Сибирское медицинское обозрение. 2017. № 2 View full textКоличество просмотров : 3094
Kuzmina O.K., Rutkovskaya N.V.
MYOCARDIUM REMODELING IN THE HEART VALVES DISORDERS
Kuzmina OK, Rutkovskaya NV. Myocardial remodeling in patients with heart valves disorders. Siberian Medical Review. 2017;(2):5-14. DOI: 10.20333/2500136-2017-2-5-14.
Kuzmina Olga Konstantinovna ; Research Institute for Complexlssues of Cardiovascular Diseases; г. Кемерово, Сосновый бульвар, д. 6; тел.: +7(3842)644317; e-mail: firstname.lastname@example.org
Rutkovskaya Natalya Vital'evna ; Research Institute for Complex Issues of Cardiovascular Diseases; г. Кемерово, Сосновый бульвар, д. 6;тел.:+7(3842)645360; e-mail: email@example.com
Acquired heart diseases are very serious pathologies, the main and most effective method of its correction remains valve apparatus prosthetic. The aim of surgical interventions is not only increasing the life expectancy of patients, but also improving its quality, it is achieved by the adequate correction of hemodynamic disorders and largely depends on the possibility of developing a reverse myocardial remodeling in the postoperative period. Currently, the remodeling process involves molecular, cellular, interstitial and gene restructuring that clinically manifest by changing the size, shape and function of the heart after damage. The rates of reverse remodeling, regression of hypertrophy and restoration of the functions of the heart chambers depend on the degree of myocardial fibrosis, regulated by the system of matrix metalloproteinases and their tissue inhibitors. This review discusses the complex approach to the evaluation of myocardial remodeling in heart valve disorders, taking into account clinical, instrumental and humoral features.
Keywords: cardiology, myocardium remodeling, acquired heart diseases.
1. Jones EC, Devereux RB, Roman MJ, LiuJE, Fishman D, Lee ET, Welty TK, Fabsitz RR, Howard BV. Prevalence and correlates of mitral regurgitation in a population-based sample (the Strong Heart Study). American Journal of Cardiology. 2001;87(3):298-304. 2. Lloyd-Jones D, Adams R, Carnethon M, De Simone G, Ferguson TB, Flegal K, Ford E, Furie K, Go A, Greenlund K, Haase N, Hailpern S, Ho M, Howard V, Kissela B, Kittner S, Lackland D, Lisa- beth L, Marelli A, McDermott M, Meigs J, Mozaffarian D, Nichol G, O'Donnell C, Roger V, Rosamond W, Sacco R, Sorlie P, Stafford R, Steinberger J, Thom T, Wasserthiel-Smoller S, Wong N, Wylie- Rosett J, Hong Y. Heart disease and stroke statistics-2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2009;119(3):480-6. DOI: 10.1161/CIRCULATIONAHA.108.191259 3. d'Arcy JL, Prendergast BD, Chambers JB, Ray SG, Bridgewater B. Valvular heart disease: the next cardiac epidemic. Heart. 2011;97(2):91-3. DOI: 10.1136/hrt.2010.205096 4. Lee R, Li S, Rankin JS, O'Brien SM, Gammie JS, Peterson ED, Mc-Carthy PM, Edwards FH. Fifteen-year outcome trends for valve surgery in North America. The Annals of Thoracic Surgery. 2011;91(3):677-84. discussion p 684. DOI: 10.1016/j.athoracsur.2010.11.009 5. Storozhanov GI, Tronina OA, Gendlin GE Acquired valvular diseases. Some features of clinical picture and treatment in the twenty-first century. Russian Heart Failure Journal. 2009;10(6):333- 41. (In Russian) 6. Bockeria LA, Gudkova RG. Cardiovascular surgery - 2015. Diseases and congenital abnormalities of the circulatory system. M.: A.N. Bakoulev Scientific Center for Cardiovascular Surgery; 2016. 208 p. (in Russian) 7. Stasev AN, Odarenko Yu N, Rutkovskaya NV, Zhuravleva IYu, Barbarash LS. Comparison analysis of short-term outcomes following the implantition of xenoaortic and xenopericardial epoxy-treated bioprothesis in the mitral position. Complex Issues of Cardiovascular Diseases. 2013;(4):12-6. (In Russian) DOI:10.17802/2306-1278-2013-4- 12-16 8. Zhuravleva IYu, Rutkovskaya NV, Odarenko YuN, Gorbunova EV. The basic principles of patients care with artificial heart valves. Guidelines for general practitioners, cardiologists. Kemerovo; 2011. 101 p (in Russian) 9. Astapov DA, Zhuravleva IYu, Klyshnikov KYu, Shcheglova NA, Demidov DP, Ovcharenko EA, Seleznev SI Experimental and clinical substantiation of implantation efficacy in the aortic position of "TIARA" bioprosthesis with a stent made of nitinol. Complex Issues of Cardiovascular Diseases. 2013;(4):17-21. (In Russian) DOI:10.17802/2306-1278-2013-4-17-21 10. Kudryavtseva Yu A. Bioprosthetic of heart valves. From idea to clinical use. Complex Issues of Cardiovascular Diseases. 2015;(4):6-16. (In Russ.) DOI: 10.17802/2306-1278-2015-4-6-16 11. Nishimura RA, Otto CM, Bonow RO, Carabello BA, Erwin JP 3rd, Guyton RA, O'Gara PT, Ruiz CE, Skubas NJ, Sorajja P, Sundt TM 3rd, Thomas JD. 2014 AHA/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Journal of the American College of Cardiology. 2014;63(22):e57-185. DOI: 10.1016/j.jacc.2014.02.536 12. Rogulina NV, Gorbunova EV, Kondyukova NV, Odarenko YuN, Barbarash LS. Comparison of the recipient life quality with mechanical and biological mitral prostheses. Russian Journal of Cardiology. 2015;(7):94-7. (In Russian) DOI: 10.15829/1560-4071-2015-7-94-97 13. Pfeffer MA, Braunwald E. Ventricular remodeling alter myocardial infarction. Experimental observations and clinical implications. Circulation. 1990; 81(4):1161-72. 14. Belenkov YuN. Left ventricle remodeling: a comprehensive ap-proach. Russian Heart Failure Journal. 2002;14(4):161-3 (In Russian). 15. Mihl C, Dassen WR, Kuipers H. Cardiac remodelling: concentric versus eccentric hypertrophy in strength and endurance athletes. Netherlans Heart Journal. 2008;16(4):129-33. 16. Riding NR, Salah O, Sharma S, Carre F, O'Hanlon R, George KP, Hamilton B, Chalabi H, Whyte GP,Wilson MG.Do big athletes have big hearts? Impact of extreme anthropometry upon cardiac hypertrophy in professional male athletes. British Journal of Sports Medicine. 2012;46 Suppl 1:i90-7. DOI: 10.1136/bjsports-2012-091258. 17. Connor T, Martin SD, Howlett KF, McGee SL. Metabolic remodelling in obesity and type 2 diabetes: pathological or protective mechanisms in response to nutrient excess? Clinical and Experimental Pharmacology and Physiology. 2015;42(1):109-15. DOI: 10.1111/1440-1681.12315. 18. Vatta M, Stetson SJ, Perez-Verdia A, Entman ML, Noon GP, Torre-Amione G, Bowles NE, Towbin JA. Molecular remodelling of dystrophin in patients with end-stagecardiomyopathies and reversal in patients on assistance-device therapy. Lancet. 2002;359(9310):936-41. 19. Koshman YE, Sternlicht MD, Kim T, O'Hara CP, Koczor CA, Lewis W, Seeley TW, Lipson KE, Samarel AM. Connective tissue growth factor regulates cardiac function and tissue remodeling in a mouse model of dilated cardiomyopathy. Journal of Molecular and Cellular Cardiology. 2015;89(Pt B):214-22. DOI: 10.1016/j.yjmcc.2015.11.003. 20. Zhang J, Xing Q, Zhou X, Zhang Y, Li Y, Li J, Tang B. Effects of Cardiac Resynchronization Therapy on Ventricular Electrical Remodeling in Patients With Heart Failure. International Heart Journal. 2015;56(5):495-9. DOI: 10.1536/ihj.15-104. 21. Tadic M, Cuspidi C. Childhood obesity and cardiac remodeling: from cardiac structure to myocardial mechanics. Journal of Cardiovascular Medicine (Hagerstown). 2015;16(8):538-46. DOI: 10.2459/JCM.0000000000000261. 22 Karaye KM, Bonny A. Right ventricular dysfunction in systemic hypertension: A call to action. International Journal of Cardiology. 2016;206:51-3. DOI: 10.1016/j.ijcard.2016.01.049. 23. Hsu PC, Lee WH, Chu CY, Lee HH, Lee CS, Yen HW, Lin TH, Voon WC, Lai WT, Sheu SH, Su HM. Prognostic role of left atrial strain and its combination index with transmitral E-wave velocity in patients with atrial fibrillation. Scientific Reports. 2016;6:17318. DOI: 10.1038/srep17318. 24. Polikutina OM, Slepynina YuS, Bazdyrev ED, Vasyutinskaya EG, Karetnikova VN, Barbarash OL. Specifics of the left heart chambers early post infarction remodeling in comorbid COPD of mild and moderate severity. Russian Journal of Cardiology. 2015;(12):80-6. (In Russian) DOI: 10.15829/1560-4071-2015-12-80-86 25. Zhang K, Liu Y, Liu X, Chen J, Cai Q, Wang J, Huang H. Apocynin improving cardiac remodeling in chronic renal failure disease is associated with up-regulation of epoxyeicosatrienoic acids. Oncotarget. 2015;6(28):24699-708. DOI: 10.18632/oncotar- get.5084. 26. Sert A, Aypar E, Pirgon O, Yilmaz H, Odabas D, Tolu I. Left ven-tricular function by echocardiography, tissue Doppler imaging, and carotid intima-media thickness in obese adolescents with nonalcoholic fatty liver disease. American Journal of Cardiology. 2013;112(3):436-43. 27. Wu Y, Zhao W, Zhang Y, Feng X, Li Z, Gao W. Effect of metformin on ventricular remodeling in patients with primary hypertension and type 2 diabetes mellitus. Zhonghua Yi Xue Za Zhi. 2015;95(44):3570-4. 28. Barbarash OL, Tavlueva EV, Krotikov YuV, Sizova IN, Barbarash LS. ACE-inhibitors effect on the process of myocardial remodeling in patients operated for chronic mitral regurgitation. Patologiya krovoobrashcheniya ikardiokhirurgiya. 2006;(1):15-20 (In Russian). 29. Strutynsky AV, Kallaeva AN, Banzelyuk EN, Gazieva PA, Glazunov AB, Baranov AP, Trishina VV, Golubev Yu Yu, Golubeva GYu. Effect of long-term treatment with lisinopril and carvedilol on the process of ischemic remodeling of the left ventricle in patients after unstable angina at rest. Russian Heart Failure Journal. 2015;16(4):224-33 (In Russian). DOI: 10.18087/rhfj.2015.4.2099 30. Kaya MG, Sarli B, Akpek M, Kaya EG, Yarlioglues M, Top- sakal R, Lam YY. Evaluation of beta-blockers on left ventricular dys- synchrony and reverse remodeling in idiopathic dilated cardiomyopathy: A randomized trial of carvedilol and metoprolol. Cardiology Journal. 2014;21(4):434-41. DOI: 10.5603/CJ.a2013.0149. 31. Kumagai K, Nakashima H, Urata H, Gondo N, Arakawa K, Saku K. Effects of angiotensin II type 1 receptor antagonist on electrical and structural remodeling in atrial fibrillation. Journal of the American College of Cardiology.2003;41(12):2197-204. 32. Moura LM, Ramos SF, Kristensen SD, Pinto FJ, Barros IM, Rocha-Gon?alves F. Rosuvastatin slows the development of diastolic dysfunction in calcific aortic stenosis. Journal of Heart Valve Disease. 2012;21(4):463-72. 33. Hagendorff A, Stoebe S, Tarr A, Pfeiffer D. Standardized transthoracic echocardiography in patients with primary and secondary mitral valve regurgitation. Ultraschall in der Medizin. 2015;36(1):10-34. DOI: 10.1055/s-0034-1385684. 34. Bockeria LA, Kosareva TI, Kuts EV, Makarenko VN, Miro- nenko VA. Evaluation of remodeling of the heart chambers in the condition of mitral valve pathology by methods of echocardiography and magnetic resonance tomography. The Bulletin of A.N. Bak- oulev Scientific Center for Cardiovascular Surgery of Russian Academy of Medical Sciences Cardiovascular Diseases. 2013;3(14):19-26 (In Russian) 35. Habibi M, Lima JA, Khurram IM, Zimmerman SL, Zipun- nikov V, Fukumoto K, Spragg D, Ashikaga H, Rickard J, Marine JE, Calkins H, Nazarian S. Association of left atrial function and left atrial enhancement in patients with atrial fibrillation: cardiac magnetic resonance study. Circulation. Cardiovascular Imaging. 2015;8(2):e002769. DOI: 10.1161/CIRCIMAGING.114.002769. 36. Rebergen SA, de Roos A.Congenital heart disease. Evaluation of anatomy and function by MRI. Herz. 2000;25(4):365-83. 37. Walters TE, Ellims AH, Kalman JM. The role of left atrial imaging in the management of atrial fibrillation. Progress in Cardiovascular Diseases. 2015;58(2):136-51. DOI: 10.1016/j.pcad.2015.07.010. 38. Stacey RB, Haag J, Hall ME, McLeod G, Upadhya B, Hundley WG, Thohan V. Mitral regurgitation in left ventricular noncompaction cardiomyopathy assessed by cardiac MRI. The Journal of Heart Valve Disease. 2014;23(5):591-7. 39. Tarasov PI, Kokov AN, Barbarash LS. Evaluation of the influence of metabolic and thrombolytic therapy on the indicators of postinfarction left ventricular remodeling using magnetic resonance imaging. 2006;78(9):38-43 (In Russian). 40. Muraru D, Badano LP, Peluso D, Dal Bianco L, Casablanca S, Kocabay G, Zoppellaro G, Iliceto S. Comprehensive analysis of left ventricular geometry and function by three-dimensional echocardiography inhealthy adults. Journal of the American Society of Echocardiography. 2013;26(6):618-28. DOI: 10.1016/j.echo.2013.03.014. 41. Leibundgut G, Rohner A, Grize L, Bernheim A, Kessel-Schae- fer A, Bremerich J, et al. Dynamic assessment of right ventricular volumes and function by real-time three-dimensional echocardiography: a comparison study with magnetic resonance imaging in 100 adult patients. Journal of the American Society of Echocardiography. 2010;23(2):116-26. DOI: 10.1016/j.echo.2009.11.016. 42. Grewal J, Majdalany D, Syed I, Pellikka P, Warnes CA. Three-dimensional echocardiographic assessment of right ventricular volume and function in adult patients with congenital heart disease: comparison with magnetic resonance imaging. Journal of the American Society of Echocardiography. 2010;23(2):127-33. DOI: 10.1016/j.echo.2009.11.002. 43. Shimada YJ, Shiota M, Siegel RJ, Shiota T. Accuracy of right ventricular volumes and function determined by three dimensional echocardiography incomparison with magnetic resonance imaging: a meta-analysis study. Journal of the American Society of Echocardiography. 2010;23(9):943-53. DOI: 10.1016/j.echo.2010.06.029. 44. Machado LR, Meneghelo ZM, Le Bihan DC, Barretto RB, Carvalho AC, Moises VA. Preoperative left ventricular ejection fraction and left atrium reverse remodeling after mitral regurgitation surgery. Cardiovascular Ultrasound. 2014;12:45. DOI: 10.1186/1476-7120-12-45. 45. Bonow RO, Castelvecchio S, Panza JA, Berman DS, Velazquez EJ, Michler RE, She L, Holly TA, Desvigne-Nickens P, Kosevic D, Rajda M, Chrzanowski L, Deja M, Lee KL, White H, Oh JK, Doenst T, Hill JA, Rouleau JL, Menicanti L; STICH Trial Investigators. Severity of Remodeling, Myocardial Viability, and Survival in Ischemic LV Dysfunction After Surgical Revascularization. JACC Cardiovascular Imaging. 2015;8(10):1121-9. DOI: 10.1016/j.jcmg.2015.03.013. 46. Jarhult SJ, Sundstrom J, Lind L. Brachial artery hyperaemic blood flow velocity and left ventricular geometry. Journal of Human Hypertension. 2012;26(4):242-6. DOI: 10.1038/jhh.2011.21. 47. Bockeria LA, Bokeria OL, Averina II, Berseneva MI. Assessment of left ventricular remodeling: a study guide for doctors. Moscow: 2009. 36 p. (In Russian) 48. Huang BT, Peng Y, Liu W, Zhang C, Huang FY, Wang PJ, Zuo ZL, Liao YB, Chai H, Li Q, Zhao ZG, Luo XL, Ren X, Huang KS, Meng QT, Chen C, Huang DJ, Chen M. Inappropriate left ventricular mass and poor outcomes in patients with angina pectoris and normal ejection fraction. Coronary Artery Disease. 2015;26(2):163-9. DOI: 10.1097/MCA.0000000000000190. 49. Dahl JS, Christensen NL, Videbsk L, Poulsen MK, Cart- er-Storch R, Hey TM, Pellikka PA, Steffensen FH, Moller JE. Left ventricular diastolic function is associated with symptom status in severe aortic valve stenosis. Circulation. Cardiovascular Imaging. 2014;7(1):142-8. DOI: 10.1161/CIRCIMAGING.113.000636. 50. D'Elia N, D'hooge J, Marwick TH. Association Between Myocardial Mechanics and Ischemic LV Remodeling. JACC Cardiovascular Imaging. 2015;8(12):1430-43. DOI: 10.1016/j.jcmg.2015.10.005. 51. Bockeria LA, Nikitina TG, Skopin II, Lomonova AT, Tciskaridze IM, Izosimova MG. Comparative analysis of results of surgical correction of mitral stenosis by MedInzh-2 prostheses. The heart valve prostheses Medinzh-2 in valvular diseases surgery. Moscow: A.N. Bakoulev Scientific Center for Cardiovascular Surgery of Russian Academy of Medical Sciences cardiovascular diseases; 2009:118-24. (In Russian). 52. Kim SJ, Samad Z, Bloomfield GS, Douglas PS. A critical review of hemodynamic changes and left ventricular remodeling after surgical aortic valve replacement and percutaneous aortic valve replacement. American Heart Journal. 2014;168(2):150-9.e1-7. DOI: 10.1016/j.ahj.2014.04.015. 53. Rader F, Sachdev E, Arsanjani R, Siegel RJ. Left ventricular hypertrophy in valvular aortic stenosis: mechanisms and clinical implications. American Journal of Medicine. 2015;128(4):344-52. DOI: 10.1016/j.amjmed.2014.10.054. 54. Gaudino M, Alessandrini F, Glieca F, Luciani N, Cellini C, Pragliola C, Morelli M, Canosa C, Nasso G, Possati G. Survival after aortic valve replacement for aortic stenosis: does left ventricular mass regression have a clinical correlate? European Heart Journal. 2005;26(1):51-7. 55. Beholz S, Repossini A, Livi U, Schepens M, El Gabry M, Matschke K, Trivedi U, Eckel L, Dapunt O, Zamorano JL. The Freedom SOLO valve for aortic valve replacement: clinical and hemodynamic results from a prospective multicenter trial. Journal of Heart Valve Disease. 2010;19(1):115-23. 56. Lim E, Ali A, Theodorou P, Sousa I, Ashrafian H, Chama- georgakis T, Duncan A, Henein M, Diggle P, Pepper J. Longitudinal study of the profile and predictors of left ventricular mass regression after stentless aortic valve replacement. Annals of Thoracic Surgery. 2008;85(6):2026-9. DOI: 10.1016/j.athoracsur.2008.02.023. 57. Ali A, Halstead JC, Cafferty F, Sharples L, Rose F, Lee E, Rusk R, Dunning J, Argano V, Tsui S. Early clinical and hemodynamic outcomes after stented and stentless aortic valve replacement: results from a randomized controlled trial. Annals of Thoracic Surgery. 2007;83(6):2162-8. 58. Jung SH, Lee JW, Je HG. Surgical Outcomes and Post-Operative Changes in Patients with Significant Aortic Stenosis and Severe Left Ventricle Dysfunction. Journal of Korean Medical Science. 2009;24(5):812-7. DOI: 10.3346/jkms.2009.24.5.812. 59. Ahmad N, Shahbaz A, Ghaffar A, Tufail Z, Waheed A, Khan JS. Early left ventricular remodeling after aortic valve replacement. Journal of Ayub Medical College, Abbottabad. 2007;19(3):10-4. 60. Hatani T, Kitai T, Murai R, Kim K, Ehara N, Kobori A, Kinoshita M, Kaji S, Tani T, Sasaki Y, Yamane T, Koyama T, Nasu M, Okada Y, Furukawa Y. Associations of residual left ventricular and left atrial remodeling with clinical outcomes in patients after aorticvalve replacement for severe aortic stenosis. Journal of Cardiology. 2016;68(3):241-7. DOI: 10.1016/j.jjcc.2015.09.017. 61. Stampehl MR, Mann DL, Nguyen JS, Cota F, Colmenares C, Dokainish H. Speckle strain echocardiography predicts outcome in patients with heart failure with both depressed andpreserved left ventricular ejection fraction. Echocardiography. 2015;32(1):71-8. DOI: 10.1111/ echo.12613. 62. Sadaba JR, Herregods MC, Bogaert J, Harringer W, Gerosa G. Left ventricular mass regression is independent of gradient drop and effective orifice area after aortic valvereplacement with a porcine bioprosthesis. Journal of Heart Valve Disease. 2012;21(6):788-94. 63. Mershina EA, Selyavko YuA, Kuzina SV, Sinitsyn VE, Dzemeskevich SL. Echocardiography and magnetic resonance tomography in the evaluation of left ventricular remodeling during the first year after aortic valve replacement. Russian Electronic Journal of Radiology. 2011;1(2):24-35. (In Russian) 64. Khromov AA, Kokov AN, Semenov SE. Evalution of left ven- tricuar remodeling in patients after surgical correction of aortic valve stenosis. «Radiology - Practice» Journal. 2013;5(60):13-7. (In Russian) 65. Candan O, Ozdemir N, Aung SM, Hatipoglu S, Karabay CY, Guler A, Gecmen C, Dogan C, Omaygenc O, Bakal RB. Atrial longitudinal strain parameters predict left atrial reverse remodeling after mitral valve surgery: a speckle tracking echocardiography study. The International Journal of Cardiovascular Imaging. 2014;30(6):1049-56. DOI: 10.1007/s10554-014-0433-9. 66. Machado LR, Meneghelo ZM, Le Bihan DCS, Barretto RBM, Carvalho AC, Moises VA. Preoperative left ventricular ejection fraction and left atrium reverse remodeling after mitral regurgitation surgery. Cardiovascular Ultrasound. 2014;12:45. DOI: 10.1186/1476-7120-12- 45. r mitral regurgitation surgery. Cardiovascular Ultrasound. 2014 Nov 6;12:45. doi: 10.1186/1476-7120-12-45. 67. Hyllen S, Nozohoor S, Meurling C, Wierup P, Sjogren J. Left atrial reverse remodeling following valve surgery for chronic degenerative mitral regurgitation in patients with preoperative sinus rhythm: effects on long-term outcome. Journal of Cardiac Surgery. 2013;28(6):619-26. DOI: 10.1111/jocs.12215. 68. Hyllen S, Nozohoor S, Meurling C, Wierup P, Sjogren J. De-terminants of left atrial reverse remodeling after valve surgery for degenerative mitral regurgitation. Journal of Heart Valve Disease. 2013;22(1):2-10. 69. Yaroslavtseva EI, Morova NA. The structural and geometric parameters of the right ventricle of heart. Kazan Medical Journal. 2008;89(1):8-11 (In Russian). 70. Lemmer Hunsinger CE, Engel ME, Stanfliet JC, Mayosi BM. Reference intervals for the echocardiographic measurements of the right heart in children and adolescents: a systematic review. Cardiovascular Ultrasound. 2014;12:3. DOI: 10.1186/1476-7120-12-3. 71. Khurs EM, Poddubnaya AV, Smolenskaya OG. Left ventricular remodeling variants and their classification. Journal of Ural Medical Academic Science. 2011;1:90-4 (in Russian). 72. Kozhevnikov ML, Stasev AN, Kazakov VA. Clinical and mor-phological parallels of left ventricular remodeling in combined acquired valvular diseases. Bulletin of Russian State Medical University. 2006;2:381-82. (In Russian). 73. Bockeria LA, Kosareva TI, Makarenko VN, Muratov RM, Skopin II. Evaluation of a ratio of heart cavities as a remodeling index in acquired mitral valve diseases. Clinical Physiology of Circula- tion.2010;1:22-30. (In Russian) 74. Kosareva TI, Makarenko VN, Fadeev AA. The impact of the type of mitral prosthesis on heart cavities remodeling: echocardiographic as-sessment. Innovative implants in surgery. Moscow: A.N. Bakoulev Scientific Center for Cardiovascular Surgery of Russian Academy of Medical Sciences cardiovascular diseases; 2014:243-245. (In Russian) 75. Wang J, Xu D, Wu X, Zhou C, Wang H, Guo Y, Cao K. Polymor-phisms of matrix metalloproteinases in myocardial infarction: a meta-analysis. Heart. 2011;97(19):1542-6. DOI: 10.1136/heartjnl-2011-300342. 76. Pecherina TB, Gruzdeva OV, Kashtalap VV, Barbarash OL. The role of matrix metalloproteinases in assessment of prognosis in patients with ST-elevation myocardial infarction during hospital stay. Russian Journal of Cardiology. 2013;6:18-24. (In Russian) 77. Goncharova NS, Moiseeva OM, Shlyakhlo EV, Aleshina GM. Matrix metalloproteinases: significance in remodeling of the myocardium in valvular heart disease. Russian Journal of Cardiology. 2007;47(12):49-53 (In Russian) 78. Banerjee T, Mukherjee S, Ghosh S, Biswas M, Dutta S, Pattari S, Chatterjee S, Bandyopadhyay A. Clinical significance of markers of collagen metabolism in rheumatic mitral valve disease. PLoS One. 2014;9(3):e90527. DOI: 10.1371/journal.pone.0090527. eCollection 2014.
