenium and copper, as well as oxides of zinc, tantalum, iron and titanium dioxide have potential therapeutic effect. Perspectives of silver application in nanoscale form for wound healing are outlined. It has been shown that noble metal nanoparticles, such as gold, palladium and platinum, act as antioxidants due to their high catalytic activity. A significant influence of matrix on the properties of nanocomposite material, on its toxicity and bioavailability in particular, is demonstrated. Thus, pharmaceutical nanotechnologies with application of metal nanoparticles are promising for the use in regenerative medicine in the nearest future.
Keywords: nanocomposite, silver nanoparticles, gold nanoparticles, selenium nanoparticles, wound healing, regenerative medicine, bioavailability.
Tatarintseva M.P., Puzyreva L.V., Mordyk A.V., Rudneva S.N.
ANALYSIS OF TUBERCULOSIS MORBIDITY IN OMSK REGION FOR THE 15-YEAR PERIOD
Tatarintseva MP, Puzyryova LV, Mordyk AV, Rudneva SN. Analysis of tuberculosis morbidity in Omsk region for the 15-year period. Siberian Medical Review. 2018;(4):38-45. DOI: 10.20333/2500136-2018-4-38-45. DOI 10.20333/2500136-2018-4-38-45
Tatarintseva Marina P the chief physician; Clinical antituberculous clinic; firstname.lastname@example.org
Puzyreva Larisa Vladimirovna Cand.Med.Sc, Assistant of the Department of Phthisiology and Phthisiosurgery; Omsk State Medical University; email@example.com
Mordyk Anna Vladimirovna Dr.Med.Sc, Associate Professor Head of the Department of Phthisiology and Phthisiosurgery; Omsk State Medical University; firstname.lastname@example.org
Rudneva Svetlana N deputy chief physician; Clinical antituberculous clinic; email@example.com
The epidemiological situation regarding tuberculosis in the Russian Federation can not be considered absolutely safe. Patients with chronic processes in pulmonary tissue and with multiple drug resistance of the pathogen worsen the epidemiological situation on tuberculosis, which creates additional reservoir of tuberculosis infection. The aim of the research was the analysis of morbidity with all forms and extra pulmonary tuberculosis in Omsk Region in comparison with the indicators of Siberian Federal District and Russia for forecasting the situation. Material and methods. The main statistical report forms were used. Results. The morbidity rate on tuberculosis in Omsk Region tends to decline from 2010, that is 9 years later than totally in Russia. The influence of the released from penitentiary institutions on tuberculosis morbidity was established, especially nowadays due to the high frequency of patients with HIV-infections registration. In some years, every fourth patient with tuberculosis in the Omsk Region fell ill with the specific process in places of liberty deprivation. In 2015, one out of five fell ill with tuberculosis in corrective labour colonies. Before 2005 morbidity of extra pulmonary forms of tuberculosis in Omsk Region was high. Subsequently, morbidity decrease was noted, but without any stable tendency, which indicates the lack of stability in this parameter. On the background of the decrease in tuberculosis morbidity in Omsk Region, the increase in tuberculosis morbidity with multiple drug resistance of pathogen has been revealed. Conclusion. Therefore, while analysing pulmonary and extra pulmonary tuberculosis morbidity, a tendency for their reduction has been registered, but, meanwhile, the forecast indicates the increase in the number of newly diagnosed forms of multidrug-resistant tuberculosis as well as the ones combined with HIV- infections among newly diagnosed patients.
Keywords: tuberculosis, morbidity, extra pulmonary tuberculosis, multiple drug resistance, slope, linear trend
Menshikova L.V., Babanskaya E.B., Bachurina S.M.