Berdnikov S.V., Berdnikova O.A.
TESTOSTERONE REPLACEMENT THERAPY AND CARDIOVASCULAR RISK
Berdnikov SV, Berdnikova OA. Testosterone replacement therapy and cardiovascular risk. Siberian Medical Review. 2017;(2):14-21. DOI: 10.20333/2500136-2017-2-14-21.
Berdnikov Sergey Valerievich ; European medical center; г. Москва, ул. Щепкина, д. 35; тел.: +7(915)2920371; e-mail: firstname.lastname@example.org
Berdnikova Olga Aleksandrovna ; General Practitioner, Nephrologist, Oryol Regional Hospital; г. Орел, ул. Победы бульвар, д. 10; тел.: +7(980)3683105; e-mail: email@example.com
Testosterone deficiency is a common problem affecting the quality of life of men. In cohort studies, a direct link between low levels of endogenous testosterone and coronary heart disease, diabetes mellitus, insulin resistance has been identified. A large number of observational researches had been conducted which studied the efficacy and safety of testosterone treatment, indicated contradictory results. At the same time, the number of patients receiving testosterone replacement therapy is steadily increasing. In this review, current data on the cardiovascular safety of testosterone replacement therapy are considered.
Keywords: testosterone deficiency, testosterone replacement therapy, cardiovascular risk
1. Alexandersen P, Haarbo J, Byrjalsen I, Lawaetz H, Christiansen C. Natural androgens inhibit male atherosclerosis: a study in castrated, cholesterol-fed rabbits. Circulation Research. 1999;84:813-9. 2. Ammar EM, Said SA, Hassan MS. Enhanced vasoconstriction and reduced vasorelaxation induced by testosterone and nandrolone in hypercholesterolemic rabbits. Pharmacol Res. 2004;50:253- 259. DOI:10.1016/j.phrs.2004.03.010. 3. Araujo AB, Dixon JM, Suarez EA, Murad MH, Guey LT, Wit-tert GA. Endogenous testosterone and mortality in men: a systematic review and meta-analysis. The Journal of Clinical Endocrinology and Metabolism. 2011;96:3007-19. DOI: 10.1210/jc.2011-1137. 4. Baillargeon J, Urban RJ, Morgentaler A, Glueck CJ, Bail- largeon G, Sharma G, Kuo YF. Risk of Venous Thromboembolism in Men Receiving Testosterone Therapy. Mayo Clinic Proceed- ings.2015;90(8):1038-1045. DOI: 10.1016/j.mayocp.2015.05.012.5. 5. Basaria S, Coviello AD, Travison TG, Storer TW, Farwell WR, Jette AM, Eder R, Tennstedt S, Ulloor J, Zhang A, Choong K, Laksh- man KM, Mazer NA, Miciek R, Krasnoff J, Elmi A, Knapp PE, Brooks B, Appleman E, Aggarwal S, Bhasin G, Hede-Brierley L, Bhatia A, Collins L, LeBrasseur N, Fiore LD, Bhasin S. Adverse events associ¬ated with testosterone administration. The New England Journal of Medicine. 2010; 363:109. DOI: 10.1056/NEJMoa1000485. 6. Basaria S, Harman SM, Travison TG, Hodis H, Tsitouras P, Budoff M, Pencina KM, Vita J, Dzekov C, Mazer NA, Coviello AD, Knapp PE, Hally K, Pinjic E, Yan M, Storer TW, Bhasin S. Effects of Testosterone Administration for 3 Years on Subclinical Atherosclerosis Progression in Older Men With Low or Low-Normal Testosterone Levels: A Randomized Clinical Trial. JAMA. 2015;314:570. DOI: 10.1001/jama.2015.8881. 7. Brand JS, van der Tweel I, Grobbee DE, Emmelot-Vonk MH, van der Schouw YT. Testosterone, sex hormone-binding globulin and the metabolic syndrome: a systematic review and meta-analysis of obser-vational studies. International Journal of Epidemiology. 2011;40:189- 207. DOI: 10.1093/ije/dyq158. 8. Bushnell C, McCullough LD, Awad IA, Chireau MV, Fedder WN, Furie KL, Howard VJ, Lichtman JH, Lisabeth LD, Pina IL, Reeves MJ, Rexrode KM, Saposnik G, Singh V, Towfighi A, Vaccarino V, Walters MR. Guidelines for the prevention of stroke in women: a statement for healthcare professionals from the American Heart As- sociation/American Stroke Association. Stroke. 2014;45:1545. DOI: 10.1161/01.str.0000442009.06663.48. 9. Calof OM, Singh AB, Lee ML, Kenny AM, Urban RJ, Tenover JL, Bhasin S. Adverse events associated with testosterone replacement in middle-aged and older men: a meta-analysis of randomized, placebo- controlled trials. The Journals of Gerontology. Series A, Biological Sciences and MedicalSciences.2005;60:1451-7. 10. Cavasin MA, Tao ZY, Yu AL, Yang XP. Testosterone enhances early cardiac remodeling after myocardial infarction, causing rupture and degrading cardiac function. American Journal of Physiology. Heart and Circulatory Physiology. 2006;290:2043-50. DOI: 10.1152/ ajpheart.01121.2005. 11. Ceballos G, Figueroa L, Rubio I, Gallo G, Garcia A, Martinez A, Yanez R, Perez J, Morato T, Chamorro G. Acute and nongenomic effects of testosterone on isolated and perfused rat heart. Journal of Cardiovascular Pharmacology. 1999;33: 691-97. 12. Corona G, Rastrelli G, Monami M et al. Hypogonadism as a risk factor for cardiovascular mortality in men: a meta-analytic study. European Journal of Endocrinology. 2011;165(5):687-701. DOI: 10.1530/EJE-11-0447. 13. Crisostomo PR, Wang M, Wairiuko GM, Morrell ED, Meldrum DR. Brief exposure to exogenous testosterone increases death signal¬ing and adversely affects myocardial function after ischemia. Ameri¬can Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 2006;290:1168-74. DOI: 10.1152/ajpregu.00833.2005. 14. Feldman HA, Longcope C, Derby CA, Johannes CB, Araujo AB, Coviello AD, Bremner WJ, McKinlay JB. Age trends in the level of serum testosterone and other hormones in middle-aged men: longi¬tudinal results from the Massachusetts male aging study. The Journal of Clinical Endocrinology and Metabolism. 2002;87:589-98. DOI: 10.1210/jcem.87.2.8201. 15. Finkle WD, Greenland S, Ridgeway GK, Adams JL, Frasco MA, Cook MB, Fraumeni JF Jr, Hoover RN. Increased risk of non¬fatal myocardial infarction following testosterone therapy prescrip¬tion in men. PLOS One. 2014;9(1):e85805. DOI: 10.1371/journal. pone.0085805. 16. Flake NM, Hermanstyne TO, Gold MS. Testosterone and estrogen have opposing actions on inflammation-induced plasma extravasation in the rat temporomandibular joint. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 2006;2291(2):R343-8. DOI: 10.1152/ajpregu.00835.2005. 17. Gagnon DR, Zhang TJ, Brand FN, Kannel WB. Hematocrit and the risk of cardiovascular disease--the Framingham study: a 34-year follow-up. American Heart Journal. 1994;127(3):674-82. 18. Glueck CJ, Wang P. Testosterone therapy, thrombosis, throm¬bophilia, cardiovascular events. Metabolism 2014; 63 (8):989-94. DOI: 10.1016/j.metabol.2014.05.005. 19. Hajjar RR, Kaiser FE, Morley JE. Outcomes of long-term testosterone replacement in older hypogonadal males: a retrospec¬tive analysis. The Journal of Clinical Endocrinology and Metabolism. 1997;82(11):3793-6. DOI: 10.1210/jcem.82.11.4387. 20. Hanafy HM. Testosterone therapy and obstructive sleep apnea: is there a real connection? The Journal of Sexual Medicine. 2007;4(5):1241-6. DOI: 10.1210/jcem.82.11.4387. 21. Hanke H, Lenz C, Hess B, Spindler KD, Weidemann W. Effect of testosterone on plaque development and androgen receptor ex-pression in the arterial vessel wall. Circulation. 2001;103(10):1382 — 5. 22. Harman SM, Metter EJ, Tobin JD, Pearson J, Blackman MR. Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging. The Journal of Clinical Endocrinology and Metabolism. 2001;86(2):724-31. DOI: 10.1210/jcem.86.2.7219. 23. Herring MJ, Oskui PM, Hale SL, Kloner RA. Testosterone and the cardiovascular system: a comprehensive review of the basic science literature. Journal of the American Heart Associa¬tion. 2013;2(4):e000271. DOI: 10.1161/JAHA.113.000271. 24. Hofbauer LC, Ten RM, Khosla S. The anti-androgen hy- droxyflutamide and androgens inhibit interleukin-6 production by an androgen-responsive human osteoblastic cell line. Journal of Bone and Mineral Research. 1999;14(8):1330-7. DOI: 10.1359/ jbmr.19188.8.131.520. 25. Hoyos CM, Killick R, Yee BJ, Grunstein RR, Liu PY. Effects of testosterone therapy on sleep and breathing in obese men with severe obstructive sleep apnoea: a randomized placebo-controlled trial. Clin Endocrinol (Oxf). 2012a; 77:599-607. 26. Hoyos CM, Yee BJ, Phillips CL, Machan EA, Grunstein RR, Liu PY. Body compositional and cardiometabolic effects of testosterone therapy in obese men with severe obstructive sleep apnoea: a ran-domised placebo-controlled trial. European Journal of Endocrinology. 2012;167(4):531-41. doi: 10.1530/EJE-12-0525. 27. Forecast of life expectancy in the Russian Federation by 2030 [Internet]. Federal Service of State Statistics. Available from: http:// www.gks.ru/wps/wcm/connect/rosstat_main/rosstat/ru/statistics/ population/demography/# 28. Kupelian V, Chiu GR, Araujo AB, Williams RE, Clark RV, McKinlay JB. Association of sex hormones and C-reactive protein levels in men. Clinical Endocrinology (Oxford). 2010;72(4):527-33. DOI: 10.1111/j.1365-2265.2009.03713.x. 29. Lakshman KM, Bhasin S, Araujo AB. Sex hormone-binding globulin as an independent predictor of incident type 2 diabetes mellitus in men. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 2010;65(5):503-9. DOI: 10.1093/gerona/glq002. 30. Layton JB, Meier CR, Sharpless JL, Sturmer T, Jick SS, Brookhart MA. Comparative Safety of Testosterone Dosage Forms. JAMA Internal Medicine. 2015;175(7):1187-96. doi: 10.1001/ jamainternmed.2015.1573. 31. Li GR, Feng J, Wang Z, Fermini B, Nattel S. Adrenergic modulation of ultrarapid delayed rectifier K+ current in human atrial myocytes. Circulation Research. 1996;78(5):903-15. 32. Liu A, Gao L, Kang S, Liu Y, Xu C, Sun H, Li D, Yan C. Testosterone enhances estradiol's cardioprotection in ovariectomized rats. The Journal of Endocrinology. 2012;212(1):61-9. DOI: 10.1530/JOE-11-0181. 33. Liu J, Tsang S, Wong TM. Testosterone is required for delayed cardioprotection and enhanced heat shock protein 70 expression induced by preconditioning. Endocrinology. 2006;147(10):4569-77. DOI: 10.1210/en.2006-0297. 34. McCrohon JA, Jessup W, Handelsman DJ, Celermajer DS. Androgen exposure increases human monocyte adhesion to vascular endothelium and endothelial cell expression of vascular cell adhesion molecule-1. Circulation. 1999;99(17):2317-22. 35. Nathan L, Shi W, Dinh H, Mukherjee TK, Wang X, Lusis AJ, Chaudhuri G. Testosterone inhibits early atherogenesis by conversion to estradiol: critical role of aromatase. Proceedings of the National Academy of Sciences of the United States of America. 2001;98(6):3589-93. 36. Ng MK, Quinn CM, McCrohon JA, Nakhla S, Jessup W, Handelsman DJ, Celermajer DS, Death AK. Androgens up-regulate atherosclerosis-related genes in macrophages from males but not females: molecular insights into gender differences in atherosclerosis. Journal of the American College of Cardiology. 2003;42(7):1306-13. 37. Papamitsou T, Barlagiannis D, Papaliagkas V, Kotanidou E, Dermentzopoulou-Theodoridou M. Testosterone-induced hypertrophy, fibrosis and apoptosis of cardiac cells-an ultrastructural and immunohistochemical study. Medical Science Monitor. 2011;17(9):BR266-73. 38. Srinath R, Hill Golden S, Carson KA, Dobs A. Endogenous testosterone and its relationship to preclinical and clinical measures of cardiovascular disease in the atherosclerosis risk in communities study. The Journal of Clinical Endocrinology and Metabolism. 2015;100(4):1602-8. DOI: 10.1210/jc.2014-3934. 39. Stellato RK, FeldmanHA, Hamdy O, Horton ES, McKinlay JB. Testosterone, sex hormone-binding globulin, and the development of type 2 diabetes in middle-aged men: prospective results from the Massachusetts male aging study. Diabetes Care. 2000;23(4):490-4. 40. Stuenkel CA, Davis SR, Gompel A, Lumsden MA, Murad MH, Pinkerton JV, Santen RJ. Treatment of Symptoms of the Menopause: An Endocrine Society Clinical Practice Guideline. The Journal of Clinical Endocrinology and Metabo- lism.2015;100(11):3975-4011. DOI: 10.1210/jc.2015-2236. 41. Tsang S, Wu S, Liu J, Wong TM. Testosterone protects rat hearts against ischaemic insults by enhancing the effects of alpha(1)-adrenoceptor stimulation. British Journal of Pharmacol¬ogy. 2008;153(4):693-709. DOI: 10.1038/sj.bjp.0707624. 42. Wu FC, Tajar A, Beynon JM, Pye SR, Silman AJ, Finn JD, O'Neill TW, Bartfai G, Casanueva FF, Forti G, Giwercman A, Han TS, Kula K, Lean ME, Pendleton N, Punab M, Boonen S, Vanderschueren D, Labrie F, Huhtaniemi IT. Identification of late-onset hypogonadism in middle-aged and elderly men. The New England Journal of Medicine. 2010;363(2):123-35. DOI: 10.1056/NEJMoa0911101. 43. Xu L, Freeman G, Cowling B, Schooling C. Testosterone therapy and cardiovascular events among men: a systematic review and meta-analysis of placebo-controlled randomized trials. BMC Medicine. 2013;11:108. DOI: 10.1186/1741-7015-11-108. 44. Garnick MB. Testosterone replacement therapy faces FDA scrutiny. JAMA. 2015;313(6):563-4. DOI: 10.1001/jama.2014.17334. 45. FDA Drug Safety Communication: FDA cautions about using testosterone products for low testosterone due to aging; requires labeling change to inform of possible increased risk of heart attack and stroke with use. The Journal of Urology. 2015;194(3):759-60. DOI: 10.1016/j.juro.2015.06.058.
Zykov M.V., Kashtalap V.V., Karetnikova V.N., Makeeva O.A., Barbarash O.L., Goncharova I.A.
THE ROLE OF POLYMORPHISMS RS4291 AND RS4343 ACE GENE IN MODIFICATION OF GRACE SCALE IN PATIENTS WITH ACUTE CORONARY SYNDROME
Zykov MV, Kashtalap VV, Karetnikova VN, Makeeva OA, Goncharova IA, Barbarash OL. The role of polymorphisms RS4291 and RS4343 ACE gene in modification of Grace scale in patients with acute coronary syndrome. Siberian Medical Review. 2017; (2):22-29. DOI: 10.20333/2500136-2017-2-22-29.
Zykov Mikhail Valerevich ; Laboratory of the Pathophysiology of Multifocal Atherosclerosis, Research Institute for Complex Issues of Cardiovascular Diseases; г. Кемерово, Сосновый бульвар, 6; адрес: Российская Федерация, 354057, г. Сочи, ул. Туапсинская, 1; тел.: +7(918)3062959; e-mail: firstname.lastname@example.org.
Kashtalap Vasiliy Vasilevich Dr. Med. Sc., Associate Professor of the Cardiology Department; Head of laborafoiy pathophysiology multifocal atherosclerosis; Kemerovo State Medical Academy; Research Institute for Complex Issues of Cardiovascular Diseases; email@example.com
Karetnikova Victoria Nicolaevna Dr. Med. Sci., Head of laboratory of blood circulation pathology; Federal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular Diseases; firstname.lastname@example.org
Makeeva Oksana Alekseevna Research Institute for Complex Issues of Cardiovascular Diseases; ; г. Кемерово, Сосновый бульвар, 6; тел.: +7(913)8593493; e-mail: email@example.com
Barbarash O. L. Dr. Med. Sci., Professor; Kemerovo State Medical University; Scientific Research Institute of Complex Problems of Cardiovascular Diseases; firstname.lastname@example.org
Goncharova Irina Aleksandrovna ; Research Institute of Medical Genetics, Research Institute for Complex Issues of Cardiovascular Diseases; г. Кемерово, Сосновый бульвар, 6, Томский национальный исследовательский медицинский центр Российской академии наук, адрес: Российская Федерация, 634050, г. Томск, Набережная реки Ушайки, 10; тел.: 8(3822)420956; e-mail: email@example.com
The aim of the research. To assess the possibility of improving the prognostic ability of the GRACE 2.0 risk scale by additional registration of the genotypes of polymorphisms rs4291 and rs4343 of the ACE gene. Material and methods. A register prospective study included 353 patients with acute coronary syndrome (ACS). The genotypes and alleles of the polymorphisms rs4291 and rs4343 of the ACE gene were determined on the Cycler iQ (BIO-RAD, USA) by the TaqMan- sample method. In 36 months after the index event, telephone contact was made with patients or relatives to identify endpoints. The patient's status "alive or dead" was found out in 96.6 ± 1.0% of cases. Mortality from any cause was 11.4 ± 1.7% (n = 39), cardiovascular mortality was 7.9 ± 1.5% (n = 26). Results. On the first stage of the study it was revealed that both the rs4343 polymorphism and the rs4291 polymorphism of the ACE gene are associated with a high risk of death within three years after ACS. Moreover, the association of these variants is stronger with cardiovascular mortality than with the general one, and the identification of patients with a combination of the risk genotypes TT polymorphism rs4291 and GG polymorphism rs4343 allows even more reliable identify the group of extremely high risk of death within three years after ACS (odds ratio 9, 10 (3.81-21.71), p <0.001, x2 = 33.20). The construction of ROC curves revealed that the combination of polymorphisms rs4291 and rs4343 of the ACE gene significantly improved the prediction by GRACE scale the above-described endpoints during three years of observation after ACS. The values of the area under the ROC curves for the prediction of the overall lethality were, respectively, for the GRACE and GRACE + ACE scales 0.71 (0.62-0.80) and 0.78 (0.70-0.86) (p <0,00001), in predicting of cardiovascular mortality - 0.72 (0.62-0.81) and 0.81 (0.73-0.88) (p <0.00001). Conclusion. Modification of the GRACE 2.0 scale by adding data about genotypes of the polymorphisms rs4291 and rs4343 of the ACE gene significantly improves the prediction of lethality within three years after ACS. Key words: acute coronary syndrome, polymorphisms rs4291 and rs4343 of the ACE gene, GRACE Scale. Citation: Zykov MV, Kashtalap VV, Karetnikova VN, Makeeva OA, Goncharova IA, Barbarash OL. The role of polymorphisms RS4291 and RS4343 ACE gene in modification of Grace scale in patients with acute coronary syndrome. Siberian Medical Review. 2017; (2):22-29. DOI: 10.20333/2500136-2017-2-22-29
Keywords: acute coronary syndrome, polymorphisms rs4291 and rs4343 of the ACE gene, GRACE Scale
1. Oganov RG, Maslennikova G Ya. Cardiovascular diseases at the beginning of the XXI century : medical, social , demographic aspects and ways of prevention [Internet]. Medicina truda, vosstanovitelnaja i profilakticheskaja medicina. Available from: http://federalbook.ru/ files/FSZ/soderghanie/Tom%2013/IV/Oganov.pdf (cited 2015 Aug 12). (In Russian) 2. Strel'chenko OV, Chernyshev VM, Mingazov IF. Key indicators of the Siberian Federal District public health and health care in 2014. The collection of statistical and analytical materials. Issue 14. Novosi¬birsk : Sibirskoe universitetskoe izdatel'stvo; 2015. 270 p. (In Russian) 3. Bawamia B, Mehran R, Qiu W, Kunadian Risk scores in acute coronary syndrome and percutaneous coronary intervention: a re¬view. American Heart Journal. 2013;165(4):441-50. DOI: 10.1016/j. ahj.2012.12.020. 4. Amsterdam EA,Wenger NK, Brindis RG, Casey DE Jr, Ganiats TG, Holmes DR Jr, Jaffe AS, Jneid H, Kelly RF, Kontos MC, Levine GN, Liebson PR,Mukherjee D, Peterson ED, Sabatine MS, Smalling RW, Zieman SJ. 2014 AHA/ACC guideline for the management of patients with non-ST-elevation acute coronary syndromes a report of the american college of cardiology: American Heart Association Task Force on Practice Guidelines. Journal of the American College of Cardiology. 2014;64(24):e139-228. DOI: 10.1016/j.jacc.2014.09.017. 5. Roffi M,Patrono C, Collet JP, Mueller C, Valgimigli M, An- dreotti F, Bax JJ, Borger MA, Brotons C, Chew DP, Gencer B, Hasenfuss G, Kjeldsen K, Lancellotti P, Landmesser U, Mehilli J, Mukherjee D, Storey RF, Windecker S, Baumgartner H, Gaem- perli O, Achenbach S, Agewall S, Badimon L, Baigent C, Bueno H,Bugiardini R, Carerj S, Casselman F, Cuisset T, Erol Q, Fitzsi- mons D, Halle M, Hamm C, Hildick-Smith D, Huber K, Iliodromi- tis E, James S, Lewis BS, Lip GY,Piepoli MF, Richter D, Rosemann T, Sechtem U, Steg PG, Vrints C, Luis Zamorano J. 2015 ESC Guide¬lines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation : task force for the management of acute coronary syndromes in patients present¬ing without persistent ST-segment elevation of the european society of cardiology (ESC). European Heart Journal. 2016;37(3):267-315. DOI: 10.1093/eurheartj/ehv320. 6. Zykov MV, Makeeva OA, Golubenko MV, Kashtalap VV, Karetnikova VN, Goncharova IA, Kulish EV, Barbarash LS, Bar- barash OL, Puzyrev VP. The study of RS1800629 (G-308A) polymor¬phism of the TNF gene in patients with myocardial infarction with elevated ST segment.Russian Journal of Cardiology. 2014;(10):13-8. DOI:10.15829/1560-4071-2014-10-13-18. (In Russian) 7. Jia EZ, Chen ZH, An FH, Li LH, Li L, Guo CY, Gu Y, Liu Z, Li ZY, Zhu TB, Wang LS, Li CJ, Kong XQ, WZ Ma, Yang ZJ. Relationship of renin-angiotensin-aldosterone system polymorphisms and phenotypes to mortality in Chinese coronary atherosclerosis patients. Scientific Re¬pots. 2014;4:4600. DOI: 10.1038/srep04600. 8. Aronov DM, Lupanov VP. Atherosclerosis and coronary heart disease: some aspects of pathogenesis. Ateroskleroz i Dislipidemii. 2011;(1):48-56. (In Russian) 9. Farheen S, Basu A, Majumder PP. Haplotype variation in the ACE gene in global populations, with special reference to India, and an alternative model of evolution of haplotypes. The Hugo Journal. 2011;5(1-4):35-45. DOI: 10.1007/s11568-011-9153-6. 10. Chung CM,Wang RY, Fann CS, Chen JW, Jong YS, Jou YS, Yang HC, Kang CS, Chen CC, Chang HC, Pan WH. Fine-mapping angiotensin-converting enzyme gene: separate QTLs identified for hypertension and for ACE activity. PLoS One. 2013;8(3):e56119. DOI: 10.1371/journal.pone.0056119. 11. Fox KA, FitzGerald G, Puymirat E, Huang W, Carruthers K,Simon T, Coste P, Monsegu J, Steg PG, Danchin N, Anderson F. Should pa¬tients with acute coronary disease be stratified for management ac-cording to their risk? Derivation, external validation and outcomes using the updated GRACE risk score. BMJ Open. 2014;4(2):e004425. DOL10.U36/bmjopen-2013-004425. 12. Martinez-Rodriguez N,Posadas-Romero C, Villarreal-Molina T, Vallejo M, Del-Valle-Mondragon L, Ramirez-Bello J, Valladares A, Cruz-Lopez M, Vargas-Alarcon G. Single nucleotide polymorphisms of the angiotensin-converting enzyme (ACE) gene are associated with essential hypertension and increased ACE enzyme levels in Mexi¬can individuals. PLoS One. 2013;8(5):e65700. DOI: 10.1371/journal. pone.0065700. 13. Irvin MR,Lynch AI, Kabagambe EK, Tiwari HK, Barzilay JI, Eck- feldt JH, Boerwinkle E, Davis BR, Ford CE, Arnett DK. Pharmacogenet- ic association of hypertension candidate genes with fasting glucose in the GenHAT Study. Journal of Hypertension. 2010;28(10):2076-83. DOI: 10.1097/HJH.0b013e32833c7a4d. 14. Su SL,Lu KC, Lin YF, Hsu YJ, Lee PY, Yang HY, Kao SY. Gene polymorphisms of angiotensin-converting enzyme and angiotensin II type 1 receptor among chronic kidney disease patients in a Chinese population. Journal of the Renin-Angiotensin-Aldosterone System. 2012;13(1):148-54. DOI: 10.1177/1470320311430989. 15. Abdollahi MR,Huang S, Rodriguez S, Guthrie PA, Smith GD, Ebrahim S, Lawlor DA, Day IN, Gaunt TR. Homogeneous assay of rs4343, an ACE I/D proxy, and an analysis in the British Women's Heart and Health Study (BWHHS). Disease Markers. 2008;24(1):11-7. 16. Chen YH,Liu JM, Hsu RJ, Hu SC, Harn HJ, Chen SP, Jeng JR, Wu CL, Ho JY, Yu CP. Angiotensin converting enzyme DD geno¬type is associated with acute coronary syndrome severity and sudden cardiac death in Taiwan: a case-control emergency room study. BMC Cardiovascular Disorders. 2012;12:6. DOI: 10.1186/1471-2261-12-6. 17. Ellis KL,Palmer BR, Frampton CM, Troughton RW, Doughty RN, Whalley GA, Ellis CJ, Pilbrow AP, Skelton L, Yandle TG, Richards AM, Cameron VA. Genetic variation in the renin-angiotensin-aldo¬sterone system is associated with cardiovascular risk factors and early mortality in established coronary heart disease. Journal of Human Hy¬pertension. 2013;27(4):237-44. DOI: 10.1038/jhh.2012.24. 18. Zhu X, Chang YP, Yan D, Weder A, Cooper R, Luke A, Kan D, Chakravarti A. Association between hypertension and genes in the rennin-angiotensin system. Hypertension. 2003;41(5):1027-34. DOI: 10.1161/01.hyp.0000068681.69874.cb 19. Villard E, Tiret L, Visvikis S, Rakotovao R, Cambien F, Soubrier F. Identification of new polymorphisms of the angiotensin I-converting enzyme (ACE) gene, and study of their relationship to plasma ACE lev¬els by two-QTL segregation-linkage analysis. American Journal of Hu¬man Genetics. 1996;58(6):1268-78. 20. Baghai TC,Binder EB, Schule C, Salyakina D, Eser D, Lu- cae S, Zwanzger P, Haberger C, Zill P, Ising M, Deiml T, Uhr M, Il- lig T, Wichmann HE, Modell S, Nothdurfter C, Holsboer F, Muller- Myhsok B, Moller HJ, Rupprecht R, Bondy B. Polymorphisms in the angiotensin-converting enzyme gene are associated with unipolar depression, ACE activity and hypercortisolism. Molecular Psychia¬try. 2006;11(11):1003-15. 21. Zhou TB, Yin SS, Qin YH. Association between angiotensin-converting enzyme insertion/deletion gene polymorphism and end- stage renal disease susceptibility. Journal of the Renin-Angiotensin-Al¬dosterone System.. 2014;15(1):22-31. DOI: 10.1177/1470320312460898. 22. Miners S,Ashby E, Baig S, Harrison R, Tayler H, Speedy E, Prince JA, Love S, Kehoe PG. Angiotensin-converting enzyme levels and activity in Alzheimer's disease: differences in brain and CSF ACE and association with ACE1 genotypes. American Jour¬nal of Translational Research. 2009;1(2):163-77. 23. Kumar A,Vivekanandhan S, Srivastava A, Tripathi M, Padma Srivastava MV, Saini N, Kumar P, Prasad K. As¬sociation between angiotensin converting enzyme gene in- sertion/deletion polymorphism and ischemic stroke in north Indian population: a case-control study and meta¬analysis. Neurological Research. 2014;36(9):786-94. DOI: 10.1179/1743132814Y.0000000335. 24. Lev EI,Kornowski R, Vaknin-Assa H, Porter A, Teplitsky I, Ben-Dor I, Brosh D, Fuchs S, Battler A, Assali A. Comparison of the predictive value of four different risk scores for outcomes of patients with ST-elevation acute myocardial infarction under¬going primary percutaneous coronary intervention. American Journal of Cardiology. 2008;102(1):6-11. DOI: 10.1016/j.amj- card.2008.02.088. 25. Erlikh AD. A Scale for early assessment of risk of death and myocardial infarction during initial hospitalization of pa¬tients with acute coronary syndromes (Based on data from the RECORD Registry). Kardiologiya. 2010;(10):11-6. (In Russian) 26. Khan SQ,Narayan H, Ng KH, Dhillon OS, Kelly D, Quinn P, Squire IB, Davies JE, Ng LL. N-terminal pro-B-type natriuretic peptide complements the GRACE risk score in predicting early and late mortality following acute coronary syndrome. Clinical Science. 2009;117(1):31-9. DOI: 10.1042/CS20080419. 27. Eggers KM,Kempf T, Venge P, Wallentin L, Wollert KC, Lindahl B. Improving long-term risk prediction in patients with acute chest pain: the Global Registry of Acute Coronary Events (GRACE) risk score is enhanced by selected nonnecrosis biomarkers. American Heart Journal. 2010;160(1):88-94. 28. Osmolovskaya VS. Polymorphism of genes of inflamma¬tion mediators system and improving risk assessment in patients undergoing coronary artery disease exacerbation. М.; 2012. 140 p. (In Russian).
Ivanova A.A., Maksimov V.N., Malyutina S.K., Novoselov V.P., Savchenko S.V., Voevoda M.I.
THE STUDY OF ASSOCIATION WITH SUDDEN CARDIAC DEATH OF NEW MOLECULAR-GENETIC MARKERS DETECTED IN OWN FULL GENOME ASSOCIATIVE RESEARCH
Maksimov VN, Malyutina SK, Novoselov VP, Savchenko SV, Voevoda Мк The study of association with sudden cardiac death of new molecular-genetic markers detected in own full genome associative research. Siberian Medical Review. 2017; (2):29-34. DOI: 10.20333/2500136-2017-2-29-34.
Ivanova Anastasiya Andreevna Junior Researcher of the Laboratory of Molecular genetic studies of internal diseases; Institution of Internal and Preventive Medicine; firstname.lastname@example.org
Maksimov Vladimir Nikolaevich Dr.Med.Sc. Associate Professort; Head of the Laboratory of Molecular genetic studies of internal diseases; Novosibirsk State Medical University; Research Institute of Therapy of the Russian Academy of Medical Science; email@example.com
Malyutina Sofia Konstantinovna ; Novosibirsk State Medical University; Institution of Internal and Preventive Medicine; г. Новосибирск, ул. Красный проспект, 52; Российская Федерация, 630089, г. Новосибирск, ул. Б. Богаткова, 175/1, e-mail: firstname.lastname@example.org
Novoselov Vladimir Pavlovich ; Novosibirsk Regional Office of Forensic Medical Examination; г Новосибирск, ул. Немировича-Данченко, 134.
Savchenko Sergey Vladimirovich Doct.Med.Sc., Professor of the Department of Forensic Medicine at the medical faculty; Novosibirsk State Medical University; Novosibirsk Regional Office of Forensic Medical Examination; email@example.com
Voevoda Michail Ivanovich Doct.Med.Sc., Professor, Corresponding Member of the Russian Academy of Sciences; Head of the Laboratory of Molecular Human Genetics; Institution of Internal and Preventive Medicine; Institute of Internal Medicine of Siberian Branch of Russian Academy of Medical Science; Mvoevola@ya.ru
The aim of the research. To search and study the association with sudden cardiac death (SCD) in the Novosibirsk population of single nucleotide polymorphisms rs13246896 of the gene HDAC9, rs35089892 of the gene CAMK2B, which are identified as associated with SCD in its own full genome associative study performed on pooled DNA. Material and methods. The SCD group was formed using the criteria of sudden cardiac death of the World Health Organization and the European Society of Cardiology (n = 391, average age 52.9 ± 9.2 years, men - 77.2%, women - 22.8%). The control group was selected by sex and age from the DNA bank of international HAPIEE projects (Health, Alcohol and Psychosocial factors in Eastern Europe), MONICA (Multinational MONItoring of trends and determinants in CArdiovascular disease) (n = 376, average age 52.4 ± 8, 8 years, men - 62.3%, women - 37.7%). DNA was picked out by phenol-chloroform extraction from myocardial tissue in the SCD group, and venous blood in the control group. Group genotyping was carried out by polymerase chain reaction method with subsequent analysis of restriction fragments length polymorphism according to the own methods. Results. There were no statistically significant differences between the groups in allele frequencies and genotypes of polymorphism rs13246896 of the HDAC9 gene. The genotype TT polymorphism rs35089892 of the CAMK2B gene is associated with protective effect according to SCD (p = 0.018, OSh = 0.52, 95% DI 0.31-0.89). Conclusion. The polymorphism rs35089892 of the CAMK2B gene is associated with SCD in the sample of the suddenly died residents of Novosibirsk.
Keywords: sudden cardiac death, single nucleotide polymorphisms, rs13246896, HDAC9, rs35089892, CAMK2B, GWAS
1. Babenko VN, Maximov VN, Kulakova EV, Safronova NS, Vo- evoda MI, Rogaev EI. Genome-wide SNP allelotyping of human co¬horts by pooled DNA samples. Russian Journal of Genetics: Applied Research. 2014;18(4-2):847-55. 2. CAMK2B calcium/calmodulin dependent protein kinase II beta [Homo sapiens (human)] [Internet]. Available from: https://www.ncbi. nlm.nih.gov/gene/816 3. Han Z, Dong X, Zhang C, Wu Y, Yuan Z, Wang X. Polymorphism of HDAC9 Gene Is Associated with Increased Risk of Acute Coronary Syndrome in Chinese Han Population. BioMed Research Internation¬al. 2016;2016:3746276. DOI: 10.1155/2016/3746276. 4. Hertz CL, Christiansen SL, Ferrero-Miliani L, Fordyce SL, Dahl M. Holst AG, Ottesen GL, Frank-Hansen R, Bundgaard H, Morling N. Next-generation sequencing of 34 genes in sudden unexplained death victims in forensics and in patients with channelopathic cardiac diseases. International Journal of Legal Medicine. 2015;129(4):793-800. DOI:10.1007/s00414-014-1105-y. 5. HDAC9 histone deacetylase 9 [Homo sapiens (human)] [Inter-net]. Available from: https://www.ncbi.nlm.nih.gov/gene/9734 6. McCauley MD, Wehrens XH. Ryanodine receptor phosphory-lation, calcium/calmodulin-dependent protein kinase II, and life- threatening ventricular arrhythmias. Trends Cardiovascular Medi¬cine. 2011;21(2):48-51. DOI: 10.1016/j.tcm.2012.02.004. 7. Morini E, Sangiuolo F, Caporossi D, Novelli G, Amati F. Appli-cation of Next Generation Sequencing for personalized medicine for sudden cardiac death. Frontiers in Genetics. 2015;6:55. DOI: 10.3389/ fgene.2015.00055. 8. Priori SG, Aliot E, Blomstrom-Lundqvist C, Blom N, Borggrefe M, Camm J, Elliott PM, Fitzsimons D, Hatala R, Hindricks G, Kirchhof P, Kjeldsen K, Kuck KH, Hernandez-Madrid A, Nikolaou N, Norekval TM, Spaulding C, Van Veldhuisen DJ. The Task Force for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death of the European Society of Cardiology (ESC). Giornale Italiano di Cardiologia. 2016;17(2):108-70. DOI: 10.1714/2174.23496. 9. Purohit A, Rokita AG, Guan X, Chen B, Koval OM, Voigt N, Neef S, Sowa T, Gao Z, Luczak ED, Stefansdottir H, Behunin AC, Li N, El-Accaoui RN, Yang B, Swaminathan PD, Weiss RM, Weh¬rens XH, Song LS, Dobrev D, Maier LS, Anderson ME. Oxidized Ca(2 + )/calmodulin-dependent protein kinase II triggers atrial fibrillation. Circulation. 2013;128(16):1748-57. DOI: 10.1161/CIRCULA- TIONAHA.113.003313. 10. Smith JD. New role for histone deacetylase 9 in athero-sclerosis and inflammation. Arteriosclerosis, Thrombosis, and Vascular Biology. 2014;34(9):1798-9. DOI: 10.1161/ATVBA- HA.114.304295. 11. Su L, Shen T, Liang B, Xie J, Tan J, Chen Q, Wei Q, Jiang H, Gu L. Association of GWAS-supported loci rs2107595 in HDAC9 gene with ischemic stroke in southern Han Chinese. Gene. 2015;570(2):282- 7. DOI: 10.1016/j.gene.2015.06.036 12. Toko H, Takahashi H, Kayama Y, Oka T, Minamino T, Okada S, Morimoto S, Zhan DY, Terasaki F, Anderson ME, Inoue M, Yao A, Nagai R, Kitaura Y, Sasaguri T, Komuro I. Ca2 + /calmodulin-depen- dent kinase IIdelta causes heart failure by accumulation of p53 in di¬lated cardiomyopathy. Circulation. 2010;122(9):891-9. DOI: 10.1161/ CIRCULATIONAHA.109.935296. 13. Qingxu G, Yan Z, Jiannan X, Yunlong L. Association Between the Gene Polymorphisms of HDAC9 and the Risk of Atherosclerosis and Ischemic Stroke. Pathology Oncology Research. 22016;22(1):103-7. DOI: 10.1007/s12253-015-9978-8. 14. Wang XB, Han YD, Sabina S, Cui NH, Zhang S, Liu ZJ, Li C, Zheng F. HDAC9 Variant Rs2107595 Modifies Susceptibility to Coro¬nary Artery Disease and the Severity of Coronary Atherosclerosis in a Chinese Han Population. PLoS One. 2016;11(8):e0160449. DOI: 10.1371/journal.pone.0160449.
Shek A.B., Kurbanov R.D., Abdullaeva G.Z., Nagay A.V., Khoshimov S.U., Nizamov U.I., Ziyaeva A.V.
CONNECTION OF THE GENETIC POLYMORPHISM CYP3A5 AND SLCO1B1 WITH THE MUSCULAR SYMPTOMS, CAUSED BY SIMVASTATIN IN PATIENTS WITH CHD, ETHNIC UZBEKS: RESULTS OF THE CASE-CONTROL STUDY
Shek BB, Kurbanov RD, Abdullaeva GJ, Nagay AV, Hoshimov SU, Nizamov UI, Ziyaeva AV. Connection of the genetic polymorphism CYP3A5 and SLCO1B1 with the muscular symptoms, caused by simvastatin in patients with CHD, ethnic uzbeks: results of the case-control study. Siberian Medical Review. 2017;(2):35-41. DOI: 10.20333/2500136-2017-2-35-41.
Shek A. B. ; Tashkent republic specialized center of cardiology of the Ministry of health of the Republic of Kazakhstan; firstname.lastname@example.org
Kurbanov Ravshanbek Davlatovich ; JS Republican Specialised Center of Cardiology; г. Ташкент, ул. Осиё, д. 4; тел.: +99871-2373816, e-mail: email@example.com
Abdullaeva Guzal Zhalalitdinova ; JS Republican Specialised Centre of Cardiology; г. Ташкент, ул. Осиё, д. 4; тел.:+99871-2373816, e-mail:firstname.lastname@example.org
Nagay Alexander Vissarionovich ; JS Republican Specialised Centre of Cardiology; г. Ташкент, ул. Осиё, д. 4; тел.: +99871-2373816, e-mail: email@example.com
Khoshimov Sh. U. ; Tashkent republic specialized center of cardiology of the Ministry of health of the Republic of Kazakhstan; firstname.lastname@example.org
Nizamov Ulugbek Irgashevich ; JS Republican Specialised Centre of Cardiology; г. Ташкент, ул. Осиё, д. 4; тел.: +99871-2373816, e-mail: email@example.com
Ziyaeva Adolat Vasicovna ; JS Republican Specialised Centre of Cardiology; г. Ташкент, ул. Осиё, д. 4; тел.: +99871-2373816, e-mail: firstname.lastname@example.org
The aim of the research. To study the possible influence of polymorphism of the genes CYP3A5 (6986A> G), CYP2C9 (430C> T), CYP2C9 (1075A> C), SLCO1B1 (521T> C) and BCRP (ABCG2,421C> A) on the occurrence of muscle symptoms in the treatment of simvastatin in patients with coronary heart disease, ethnic Uzbeks. Material and methods. In the "case-control" study, 63 patients with chronic coronary heart disease (CHD) were included. The "case" group was consisted of 13 patients who had clinical signs of myopathy, and 4 of them simultaneously showed an increase in the level of transaminases > 3 times. The "control" group included 50 patients with chronic coronary heart disease, without side effects when treated with simvastatin. Genotyping was performed by the PCR-RFLP method. Results. When comparing the prevalence of the most common homozygous genotypes with variant, it turned out that the genotype *3 / *3 of the CYP3A5 gene was prevailed in the "case" group (OSh 8.56, 95% DI 2.14-34.1, P = 0.003). When comparing the distribution frequency of alleles the SLCO1B1 gene in the group "case" the carriage of allele C was prevailed (OSh 3.54, 95%, DI 1.35-9.27, f = 5.7, P = 0.017). Conclusion. In patients with CHD, ethnic Uzbeks, the carriage of the genotype *3/*3 of the CYP3A5 gene and the C allele of SLCO1B1 gene is associated with muscular symptoms caused by simvastatin.