PERINATAL TERMINATIONS AND CLINICAL CHARACTERISTICS OF PREGNANT WOMEN WITH COMPROMISED OBSTETRIC HISTORY
Menshikova LV, Babanskaya EB, Bachurina SM. Perinatal terminations and clinical characteristics of pregnant women with compromised obstetric history. Siberian Medical Review. 2018;(4):46-52. DOI: 10.20333/2500136-2018-4-46-52. DOI 10.20333/2500136-2018-4-46-52
Menshikova Larisa V Dr.Med.Sci, Professor; Irkutsk State Medical Academy of Postgraduate Education; firstname.lastname@example.org,
Babanskaya Evgenia B Dr.Med.Sci.; Irkutsk State Medical Academy of Postgraduate Education; email@example.com
Bachurina Svetlana M Cand.Med.Sci.; Irkutsk State Medical Academy of Postgraduate Education; firstname.lastname@example.org
The aim of the research is to study clinical characteristics of pregnant women with compromised obstetric history, to analyse perinatal terminations and the state of the new-borns. Material and methods. In general, data on 716 pregnant women were included in the analysis, two groups were identified for the study: the 1-st group with compromised obstetrical history (COH) – 46.6 % (334 women) and the 2-nd group with non-compromised obstetrical history – 53.4 % (382). The age of women, obstetric-gynaecological history, number of pregnancies, objective examination data, laboratory and instrumental examination data, revealed or available somatic pathology, pregnancy terminations and methods of delivery, the condition of the new-borns were taken into consideration. Results. Pregnant women with COH were in 7 times more likely to have infectious diseases, including HIV, sexually transmitted diseases – in 2.3 times, TORCH infections – in 13.5 times, blood diseases – in 1.3 times against the comparison group, as well as obesity and smoking. Extra genital pathology was diagnosed in half of pregnant women in both groups. Differences in ultrasound characteristics, assessing the condition of fetus and placenta concerning the development of fetoplacental insufficiency and the threat of its occurrence, violation of utero-placental blood flow and the delay in intrauterine development of the fetus have been determined. In regard with pregnancy terminations and methods of delivery, women with compromised obstetrical history more often had indications for Cesarean operation and the risk of premature birth. Conclusion. The analysis justified allocation of a particular risk group of pregnant women belonging to the category of the ones with compromised obstetrical history. The information obtained will be mostly useful for general practitioners (family doctors) and therapists, providing medical care for pregnant outpatients along with gynaecologists.
Keywords: pregnant women, compromised obstetrical history, somatic pathology, infectious diseases, anemia, obesity, smoking, perinatal terminations
Zykov M.V., Hryachkova O.N., Kashtalap V.V., Shibanova I.A., Barbarash O.L.
CORRELATION OF TESTOSTERONE WITH MINERAL-BONE EXCHANGE INDICATORS AND METABOLIC SYNDROME IN MEN
Zykov MV, Hryachkova ON, Kashtalap VV, Shibanova IA, Barbarash OL. Correlation of testosterone with mineral bone exchange indicators and metabolic syndrome in men. Siberian Medical Review. 2018;(4):53-59. DOI: 10.20333/2500136-2018-4-53-59. DOI 10.20333/2500136-2018-4-53-59
Zykov Mikhail Valerevich ; Laboratory of the Pathophysiology of Multifocal Atherosclerosis, Research Institute for Complex Issues of Cardiovascular Diseases; г. Кемерово, Сосновый бульвар, 6; адрес: Российская Федерация, 354057, г. Сочи, ул. Туапсинская, 1; тел.: +7(918)3062959; e-mail: email@example.com.