Keywords: statin intolerance, polymorphisms of the genes CYP3A5, CYP2C9, SLCO1B1, BCRP
1. Reiner Z, Catapano AL, De Backer G, Graham I, Taskinen MR, Wiklund O, Agewall S, Alegria E, Chapman MJ, Durrington P, Erdine S, Halcox J, Hobbs R, Kjekshus J, Filardi PP, Riccardi G, Storey RF, Wood D.. ESC/EAS guidelines for the management of dyslipidaemias: the Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS). European Heart Journal. 2011;32 (14):1769 — 1818.DOI: 10.1093/ eurheartj/ehr158. 2. Baigent C, Keech A, Kearney PM, Blackwell L, Buck G, Pollicino C, Kirby A, Sourjina T, Peto R, Collins R, Simes R.. Cholesterol Treatment Trialists' (CTT) Collaborators. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins.. Lancet. 2005; 366 (9493):1267-78.DOI: 10.1016/S0140-6736(05)67394-1. 3. Hague WE, Simes J, Kirby A, Keech AC, White HD, Hunt D, Nestel PJ, Colquhoun DM.. Long-Term Effectiveness and Safety of Pravastatin in Patients With Coronary Heart Disease: Sixteen Years of Follow-Up of the LIPID Study. Circulation. 2016; 133(19):1851-60.DOI: 10.1161/ CIRCULATTONAHA.115.018580. 4. Ford ES, Ajani UA, Croft JB, Critchley JA, Labarthe DR, Kottke TE, Giles WH, Capewell S. Explaining the decrease in U.S. deaths from coronary disease, 1980-2000. The New England Journal of Medicine. 2007; 356 (23):2388-98.DOI: 10.1056/NEJMsa053935. 5. Bays H. Statin safety: an overview and assessment of the data- 2005.. Statin safety: an overview and assessment of the data-2005. The American Journal of Cardiology. 2006;97(8A):6C-26C.DOI: 10.1016/j. amjcard.2005.12.006. 6. Maningat P, Breslow JL.. Needed: Pragmatic Clinical Trials for Statin-Intolerant Patients.. The New England Journal of Medicine. 2011;365((24)):2250-2251.DOI: 10.1056/NEJMp1112023. 7. Stroes ES, Thompson PD, Corsini A, Vladutiu GD, Raal FJ, Ray KK, Roden M, Stein E, Tokgozoglu L, Nordestgaard BG, Bruckert E, De Backer G, Krauss RM, Laufs U, Santos RD, Hegele RA, Hovingh GK, Leiter LA, Mach F, Marz W, Newman CB, Wiklund O, Jacobson TA, Catapano AL, Chapman MJ, Ginsberg HN.. Statin-associated muscle symptoms: impact on statin therapy-European Atherosclerosis Society Consensus Panel Statement on Assessment, Etiology and Management. European Heart Journal. 2015; 36 (17):1012-22.DOI: 10.1093/eurheartj/ ehv043. 8. Thompson PD, Clarkson P, Karas RH.. Statin-associated myopathy. JAMA. 2003; 289(13):1681-90.DOI: 10.1001/jama.289.13.1681. 9. Mancini GB, Tashakkor AY, Baker S, Bergeron J, Fitchett D, Frohlich J, Genest J, Gupta M, Hegele RA, Ng DS, Pearson GJ, Pope J.. Diagnosis, prevention, and management of statin adverse effects and intolerance: CanadianWorking Group Consensus update. The Ca¬nadian Journal of Cardiology. 2013; 29 (12):1553-1568.DOI: 10.1016/j. cjca.2013.09.023. 10. Nissen SE, Dent-Acosta RE, Rosenson RS, Stroes E, Sattar N, Preiss D, Mancini GBJ, Ballantyne CM, Catapano A, Gouni-Berthold I, Stein EA, Xue A, Wasserman SM, Scott R, Thompson PD.. Comparison of PCSK9 Inhibitor Evolocumab vs Ezetimibe in Statin-Intolerant Patients: Design of the Goal Achievement After Utilizing an Anti-PCSK9 Antibody in Statin-Intolerant Subjects 3 (GAUSS-3) Trial. Clinical Cardiology. 2016; 39 (3): 137 — 144.DOI: 10.1002/clc.22518. 11. Bruckert E, Hayem G, Dejager S, Yau C, Begaud B. Mild to moderate muscular symptoms with high-dosage statin therapy in hyperlipidemic patients-the PRIMO study. Cardiovascular Drugs and Therapy. 2005; 19(6):403 — 414.DOI: 10.1007/s10557-005-5686-z. 12. Banach M, Rizzo M, Toth PP, Farnier M, Davidson MH, Al- Rasadi K, Aronow WS, Athyros V, Djuric DM, Ezhov MV, Greenfield RS, Hovingh GK, Kostner K, Serban C, Lighezan D, Fras Z, Moriarty PM, Muntner P, Goudev A, Ceska R, Nicholls SJ, Broncel M, Nikolic D, Pella D, Puri R, Rysz J, Wong ND, Bajnok L, Jones SR, Ray KK, Mikhailidis DP. Statin intolerance - an attempt at a unified definition. Position paper from an International Lipid Expert Panel. Archives of Medical Science. 2015; 11(1):(1).DOI: 10.5114/aoms.2015.49807. 13. Birmingham BK, Bujac SR, Elsby R, Azumaya CT, Wei C, Chen Y, Mosqueda-Garcia R, Ambrose HJ.. Impact of ABCG2 and SLCO1B1 polymorphisms on pharmacokinetics of rosuvastatin, atorvastatin and simvastatin acid in Caucasian and Asian subjects: a class effect? Euro-pean Journal of Clinical Pharmacology. 2015; 71(3):341-55.DOI: 10.1007/ s00228-014-1801-z. 14. Furge LL, Guengerich FP. Cytochrome P450 enzymes in drug metabolism and chemical toxicology: An introduction. Biochemistry and Molecular Biology Education. 2006; 34(2):66-74.DOI: 10.1002/ bmb.2006.49403402066. 15. Guengerich FP. Cytochrome p450 and chemical toxicology. Chemical Research in Toxicology. 2008;21((1)):70-83.DOI:10.1021/ tx700079z. 16. Paulussen A, Lavrijsen K, Bohets H, Hendrickx J, Verhasselt P, Luyten W, Konings F, Armstrong M.. Paulussen A, Lavrijsen K, Bohets H, Hendrickx J, Verhasselt P, Luyten W, Konings F, Armstrong M. Pharmacogenetics. 2000; 10(5):415-424. 17. Kuehl P, Zhang J, Lin Y, Lamba J, Assem M, Schuetz J, Watkins PB, Daly A, Wrighton SA, Hall SD, Maurel P, Relling M, Brimer C, Yasuda K, Venkataramanan R, Strom S, Thummel K, Boguski MS, Schuetz E.. Sequence diversity in CYP3A promoters and characterization of the genetic basis for polymorphic CYP3A5 expression. Nature Genetics. 2001; 27(4): 383-91.DOI: 10.1038/86882. 18. Prueksaritanont T, Ma B, Yu N.. The human hepatic metabolism of simvastatin hydroxy acid is mediated primarily by CYP3A, and not CYP2D6. British Journal of Clinical Pharmacology. 2003; 56(1):120-4. 19. Lilja JJ, Kivisto KT, Neuvonen PJ.. Duration of effect of grapefruit juice on the pharmacokinetics of the CYP3A4 substrate simvastatin. Clini¬cal Pharmacology and Therapeutics. 2000; 68(4):384-90.DOI: 10.1067/ mcp.2000.110216. 20. Hustert E, Haberl M, Burk O, Wolbold R, He YQ, Klein K, Nuessler AC, Neuhaus P, Klattig J, Eiselt R, Koch I, Zibat A, Brockmoller J, Halpert JR, Zanger UM, Wojnowski L. The genetic determinants of the CYP3A5 polymorphism. Pharmacogenetics. 2001; 11(9):773-779. 21. Kim KA, Park PW, Lee OJ, Kang DK, Park JY.. Effect of polymorphic CYP3A5 genotype on the single-dose simvastatin pharmacokinetics in healthy subjects. Journal of Clinical Pharmacology. 2007; 47(1):87—93.DOI: 10.1177/0091270006295063. 22. Kitzmiller JP, Luzum JA, Baldassarre D, Krauss RM, Medina MW.. CYP3A4*22 and CYP3A5*3 are associated with increased levels of plasma simvastatin concentrations in the cholesterol and pharmacogenetics study cohort. Pharmacogenetics and Genomics. 2014; 24(10):486 — 491. DOI: 10.1097/FPC.0000000000000079. 23. Kivisto KT, Niemi M, Schaeffeler E, Pitkala K, Tilvis R, Fromm MF, Schwab M, Eichelbaum M, Strandberg T.. Lipid-lowering response to statins is affected by CYP3A5 polymorphism. Pharmacogenetics. 2004; 14(8):523—5. 24. Li YP, Zhang LR, Jia M, Hu XJ.. CYP3AP1*3 allele is associated with lipid-lowering efficacy of simvastatin and atorvastatin in Chinese women. Journal of Clinical Pharmacology. 2011;51(2):181—8.DOI: 10.1177/0091270010370589. 25. Fiegenbaum M, da Silveira FR, Van der Sand CR, Van der Sand LC, Ferreira ME, Pires RC, Hutz MH.. The role of common variants of ABCB1, CYP3A4, and CYP3A5 genes in lipid-lowering efficacy and safety of simvastatin treatment. Clinical Pharmacology and Therapeutics. 2005; 78(5):551 —558.DOI: 10.1016/j.clpt.2005.08.003. 26. Sata F, Sapone A, Elizondo G, Stocker P, Miller VP, Zheng W, Raunio H, Crespi CL, Gonzalez FJ.. CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: evidence for an allelic variant with altered catalytic activity. Clinical Pharmacology and Therapeu- tics.2000;67(1):48-56.DOI: 10.1067/mcp.2000.104391. 27. Evans WE, McLeod HL.. Pharmacogenomics - drug disposition, drug targets, and side effects. The New England Journal Medicine. 2003; 248 (6):538-49.DOI: 10.1056/NEJMra020526. 28. Skottheim IB, Gedde-Dahl A, Hejazifar S, Hoel K, Asberg A.. Statin induced myotoxicity: the lactone forms are more potent than the acid forms in human skeletal muscle cells in vitro. European Journal of Pharmaceu¬tical Sciences. 2008; 33(4-5):317 — 325.DOI: 10.1016/j.ejps.2007.12.009. 29. Pasanen MK, Neuvonen M, Neuvonen PJ, Niemi M. SLCO1B1 polymorphism markedly affects the pharmacokinetics of simvastatin acid. Pharmacogenetics and Genomics.. 2006;16(12):873-879.DOI: 10.1097/01.fpc.0000230416.82349.90. 30. Link E, Parish S, Armitage J, Bowman L, Heath S, Matsuda F, Gut I, Lathrop M, Collins R.. SLCO1B1 variants and statin-induced myopathy - a genomewide study. The New England Journal of Medicine. 2008;359(8):789-799.DOI: 10.1056/NEJMoa0801936.
LOCAL AND REGIONAR VASCULAR STIFFNESS IN PATIENTS WITH CORONARY HEART DISEASE AND DIABETES MELLITUS OF 2 TYPE WITH HIGH VALUES OF THE ANKLE-BRACHIAL INDEX
Genkel VV. Local and regionar vascular stiffness in patients with coronary heart disease and diabetes mellitus of 2 type with high values of the ankle-brachial index. Siberian Medical Review. 2017;(2):41-47. DOI: 10.20333/2500136-2017-2-41-47.
Genkel Vadim Victorovich ; South-Ural State Medical University; г. Челябинск, ул. Воровского, д. 64; тел.: + (351) 232-73-47; e-mail: email@example.com
The aim of the research. To study the indices of local and regional vascular stiffness of muscular and elastic types of arteries in patients with pathological values of the ankle-brachial index (ABI). Material and methods. The study included 133 patients, 75 men and 58 women, the average age was 57.8 ± 10.7 years. Depending on the values of the ABI, patients were divided into four groups. There were conducted a clinical examination, the collection of anamnestic data, the definition of laboratory indicators. Measurement of ABI was carried out in accordance with the recommendations of the American Heart Association scientific report. Regionar aortic stiffness and arterial stiffness of muscular type were determined by recording the pulse wave velocity. Indices of local vascular stiffness were determined at the site of the common carotid artery (CCA). Results. In patients with ABI > 1.4, the extensibility of the CCA was significantly less than in patients with normal ABI. Patients with ABI > 1.4 also differed from patients with normal ABI with higher values of the Peterson module - 931 mm Hg. (695; 1025) against 726 mm Hg. (540, 916), as well as a decrease in CCA strain of 5.49% (5.07, 6.07) vs. 7.40% (6.07, 9.33) in patients with normal ABI and 9.52% (7.02, 11.3) in patients with reduced ABI, which indicates an increase in local rigidity of CCA in these patients. The values of aortic stiffness were significantly higher among patients with ABI > 1.4 -14.1 m / s (11.8,17.2) compared with patients with normal ABI -11.6 m / s (9.64; 13.4) and reduced ABI -11.8 m / s (10.8,13.1). Conclusion. Patients with pathologically heightened ABI > 1.4 differed significantly in larger values of local and regionar vascular stiffness, in comparison at patients with both normal and decreased ABI.
Keywords: vascular stiffness, ankle-brachial index, arteries of lower limbs, pulse wave velocity, peripheral arterial atherosclerosis
1. Winsor T. Influence of arterial disease on the systolic blood pres¬sure gradients of the extremity. American Journal of the Medical Sciences. 1950;220(2):117-26.DOI: 10.1097/00000441-195008000-00001. 2. Tendera M, Aboyans V, Bartelink ML, Baumgartner I, Clement D, Col¬let JP, Cremonesi A, De Carlo M, Erbel R, Fowkes FG, Heras M, Kownator S, Minar E, Ostergren J, Poldermans D, Riambau V, Roffi M, Rother J, Sievert H, van Sambeek M. ESC Guidelines on the diagnosis and treatment of periph¬eral artery diseases: Document covering atherosclerotic disease of extracra¬nial carotid and vertebral, mesenteric, renal, upper and lower extremity ar¬teries: the Task Force on the Diagnosis and Treatm. European Heart Journal. 2011;32(22):2851-906.DOI: 10.1093/eurheartj/ehr211. 3. Mancia G, Fagard R, Narkiewicz K, Redon J, Zanchetti A, B hm M, Christi- aens T, Cifkova R, De Backer G, Dominiczak A, Galderisi M, Grobbee DE, Jaars- ma T, Kirchhof P, Kjeldsen SE, Laurent S, Manolis AJ, Nilsson PM, Ruilope LM. 2013 ESH/ESC Guidelines for the management of arterial hypertension: the Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Journal of Hypertension. 2013;31(7):1281-357.DOI: 10.1093/eurheartj/eht151. 4. Piepoli MF, Hoes AW, Agewall S, Albus C, Brotons C, Catapano AL, Cooney MT, Corra U, Cosyns B, Deaton C, Graham I, Hall MS, Hobbs FD, Lochen ML, Lollgen H, Marques-Vidal P, Perk J, Prescott E, Redon J, Richter DJ, Sattar N. 2016 European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Car¬diology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice. European Journal of Preventive Cardiology. 2016;23(11):1-96.DOI: 10.1177/2047487316653709. 5. Sumin AN, Kolmykova YuA, Kukhareva IN, Ott MV, Sumin DA, Vodo¬pyanova NI, Morkvenas AA, Trubnikova OA, Kovalenko AV. Pathological ABI at patients with acute ischemic stroke: prevalence and factors associated with its presence. The Journal of Atherosclerosis and Dyslipidemias. 2016;2(2):48-57. (In Russian) 6. Sumin AN, Kolmykova YuA, Kukhareva IN, Ott MV, Sumin DA, Vodo¬pyanova NI, Morkvenas AA, Trubnikova OA, Kovalenko AV. Clinical sig¬nificance of pathological ankle-brachial index in patients with acute ischemic stroke. The Neurological Journal. 2016;21(3):158-164.DOI: 10.18821/1560- 9545-2016-21-3-158-164. (In Russian) 7. Aboyans V, Criqui MH, Abraham P, Allison MA, Creager MA, Diehm C, Fowkes FG, Hiatt WR, Jonsson B, Lacroix P, Marin B, McDermott MM, Norgren L, Pande RL, Preux PM, Stoffers HE, Treat-Jacobson D. Measurement and interpretation of the ankle-brachial index: a scientific statement from the American Heart Association. Circulation. 2012;11(126):2890-909.DOI: 10.1161/ cir.0b013e318276fbcb. 8. Allison MA, Hiatt WR, Hirsch AT, Coll JR, Criqui MH. A high ankle- brachial index is associated with increased cardiovascular disease morbid¬ity and lower quality of life. Journal of the American College of Cardiology. 2008;51(13):292-8.DOI: 10.1016/j.jacc.2007.11.064. 9. Criqui MH, McClelland RL, McDermott MM, Allison MA, Blumenthal RS, Aboyans V, Ix JH, Burke GL, Liu K, Shea S. The ankle-brachial index and incident cardiovascular events in the MESA (Multi-Ethnic Study of Atheroscle¬rosis). Journal of the American College of Cardiology. 2010;26(56):1506-12.DOI: 10.1016/j.jacc.2010.04.060. 10. Lanzer P, Boehm M, Sorribas V, Thiriet M, Janzen J, Zeller T, St Hilaire C, Shanahan C. Medial vascular calcification revisited: review and perspectives. European Heart Journal. 2014;14(35):1515-25.DOI: 10.1093/eurheartj/ehu163. 11. Potier L, Abi Khalil C, Mohammedi K, Roussel R. Use and Utility of Ankle Brachial Index in Patients with Diabetes. European Journal of Vascular and Endovascular Surgery. 2011;41(11):110-6.DOI: 10.1016/j.jvs.2010.11.062. 12. Couri CE, da Silva GA, Martinez JA, Pereira F de A, de Paula FJ. Monckeberg's sclerosis - is the artery the only target of calcification? BMC Car¬diovascular Disorder. 2005;12(5):34.DOI: 10.1186/1471-2261-5-34. 13. Micheletti RG, Fishbein GA, Currier JS, Fishbein MC. Monckeberg sclerosis revisited: a clarification of the histologic definition of Monckeberg sclerosis. Archives of Pathology and Laboratory Medicine. 2008;132(1):43-7. DOI: 10.1043/1543-2165(2008)132[43:MSRACO]2.0.CO;2. 14. Georgiadis GS, Argyriou C, Antoniou GA, Kantartzi K, Kriki P, The- odoridis M, Thodis E, Lazarides MK. Upper limb vascular calcification score as a predictor of mortality in diabetic hemodialysis patients. Journal of Vascular Surgery. 2015;61(6):1529-37.DOI: 10.1016/j.jvs.2015.01.026. 15. Ladich E, Yahagi K, Romero ME, Virmani R. Vascular diseases: aor¬titis, aortic aneurysms, and vascular calcification. Cardiovascular Pathology. 2016;25(5):432-41.DOI: 10.1016/j.carpath.2016.07.002. 16. Lilly SM, Jacobs DR Jr, Kronmal R, Bluemke DA, Criqui M, Lima J, Al¬lison M, Duprez D, Segers P, Chirinos JA. Arterial compliance across the spec¬trum of ankle-brachial index: the Multiethnic Study of Atherosclerosis. Athero¬sclerosis. 2014;233(2):691-6.DOI: 10.1016/j.atherosclerosis.2014.01.029. 17. Pan CR, Staessen JA, Li Y, Wang JG. Comparison of three measures of the ankle-brachial blood pressure index in a general population. Hypertension Research. 2007;30(6):555-61.DOI: 10.1291/hypres.30.555. 18. Li Q, Zeng H, Liu F, Shen J, Li L, Zhao J, Zhao J, Jia W. High An¬kle-Brachial Index Indicates Cardiovascular and Peripheral Arterial Dis¬ease in Patients With Type 2 Diabetes. Angiology. 2015;66(10):918-24.DOI: 10.1177/0003319715573657. 19. Hendriks EJ, Westerink J, de Jong PA, de Borst GJ, Nathoe HM, Mali WP, van der Graaf Y, van der Schouw YT, Beulens JW. Association of High Ankle Brachial Index With Incident Cardiovascular Disease and Mortality in a High-Risk Population. Arteriosclerosis, Thrombosis, and Vascular Biology. 2016;36(2):412-7.DOI: 10.1161/ATVBAHA.115.306657. 20. Wohlfahrt P, Palous D, Ingrischova M, Krajcoviechova A, Se- idlerova J, Galovcova M, Bruthans J, Jozifova M Adamkova V, Filipovsky J, Cifkova R. A high ankle-brachial index is associated with increased aortic pulse wave velocity: the Czech post-MONICA study. European Journal of Cardiovascular Prevention and Rehabilitation. 2011;18(6):790-6.DOI: 10.1177/1741826711398840. 21. van Sloten TT, Schram MT, van den Hurk K, Dekker JM, Nijpels G, Henry RM, Stehouwer CD. Local stiffness of the carotid and femoral artery is as¬sociated with incident cardiovascular events and all-cause mortality: the Hoorn study. Journal of the American College of Cardiology. 2014;6(63):1739-47.DOI: 10.1016/j.jacc.2013.12.041. 22. Kuznetsova AS, Melnikov IYu, Dolgushina AI, Savochkina AYu, Sumerkina VA, Emelyanova NB, Vasilenko AG. The study of lipid disorders and vascular stiffness in patients with nonalcoholic fatty liver disease and insulin resistance. Prevention of polypathy in cardiology: Materials of All-Russian scientific-practical conference devoted to the National Year of the fight against cardiovascular disease. Chelyabinsk;2015:64-6. (In Russian) 23. Ershova AI, Meshkov AN, Kalinina MV, Rozhkova TA, Rogoza AN, Ba-lakhonova TV, Boytsov SA. Features of carotid and aortic stiffness in patients with familial hypercholesterolemia. Rehabilitation and Secondary Prevention in Cardiology: X Scientific and practical conference on 21-22 March 2013. Mos- cow;2013:31-2. (In Russian) 24. Vasyuk YuA, Ivanov SV, Shkolnik EL, Kotovskaya YuV, Milyagin VA, Oleynikov VE, Orlova YaA, Sumin AN, Baranov AA, Boytsov SA, Galyavich AS, Kobalava ZhD, Kozhevnikova OV, Conradi AO, Lopatin YuM, Mareev VYu, Novikova DS, Oganov R.G Consensus of Russian experts on the evaluation of arterial stiffness in clinical practice. Cardiovasculat Therapy and Prevention. 2016;15(2):4-19.DOI: 10.15829/1728-8800-2016-2-4-19. (In Russian) 25. Kubozono T, Ohishi M. Prognostic Significance of Regional Ar¬terial Stiffness for Stroke in Hypertension. Pulse. 2015;3(2):98-105.DOI: 10.1159/000381795.
Gavrilova E.S., Yashina L.M.
EVALUATION OF CARDIOVASCULAR RISK FACTORS AND EDUCATIONAL TECHNOLOGIES OF THE CORRECTION IN YOUTH POPULATION
Gavrilova ES, Yashina LM. Evaluation of cardiovascular risk factors and educational technologies of the correction in youth population. Siberian Medical Review. 2017;(2):48-55. DOI: 10.20333/2500136-2017-2-48-55.
Gavrilova Elena Sergeevna ; South Ural State Medical University; г. Челябинск, ул. Воровского, 64; тел.: +7(968)1124711; e-mail: firstname.lastname@example.org
Yashina Lydmila Michailovna ; South Ural State Medical University; г. Челябинск, ул. Воровского, 64; тел.: +7(912)7706118; e-mail: email@example.com.
The aim of the research. To estimate the prevalence of the main factors of cardiovascular risk among students of the South Ural State Medical University (SUSMU), and also to determine the effectiveness of the influence of training in the "Health School" on the parameters of these factors. Material and methods. Examination of 1556 graduate students of SUSMU was conducted, the average age was 23.2 ± 1.7 years. The parameters of behavioral and biological risk factors of cardiovascular diseases, as well as anxiety-depressive symptoms were evaluated. The clinical observation group (n = 84) was divided by simple randomization into 2 subgroups, comparable in gender and age. In the first group training was in the "Health School", in the second group there was no training; reassessment of the parameters of cardiovascular risk factors in both groups was performed after 6 months. Results. Among the graduate students of the medical university, a high prevalence of active and passive smoking, alcohol consumption, irrational nutrition, low physical activity, abdominal obesity is revealed. In the female population compared with the male population, the prevalence of body mass deficit, low physical activity, anxiety is significantly higher, and lower - active smoking, excessive alcohol consumption, irrational nutrition, obesity, abdominal obesity, hypertension. The risk of hyperleptinemia increases with the presence of burdened heredity for cardiovascular diseases, abdominal obesity, overweight, deficiency of final metabolites of nitric oxide, hyperuricemia, and decreases with a normal body mass index and an average academic rating of ≥ 4.5. The training of 6th year students of the SUSMU with cardiovascular risk factors in the "Health School" leads to a decrease in the body mass index, waist circle, the number of cigarettes smoked per day, the amount of alcohol consumed per day, and the level of anxiety and depression. Conclusion. In the population of the graduates of the Medical University is established the unfavorable situation in the prevalence of the main factors of cardiovascular risk. Adequate control over these factors is achieved by training students in the "Health School".