Hryachkova Oksana N Junior Researcher; Research Institute for Complex Issues of Cardiovascular Diseases; firstname.lastname@example.org
Kashtalap Vasiliy Vasilevich Dr. Med. Sc., Associate Professor of the Cardiology Department; Head of laborafoiy pathophysiology multifocal atherosclerosis; Kemerovo State Medical Academy; Research Institute for Complex Issues of Cardiovascular Diseases; email@example.com
Shibanova Irina A. Cand. Med. Sci.; Research Institute for Complex Problems of cardiovascular disease; firstname.lastname@example.org
Barbarash O. L. Dr. Med. Sci., Professor; Kemerovo State Medical University; Scientific Research Institute of Complex Problems of Cardiovascular Diseases; email@example.com
The aim of the research is to study correlation of testosterone with various indicators of mineral-bone metabolism disturbance and metabolic syndrome markers in male patients with IHD. Material and methods. The study included 111 men with stable angina of II-III functional class without clinically significant concomitant pathology and planned open myocardial revascularization by coronary artery bypass grafting. Along with general clinical methods, all patients underwent blood sampling on an empty stomach prior to surgery. The following biological markers (total testosterone and estradiol, calcitonin, osteocalcin, parathyroid hormone (PTH), osteoprotegerin, osteopontin and bone isoenzyme of alkaline phosphatase) were determined from the obtained plasma or serum, in addition to a number of standard biochemical indices (lipidograms, ionized calcium, phosphorus, alkaline phosphatase, glycaemia, insulin): Results. When analysing biochemical markers described above, a correlation has been established between the levels of total testosterone, on the one hand, and insulin (r = -0.20, p = 0.047), PTH (r = 0.34, p = 0.0002), on the other. From all lipidogram parameters, a significant negative bond of total testosterone concentration was found only with the level of triglycerides (TG): r = -0.19; p = 0.047. In patients younger than 60, and having neither obesity nor type 2 diabetes, the correlation of total testosterone with insulin and TG increased significantly: r = -0.38 (p = 0.017) and r = -0.33 (p = 0.046). At the same time, there was no correlation with other investigated parameters in this subgroup, and the correlation with PTH became unreliable (p = 0.29). However, in a particular correlation analysis with consequent introduction of age, body mass index, diabetes corrections reliable bond of total testosterone with PTH has remained: correlation coefficient (r) varied from 0.30 to 0.29 at p = 0.002. Conclusion. In the present study, it was found that in men with IHD there is a positive bond between concentration of total testosterone with the level of PTH and negative one with insulin and TG.
Keywords: ischemic heart disease, men, testosterone, mineral-bone disorders, metabolic syndrome, insulin
Kuzhel D.A., Matyushin G.V., Savchenko E.A., Sakovitch O.M.
FUNCTION OF THE LEFT ATRIUM WITH BLOCKADE OF THE LEFT LEG OF A BUNCH OF GIS
Kuzhel DA, Matyushin GV, Savchenko EN, Sakovich OM. Function of the left atrium with blockade of the left leg of a bunch of Gis. Siberian Medical Review.2018;(4):60-68. DOI: 10.20333/2500136-2018-4-60-68. DOI 10.20333/2500136-2018-4-60-68
Kuzhel D. A. ; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; firstname.lastname@example.org
Matyushin Gennady Vasilievich Doctor of Medical Sciences, Professor, Head of the Department of Cardiology and Functional Diagnostics; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; email@example.com
Savchenko E. A. ; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; firstname.lastname@example.org
Sakovitch Olga M Cand.Med.Sci., Associate Professor; Professor V. F. VoinoYasenetsky Krasnoyarsk State Medical University; email@example.com
The aim of the research is to study the function of the left atrium (LA), left ventricular twist (LV) and to establish their possible correlation in cases of intraventricular conduction without obvious cardiac diseases. Material and methods. 52 patients without known cardiac diseases were examined. All patients were divided into BLLBG group with average duration of QRS 153 ± 24 ms and a control group with normal intraventricular conduction. BLLBG group included 34 patients (14 (41%) men and 20 (59%) women), 18 persons (8 (44%) men and 10 (56%) women were included in control group. Coronary ventriculography, echocardiography (echocardiography) with determination of hemodynamic parameters, longitudinal deformation of LV and LP, rotation and LV twisting at rest and after the loading test were performed in all patients. Results. In BLLBG group, there was noted a decrease in global longitudinal deformation of the LV (-15.6 ± 4.7% and -18.4 ± 3.1%, p = 0.037), global longitudinal deformation of the LA “εtotal” (31,8 ± 15,1% and 44,3 ± 11,7%, р = 0,0086) and LV twisting (9,08 ± 4,59 º and 13,96 ± 4,61 º, р = 0.0156), whereas differences in the parameters of the ejection fraction, end systolic and terminal diastolic LV volume were absent. After conducting loading test in BLLBG group, there was no increase in torsion of LV Δtorsion (respectively, 2.05 ± 8.35% and 4.66 ± 8.49%, р = 0.0463) in comparison with the control one. The described changes in the LV twist during loading test were obtained against the background of persistent changes in the global longitudinal strain of LA (43.5 ± 13.3% and 56.9 ± 14.7%, p = 0.0286) and changes in the systolic fraction of the pulmonary veins (57.6 ± 4.4% and 66.5 ± 4.2%, p = 0.0127). Conclusion. Decrease in LV twisting at rest and lack of adequate growth during stress test in BLLBG can be accompanied by changes in pulmonary veins flow and LA properties deformation.