Keywords: risk factor, cardiovascular diseases, leptin, Health School
1. Lim SS, Vos T, Flaxman AD, Danaei G, Shibuya K, Adair-Rohani H. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380(9859):2224–60. DOI: 10.1016/S0140-6736(12)61766-8. 2. Cardiovascular diseases [Internet] : Fact sheet N°317. World Health Organization, March 2013. Available from: http://www.who.int/ cardiovascular_diseases/en/ 3. Rayevsky RT, Kanishevsky SM. Health, wellness and healthy lifestyle of students. Odessa: Science and technology; 2008. 556 p. (In Russian) 4. Sarpong DF, Curry IY, Williams M. Assessment of Knowledge of Critical Cardiovascular Risk Indicators among College Students: Does Stage of Education Matter? International Journal of Environmental Research and Public Health. 2017;14(3):E250. DOI: 10.3390/ijerph14030250. 5. Hung CC, Chang HY, Chiang YC, Wu WC, Yen LL. Factors Associated With Levels of Risky Drinking in Adolescent Alcohol Users in Taiwan: A Secondary Data Analysis. The Jurnal of Nursing Research. 2017;25(2):163–72. DOI: 10.1097/JNR.0000000000000151. 6. Muromtseva GA, Kontsevaya AV, Konstantinov VV, Artamonova GV, Gatagonova TM, Duplyakov DV, Efanov AYu, Zhernakova Yu V, Il'in VA, Konradi AO, Libis RA, Minakov EV, Nedogoda SV, Oschepkova EV, Romanchuk SV, Rotar’ OP, Trubacheva IA, Deev AD, Shal’nova SA, Chazov EI, Shlyakhto EV, Boytsov SA. The prevalence of non-infectious diseases risk factors in Russian population in 2012-2013. The results of ECVD-RF. Cardiovascular Therapy and Prevention. 2014;13(6):4–11. (In Russian) 7. Gavrilova ES, Yashina LM, Yashin DA. Prevalence of risk factors of chronic noninfectious diseases and their interconnection with anxiety-depressive symptoms among students. Vrach-aspirant. 2014;4.1(65):145–51. (In Russian) 8. Yashin DA, Kaleva NG, Kalev OF, Yashina LM. Increase of the epidemic of active and passive smoking by adults and children. Medical Science and Education in the Urals. 2011;12(4):175–9. (In Russian) 9. Gavrilova ES, Yashina LM, Yashin DA., Sumerkina VA Prevalence of biological risk factors of chronic noninfectious diseases and anxietydepressive symptoms in their interconnection with level of blood serum leptin among students. Fundamental Research. 2015;1(3):478–82. (In Russian) 10. Yashin DA, Kaleva NG, Kalev OF, Yashina LM. The prevalence of overweight and obesity among workers in an industrial enterprise according to the data of long-term research. Kazanskii Medical Journal. 2012;93(3):529–32. (In Russian) 11. Yashin DA, Kaleva NG, Kalev OF, Yashina LM. Prevalence of arterial hypertension in the organized populations of adults and children according to the data of long-term research. Medical Science and Education in the Urals. 2011;(3):21-6. (In Russian) 12. Qobadi M, Payton M. Racial Disparities in Obesity Prevalence in Mississippi: Role of Socio-Demographic Characteristics and Physical Activity. International Journal of Environmental Research and Public Health. 2017;14(3):E258. DOI: 10.3390/ijerph14030258. 13. Chubenko EA, Belyaeva OD, Berkovitch OA, Baranova EI. Meaning of leptine in forming of metabolic syndrome. Women's health issues. 2010;5(1):45–60. (In Russian) 14. Bray GA. Overweight and obesity: the pathogenesis of cardiometabolic risk. Clinical Cornerstone. 2009;9(4):30–40. 15. Chulkov VlS, Sumerkina VA, Chulkov VS. Markers of endothelial dysfunction and adipokines in young women with hypertension and abdominal obesity. Ural Medical Journal. 2015;6(129):118–21. (In Russian) 16. Sumerkina VA, Chulkov VlS, Chulkov VS, Ozhigina EV. Hemostatic system state and cytokine profile in patients with metabolic syndrome. Kazanskii Medical Journal. 2015;96(5):728–34. DOI: 10.17750/ KMJ2015-728. (In Russian) 17. Chulkov VlS, Sumerkina VA, Abramovskikh OS, Chulkov VS. Frequency of nonalcoholic fatty liver disease in young patients with abdominal obesity on a background of an arterial hypertensia. Eksperimental’naya i Klinicheskaya Gastroenterologiya. 2014;111(11):42–5. (In Russian) 18. Martínez-Torres J, Correa-Bautista JE, González-Ruíz K, Vivas A, Triana-Reina HR, Prieto-Benavidez DH, Carrillo HA, Ramos-Sepúlveda JA, Villa-González E, García-Hermoso A, Ramírez-Vélez R. Cross-Sectional Study of the Prevalence of Metabolic Syndrome and Associated Factors in Colombian Collegiate Students: The FUPRECOL-Adults Study. International Journal of Environmental Research and Public Health. 2017;14(3):E233. DOI: 10.3390/ijerph14030233 19. Rosengren A, Hawken S, Ounpuu S, Sliwa K, Zubaid M, Almahmeed WA, Blackett KN, Sitthi-amorn C, Sato H, Yusuf S. Association of psychosocial risk factors with risk of acute myocardial infarction in 11 119 cases and 13 648 controls from 52 countries (the INTERHEART Study): case-control study. Lancet. 2004; 364(9438):953–62. 20. Shal'nova SA, Evstifeeva SE, Deev AD, Artamonova GV, Gatagonova TM, Duplyakov DV, Efanov AYu, Zhernakova YuV, Konradi AO, Libis RA, Minakova AV, Nedogoda SV, Oshchepkova EV, Romanchuk SA, Rotar' OP, Trubacheva IA, Shliakhto EV, Boitsov SA. The prevalence of anxiety and depression in different regions of the Russian Federation and its association with sociodemographic factors (according to the data of the ESSE-RF study). Therapeutic Archive. 2014;(12):52–9. (In Russian) 21. Gavrilova ES, Yashina LM, Yashin DA. Prevalence of anxiety and depression among students and its interconnection with risk factors of chronic noninfectious deseases [Internet]. Science-education. 2 015;(5). Available from: http://www.science-education.ru/128-22163. (In Russian) 22. Mucci N, Giorgi G, De Pasquale Ceratti S, Fiz-Pérez J, Mucci F, Arcangeli G. Anxiety, Stress-Related Factors, and Blood Pressure in Young Adults. Frontiers in Psychology. 2016;(7):1682. DOI: 10.3389/ fpsyg.2016.01682. 23. Nationwide integrated programme for the prevention of noninfectious diseases (CINDI): a protocol and practical guide. WHO. Copenhagen, 1996. 124 p. (In Russian) 24. Follow-up measures in the context of the Political Declaration of the high-level Meeting of the General Assembly on NCD prevention and control [Internet]. Resolution of the 66th session of the world health Assembly, may 27, 2013. App. WHA66.10, Geneva: World Health Organization, 2013. Available from: http://apps.who.int/gb/ebwha/pdf_files/WHA66/A66_ R10-ru.pdf?ua=1. 25. Obesity: preventing and managing the global epidemic. Report of a WHO Consultation. WHO Technical Report Series 894. Geneva: World Health Organization; 2000. 252 р. 26. Diagnosis and treatment of metabolic syndrome. In. National clinical guidelines. Section V. 3-ed. Moscow: Silicea-Polygraf; 2010:277– 316. (In Russian) 27. Chazova IE, Oshchepkova EV, Rogoza AN, Danilov NM, Chikhladze NM, Zhernakova YuV. Diagnosis and treatment of hypertension : clinical guidelines. M.; 2013. 64 p. (In Russian) 28. Zigmond AS, Snaith RP. The Hospital Anxiety and Depression scale. Acta Psychiatrica Scandinavica. 1983;67:361–70. 29. Diagnosis and correction of lipid metabolism disorders to prevent and treat of atherosclerosis: Russian recommendations. V revision. M.; 2012. 50 p. (In Russian) 30. About approval of the procedure of carrying out of prophylactic medical examination of certain groups of adult population : Order of Ministry of Health of Russia №36аn from February 3, 2015. M.; 2015. 21 p. (In Russian) 31. Emchenko NL, Tsyganenko OI, Kovalevskaya TV. Universal method for the determination of nitrate in biological environment of the organism. Clinical Laboratory Diagnostics. 1994;6:19–20. (In Russian) 32. Ghambaryan MG, Kalinina AM. Medical aid for the prevention and cessation of smoking : methodological recommendations. M.; 2012. 42 p. 33. Eganyan RA, Izmailova OV, Karamnova NA, Kalinina AM. The provision of medical aid to reduce excess body mass: methodological recommendations. M.; 2012. 52 p. (In Russian) 34. Boytsov SA, ed. Medical aid to adult population on optimization of physical activity: methodical recommendations. M.; 2012. 33 p. (In Russian) 35. Dekhar’ VV, Osipov AG, Sopotova IV, Denisova DV, Osipova IV. The impact of immersed preventive counseling on risk factors of cardiovascular diseases in students of Barnaul city . Complex Problems of Cardiovascular Diseases. 2014;(3):42. (In Russian) 36. Pyrikova NV, Osipova IV, Zaltsman AG, Antropova ON, Kurbatova AI. Health School and individual preventive counseling as a way to preserve the professional longevity of employees. Arterial Hypertension: from Theory to Practice. Moscow, 2015:90–1. (In Russian)
Ankudinov A.S., Kalyagin A.N., Omana S.S.
FACTORS OF PREDICTION OF CHRONIC HEART FAILURE IN HIGHLY-COMPLIANCE PATIENTS
Ankudinov AS, Kalyagin АN, Omana SS. Factors of prediction of chronic heart failure in highly-compliance patients. Siberian Medical Review. 2017;(2):56-60. DOI: 10.20333/2500136-2017-2-56-60.
Ankudinov Andrey Sergeevich ; Irkutsk State Medical University; г. Иркутск, ул. Красного Восстания, д. 1; тел.: +7(3952)229933; email: firstname.lastname@example.org
Kalyagin Aleksey Nicolaevich ; Irkutsk State Medical University; г. Иркутск, ул. Красного Восстания, д. 1; тел.: +7(3952)708661; email: email@example.com
Omana Suman Soman ; Irkutsk State Medical University; г. Иркутск, ул. Красного Восстания, д. 1; тел.: +7(3952)708661; email: firstname.lastname@example.org
The aim of the research. To identify the clinical parameters that influence to the evaluation of the prognosis of chronic heart failure (CHF) in highly-compliance patients, depending on its etiology. Material and methods. The study included 260 highly-compliance patients suffering from heart failure III-IV functional class according to NYHA. All patients included in the study gave a written agreement for the study. The adherence of patients to the therapy was assessed using the Moriski-Green test. The diagnosis of heart failure is based on an assessment of the level of the brain natriuretic peptide and evaluation of the morphological changes in the myocardium by echocardiography, including an evaluation of the transmittal flow parameters. The diagnosis of heart failure is based on an assessment of the level of the brain natriuretic peptide and evaluation of the morphological changes in the myocardium by echocardiography, including an evaluation of the transmittal flow parameters. The etiology of heart failure was analyzed in details: in 160 patients heart failure developed against coronary heart disease, confirmed by coronary angiography. 100 patients suffered CHF on the background of other causes: hypertensive disease (HD), acquired heart disease, pulmonary heart, idiopathic cardiomyopathy, chemotherapy. A comparative analysis of clinical data as well as a regression analysis of the studied parameters influence to the prognosis of heart failure during a two-year control. Results. The study revealed significant differences of the frequency of stable heart failure in the study groups and deaths. Notable differences in the reasons for repeated hospitalizations in the study groups were marked. Significant target levels of lipidogram indices, renal function and troponin T concentration were obtained, the achievement of which positively affects to the outcome of heart failure. Conclusion. The appointment of prolonged intensive lipid-lowering therapy may possibly have a positive effect on the outcome of heart failure in the absence of coronary heart disease. It was found that the presence of a preserved renal function also positively affects to the outcome of heart failure, regardless of its etiology. However, these hypotheses should be checked by a longer observation period
Keywords: chronic heart failure, ischemic disease, prognostic factors, adherence to treatment, model
1. Belenkov YuN, Fomin IV, Mareev VYu. The prevalence of chronic heart failure in the European part of the Russian Federation-data AGE–CHF (part 2). Journal of Heart Failure. 2006;7(3):3-7. (In Russian) 2. Heidenreich PA, Trogdon JG, Khavjou OA. Forecasting the future of cardiovascular disease in the United States: a policy statement from the American Heart Association. Circulation. 2011;123(8):933–44. DOI:10.1161/ cir.0b013e31820a55f5. 3. Dokainish H, Nguyen JS, Bobek J. Assessment of the American Society of Echocardiography-European Association of Echocardiography guidelines for diastolic function in patients with depressed ejection fraction: an echocardiographic and invasive haemodynamic study. European Journal of Echocardiography. 2011;12(11):857–64. DOI:10.1093/ejechocard/jer157. 4. Liao JK. Statin therapy for cardiac hypertrophy and heart failure. Journal of Investigative Medicine. 2004;52(4):248–53. DOI: 10.2310/6650.2004.04015. 5. Mareev VYu, Ageev FT, Arutyunov GP. National recommendations PRAS cardiology and internal medicine on the diagnosis and treatment of chronic heart failure (fourth revision). Journal of Heart Failure. 2013;14(7):379-472. (In Russian) 6. Beller GA. SPECT imaging for detecting coronary artery disease and determining prognosis by noninvasive assessment of myocardial perfusion and myocardial viability. Journal of Cardiovascular Translational Research. 2011;4(4):416–24. DOI:10.1007/s12265-011-9290-2. 7. Khand A, Gemmel I, Clark AL. Is the prognosis of heart failure improving. Journal of the American College of Cardiology. 2000;36(7):2284–6. DOI:10.1016/s0735-1097(00)00995-5. 8. Kalyagin AN. Chronic heart failure: modern understanding of the problem. Definition and epidemiology (the message 1). Sibirskij Medicinskij Zurnal (Irkutsk). 2006;61(3):93–7. (In Russian) 9. Yusuf S, Hawken S, Ounpuu S. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet. 2004;364(9438):937–52. DOI:10.1016/s0140-6736(04)17018-9. 10. Heidenreich PA, Trogdon JG, Khavjou OA. Forecasting the future of cardiovascular disease in the United States: a policy statement from the American Heart Association. Circulation. 2011;123(8):933–44. DOI:10.1161/ cir.0b013e31820a55f5. 11. Oudejans I, Mosterd A, Bloemen JA. Clinical evaluation of geriatric outpatients with suspected heart failure: value of symptoms, signs, and additional tests. European Journal of Heart Failure. 2011;13(5):518–27. DOI:10.1093/eurjhf/ hfr021. 12. Wouters OJ, O`Donoghue DJ, Ritchie J. Early chronic kidney disease: diagnosis, management and models of care. Nature Reviews. Nephrology. 2015;11(8):491–502. DOI:10.1038/nrneph.2015.85. 13. Zile MR. New concepts in diastolic dysfunction and diastolic heart failure: Part I; diagnosis, prognosis, and measurements of diastolic function. Circulation. 2002;105(11):1387–93. DOI:10.1161/hc1102.105289. 14. Porapakkham P, Zimmet H. B-type natriuretic peptide-guided heart failure therapy: A meta-analysis. Internal Medicine. 2010;170(6):507–14. DOI:10.1001/ archinternmed.2010.35. 15. Tavazzi L, Maggioni AP, Marchioli R. Effect of rosuvastatin in patients with chronic heart failure (the GISSI–HF trial): a randomised, double-blind, placebocontrolled trial (part I). Lancet. 2008;372(9645):1231–9. DOI: 10.1016/s0140- 6736(08)61240-4. 16. Beller GA. Stress myocardial perfusion imaging for assessing prognosis: an update. JACC. Cardiovascular Imaging. 2011;4(12):1305–19. DOI:10.1016/j. jcmg.2011.10.003. 17. Ketchum ES, Levy WC. Establishing prognosis in heart failure: a multimarker approach. Progress in Cardiovascular Diseases. 2011;54(2):86–96.DOI:10.1016/j.pcad.2011.03.003. 18. Khand A, Gemmel I, Clark AL. Is the prognosis of heart failure improving? Journal of the American College of Cardiology. 2000;36(7):2284–6. DOI:10.1016/s0735-1097(00)00995-5. 19. Rebrova OYu. Statistical analysis of medical data. Application software package STATISTICA. M.: Media Sphere; 2008. 200 p. (In Russian) 20. Oudejans I, Mosterd A, Bloemen JA. Clinical evaluation of geriatric outpatients with suspected heart failure: value of symptoms, signs, and additional tests. European Journal of Heart Failure. 2011;13(5):518–27. DOI:10.1093/eurjhf/ hfr021. 21. Kelder JC, Cramer MJ, Wijngaarden van J. The diagnostic value of physical examination and additional testing in primary care patients with suspected heart failure. Circulation. 2011;124(25):2865–73. DOI:10.1161/ circulationaha.111.019216. 22. Clark AL. Excessive breathlessness in patients with diastolic heart failure. Heart. 2006;92(10):1425–9. DOI:10.1136/hrt.2005.081521. 23. Ewald B. Meta-analysis of B type natriuretic peptide and N-terminal pro B natriuretic peptide in the diagnosis of clinical heart failure and population screening for left ventricular systolic dysfunction. Internal Medicine Journal. 2008;38(2):101–13. DOI:10.1111/j.1445-5994.2007.01454.x. 24. Horwich TB, MacLellan R, Fonarow GC. Statin therapy is associated with improved survival in ischemic and non-ischemic heart failure. Journal of the American College of Cardiology. 2004;43(4):642–48. DOI:10.1016/j.jacc.2003.07.049. 25. McMurray J.J. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: the task force for the diagnosis and treatment of acute and chronic heart failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. European Heart Journal. 2012;33(14):1787–1847. DOI:10.1093/eurheartj/ehs370.
Orlov A.V., Rotar O.P., Boyarinova M.A., Alieva A.S., Moguchaia E.V., Paskar N.A., Solntsev V.N., Baranova E.I., Konradi A.O.
ANXIETY-DEPRESSIVE DISORDERS - CONNECTING LINK BETWEEN SOCIALECONOMIC, BEHAVIORAL AND BIOLOGICAL CARDIOVASCULAR RISK FACTORS ?
Orlov АV, Rotar OP, Boyarinova MA, Alieva AS, Moguchaia EV, Paskar NN, Solntsev VN, Baranova EA, Konradi AO. Anxiety-depressive disorders – connecting link between social-economic, behavioral and biological cardiovascular risk factors? Siberian Medical Review. 2017;(2):60- 66. DOI: 10.20333/2500136-2017-2-60-66.