Keywords: echocardiography, deformation, left ventricular twist, hemodynamic state, left atrial function, blockade of left leg of a bunch of Gis.
DAILY PROFILE OF ARTERIAL PRESSURE IN ARTERIAL HYPERTENSION AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE IN WORKERS WHO CONTACT INDUSTRIAL AEROSOLS
Erikhova SM. Daily profile of arterial pressure in arterial hypertension and chronic obstructive pulmonary disease in workers who contact industrial aerosols. Siberian Medical Review.2018;(4):69-75. DOI: 10.20333/2500136-2018-4-69-75. DOI 10.20333/2500136-2018-4-69-75
Erikhova Svetlana M graduate student; Novosibirsk state medical university; firstname.lastname@example.org
The aim of the research is to study daily profile of arterial pressure (DPAP) in workers with arterial hypertension (AH) combined with chronic obstructive pulmonary disease (COPD) who contact industrial aerosols (IA). Material and methods. 210 men diagnosed AH I-II degree, risk 1-2 were examined. Among them, 160 people had industrial contact with IA of toxic and chemical action and were divided into 2 subgroups, 80 of whom were diagnosed with only AH, the remaining 80 had AH combined with COPD, stage I, categories A and B (Groups 1 and 2). The comparison group (group 3) comprised 50 people with AH I-II degree, risk 1-2, having no contact with IA. Distribution of patients by AH degree in all three groups did not differ significantly. All patients were comparable in age (average age – 42.8 ± 4.4 years) and smoking experience (average length of smoking – 9.7 ± 3.5 years). Work experience with IA exposure varied on average 9.3 ± 3.2 years, AH duration lasts 7.9 ± 2.8 years. AH was diagnosed in accordance with clinical recommendations of the RSC 2013, ESH / ESC 2013. Daily monitoring of blood pressure (DMBP) was performed on BPLab (“Petr Telegin”, Russia). COPD diagnosis is based on the criteria of Global Strategy for Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease (2016). Spirography was performed in patients with COPD (group 2) on microprocessor-based spirograph “SMP-21 / 01-”R-D”. Results. The results of SMAD showed that in patients with AH and with combined pathology in day time, parameters of average systolic AP (SAP) were 127.43 ± 0.63 mm Hg. Art. and 128.31 ± 0.74 mm Hg. Art. statistically exceeded significantly the values of the comparison group (p <0.05). The indices of diastolic AP (DAP) in the group of people with comorbid pathology had significant differences from the values of the comparison group (81.22 ± 0.58 mm Hg). The time index (TI) of SAP and IV DAP (indicators, characterizing the percentage of time during which the AP exceeds the critical level for certain period of time), that was also statistically significant (p <0.01 and p <0.05), were increased in people with AH and with a comorbid pathology. The parameters of TI of SAP and TI of DAP combined with pathology were mainly increased in reference to the values of comparison group (p <0.01; p <0.05). In patients of all three groups, variant of SMAD Non-dippers prevailed. Conclusion. SMAD data in patients with AH, combined with COPD with IA contact, showed more significant increase of average SAP and DAP, time index of SAP and time index of DAP, SAP and DAP variability, morning SAP and DAP rise, high speed of morning SAP and DAP increase, as well as high frequency of increased variability of SAP and DAP. With the combined pathology, the pathological types of SMAD Non-dippers prevail.
Keywords: arterial pressure, chronic obstructive pulmonary disease, hypertension, daily blood pressure profile, industrial aerosols, variability.
Evert L.S., Bakhshieva S.A., Potupchik T.V., Bobrova E.I., Akhmeldinova J.R.
RECURRENT HEADACHES IN CHILDREN AND ADOLESCENTS WITH ASTHENIC SYNDROME
Evert LS, Bakhshiyeva SA, Potupchik TV, Bobrova EI, Akhmeldinova YuR. Recurrent headaches in children and adolescents with asthenic syndrome. Siberian Medical Review.2018;(4):76-82. DOI: 10.20333/2500136-2018-4-76-82. DOI 10.20333/2500136-2018-4-76-82
Evert L. S. ; 2Scientific Research Institute for Medical Problems of the North of Siberian Division of Russian Academy of Medical Sciences; email@example.com
Bakhshieva Svetlana A assistant; Krasnoyarsk State Medical University; firstname.lastname@example.org
Potupchik Tatyana V Cand.Med.Sci., Associate Professor; Professor V. F. Voino-Yasenetsky Krasnoyarsk State Medical University;; email@example.com
Bobrova Elena I functional diagnostics doctor; Federal Siberian Scientific and Clinical Center of the Federal Medical and Biological Agency; firstname.lastname@example.org
Akhmeldinova Julia R student; Professor V. F. Voino-Yasenetsky Krasnoyarsk State Medical University; email@example.com
The aim of the research. To reveal occurrence frequency, structure and features of clinical manifestations of recurrent headaches in children and adolescents with asthenic syndrome (AS). Material and methods. 785 patients of children’s somatic department, aged 7-17 years (386 boys and 399 girls) were examined by method of questioning. Comparison of indicators was carried out in 2 groups – the main one (with AC, n = 344) and the comparison group (without AC, n = 441). Cephalalgia type was verified in accordance with the criteria of International Classification of Headache (2005). Presence of asthenic syndrome and the degree of asthenia severity were assessed according to the Scale of Asthenic State (SAS) by L.D. Malkova and T.G Chertova. Results. It was established that recurrent headaches, in most cases, are recorded in children and adolescents with asthenic syndrome: they are characterized by high incidence of infrequent episodic and chronic tension headache (TH). The proportion of girls in the group with asthenic syndrome is greater than in the group without this syndrome. In overwhelming majority of children with asthenic syndrome, the severity of asthenia was weak and the minority had moderate severity. Episodic TH (mostly infrequent) was the prevailing form of cephalalgia in the examined patients. Chronic TH was significantly more frequent in girls than in boys, and more often in older age group (12-17 years) than in younger one (7-11 years). Conclusion. The study established the fact of more frequent occurrence of asthenic syndrome in girls in comparison with boys, and higher frequency of the syndrome in older age group relatively younger one. It is shown that the presence of asthenic syndrome in children and adolescents is associated with greater incidence of infrequent episodic and chronic tension headaches
Keywords: children, adolescents, asthenic syndrome, recurrent headache, cephalgia, psychosomatic syndromes.
Prikhodko M.N., Prikhodko L.O., Trofimova N.P., Simonova Z.G.
PECULIARITIES OF CORONARY BED IN PATIENTS WITH STABLE ANGINA COMBINED WITH H. PYLORI-ASSOCIATED GASTRODUODENAL PATHOLOGY
Prikhodko MN, Prikhodko LO, Trofimova NP, Simonova ZhG. Peculiarities of coronary bed in patients with stable angina combined with H. Pylori-associated gastroduodenal pathology. Siberian Medical Review. 2018;(4):83-88. DOI: 10.20333/2500136-2018-4-83-88. DOI 10.20333/2500136-2018-4-83-88
Prikhodko Maksim N Post-graduate; Kirov State Medical University; firstname.lastname@example.org
Prikhodko Lubov O Post-graduate; Vyatka State Agricultural Academy; Luba210493@yandex.ru
Trofimova Nataly P Cand.Med.Sci., assistant; Kirov State Medical University; email@example.com
Simonova Zhanna G Dr.Med.Sci., Professor; Kirov State Medical University; firstname.lastname@example.org
The aim of the research is to study peculiarities of coronary bed in patients with coronary heart disease (CHD) combined with gastroduodenal pathology (GDP) depending on Helicobacter pylori infection. Material and methods. The study consistently included 68 patients with stable angina combined with CHD. During the study, groups of patients were formed on the basis of H. pylori infection and the intensity degree of serological test (the level of antibody titer to H. pylori). Group I (n = 26) consisted of patients who had up to 1: 699 titers of antibodies to H. pylori, group II (n = 23) – patients who had more than 1: 700 antibody titers, III (control) group (n = 19) – patients who are not infected with H. pylori. Results. Patients with stable angina combined with CHD, associated with H. pylori, compared to patients with stable angina without H. pylori – associated CHD, have more evident changes in brachiocephalic arteries (BCA), and the severity of the atherosclerotic process is more significant in patients with higher value of antibody titers to H. pylori. Patients with stable angina infected by H. pylori, have more evident and increasing lesion of the coronary arteries, that is worsened by extended number of antibody titers. An increase value of antibody titers to H. pylori in patients with stable angina, combined with CHD, is accompanied by a more evident level of uric acid, fibrinogen and a decrease in glomerular filtration rate (GFR). Conclusion. Patients with stable angina combined with CHD, associated with H. pylori, have more evident significance of atherosclerotic process, which is mainly manifested by vascular lesions both of coronary bed and brachiocephalic arteries
Keywords: coronary heart disease, gastroduodenal pathology, Helicobacter pylori, coronaroangiography, coronary arteries, atherosclerosis.