Orlov Alexander Viktorovich ; Almazov Federal North-West Medical Research Centre; Санкт-Петербург, ул. Аккуратова, д. 2, тел.: +7 (812) 702-37-56; e-mail: email@example.com
Rotar Oxana Petrovna ; Almazov Federal North-West Medical Research Centre; Санкт-Петербург, ул. Аккуратова, д. 2, тел.: +7 (812) 702-37-56; e-mail: firstname.lastname@example.org
Boyarinova Maria Anatol’evna ; Almazov Federal North-West Medical Research Centre; Санкт-Петербург, ул. Аккуратова, д. 2, тел.: +7 (812) 702-37-56; e-mail: email@example.com
Alieva Asiat Sajgidovna ; Almazov Federal North-West Medical Research Centre; Санкт-Петербург, ул. Аккуратова, д. 2, тел.: +7 (812) 702-37-56; e-mail: firstname.lastname@example.org
Moguchaia Ekaterina Viktorovna ; Almazov Federal North-West Medical Research Centre; Санкт-Петербург, ул. Аккуратова, д. 2, тел. +7 (812) 702-37-56; e-mail: email@example.com
Paskar Nadezhda Andreevna ; Almazov Federal North-West Medical Research Centre; Санкт-Петербург, ул. Аккуратова, д. 2, тел.: +7 (812) 702-37-56; e-mail: firstname.lastname@example.org
Solntsev Vladislav Nikolaevich ; Almazov Federal North-West Medical Research Centre; Санкт-Петербург, ул. Аккуратова, д. 2, тел.: +7 (812) 702-37-56; e-mail: email@example.com
Baranova Elena Ivanovna ; Pavlov First St Petersburg State Medical University; Санкт-Петербург, ул. Льва Толстого, д. 6-8, тел.: +7 (812) 702-37-56; e-mail: firstname.lastname@example.org
Konradi Alexandra Olegovna ; Almazov Federal North-West Medical Research Centre; Санкт-Петербург, ул. Льва Толстого, д. 6-8, тел.: +7 (812) 702-37-56; е-mail: email@example.com
The aim of the research. Assessment of the relationship between behavioral and biological risk factors among themselves, as well as with anxiety-depressive disorders in a random sample of residents of St.-Petersburg. Material and methods. Within the framework of the transverse epidemiological observational study of ESSE-RF, a random sample of 1600 inhabitants of St.-Petersburg, stratified by sex and age, was formed. Participants wrote in a standard questionnaire on lifestyle, concomitant diseases and therapy. Anthropometry, measurement of blood pressure, determination of the lipid spectrum and the level of glycemia were performed according to standard procedures. Emotional status was assessed using the Hospital scale of depression and anxiety. Results. The increased level of depression was registered in 334 (20.9%) participants, anxiety - in 778 (48.7%), clinically significant level of depression and anxiety was noted in 103 (30.8%) and 277 (35.6% ) of participants, respectively. Arterial hypertension and obesity were associated with depression and anxiety. Most of the behavioral risk factors were associated with a particular psychological disorder. Depression and anxiety were associated with low incomes (OR = 2.1 (95% CI 1.4-3.1) and OR = 2.3 (95% CI 1.7-2.8), respectively p <0.001 ), hypodynamia (OR = 1.3 (95% CI 1.2-1.4) and OR = 1.2 (95% CI 1.1-1.3), respectively, p <0.05), insufficient consumption of vegetables and fruit (OR = 1.4 (95% CI 1.2-1.7) and OR = 1.4 (95% CI 1.2-1.6), respectively, p <0.05). Conclusion. In a random sample of inhabitants of St.-Petersburg some associations between socio-economic, behavioral and biological risk factors were identified, but multiple regression analysis did not show any. Psychological disorders can partially explain the mutual influences in these groups of risk factors, because they are associated with both social factors, unhealthy lifestyle and nutrition, and with hypertension and obesity
Keywords: anxiety, depression, risk factors, cardiovascular diseases
1. Chen J, Millar WJ. Health effects of physical activity. Health Reporys. 1999;11(1):21-31. 2. Scientific Organizing Committee of the ESSE-RF. Epidemiology of cardiovascular diseases in different regions of Russia (ESSE-RF). Rationale and study design. Preventive Medicine. 2013;(6):25-34. (In Russian) 3. National Guidelines on Cardiovascular Prevention. Cardiovascular Therapy and Prevention. 2011;10(6, Issue 2):2-64. (In Russian) 4. Alberti K, Eckel R, Grundy S, Zimmet P, Cleeman J, Donato K, Fruchart JC, James WP, Loria CM, Smith SC. National Heart, Lung and Blood Institute, American Heart Association, World Heart Federation, International Atherosclerosis Society, International Association for the Study of Obesity. Circulation. 2009;120(16):1640–5. DOI: 10.1161/ CIRCULATIONAHA.109.192644. 5. Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatrica Scandinavica. 1983; 67(6):361-70. 6. Orlov AV, Rotar' OP, Boyarinova MA, Alieva AS, Dudorova EA, Kolesova EP, Moguchaya EV, Paskar' NA, Solntsev VN, Baranova EA, Konradi AO. Gender features of the prevalence of behavioral risk factors in Saint-Petersburg inhabitants. Annals of the Russian Academy of Medical Sciences. 2015;70(5):585-91. DOI:10.15690/vramn.v70.i5.1446. (In Russian) 7. Vandenheede H, Vikhireva O, Pikhart H, Kubinova R, Malyutina S, Pajak A, Tamosiunas A, Peasey A, Simonova G, Topor-Madry R, Marmot M, Bobak M. Socioeconomic inequalities in all-cause mortality in the Czech Republic, Russia, Poland and Lithuania in the 2000s: findings from the HAPIEE Study. Journal of Epidemiol ogy and Community Health. 2014;68(4):297–303. DOI:10.1136/ jech-2013-203057. 8. Orlov A, Rotar O, Moguchaya E, Boyarinova M, Erina A, Kolesova E, Konradi A, Boeing H. Peculiarities of nutrition as a risk factor for noninfectious diseases of the Russian and Estonian populations. Translational Medicine. 2014;(1):82-91. (In Russian) 9. Jinjing Li, Kinfu Y. Impact of socioeconomic and risk factors on cardiovascular disease and type II diabetes in Australia: comparison of results from longitudinal and cross-sectional designs. BMJ Open. 2016;6(4):e010215. DOI: 10.1136/bmjopen-2015-010215. 10. Winkleby MA, Jatulis DE, Frank E, Fortmann SP. Socioeconomic status and health: how education, income, and occupation contribute to risk factors for cardiovascular disease. American Journal of Public Health. 1992;82(6):816-20. 11. Ginter E. Cardiovascular risk factors in the former communist countries. Analysis of 40 European MONICA populations. European Journal of Epidemiology. 1995;11(2):199–205. 12. Zatonski WA, McMichael AJ, Powles JW. Ecological study of reasons for sharp decline in mortality from ischaemic heart disease in Poland since 1991. BMJ. 1998;316(7137):1047–51. 13. Connor SL, Ojeda LS, Sexton G, Weidner G, Connor WE. Diets lower in folic acid and carotenoids are associated with the coronary disease epidemic in Central and Eastern Europe. Journal of the American Dietic Ass ociation.2004;104(12):1793–9. DOI: 10.1016/j.jada.2004.09.023. 14. Kant AK. Dietary patterns and health outcomes. Journal of the American Dietic Association. 2004;104(4):615–35. DOI: 10.1016/j. jada.2004.01.010. 15. Singh M. Mood, food, and obesity. Frontiers in Psychology. 2014;5:925. DOI: 10.3389/fpsyg.2014.00925. 16. Macht M. How emotions affect eating: a five-way model. Appetite. 2008;50(1):1–11. DOI: 10.1016/j.appet.2007.07.002. 17. Dubé L, LeBel JL, Lu J. Affect asymmetry and comfort food consumption. Physiology and Behavior. 2005; 86(4):559-67. DOI: 10.1016/j. physbeh.2005.08.023. 18. Quirk SE, Williams LJ, O’Neil A, Pasco JA, Jacka FN, Housden S, Berk M, Brennan SL. The association between diet quality, dietary patterns and depression in adults: a systematic review. BMC Psychiatry. 2013;13:175. DOI: 10.1186/1471-244X-13-175. 19. Jacka FN, Pasco JA, Mykletun A, Williams LJ, Hodge AM, O'Reilly SL, Nicholson GC, Kotowicz MA, Berk M. Association of Western and traditional diets with depression and anxiety in women. The American Journal of Psychiatry.2010;167(3):305-11. DOI: 10.1176/appi.ajp.2009.09060881. 20. Jacka FN, Mykletun A, Berk M, Bjelland I, Tell GS. The association between habitual diet quality and the common mental disorders in community-dwelling adults: the Hordaland Health study. Psychosomatic Medicine. 2011;73(6):483-90. DOI: 10.1097/PSY.0b013e318222831a. 21. Bauman A, Lewicka M, Schöppe S. The Health Benefits of Physical Activity in Developing Countries [Internet]. Geneva: World Health Organization, 2005; 57 p. Available from: http://apps.who.int/iris/bitstre am/10665/44399/1/9789241599979_eng.pdf 22. Cook I, Alberts M, Lambert EV. Relationship between adiposity and pedometer- assessed ambulatory activity in adult, rural African women. International Journal of Obesity. 2008;32(8):1327–30. DOI: 10.1038/ijo.2008.26. 23. Nocon M, Hiemann T, Müller-Riemenschneider F, Thalau F, Roll S, Willich SN. Association of physical activity with all-cause and cardiovascular mortality: a systematic review and meta-analysis. European Journal of Cardiovascular Prevention &Rehabilitation. 2008;15(3):239–46. DOI: 10.1097/ HJR.0b013e3282f55e09. 24. Weinberger NA, Kersting A, Riedel-Heller SG, Luck-Sikorski C. Body Dissatisfaction in Individuals with Obesity Compared to Normal-Weight Individuals: A Systematic Review and Meta-Analysis. Obes Facts. 2016;9(6):424-41. DOI: 10.1159/000454837. 25. Shal’nova SA, Evstifeeva SE, Deev AD, Artamonova GV, Gatagonova TM, Duplyakov DV, Efanov AYu, Zhernakova YuV, Kaveshnikov VS, Konradi AO, Libis RA, Minakov EV, Nedogoda SV, Oshchepkova EV, Romanchuk SA, Rotar’ OP, Shlyakhto EV, Boitsov SA, Chazov EI. The prevalence of anxiety and depression in different regions of the Russian Federation and its association with sociodemographic factors (according to the data of the ESSE-RF study). Terapevticheskij Arkhiv. 2014;(12):52- 9. (In Russian) 26. Carnevali L, Montano N, Statello R, Sgoifo A. Rodent models of depression- cardiovascular comorbidity: Bridging the known to the new. Neuroscience and Biobehavioral Reviews. 2017 Jan 16. pii: S0149-7634(16)30449-3. DOI: 10.1016/j.neubiorev.2016.11.006. 27. Hayashi K, Kawachi I, Ohira T, Kondo K, Shirai K, Kondo N. Laughter is the Best Medicine? A Cross-Sectional Study of Cardiovascular Disease Among Older Japanese Adults. Journal of Epidemiology. 2016;26(10):546-52. DOI: 10.2188/jea.JE20150196. 28. van Dooren FE, Schram MT, Schalkwijk CG, Stehouwer CD, Henry RM, Dagnelie PC, Schaper NC, van der Kallen CJ, Koster A, Sep SJ, Denollet J, Verhey FR, Pouwer F. Associations of low grade inflammation and endothelial dysfunction with depression - The Maastricht Study. Brain, Behavior and Immunity. 2016;56:390-6. DOI: 10.1016/j.bbi.2016.03.004. 29. Dubinina EA, Korostovtseva LS, Rotar’ OP, Moguchaya EV, Boyarinova MA, Kolesova EP, Alieva AS, Kravchenko SO, Paskar’ NA, Sviryaev YuV, Alekhin AN, Konradi AO. Interrelation of subjective sleep disorders and emotional complaints (screening results in a representative sample of adult inhabitants of St.-Petersburg). Arterial’naya Gipertenziya (Arterial Hypertension). 2014;20(4):269-79. DOI:10.18705/1607-419X-2014-20-4-269-279. (In Russian)
COMPARATIVE ANALYSIS OF THE EXPRESSION OF THE LEFT VENTRICLE HYPERTROPHY AND MYOCARDIAL CONTRACTILE FUNCTION IN ELDERLY AND SENILE PERSONS WITH ARTERIAL HYPERTENSION
Alexeev IA. Comparative analysis of the expression of the left ventricle hypertrophy and myocardial contractile function in elderly and senile persons with arterial hypertension. Siberian Medical Review. 2017;(2):66-71. DOI: 10.20333/2500136-2017-2-66 -71.
Alexeev Igor Alexandrovich ; Professor V. F. Voino-YasenetskyKrasnoyarsk State Medical University; г. Красноярск, ул. Партизана Железняка, д. 1; тел. +7(913)5152549; e-mail: firstname.lastname@example.org
The aim of the research. To study the expression of left ventricular hypertrophy in patients of older age groups with arterial hypertension. Material and methods. It was conducted the comparison of echocardiographic parameters in 535 patients with arterial hypertension aged 45 to 90 years old living in Krasnoyarsk. All patients were divided by sex and age. The average age was 65.24 ± 0.43 years. There were 246 men (46%, mean age 63.56 ± 0.62 years) and 289 women (54%, mean age 66.67 ± 0.58 years). The following parameters were compared: the thickness of the back wall of the left ventricle in the diastole, the thickness of the interventricular septum in the diastole, the mass of the myocardium of the left ventricle, the ejection fraction. Results. In elderly and senile age there was a decrease in the ejection fraction compared to the control group. By the size of the left atrium there were large values in the older age groups. By the thickness of the back wall of the left ventricle and the thickness of the interventricular septum in elderly and senile patients tere were determined higher values than in the control group. There were no significant differences in the mass of the myocardium of the left ventricle. Conclusion. In elderly and senile age there were noted more expressed hypertrophy of the left ventricle than in the control group. Also in these age groups, lower values of the ejection fraction were noted, that may indicate to the higher frequency of heart failure in older age groups.
Keywords: arterial hypertension, elderly and senile persons, echocardiography, left ventricular hypertrophy
1. Chandbry KM, Chavez PA. Hypertension in the elderly: some practical considerations. Cleveland Clinic Journal of Medicine. 2012;79(10):694-704.DOI: 10.3949/ccjm.79a.12017. 2. Khamidov HN, Amindzhanova SS, Khursanov NM. Influence of hypotensive therapy on blood lipids at patients of older ages with the isolated systolic arterial hypertension. Avicenna's Messenger. 2012;(3):102-106. (In Russian). 3. Yakovlev VM, Khayt GYa. Fundamentals of geriatric cardiology : guide for the practicing doctors. Moscow : Vidar;2011.424 p. (In Russian). 4. Shabalin VN. Guide on gerontology : the textbook for medical higher education institutions. Moscow : Tsitadel-trade;2005.800 p. (In Russian). 5. Odinayev ShF, Rafiyev KhA, Asadullayev SKh. Frequency of complications from arterial hypertension at elderly people. Avicenna's Messenger. 2012;(1):84-8. (In Russian). 6. Malov YuS, Kulikov AN. Disfunction of the myocardium in patients with arterial hypertension. Vestnik rossiiskoi voenno-meditsinskoi akademii. 2012;39(3):91-6. (In Russian). 7. Surovtseva MV, Koziolova NA, Chernyavina AI, Shatunova IM. The analysis of markers of the increased risk of sudden heart death in patients with stable stenocardia and arterial hypertension depending on expressiveness of the left ventricle hypertrophy. Russian Сardiology Journal. 2012;97(5):52-7. (In Russian). 8. Myerburg RJ, Junttila MJ. Sudden cardiac death caused by coronary heart disease. Circulation. 2012;125(8):1043-52.DOI: 10.1161/CIRCULATIONAHA. 111.023846. 9. Erbel R, Budoff M. Improvement of cardiovascular risk prediction using coronary imaging: subclinical atherosclerosis: memory of lifetime risk factor exposure. European Heart Journal. 2012;33(10):1201-13.DOI: 10.1093/eurheartj/ehs076. 10. Barison A, Vergaro G, Pastormerlo LE, Ghiadoni L, Emdin M, Passino C. Markers of arrhythmogenic risk in hypertensive subjects. Current Pharmaceutical Design. 2011;17(28):3062-73. 11. Paoletti E, Specchia C, Di Maio G, Bellino D, Damasio B, Cassottana P, Cannella G. The worsening of left ventricular hypertrophy is the strongest predictor of sudden cardiac death in haemodialysis patients: 10 year survey. Nephrology, Dialysis, Transplantation. 2004;19(7):1829-34.DOI: 10.1093/ndt/gfh288. 12. Bang CN, Gerdts E, Aurigemma GP, Boman K, de Simone G, Dahlöf B, Køber L, Wachtell K, Devereux RB. Four-group classification of left ventricular hypertrophy based on ventricular concentricity and dilatation identifies a low-risk subset of eccentric hypertrophy in hypertensive patients. Circulation. Cardiovascular Imaging. 2014;7(3):422-9.DOI: 10.1161/CIRCIMAGING.113.001275. 13. Venkatesh BA, Volpe GJ, Donekal S, Mewton N, Liu ChY, Shea S, Liu K, Burke G, Wu C, Bluemke DA, Lima JAC. Association of longitudinal changes in left ventricular structure and function with myocardial fibrosis: multi-ethnic study of atherosclerosis study. Hypertension. 2014;64(3):508-15.DOI: 10.1161/HYPERTENSIONAHA.114.03697. 14. Rebrov AP, Nikitina NM, Karoli NA, Magdeeva NA, Kharitonova IA, Kondakova DA. Rigidity of arteries depending on existence of risk factors of cardiovascular diseases development. The Therapeutic Archive. 2009;(3):54-7. (In Russian). 15. Ryabikhin ЕА, Mozheyko МЕ, Kapustina ТЕ, Nazarova ОА. Structural changes of myocardium and elastic properties of the vascular wall in patients of older and senile age with arterial hypertension. The Messenger of Ivanovo Medical Academy. 2014;19(1):34-7. (In Russian). 16. Kireev TR, Safuanova GSh, Zagidullin IM. Condition of the brain bloodgroove in patients of older age with arterial hypertension. Medical Bulletin of Bashkortostan. 2013;8(5):53-6. (In Russian). 17. Golovanova ED, Silayeva NN, Kovalyov DYu. A comparative assessment of indicators of cerebral blood-groove in patients of older and senile age with arterial hypertension and postinfarction cardiosclerosis. Clinical Gerontology. 2008;14(9):73-4. (In Russian). 18. Malinova LI, Sadzhaya LA, Tikhonova LA. Dinamic regulation of the cerebral blood-groove and its clinico-laboratory markers in patients of older age with arterial hypertension. Saratov Scientific Medical Journal. 2011;7(4):842-5. (In Russian). 19. Storozhakov GI, Chervyakova YuB, Vereshchagina GS, Malysheva NV. Elastic properties of the arterial wall in patients with arterial hypertension of older age. Clinical Gerontology. 2006;(10):33-8. (In Russian). 20. Gardin JM, Lauer MS. Left ventricular hypertrophy: next treatable, silent killer? JAMA. 2004;292(19):2396-8.DOI: 10.1001/jama.292.19.2396. 21. National High Blood Pressure Education Program Working Group on High BloodPressure in Children and Adolescents. The fourth report on the diagnosis, evaluation, and treatmentof high blood pressure in children and adolescents. Pediatrics. 2004;114(2 Suppl 4th Report):555-76. 22. Guidelines for the treatment of arterial hypertension of ESH/ESC 2013. Russian Cardilogy Journal. 2014;(1):7-94. (In Russian). 23. Zadorozhnaya MP, Razumov VV. Variety of echocardiographic criteria of definition the left ventricle myocardium hypertrophy (analytical review). Modern Tendencies of Development of Science and Technics. 2015;(7):77-85. (In Russian). 24. Barsukov AV, Zobnina MP, Talantseva MS. Left ventricle hypertrophy and prognosis: data of five years' retrospective supervision over patients with essentsiality hypertension. Arterial Hypertension. 2012;8(5):385-97. (In Russian). 25. Larstorp ACK, Okin PM, Devereux RB. Regression of ECG-LVH is associated with lower risk of new-onset heart failure and mortality in patients with isolated systolic hypertension; LIFE study. American Journal of Hypertension. 2012;25(10):1101-9.DOI: 10.1038/ajh.2012.86. 26. Brandt MC, Mahfoud F, Reda S, Schirmer SH, Erdmann E, Böhm M, Hoppe UC. Renal sympathetic denervation reduces left ventricular hypertrophy and improves cardiac function in patients with resistant hypertension. Journal of the American College of Cardiology. 2012;59(10):901-9.DOI: 10.1016/j. jacc.2011.11.034. 27. Zile MR, Le Winter MM. Left ventricular end diastolic volume is normal in patients with heart failure and a normal ejection fraction: a renewed consensus in diastolic heart failure. Journal American College Cardiology. 2007;49(9):982-985. 28. Shammas RL, Khan NU, Nekkanti R, Movahed A. Diastolic heart failure and left ventricular diastolic dysfunction: what we know, and what we don’t know! International Journal Cardiology. 2007;115(3):284-292. 29. Davenport A, Anver SD, Mebazaa A. ADQI 7th: the clinical management of the cardio-renal syndromes: workgroup statements from the 7th ADQI Consensus Conference. Nephrology Dialysis Transplantation. 2010;252094-2106. 30. Demikhova NV, Vlasenko MA. Features of remodeling of the left ventricle in patients with a renoparenchymatous arterial hypertension with the preserved renal function. The Messenger of the KNU named atter V. N. Karazin. 2012;(1024):18-22. 31. Teregulov YuE, Mayanskaya SD, Latipova ZK, Abzalova GF, Sadriyeva AA, Teregulova ET, Mangusheva MM. An assessment of indicators of haemodynamics in patients with arterial hypertension at various types of remodeling of the left ventricle. Practical medicine. 2014;6(82):88-94. 32. Kobalava ZhD, Kotovskaya YuV. Arterial hypertension: keys to diagnostics and treatment : . Moscow : ;2007.432. 33. Messerli FH, Wiliams B, Ritz E. Essential hypertension. Lancet. 2007;370591-603. 34. Surovtseva MV, Koziolova NA, Eltsova MA, Chernyavina AI. Clinicopatogenetic features of patients with stable angina pectoris and arterial hypertension depending on expressiveness of the left ventricle hypertrophy. Health of a family-21 century. 2012;2(2):1-17.
ANTICOAGULANT THERAPY IN COMORBIDAL PATIENTS WITH DIFFERENT FORMS OF FIBRILLATION OF AURICLES (RETROSPECTIVE HOSPITAL ANALYSIS)
Rubanenko OA. Anticoagulant therapy in comorbidal patients with different forms of fibrillation ofauricles (retrospective hospital analysis). Siberian Medical Review. 2017;(2): . DOI: 10.20333/2500136-2017-2-71-76.
Rubanenko Olesya Anatolevna ; Samara State Medical University; Самара, ул. Чапаевская, д. 89; тел.: +7(937)1887780; e-mail: email@example.com
The aim of the research. To study retrospectively the features of the choice of anticoagulant therapy in comorbid patients with different forms of atrial fibrillation in real hospital practice. Material and methods. A total of 1716 patients in the cardiac department of the SOKKD from January 2013 to July 2014 were examined. There were 502 patients (29.3%) among them with AF (303 men and 199 women, the average age was 68.7 ± 10.7 years). Patients were divided into 3 groups depending on the form of AF: group I - patients with paroxysmal form, II - with persistent, III - with constant. Results. Most of the patients with CVD, represented by men, had a permanent form of AF. Arterial hypertension, diabetes mellitus, diseases of the gastrointestinal tract were observed with the same frequency in all three categories. The comorbid pathology (previous myocardial infarction (PMI), cerebral circulation disorder (CCD), respiratory and urinary diseases) was noted mainly in patients with a permanent form of AF. NYHA III and NYHA IV were significantly more common in group III. As per analysis of the use of anticoagulant therapy, in the I group were prescribed warfarin to 65 patients, rivaroxaban - 20, dabigatran etexilate - 12; in the II group warfarin - 93 patients, rivaroxaban - 17, dabigatran - 4; in the III group warfarin 111 patients, rivaroxaban - 24, dabigatran - 8. In most cases, the causative factor of anticoagulant absence in therapy of AF is not indicated. Low compliance was found in 3.9% of patients. Conclusion. In our study among patients with CVD, patients with a constant form of AF were prevailed, most of them were of male sex, with different comorbid pathology. Anticoagulant therapy, mainly warfarin, was prescribed in 53.6% of patients
Keywords: atrial fibrillation, cardiovascular diseases, anticoagulants
1. Go AS, Hylek EM, Phillips KA, Chang Y, Henault LE, Selby JV, Singer DE. Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study. JAMA. 2001;285(18):2370–5. 2. McMurray JJ, Ezekowitz JA, Lewis BS, Lewis BS, Gersh BJ, van Diepen S, Amerena J, Bartunek J. Left ventricular systolic dysfunction, heart failure, and the risk of stroke and systemic embolism in patients with atrial fibrillation: insights from the ARISTOTLE trial. Circulation. Heart Failure. 2013;6(3):451-60.DOI: 10.1161/CIRCHEARTFAILURE. 112.000143. 3. Le Heuzy JY, Paziaud О, Piot О, Said MA, Copie X, Lavergne T, Guize L. Cost of care distribution in atrial fibrillation patients: The COCAF study. American Heart Journal. 2004;147(1):121–36. 4. Rubanenko AO, Shchukin YuV. Factors associated with thrombosis of the left atrial appendage in patients with chronic atrial fibrillation. Klinicheskaja Medicina. 2014;92(11):29-34. (In Russian) 5. McGrath ER, Kapral MK, Fang J, Eikelboom JW, Conghaile Aó, Canavan M, O'Donnell MJ; Investigators of the Ontario Stroke Registry. Association of atrial fibrillation with mortality and disability after ischemic stroke. Neurology. 2013;81(9):825-32.DOI: 10.1212/ WNL.0b013e3182a2cc15. 6. Vanbeselaere V, Truyers C, Elli S, Buntinx F, De Witte H, Degryse J, Henrard S, Vaes B. Association between atrial fibrillation, anticoagulation, risk of cerebrovascular events and multimorbidity in general practice: a registry-based study. BMC Cardiovascular Disorders. 2016(16):61.DOI: 10.1186/s12872-016-0235-1. 7. Bulanova NA, Stazhadze LL, Alekseeva LA, Dubrovina EV, Dorofeeva EV. Prevalence of atrial fibrillation among patients under observation by an outpatient clinic. Kardiologiya. 2011;51(12):29-35. (In Russian) 8. Rubanenko AO, Shchukin YuV, Tereshina OV. Prevalence of arrhythmias in elderly therapeutic patients. Sovremennye Tendencii Razvitija Nauki i Tehnologij. 2015(3-2):134-7. (In Russian) 9. Jones JD, Khand AU, Douglas H, Ashrafi R, Shaw M, Cleland JG. The intersection of atrial fibrillation and heart failure in a hospitalised population. Acta Cardiologica. 2013;68(4):395-402. 10. Lara-Vaca S, Cordero-Cabra A, Martínez-Flores E, Iturralde-Torres P. The Mexican Registry of Atrial Fibrillation (ReMeFa). Gaceta Médica de México. 2014;150(1):48-59. 11. Shantsila E, Wolff A, Lip GY, Lane DA. Optimising stroke prevention in patients with atrial fibrillation: application of the GRASP-AF audit tool in a UK general practice cohort. The British Journal of General Practice. 2015;65(630):e16-23.DOI: 10.1111/ijcp.12625. 12. Misirli HC, Yanar HT, Erdogan SN, Akkilic EC, Ozkan D, Bayram T, Araz O. Frequency of left atrial dilatation in ischemic stroke. Northern Clinics of Istanbul. 2015;2(1):7-12.DOI: 10.14744/nci.2015.83007. 13. Chiang CE, Wang KL, Lin SJ. Asian strategy for stroke prevention in atrial fibrillation. Europace. 2015;17(2):ii31-9.DOI: 10.1093/europace/ euv231. 14. Testa S, Tripodi A, Legnani C, Pengo V, Abbate R, Dellanoce C, Carraro P, Salomone L, Paniccia R, Paoletti O, Poli D, Palareti G; START-Laboratory Register. Plasma levels of direct oral anticoagulants in real life patients with atrial fibrillation: Results observed in four anticoagulation clinics. Thrombosis Research. 2016;137:178-83.DOI: 10.1016/j. thromres.2015.12.001. 15. Chao TF, Lip GY, Liu CJ, Tuan TC, Chen SJ, Wang KL, Lin YJ, Chang SL, Lo LW, Hu YF, Chen TJ, Chiang CE, Chen SA. Validation of a Modified CHA2DS2-VASc Score for Stroke Risk Stratification in Asian Patients With Atrial Fibrillation: A Nationwide Cohort Study. Stroke. 2016;47(10):2462-9.DOI: 10.1161/STROKEAHA.116.013880. 16. van den Ham HA, Klungel OH, Singer DE, Leufkens HG, van Staa TP. Comparative Performance of ATRIA, CHADS2, and CHA2DS2-VASc Risk Scores Predicting Stroke in Patients With Atrial Fibrillation: Results From a National Primary Care Database. Journal of the American College of Cardiology. 2015;66(17):1851-9.DOI: 10.1016/j.jacc.2015.08.033. 17. Polenz GF, Leiria TL, Essebag V, Kruse ML, Pires LM, Nogueira TB, Guimarães RB, Santanna RT, DE Lima GG. CHA2 DS2 VASc Score as a Predictor of Cardiovascular Events in Ambulatory Patients without Atrial Fibrillation. Pacing and Clinical Electrophysiology. 2015;38(12):1412-7. DOI: 10.1111/pace.12744. 18. Hijazi Z, Oldgren J, Lindbäck J, Alexander JH, Connolly SJ, Eikelboom JW, Ezekowitz MD, Held C, Hylek EM, Lopes RD, Siegbahn A, Yusuf S, Granger CB, Wallentin L; ARISTOTLE and RE-LY Investigators. The novel biomarker-based ABC (age, biomarkers, clinical history)- bleeding risk score for patients with atrial fibrillation: a derivation and validation study. Lancet. 2016;387(10035):2302-11.DOI: 10.1016/ S0140-6736(16)00741-8. 19. Yao X, Abraham NS, Alexander GC, Crown W, Montori VM, Sangaralingham LR, Gersh BJ, Shah ND, Noseworthy PA. Effect of Adherence to Oral Anticoagulants on Risk of Stroke and Major Bleeding Among Patients With Atrial Fibrillation. Journal of the American Heart Association. 2016;5(2):e003074.DOI: 10.1161/JAHA.115.003074. 20. Carter L, Gardner M, Magee K, Fearon A, Morgulis I, Doucette S, Sapp JL, Gray C, Abdelwahab A, Parkash R. An Integrated Management Approach to Atrial Fibrillation. Journal of the American Heart Association. 2016;5(1):e002950.DOI: 10.1161/JAHA.115.002950. 21. Barón-Esquivias G, Gómez S, Brufau H, García L, Amo C, Gutiérrez JM, Wu L, Salmerón F, Pinilla S, López V. Care Indicators in Patients With Atrial Fibrillation: Assessment of Sex Differences and Management of Clinical Problems. Revista Española de Cardiología (English ed.). 2016;69(4):384-91.DOI: 10.1016/j.rec.2015.08.021. 22. Barrios V, Escobar C, Prieto L, Osorio G, Polo J, Lobos JM, Vargas D, García N. Anticoagulation Control in Patients With Nonvalvular Atrial Fibrillation Attended at Primary Care Centers in Spain: The PAULA Study. Revista Española de Cardiología (English ed.). 2015;68(9):769-76.DOI: 10.1016/j.rec.2015.04.017. 23. Cullen MW, Kim S, Piccini JP Sr, Ansell JE, Fonarow GC, Hylek EM, Singer DE, Mahaffey KW, Kowey PR, Thomas L, Go AS, Lopes RD, Chang P, Peterson ED, Gersh BJ. Risks and Benefits of Anticoagulation in Atrial Fibrillation: Insights From the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) Registry. Circulation. Cardiovascular Quality and Outcomes. 2013;6(4):461-9.DOI: 10.1161/ CIRCOUTCOMES.113.000127. 24. Patel SI, Cherington C, Scherber R, Barr K, McLemore R, Morisky DE, Cha S, Mookadam F, Shamoun F. Assessment of Patient Adherence to Direct Oral Anticoagulant vs Warfarin Therapy. Circulation. Cardiovascular Quality and Outcomes. 2017;117(1):7-15.DOI: 10.7556/ jaoa.2017.002. 25. Dai Y, Yang J, Gao Z, Xu H, Sun Y, Wu Y, Gao X, Li W, Wang Y, Gao R, Yang Y. Atrial fibrillation in patients hospitalized with acute myocardial infarction: analysis of the china acute myocardial infarction (CAMI) registry. BMC Cardiovascular Disorders. 2017;17(1):2.DOI: 10.1186/s12872-016-0442-9. 26. Virdee MS, Stewart D. Optimizing the use of oral anticoagulant therapy for atrial fibrilation in primary care: a pharmacist-led intervention. International Journal of Clinical Pharmacy. 2017 Jan 3:.DOI: 10.1007/ s11096-016-0419-x. [Epub ahead of print].. 27. Rubanenko OA. The prognostication and prevention of cardioembolic stroke in patients with atria fibrillation. Medical Journal of Russian Federation. 2015(6):5-8. (In Russian)
Bazdyrev E.D., Polikutina O.M., Kalichenko N.A., Slepynina Y.S., Barbarash O.L.