Zubkov R.A., Rasulov R.I., Zagaynov A.S., Baryshnikov E.S., Golodnikov M.A.
RESULTS OF UNCUT ROUX APPLICATION AT GASTRECTOMY
Zubkov RA, Rasulov RI, Zagajnov AS, Baryshnikov ES, Golodnikov MA. Results of uncut Roux application at gastrectomy. Siberian Medical Review.2018;(4):89-93. DOI: 10.20333/2500136-2018-4-89-93. DOI 10.20333/2500136-2018-4-89-93
Zubkov Roman A Cand.Med.Sci., Assistant; Irkutsk State Medical Academy of Postgraduate Education; email@example.com
Rasulov Rodion I Dr.Med.Sciences, Professor; Irkutsk State Medical Academy of Postgraduate Education; firstname.lastname@example.org
Zagaynov Alexander S surgeon; Irkutsk Regional Cancer Center; email@example.com
Baryshnikov Evgenij S surgeon; Irkutsk Regional Cancer Center; firstname.lastname@example.org
Golodnikov Mihail A. graduate student; Irkutsk State Medical Academy of Postgraduate Education; email@example.com
The aim of the research is to study the possibility of applying uncut Roux technique in patients with disseminated gastric cancer. Material and methods. 269 people participated in the study, who were divided into 2 groups, being operated on in State Budget Institution of Healthcare “Regional Oncological Clinic” in 2010-2017. Control group included 164 patients. In this group, standard esophagus-enteroanastomosis on a long loop with Brownian anastomosis was applied. The main group included 105 patients. In this group, standard esophagous enteroanastomosis on a long loop with a Brownian anastomosis was also applied, reconstructive stage was followed by application of uncut Roux technique. Results. In control group, 19 patients, which amounted to 11.7 %, had complications. In the main group, 15 people, which was 14.4 %, had complicated period There were two lethal outcomes in control group, so postoperative mortality was 1.2 %. In the main group, postoperative mortality was 0.9 %. The frequency of reflux esophagitis in control group was 56.8 %, in the main group –21.1 %. In the control group, 19 patients had reflux esophagitis of C and D degree. Conclusion. Application of uncut Roux technique can reduce the amount and severity of esophagitis reflux to a great extend, that, in turn, helps to improve the quality of life significantly.
Keywords: gastric cancer, gastrectomy, esophagoenteroanastomosis, reconstruction after gastrectomy, reflux-zofagit
Anishchenko V.V., Kovgan Y.M., Kim D.A.
COMPREHENSIVE ESTIMATION OF THE RESULTS OF ESOPHAGO-CARDIOFUNDOPLASTICS IN STAGE III-IV ACHALASIA CARDIA
Anishchenko VV, Kovgan YM, Nalbandyan AG, Kim DA, Nalbandyan IV. Comprehensive estimation of the results of esophago-cardiofundoplastics in stage III-IV achalasia cardia. Siberian Medical Review.2018;(4):94-101. DOI: 10.20333/2500136-2018-4-94-101. DOI 10.20333/2500136-2018-4-94-101
Anishchenko Vladimir Vladimirovich ; Novosibirsk State Medical University; г. Новосибирск, Красный проспект, 52; тел.: +7 (383) 2293522; e-mail: firstname.lastname@example.org
Kovgan Yuliy Mikhailovich ; Novosibirsk State Medical University; г. Новосибирск, Красный проспект, 52; тел.: +7 (383) 2293522; e-mail: email@example.com
Kim Denis Alexandrovich ; Novosibirsk State Medical University; г. Новосибирск, Красный проспект, 52; тел.: +7 (383) 2293522; e-mail: firstname.lastname@example.org
The aim of the research is evaluation of immediate and long-term results of esophago-cardio-fundoplastics with fundoplication according to Hill in stage III-IV achalasia cardia. Material and methods. Retrospective and prospective analysis of 51 cases of stage III-IV achalasia cardia according to the results of endoscopy, fluoroscopy, esophagus manometry and histology of the esophageal mucosa. Statistical processing is performed to determine the norm of distribution. Comparative analysis is the assistance of Wilcoxon and Friedman criteria. Results. The duration of patients monitoring varied from 1 and 14 years. The relief of dysphagia occurred in 92.16 % of cases. Gastroesophageal reflux appearance was noted in 7.84 %. The cause of recurrence of 4 case of dysphagia from 5 (9.8 %) was the absence of peristalsis of the esophagus under stage IV. In one case, it happened due to evident adhesive process in the subdiaphragmatic space. The patient was reoperated in the volume of adhesiolysis and the weakening of the fundoplication cuff with good effect. Restoration of esophagus patency is confirmed by the increase in patients’ body mass index from 22.9 ± 0.6 to 24.7 ± 0.6. The reduction of esophagus diameter, independently from the degree of esophagus expansion prior to surgery and the duration of history of the disease was demonstrated. Normalization of the resting pressure and residual pressure of the lower esophageal sphincter were noted. Cases of esophageal cancer or lethal outcomes were not reported. Conclusion. Esophago-cardio-fundoplastics with fundoplication according to Hill has demonstrated long-term, stable result in dysphagia relief, even in cases with advanced forms of cardiac achalasia. The number of dysphagia relapses or gastroesophageal reflux occurrence did not exceed 10% and is not related to the technical aspects of surgery. This circumstance makes it possible to recommend this operation as an alternative one to the existing cardioplastic operations, such as Heller myelotomy and to secure a patient against esophagus extirpation.
Keywords: laparoscopic surgery, esophagus diseases, achalasia cardia, esophagus achalasia, cardiospasm, dysphagia, cardioplasty
Gladkikh N.N., Svyazov E.A., Zavadovsky K.V., Baev A.E., Gorlova A.A., Vasiltseva O.Y., Boshchenko A.A.
ANOMALOUS ORIGIN OF ANTERIOR DESCENDING ARTERY FROM PULMONARY ARTERY IN AN ELDERLY WOMAN. VISUALIZATION POSSIBILITIES
Gladkikh NN, Svyazov EA, Zavadovsky KV, Baev AE, Gorlova AA, Vasiltseva OYa, Boshchenko AA. Anomalous origin of anterior descending artery from pulmonary artery in an elderly woman. Visualization possibilities. Siberian Medical Review. 2018;(4):102-106. DOI: 10.20333/2500136-2018-4-102-106. DOI 10.20333/2500136-2018-4-102-106
Gladkikh Natalia N Cand.Med.Sci.; Cardiology Research Institute, Tomsk National Research Medical Center; email@example.com
Svyazov Evgenii A cardiovascular surgeon; Cardiology Research Institute, Tomsk National Research Medical Center; firstname.lastname@example.org
Zavadovsky Konstantin V Dr.Med.Sci.; Cardiology Research Institute, Tomsk National Research Medical Center; Konstz@cardio-tomsk.ru
Baev Andrei E Cand.Med.Sci.; Cardiology Research Institute, Tomsk National Research Medical Center; email@example.com
Gorlova Anastasiya A. Postgraduate student; Cardiology Research Institute, Tomsk National Research Medical Centre, Russian Academy of Sciences; firstname.lastname@example.org
Vasiltseva Oksana Ya. Dr. Med. Sci., Researcher; Cardiology Research Institute, Tomsk National Research Medical Centre, Russian Academy of Science; email@example.com
Boshchenko Alla A Dr.Med.Sci., Assistant professor; Cardiology Research Institute, Tomsk National Research Medical Center; firstname.lastname@example.org
A clinical case of anomalous origin of anterior descending artery from pulmonary artery (ALCAPA syndrome) in an elderly woman is described. A peculiar feature of the presented clinical case is congenital heart disease manifestation in the elderly age. Clinical manifestations of coronary heart disease, risk factors allowed, first of all, to assume the presence of significant coronary atherosclerosis. Nevertheless, the data of modern visualization technologies indicate the possibility of diagnosing coronary artery anomaly in elderly patients. In the description and discussion of the clinical case, there are features of coronary arteries transthoracic visualization with determination of the direction and the velocity of blood flow along the main coronary arteries and intercoronary anastomoses, as well as the importance of conducting multispiral computer tomography of coronary arteries in order to identify “adult” type of ALCAPA syndrome.