DISORDERS OF RESPIRATORY FUNCTION OF LUNGS IN PATIENTS WITH ISCHEMIC HEART DISEASE BEFORE PLANNING CORONARY BYPASS GRAFTING
Bazdyrev ED, Polikutina OM, Kalichenko NA, Slepynina YuS, Barbarash OL. Disorders of respiratory function of lungs in patients with ischemic heart disease before planning coronary bypass grafting. Siberian Medical Review. 2017;(2):77-84. DOI: 10.20333/2500136-2017-2-77-84.
Bazdyrev Evgeny Dmitrievich Cand.Med.Sc., senior research associate of the laboratory of pathophysiology of multifocal atherosclerosis; Federal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular Diseases; firstname.lastname@example.org
Polikutina Olga Mikhailovna Cand.Med.Sc, Head of Laboratory of Ultrasonic and Electrophysiological Methods; Research Institute for Complex Issues of Cardiovascular Diseases; mailto:email@example.com
Kalichenko Nadezhda Anatolievna cardiologist cardiology emergency room; ; firstname.lastname@example.org
Slepynina Yulia Sergeevna Research Scientist of Laboratory of Ultrasonic and Electrophysiological Methods; Research Institute for Complex Issues of Cardiovascular Diseases; mailto:email@example.com
Barbarash O. L. Dr. Med. Sci., Professor; Kemerovo State Medical University; Scientific Research Institute of Complex Problems of Cardiovascular Diseases; firstname.lastname@example.org
The aim of the research. To identify the main types of respiratory disorders in patients with coronary heart disease (CHD) that came for routine coronary artery bypass grafting (CABG). Material and methods. Patients with CHD that had come to the planned CABG were examined. The formation of groups was based both on the presence in the anamnesis, and the revealed respiratory pathology at the preoperative stage. In order to identify respiratory disorders, a set of studies including spirometry, bodipletizmography and determination of the diffusivity of the lungs on the EliteDl-220v bodipletizmograph (MedicalGraphicsCorporation, USA) was performed. Results. In patients of all the examined groups, respiratory parameters were within the proper values, with the exception of the Tiffno index - in patients with a newly diagnosed pathology of the respiratory system that was lower and the level of diffusivity of the lungs - in patients with a respiratory system pathology (as previously known and revealed at the stage of admission to the CABG) in comparison with isolated CHD. Among all types of ventilation disorders, the predominant one was respiratory tract obstruction. Signs of the formation of the "air trap" were more common than the hyperinflation of lung tissue. Conclusion. Signs of dysfunction of the respiratory system have been verified in the majority of patients with CHD admitted for cardiac surgery. Among all types of ventilation disorders, the obstructive pattern was prevalent
Keywords: respiratory system, ischemic heart disease, types of respiratory disorders, coronary bypass grafting
1. Kamenskaya OV, Klinkova AS, Lomivorotova VV, Ponomarev DN, Cherniavsky AM, Karas’kov AM. Risks of complications in coronary artery bypass grafting taking into account efficiency of pulmonary ventilation. Patologija Krovoobrashhenija i Kardiohirurgija. 2015;19(3):68-73. (In Russian) 2. Boytsov SA, Nikulina NN, Yakushin SS, Akinina SA, Furmenko GI. Sudden cardiac death in patients with coronary heart disease: results of the Russian multi-cEntre epidemiological Study of mOrtality, morbidity, and diagNostics and treAtmeNt quality in aCutE CHD (RESONANCE). Rossijskij Kardiologicheskij Zhurnal. 2011;(2):59-64. (In Russian) 3. Polikutina OM, Slepynina YuS, Bazdyrev ED, Karetnikova VN, Barbarash OL. New-onset chronic obstructive pulmonary disease and its clinical significance in patients with ST-segment elevation myocardial infarction. Terapevticheskij arhiv. 2014;86(3):14-9. (In Russian) 4. Polikutina OM, Slepynina YuS, Bazdyrev ED, Karetnikova VN, Barbarash OL. COPD - marker of negative long-term prognosis of myocardial infarction. Siberian Medical Review. 2016;(1):48-55. DOI 10.20333/25000136- 2016-1-48-55. (In Russian) 5. Efros LA, Samorodskaya IV. Features of structure and influence of concomitant diseases on long-term prognosis after coronary bypass grafting. Bjulleten' NCSSH im. A.N. Bakuleva RAMN. Serdechno-Sosudistye Zabolevanija. 2013;14(1): 33-41. (In Russian) 6. Efros LA, Samorodskaya IV. Fасtors affecting long-term survival after coronary artery bypass surgery. Sibirskij Medicinskij Zhurnal (Tomsk). 2013;28(2):7-14. (In Russian) 7. Zafiraki VK, Skaletsky KV, Kosmacheva ED, Shulzhenko LV, Ramazanov JM, Omarov AA. Myocardial revascularization in patients with chronic ischemic heart disease combined with chronic obstructive pulmonary disease. Kardiologija. 2016;56(1):51-5. DOI: 10.18565/cardio.2016.1.51-55. (In Russian) 8. Nazarov BM, Zykov KA, Ratova LG, Agapova OYu, Dolgusheva YuA, Chazova IE. Is it necessary to do spirometry for patients with cardiovascular diseases? Sistemnye Gipertenzii. 2013;(2):69-74. (In Russian) 9. Bazdyrev ED, Bayrakova YuV, Kazachek YaV, Bezdenezhnykh NA, Polikutina OM, Slepynina YuS, Barbarash OL. Respiratory pathology in ischemic heart disease patients. Sibirskij Medicinskij Zhurnal (Irkutsk). 2012;112(5):46-50. (In Russian) 10. Bazdyrev ED, Bayrakova YuV, Kalichenko NA, Polikutina OM, Slepynina YuS, Barbarash OL. Lung function in patients with coronary heart disease and diabetes. Serdce. 2013;12(4):219-22. (In Russian) 11. Scherban’ NA, Landyshev YuS., Putintsev DV. Pathology of bronchopulmonary system in chronic kidney disease. Amurskij medicinskij zhurnal. 2013;1:22-5. (In Russian) 12. Chen SC, Liu WC, Lee CH, Chang JM, Chen HC. Nephrotic syndrome complicated by life-threatening pulmonary embolism in an adult patient. The Kaohsiung Journal of Medical Sciences. 2010;26(2):89-95. 13. Daneschvar HL, Seddighzadeh A, Piazza G, Goldhaber SZ. Deep vein thrombosis in patients with chronic kidney disease. Thrombosis and Haemostasis. 2008;99(6):1035-9. DOI: 10.1160/TH08-02-0107. 14. Polikutina OM, Slepynina YuS, Bazdyrev ED, Karetnikova VN. Pulmonary function and cardiovascular diseases. Sibirskij medicinskij zhurnal (Irkutsk). 2012;112(5):14-8. (In Russian) 15. Miller MR, Crapo R, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Enright P, van der Grinten CP, Gustafsson P, Jensen R, Johnson DC, MacIntyre N, McKay R, Navajas D, Pedersen OF, Pellegrino R, Viegi G, Wanger J. General considerations for lung function testing. European Respiratory Journal. 2005;26(1):153-61. 16. Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Crapo R, Enright P, van der Grinten CP, Gustafsson P, Jensen R, Johnson DC, MacIntyre N, McKay R, Navajas D, Pedersen OF, Pellegrino R, Viegi G, Wanger J. Standardisation of spirometry. European Respiratory Journal. 2005;26(2):319-38. 17. Wanger J, Clausen JL, Coates A, Pedersen OF, Brusasco V, Burgos F, Casaburi R, Crapo R, Enright P, van der Grinten CP, Gustafsson P, Hankinson J, Jensen R, Johnson D, Macintyre N, McKay R, Miller MR, Navajas D, Pellegrino R, Viegi G. Standardisation of the measurement of lung volumes. European Respiratory Journal. 2005;26(3):511-22. 18. Macintyre N, Crapo RO, Viegi G, Johnson DC, van der Grinten CP, Brusasco V, Burgos F, Casaburi R, Coates A, Enright P, Gustafsson P, Hankinson J, Jensen R, McKay R, Miller MR, Navajas D, Pedersen OF, Pellegrino R, Wanger J. Standardisation of the single-breath determination of carbon monoxide uptake in the lung. European Respiratory Journal. 2005;26(4):720-35. 19. Pellegrino R, Viegi G, Brusasco V, Crapo RO, Burgos F, Casaburi R, Coates A, van der Grinten CP, Gustafsson P, Hankinson J, Jensen R, Johnson DC, MacIntyre N, McKay R, Miller MR, Navajas D, Pedersen OF, Wanger J. Interpretative strategies for lung function tests. European Respiratory Journal. 2005;26(5):948-68. DOI: 10.1183/09031936.05.00035205 20. Kosarev VV, Babanov SA. Occupational chronic obstructive pulmonary disease. Vrach. 2015;(7):2-7. (In Russian) 21. Chuchalina AG, ed. Functional diagnostics in Pulmonology: a practical guide. Moscow : Atmosfera; 2009. 192 p. (In Russian) 22. Body plethysmography: Theoretical and clinical aspects: guidelines. Moscow : GVKG im. N.N. Burdenko; 2014. 45 p. (In Russian) 23. Ballanova YuA, Kontsevaya AV, Shal'nova SA, Deev AD, Artamonova GV, Gatagonova TM, Duplyakov DV, Efanov AYu, Zhernakova YuV, Il'in VA, Konradi AO, Libis RA, Minakov AV, Nedogoda SV, Oganov RG, Oshchepkova EV, Romanchuk SA, Rotar' OP, Trubacheva IA, Shlyakhto EV, Boitsov SA, Muromtseva GA, Evstifeeva SE, Kapustina AV, Konstantinov VV, Mamedov MN, Baranova EI, Nazarova OA, Shutemova OA, Furmenko GI, Babenko NI, Azarin OG, Bondartsov LV, Khvostikova AE, Ledyaeva AA, Chumachek EV, Isaeva EN, Basyrova IR, Kondratenko VYu, Lopina EA, Safonova DV, Skripchenko AE, Indukaeva EV, Cherkass NV, Maksimov SA, Danil'chenko YaV, Mulerova TA, Shalaev SV, Medvedeva IV, Shava VP, Storozhok MA, Tolparov GV, Astahova ZT, Toguzova ZA, Kaveshnikov VS, Karpov RS, Serebryakova VN. The prevalence of behavioral risk factors for cardiovascular diseases in the Russian population according to the study ESSE-RF. Profilakticheskaja Medicina. 2014;(5):42-52. (In Russian) 24. Struchkov PV, Drozdov DV, Lukina OF. Spirometry: a guide for physicians. Moscow : GJeOTAR-Media; 2015. 96 p. (In Russian) 25. Pashkova TL. The use of tiotropium bromide in chronic obstructive pulmonary disease and its effect on hyperinflation and physical performance. Jeffektivnaja Farmakoterapija. 2010;27:45-52. (In Russian) 26. Avdeev SN. Pulmonary hyperinflation in COPD patients. Prakticheskaja Pul'monologija. 2006;(2):11-17. (In Russian) 27. Neklyudova GV, Chernyak AV. The clinical significance of the study of the diffusion capacity of the lungs. Prakticheskaja Pul'monologija. 2013;(4):54-9. (In Russian) 28. Schunemann HJ, Dorn J, Grant BJB, Winkelstein W, Trevisan M. Pulmonary function is a long-term predictor of mortality in the general population 29-year follow-up of the Buffalo Health Study. Chest. 2000;118(3):656-64. Нарушение респираторной функции легких у пациентов с ИБС перед плановым проведением коронарного шунтирования 29. Engström G, Janzon L. Risk of developing diabetes is inversely related to lung function: a population-based cohort study. Diabetic Medicine. 2002;19(2):167-70. 30. Masmoudi K, Choyakh F, Zouari N. Ventilatory mechanics and alveolo-capillary diffusion in diabetes. Tunisie Medicale. 2002;80(9):524-30. 31. Koroleva OS, Zateyshchikov DA. Biomarkers in cardiology: registration of intravascular inflammation. Farmateka. 2007;(8/9):30-6. (In Russian) 32. Kremser СВ, O'Toole MF, Leff AR. Oscillatory hyperventilation in severe congestive heart failure secondary to idiopathic dilated cardiomyopathy or to ischemic cardiomyopathy. American Journal of Cardiology. 1987;59(8):900-5. 33. McMurray JJ, Stewart S.Epidemiology, aethiology and prognosis of heart failure. Heart. 2000;83:596-602. DOI:10.1136/heart.83.5.596 34. Bazdyrev ED, Bayrakova YuV, Polikutina OM, Bezdenezhnykh NA, Slepynina YuS, Barbarash OL. Relationship between respiratory function and myocardial structure and function in patients with type 2 diabetes mellitus and ischemic heart disease. Kardiologija. 2015;55(1):4-8. DOI: http://dx.doi. org/10.18565/cardio.2015.1.4-8 (In Russian) 35. Barbarash OL, Rutkovskaya NV, Smakotina SA, Chesnokova YuL, Bazdyrev ED, Chernyavskaya EYu, Kudryavtseva IA. Lung injury in patients with hypertensive disease. Kardiologija. 2010;(3):31-6. (In Russian) 36. Barbarash OL, Rutkovskaya NV, Smakotina SA. Lung function in young and middle-aged patients with hypertensive disease. Siberian Medical Review. 2009;(2):19-27. (In Russian) 37. Bazdyrev ED, Ivanov SV, Pavlova VYu, Barbarash OL. Prevention of respiratory complications in patients with coronary heart disease when performing planned coronary artery bypass grafting. Kompleksnye Problemy Serdechno-Sosudistyh Zabolevanij. 2016;(1):37-50. DOI: http://dx.doi. org/10.17802/2306-1278-2016-1-37-50 (In Russian) 38. Panova EI, Martyshina OV, Danilov VA. Associated pathology with obesity: frequency, character and some formation mechanisms. Sovremennye Tehnologii v Medicine. 2013;5(2):108-15. (In Russian)
Revich B.A., Shaposhnikov D.A.
INFLUENCE FEATURES OF COLD AND HEAT WAVES TO THE POPULATION MORTALITY - THE CITY WITH SHARPLY CONTINENTAL CLIMATE
Revich BA, Shaposhnikov DA. Influence features of cold and heat waves to the population mortality – the city with sharply continental climate. Siberian Medical Review. 2017;(2):84-90. DOI: 10.20333/2500136-2017-2-84-90.
Revich Boris Aleksandrovich ; Institute of Economic Forecasting of Russian Academy of Sciences; г. Москва, Нахимовский проспект, 47; тел. +7(499)1291800; e-mail: email@example.com
Shaposhnikov Dmitry Anatolievich ; Institute of Economic Forecasting of Russian Academy of Sciences; г. Москва, Нахимовский проспект, 47; тел. +7(499)1291800; e-mail: firstname.lastname@example.org
The aim of the research. The choice of the best predictor of mortality during the heat and cold waves in a sharply continental climate. Stratification of mortality risks during such waves in Krasnoyarsk for the main reasons and age groups for revealing the main temperature factors of increased mortality. Comparison of risks with similar results obtained in the southern cities of Russia. Material and methods. Meteodata for 6 selected cities in Siberia with sharply continental climate were obtained from the site of Roshydromet. To analyze the impact of long periods of extreme air temperatures on mortality, Krasnoyarsk was chosen as the largest of the studied cities; data on the daily mortality in Krasnoyarsk were provided by Rosstat. To calculate the relative risks of mortality during heat and cold waves, the Poisson regression model of daily mortality was used, corrected for the long-term and seasonal mortality trends, day of the week and daily temperature difference. Results. For the period 1999-2014 in Bratsk, Barnaul, Irkutsk, Kemerovo, Krasnoyarsk and Chita, a total of 73 waves of heat and 83 cold waves were identified. For heat, the effective air temperature is a better predictor of mortality than the temperature of a dry thermometer, and for the cold, the best predictor is the wind-cold index. For the majority of the studied indicators, statistically reliable estimates of the death rate increases were obtained both during the heat waves and during the cold waves and it was shown that during the heat they were more significant. Conclusion. The main contribution to increased mortality during extreme temperatures is provided by cerebrovascular diseases. The risks from heat waves in Krasnoyarsk are less pronounced than in the southern cities of the European part of Russia; on the waves of cold there were no significant differences
Keywords: health, cerebrovascular diseases, respiratory diseases, Krasnoyarsk, sharply continental climate, action plans during the heat wave
1. The Second Assessment Report of Rosgidromet on climate change and their impact on the territory of the Russian Federation, the Technical Summary. М. : Rosgidromet; 2014. 93 p. (In Russian) 2. Ageev FT, Smirnova MD, Rodnenkov OV. The heat and the cardiovascular system. M. : Praktika; 184 p. (In Russian) 3. BacciniM, BiggeriA, Accetta G, Kosatsky T, Katsouyanni K, Analitis A, Anderson HR, Bisanti L, DʼIppoliti D, Danova J, Forsberg B, Medina S, Paldy A, Rabczenko D, Schindler C, Michelozzi P. Heat effects on mortality in 15 European cities. Epidemiology. 2008;19(5):711–9. DOI:10.1097/EDE.0b013e318176bfcd. 4. Leone M, D’Ippoliti D, De Sario M, Analitis A, Menne B, Katsouyanni K, de’ Donato FK, Basagana X, Salah AB, Casimiro E, Dörtbudak Z, Iñiguez C, Peretz C, Wolf T, Michelozzi P. A time series study on the effects of heat on mortality and evaluation of heterogeneity into European and Eastern-Southern Mediterranean cities: results of EU CIRCE project. Environ Health. 2013;12:55. DOI:10.1186/1476-069X-12-55. 5. Ma W, Chen R, Kan H. Temperature-related mortality in 17 large Chinese cities: How heat and cold affect mortality in China. Environmental Research. 2014;134:127–33. DOI:10.1016/j.envres.2014.07.007. 6. Heo S, Lee E, Kwon BY, Lee S, Jo KH, Kim J. Long-term changes in the heat–mortality relationship according to heterogeneous regional climate: a time-series study in South Korea. BMJ Open. 2016;6(8):e011786. DOI:10.1136/ bmjopen-2016-011786. 7. Implementing the European Regional Framework for Action to protect health from climate change: A status report / WHO Regional Office for Europe. Copenhagen: World Health Organization; 2015. 50 p. 8. Revich BA, Shaposnikov DA, Podol’naya MA, Khor’kova TL, Kvasha EA. Heat waves on Southern Cities of European Russia as a Risk a Risk Factor for Premature Mortality. Studies on Russian Economic Development. 2015;26(2):142-50. DOI: 10.1134/S1075700715020100. 9. Revich BA, Shaposnikov DA. Cold waves in Southern Cities of European Russia and Premature Mortality. Studies on Russian Economic Development. 2016;27(2):210–5. DOI:10.1134/S107570071602012X. 10. Revich B, Shaposhnikov D. Excess mortality during heat waves and соld spells in Moscow, Russia. Occupational and Environmental Medicine. 2008;65:691– 6. DOI:10.1136/oem.2007.033944. 11. Shaposhnikov D, Revich B, Bellander T, Bedada GB, Bottai M, Kharkova T, Kvasha E, Lezina E, Lind T, Semutnikova E, Pershagen G. Mortality related to interactions between heat wave and wildfire air pollution during the summer of 2010 in Moscow. Epidemiology. 2014;25:359–64. DOI:10.1097/ede.0000000000000090. 12. Shaposhnikov D, Revich B. Toward meta-analysis of impacts of heat and cold waves on mortality in Russian North. Urban Climate. 2016;15:16–24. DOI:10.1016/j. uclim.2015.11.007. 13. Steadman RG. Norms of apparent temperature in Australia. Australian Meteorological Magazine. 1994;43:1–16. 14. Rothfusz LP. The heat index equation. NWS Southern Region Technical Attachment, SR/SSD 90–23. Fort Worth, Texas; 1990. 15. Anderson GB, Bell ML, Peng RD. Methods to calculate the heat index as an exposure metric in environmental health research. Environ Health Perspect. 2013;121:1111–9. DOI:10.1289/ehp.1206273. 16. D'Ippoliti D, Michelozzi P, Marino C, de'Donato F, Menne B, Katsouyanni K, Kirchmayer U, Analitis A, Medina-Ramón M, Paldy A, Atkinson R, Kovats S, Bisanti L, Schneider A, Lefranc A, Iñiguez C, Perucci C. The impact of heat waves on mortality in 9 European cities: results from the EuroHEAT project. Environ Health. 2010;9:37. DOI:10.1186/1476-069X-9-37. 17. Almeida SP, Casimiro E, Calheiros J. Effects of apparent temperature on daily mortality in Lisbon and Oporto, Portugal. Environ Health. 2010;9:12. DOI:10.1186/1476-069X-9-12. 18. Report on Wind Chill Temperature and extreme heat indices: Evaluation and improvement projects. U.S. Department of Commerce / National Oceanic and Atmospheric Administration, Office of the Federal Coordinator for Meteorological Services and Supporting Research, FCM-R19-2003. Washington D.C; 2003. 75 p. 19. Toronto Public Health. Health Impacts of Cold Weather. Technical Report. June 2014 [Internet]. Available from: http://www.mississauga.ca/file/COM/ Health%20Impacts%20of%20Cold%20Weather.pdf (cited 2016 Dec 4). 20. Kunst AE, Groenhof F, Mackenbach JP. The association between two windchill indices and daily mortality variation in The Netherlands. American Journal of Public Health. 1994;84(11):1738–42. DOI:10.2105/AJPH.84.11.1738. 21. Eng H, MercerJB. The relationship between mortality caused by cardiovascular diseases and two climatic factors in densely populated areas in Norway and Ireland. Journal of Cardiovascular Risk. 2000;7:369– 75. DOI:10.1177/204748730000700510 7(5):369-75. 22. Carder M, McNamee R, Beverland I, Elton R, Cohen GR, Boyd J, Agius RM. The lagged effect of cold temperature and wind chill on cardiorespiratory mortality in Scotland. Occupational and Environmental Medicine. 2005;62:702–10. DOI:10.1136/oem.2004.016394 23. Deschênes O, Moretti E. Extreme Weather Events, Mortality, and Migration. The Review of Economics and Statistics. 2009;91:659–81. DOI:10.3386/w13227.