Keywords: Congenital heart disease, transthoracic ultrasound study of coronary arteries, Strain, ALCAPA, adult type, multispiral computer tomography.
Vazemiller O.A., Vasil'eva E.M., Karpova L.N., Salmina A.B., Emelyanchik E.Y.
TWO-YEAR CATAMNESIS OF A CHILD WITH TRANSIENT MYOCARDIAL ISCHEMIA IN NEONATAL PERIOD
Vazemiller OA, Vasileva EM, Karpova LN, Salmina AB, Emelianchik EIu. Two-year catamnesis of a child with transient myocardial ischemia in neonatal period. Siberian Medical Review.2018;(4):107-110. DOI: 10.20333/2500136-2018-4-107-110. DOI 10.20333/2500136-2018-4-107-110
Vazemiller Oksana Aleksandrovna ; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; email@example.com
Vasil'eva Elena Mihajlovna 2а, Acad. Kirenskiy Str. 2, Krasnoyarsk, 660074, RF; Phone: +7 (391)2220273; e-mail:firstname.lastname@example.org; Krasnoyarsk Regional Clinical Center of Maternity and Childhood;
Karpova Lyudmila N Cand.Med.Sci., assistant; Krasnoyarsk Regional Clinical Center for Maternity and Childhood Protection; email@example.com
Salmina Alla Borisovna PhD, Dr.Med.Sc., Professor, Head of the Department of Biological Chemistry with the Course of Medical, Pharmaceutical and Toxicological Chemistry; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; firstname.lastname@example.org
Emelyanchik Elena Yurievna Dr.Med.Sc., Professor of the Pediatric Department IPE; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; email@example.com
The article presents the history of the patient with transient myocardial ischemia in neonatal period against old perinatal hypoxia, while secondary cardiomyopathy developed beyond the early neonatal period, and at the age of 2 months, infectious heart disease occurred. “Transient myocardial ischemia” is not often diagnosed in the practice of neonatology due to the lack of unified diagnostic criteria, but this condition can be masked and, as a result, worsen the course of respiratory pathology, which requires differential diagnosis and is important for choosing the right tactics for patients’ treatment.
Keywords: new-born, transient myocardial ischemia, infectious myocarditis, cytomegalovirus infection, neonatal period, catamnesis
Pervova O.V., Chipura A.O., Takhtobin E.G., Pirova A.S.
TO THE ANNIVERSARY OF PROFESSOR DMITRY VLADIMIROVICH CHERDANTSEV
Pervova OV, Takhtobin EG, Chipura AO, Pirova ASh. To the anniversary of professor Dmitry Vladimirovich Cherdantsev. Siberian Medical Review. 2018;(4):111-116. DOI: 10.20333/2500136-2018-4-111-116. DOI 10.20333/2500136-2018-4-111-116
Pervova Olga Vladimirovna Dr. Med. Sc, Professor; Professor V. F. Voino-Yasenetsky Krasnoyarsk State Medical University; firstname.lastname@example.org
Chipura Alexey O the graduate student; Professor V. F. Voino-Yasenetsky Krasnoyarsk State Medical University; email@example.com
Takhtobin Evgeniy G. Student; Professor V. F. Voino-Yasenetsky Krasnoyarsk State Medical University; firstname.lastname@example.org
Pirova Alyona S student; Professor V. F. Voino-Yasenetsky Krasnoyarsk State Medical University; email@example.com