Tsygankova D.P., Mulerova T.A., Ogarkov M.Y., Saarela E.Y., Kuz'mina A.A., Kazachek Y.V., Barbarash O.L.
PREVALENCE DYNAMICS OF CARDIOVASCULAR DISEASES RISK FACTORS AMONG SHORIANS UNDER INFLUENCE OF CHANGED LIVING CONDITIONS
Tsygankova Dar'ya Pavlovna ; Research Institute for Complex Issues of Cardiovascular Diseases; Kemerovo State Medical University; Кемерово, Сосновый бульвар, 6; ул. Ворошилова, д. 22а; тел. +7(923)5128909; e-mail: email@example.com
Mulerova Tat'yana Aleksandrovna ; Research Institute for Complex Issues of Cardiovascular Diseases; Кемерово, Сосновый бульвар, 6; тел. +7(960) 9063656; e-mail: firstname.lastname@example.org
Ogarkov Mikhail Yur'evich ; Research Institute for Complex Issues of Cardiovascular Diseases; Novokuznetsk State Institute of Postgraduate Medicine; Кемерово, Сосновый бульвар, 6; Новокузнецк, проспект Строителей, д. 5; тел. +7(905)9009380; e-mail: email@example.com
Saarela Ekaterina Yur'evna ; Kemerovo State Medical University; Кемерово, ул. Ворошилова, д. 22а; тел. +7(904)3759008; e-mail: firstname.lastname@example.org
Kuz'mina Anastasiya Aleksandrovna ; Research Institute for Complex Issues of Cardiovascular Diseases; Кемерово, Сосновый бульвар, 6; e-mail: email@example.com
Kazachek Y. V. ; Research Institute for Complex Issues of Cardiovascular Diseases under the Siberian Branch of the Russian Academy of Medical Sciences; firstname.lastname@example.org
Barbarash O. L. Dr. Med. Sci., Professor; Kemerovo State Medical University; Scientific Research Institute of Complex Problems of Cardiovascular Diseases; email@example.com
The aim of the research. To assess the dynamics of the indicators of the main risk factors for cardiovascular diseases (hypercholesterolemia, hyperglycemia, hypertension, obesity, smoking and alcohol overindulgence) during the last decade among the indigenous inhabitants of Gornaya Shoriya, in connection with the changed living conditions. Material and methods. The study was carried out under expeditionary conditions by a continuous method in two stages. The first stage - in the period of 1998-2002, the second - 2012-2015. 631 and 434 aboriginals were examined, respectively. The examinations were carried out according to a single program and standard methods at the feldsher-midwife stations and in outpatient clinics of district hospitals. Results. During the analyzed 15-year period, the females Shorians were more susceptible to the change in biochemical and clinicalanthropometric indicators than the males Shorians. From all the indicators studied, only the level of blood pressure showed a positive dynamics in the form of a decrease in the mean values of SBP and DBP levels in both sexes, in contrast to the mean values of OXC and glycemia. The average level of fasting glycemia significantly increased in all age groups in both sexes. The most susceptible to the dynamics of behavioral risk factors were the male Shorians: a decrease in smoking in young and middle-aged people was detected, and there was a decrease in the number of people, consumed moderate amounts of alcohol in the younger age group and did not drink alcohol in the older age group. In the above mentioned cohorts there was an increase in the number of people who abused and consumed alcohol in moderate amounts, respectively. At the same time, it was noted the increase in the number of smokers in female Shorians only at the age of 50-59 years. Conclusion. Among the indigenous population of Mountain Shoria over the past 15 years there were some changes in the prevalence of the main RF of the CVD.
Keywords: indigenous people, risk factors, cardiovascular diseases, Shorians, living conditions
1.Oganov RG, Gerasimenko NF, Pogosova GV, Koltunov IE. Cardiovascular prevention: development strategies. Cardiovascular Therapy and Prevention. 2011;10(3):5-7. (In Russian). 2. Maslennikova GYa, Oganov RG, Axelrod SV, Boitsov SA. Reducing mortality from cardiovascular and other non-infectious diseases in economies with high per capita income: the activity of non-government institutions. Cardiovascular Therapy and Prevention. 2015;(6):5-9. (In Russian). 3. Bykovskaya TYu, Piktoushanskaya ТЕ. Regional features of mortality among working aged men in the contemporary conditions. Meditsina Truda i Promyshlennaya Ekologiya. 2011;(2):28-33. (In Russian). 4. Efremova NP, Valeullina NN, Sokolov VD. Dynamics of risk factors distribution of cardiovascular diseases in Chelyabinsk region according to monitoring results for 2002-2010. Meditsina i Obrazovanie v Sibiri. 2014;(1):19- 29. (In Russian). 5. Oganov RG, Timofeeva TN, Koltunov IE, Konstantinov VV, Balanova YuA, Kapustina AV, Lel’chuk IN, Shal’nova SA, Deev AD. Arterial hypertension epidemiology in Russia; the results of 2003-2010 federal monitoring. Cardiovascular Therapy and Prevention. 2011;10(1):9-13. (In Russian). 6. Balanova YuA, Kontsevaya AV, Shal'nova SA, Deev AD, Artamonova GV, Gatagonova TM, Dupliakov DV, Efanov AYu, Zhernakova YuV, Il'in VA, Konradi AO, Libis RA, Minakov AV, Nedogoda SV, Oganov RG, Oshchepkova EV, Romanchuk SA, Rotar' OP, Trubacheva IA, Shlyakhto EV, Boitsov SA. Prevalence of behavioral risk factors for cardiovascular disease in the Russian population: Results of the ESSE-RF epidemiological study. Preventive Medicine. 2014;(5):42-52. (In Russian). 7. Korneeva EV, Trekina NE, Mamina AA. The influence of food related behavior and physical activity on the development of metabolic syndrome in young economically active population living in the Far North areas. Cardiovascular Therapy and Prevention. 2015;14(1):41-6. (In Russian). 8. Ogarkov MYu, Barbarash OL, Kazachek YaV, Kvitkova LV, Policutina OM, Barbarash LS. The prevalence of components of metabolic syndrome X in the indigenous and non-indigenous populations of Gornaya Shoriya. Sibirskiy Nauchnyy Meditsinskiy Zhurnal. 2004;24(1):108-11. (In Russian). 9. Domarkiene S, Tamosiūnas A, Reklaitiene R, Sidlauskiene D, Jureniene K, Margeviciene L, Buivydaite K, Kazlauskaite M. Trends in main cardiovascular risk factors among middle-aged Kaunas population between 1983 and 2002. Medicina (Kaunas). 2003;39(12):1193-9. (In Russian). 10. Akimova EV, Akimov AM, Gakova EI, Kayumova MM, Gafarov VV, Kuznetsov VA. Behavioral risk factors for cardiovascular diseases in men having different work patterns: Results of a cross-sectional epidemiological study. Preventive Medicine. 2016;19(3):49-53. (In Russian). 11. Nemtsov AV. Mortality in Russia in light of the in alcohol consumption. Demographic Review. 2015;2(4):111-35. (In Russian). 12. Dedov II,Shestakova MV, Galstyan GR. The prevalence of type 2 diabetes mellitus in the adult population of Russia (NATION study). Diabetes Mellitus. 2016;19(2):104-12. (In Russian). DOI: 10.14341/DM2004116-17. 13. Dedov II, Shestakova MV, Vikulova OK. National register of diabetes mellitus in Russian Federation: status on 2014. Diabetes Mellitus. 2015;18(3):5- 23. (In Russian). DOI: 10.14341/DM201535-22. 14. Suntsov YuI, Bolotskaya LL, Maslova OV, Kazakov IV. Epidemiology of diabetes mellitus and prognosis of its prevalence in the Russian Federation. Diabetes Mellitus. 2011;(1):15-8. (In Russian). 15. Maslova OV, Suntsov YuI. Epidemiology of diabetes mellitus and microvascular complications. Diabetes Mellitus. 2011;(3):6-11. (In Russian). 16. Suplotova LA, Bel’chikova LN, Rozhnova NA. Epidemiological aspects of type 2 diabetes with the manifestation of the disease at a young age. Diabetes Mellitus. 2012;(1):11–3. (In Russian). 17. Giampaoli S, Vannucchi S. Obesity and diabetes, a global problem: what does recent data tell us? Igiene e Sanità Pubblica. 2016;72(6):561-70. 18. Zhou B, Lu Y, Hajifathalian K, Bentham J, Di Cesare M, Danaei G, Bixby H, Cowan MJ, Ali MK, Taddei C, Lo WC, Reis-Santos B, Stevens GA, Riley LM, Miranda JJ, Bjerregaard P, Rivera JA, Fouad HM, Ma G, Mbanya JC, McGarvey ST, Mohan V, Onat A, Pilav A, Ramachandran A, Romdhane HB, Paciorek CJ, Bennett JE, Ezzati M, Abdeen ZA, Abdul Kadir K, Abu-Rmeileh NM, Acosta-Cazares B, Adams R, Aekplakorn W, Aguilar-Salinas CA, Agyemang C, Ahmadvand A, Al-Othman AR, Alkerwi A, Amouyel P, Amuzu A, Andersen LB, Anderssen SA, Anjana RM, Aounallah-Skhiri H, Aris T, Arlappa N, Arveiler D, Assah FK, Avdicová M, Azizi F, Balakrishna N, Bandosz P, Barbagallo CM, Barceló A, Batieha AM, Baur LA, Romdhane HB, Benet M, Bernabe-Ortiz A, Bharadwaj S, Bhargava SK, Bi Y. Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants. Lancet. 2016;387(10027):32-9. DOI: 10.1016/S0140-6736(16)00618-8. 19. Danaei G, Finucane MM, Lu Y, Singh GM, Cowan MJ, Paciorek CJ, Lin JK, Farzadfar F, Khang YH, Stevens GA, Rao M, Ali MK, Riley LM, Robinson CA, Ezzati M, Abdeen Z, Aekplakorn W, Afifi MM, Agabiti-Rosei E, Salinas CA, Alnsour M, Ambady R, Barbagallo CM, Barceló A, Barros H, Bautista LE, Benetos A, Bjerregaard P, Bo S, Bovet P, Bursztyn M, Cabrera de León A, Castellano M, Castetbon K, Chaouki N, Chen CJ, Chua L, Cífková R, Corsi AM, Delgado E, Doi Y, Esteghamati A, Fall CH, Fan JG, Ferreccio C, Fezeu L, Fuller EL, Giampaoli S, Gómez LF, Carvajal RG, Herman WH, Herrera VM, Ho S, Hussain A, Ikeda N, Jafar TH, Jonas JB, Kadiki OA, Karalis I, Katz J, Khalilzadeh O, Kiechl S, Kurjata P, Lee J, Lee J, Lim S, Lim TO, Lin CC, Lin X, Lin HH, Liu X. National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2-7 million participants. Lancet. 2011;378(9785):557-60. DOI: 10.1016/ S0140-6736(11)60679-X. 20. Defazio G, Esposito M, Abbruzzese G, Scaglione CL, Fabbrini G, Ferrazzano G, Peluso S, Pellicciari R, Gigante AF, Cossu G, Arca R, Avanzino L, Bono F, Mazza MR, Bertolasi L, Bacchin R, Eleopra R, Lettieri C, Morgante F, Altavista MC, Polidori L, Liguori R, Misceo S, Squintani G, Tinazzi M, Ceravolo R, Unti E, Magistrelli L, Coletti Moja M, Modugno N, Petracca M, Tambasco N, Cotelli MS, Aguggia M, Pisani A, Romano M, Zibetti M, Bentivoglio AR, Albanese A, Girlanda P, Berardelli A. The Italian Dystonia Registry: rationale, design and preliminary findings. Neurological Sciences. 2017. DOI: 10.1007/s10072-017-2839-3. [Epub ahead of print] 21. Shestakova MV, Dedov II. Diabetes mellitus and chronic kidney disease. Moskva : Meditsinskoe informatsionnoe agentstvo; 2009. 482 c. (In Russian). 22. Leung L. Diabetes mellitus and the Aboriginal diabetic initiative in Canada: An update review. Journal of Family Medicine and Primary Care. 2016;5(2):259-65. DOI: 10.4103/2249-4863.192362. 23. Ryabova TI. Some questions in the epidemiology of diabetes type 2 among indigenous peoples of the northern territories. Zdravookhranenie Dal'nego Vostoka. 2011;(4):57-60. (In Russian) 24. Babenko LG, Boiko ER. Ethno-social features of obesity and diabetes mellitus morbidity among residents of Russian European North. Proceedings of the Komi Science Centre of the Ural Division of the Russian Academy of Sciences. 2010;(2):32-9. (In Russian). 25. Lyudinina AYu, Potolitsyna NN, Eseva TV, Solonin YuG, Osadchuk LV, Vas’kovskiy VE, Boiko ER. Influence of lifestyle and nutrition types on plasma lipid fatty acids composition in indigenous inhabitants of Russian European North. Izvestiya Samarskogo Nauchnogo Tsentra Rossiyskoy Akademii Nauk. 2012;14(5-2):557-60. (In Russian)
Gerasimov S.N., Posnenkova O.M., Kiselev A.R., Popova Y.V., Popov I.A., Gridnev V.I.
CHARACTERISTICS OF PATIENTS WITH ARTERIAL HYPERTENSION INFLUENCING TO THE ACHIEVEMENT OF TARGET PRESSURE: DATA OF POLYCLINICS OF THE WORKING VILLAGE
Gerasimov SN, Posnenkova OM, Kiselev AR, Popova YuV, Popov IA, Gridnev VI. Characteristics of patients with arterial hypertension influencing to the achievement of target pressure: data of polyclinics of the working village. Siberian Medical Review. 2017;(2):97-103. DOI: 10.20333/2500136-2017-2-97-103.
Gerasimov Stasnislav Nikolaevich ; Saratov State Medical University n.a. V.I. Razumovsky; г. Саратов, ул. Большая Казачья, д. 112; тел.: +7(8452)393978; e-mail: firstname.lastname@example.org.
Posnenkova Olga Mikhailovna, ; Saratov State Medical University n.a. V.I. Razumovsky; г. Саратов, ул. Большая Казачья, д. 112; тел.: +7(8452)393978; e-mail: email@example.com.
Kiselev Anton Robertovich ; Saratov State Medical University n.a. V.I. Razumovsky; Саратов, ул. Большая Казачья, д. 112; тел.: +7(8452)393978; e-mail: firstname.lastname@example.org.
Popova Yulia Viktorovna ; Saratov State Medical University n.a. V.I. Razumovsky; Саратов, ул. Большая Казачья, д. 112; тел.: +7(8452)393978; e-mail: email@example.com.
Popov Ivan Alexseevich ; Saratov State Medical University n.a. V.I. Razumovsky; Саратов, ул. Большая Казачья, д. 112; тел.: +7(8452)393978; e-mail: firstname.lastname@example.org.
Gridnev Vladimir Ivanovich ; Saratov State Medical University n.a. V.I. Razumovsky; г. Саратов, ул. Большая Казачья, д. 112; тел.: +7(8452)393978; e-mail: email@example.com.
The aim of the research. To reveal the clinical characteristics influencing to the achievement of target BP in patients with AH, observed in the polyclinic of the working village of the Saratov region. Material and methods. The data of outpatient cards of 182 patients with essential hypertension (mean age 64.6 ± 11.3 years, 48.5% - men) were studied, they asked for medical care in the polyclinic of the working village of the Saratov region in the period from 01.07.2015 to 31.07 .2015 - the first stage (n = 88) and from 01.07.2016 to 31.07.2016 - the second stage (n = 94). There were included all consecutive patients, visited a district doctor, general practitioner or cardiologist during one randomly chosen reception at the first and second stages. To identify the factors associated with achieving the target blood pressure, we used discriminant analysis. Results. In the study group (n = 182), BP corresponded to the target level in 93 patients with AH (51%). Patients with targeted BP were rarely females (53.8% vs. 69.7, p = 0.028), more likely to have a history of myocardial infarction (22.6% vs. 10.1%, p = 0.024), less likely to have other forms of stable ischemic heart disease (55.9% vs. 73%, p = 0.016), received fewer antihypertensive drugs: 1.63 ± 0.12 versus 1.98 ± 0.11 (p = 0.018). The constructed discriminant model had a high predictive value (OR 5.4 (95% CI 2.7-10.7), p <0.001) and took into account two most significant factors: previous myocardial infarction in the anamnesis (OR 2.6 (95% CI) 1,1 - 6,6), p = 0,032) and the number of prescribed antihypertensive drugs ≥ 2 (OW 0.4 (95% CI 0.2-0.7), p = 0.003). Conclusion. In patients, underwent myocardial infarction and received less than two antihypertensive drugs, the probability of achieving the target blood pressure is 5.4 times higher than in the absence of these factors.
Keywords: hypertension, target arterial pressure, polyclinic, clinical characteristics of patients, blood pressure control
1. Chazova IE, Ratova LG, Boitsov SA, Nebieridze DV. Diagnosis and treatment of arterial hypertension. Russian recommendations (forth revision). Sistemnyie Gipertensii. 2010;(3):5-26. (In Russian) 2. 2013 ESH/ESC Guidelines for the treatment of arterial hypertension. The Task Force for the treatment of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Russian Journal of Cardiology. 2014;1(105):7-94. (In Russian) 3. James PA, Oparil S, Carter BL, Cushman WC, Dennison-Himmelfarb C, Handler J, Lackland DT, LeFevre ML, MacKenzie TD, Ogedegbe O, Smith SC Jr, Svetkey LP, Taler SJ, Townsend RR, Wright JT Jr, Narva AS, Ortiz E. 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). Journal of the American Medical Association. 2014;311(5):507–20. 4. Drozda J Jr, Messer JV, Spertus J, Abramowitz B, Alexander K, Beam CT, Bonow RO, Burkiewicz JS, Crouch M, Goff DC Jr, Hellman R, James T 3rd, King ML, Machado EA Jr, Ortiz E, O'Toole M, Persell SD, Pines JM, Rybicki FJ, Sadwin LB, Sikkema JD, Smith PK, Torcson PJ, Wong JB. ACCF/AHA/AMA-PCPI 2011 Performance Measures for Adults With Coronary Artery Disease and Hypertension: A Report of the American College of Cardiology Foundation/ American Heart Association Task Force on Performance Measures and the American Medical Association – Physician Consortium for Performance Improvement. Circulation. 2011;124:248-70. 5. Posnenkova OM, Korotin AS, Kiselev AR, Gridnev VI, Belova OA, Rachkova SA, Romanchuk SV, Dovgalevsky PYa, Oshchepkova EV. Performance of recommended measures on risk factors control in patients with hypertension, coronary artery disease and chronic heart failure: the data from 2014 Russian registry. Cardio-IT. 2015;2(1):e0102. (In Russian) 6. Belova OA, Rachkova SA, Shutemova EA, Romanchuk SV. Risk factors control in patients with cardiovascular diseases in Ivanovo region: possibilities of a regional registry. Cardio-IT. 2016;3(1):e0102. (In Russian) 7. Gu Q, Burt VL, Dillon CF, Yoon S. Trends in antihypertensive medication use and blood pressure control among United States adults with hypertension. The National Health and Nutrition Examination Survey, 2001 to 2010. Circulation. 2012;126:2105–14. 8. Boitsov SA, Balanova YuA, Shal’nova SA et al. Arterial hypertension among individuals of 25-64 years old: prevalence, awareness, treatment and control. By the data from ECCD. Cardiovascular Therapy and Prevention. 2014;14(4):4-14. 9. Kjeldsen SE, Naditch-Brule L, Perlini S, Zidek W, Farsang C. Increased prevalence of metabolic syndrome in uncontrolled hypertension across Europe: the global cardiometabolic risk profile in patients with hypertension disease survey. Journal of Hypertension. 2008;26(10):2064-70. 10. Pablos-Velasco P, Gonzalea-Albarran O, Estopinan V, Khanbhai A. Blood pressure, antihypertensive treatment and factors associated with good blood pressure control in hypertensive diabetics: the Tarmidas study. Journal of Human Hypertension. 2007;21:664-72. 11. Posnenkova OM, Kiselev AR, Gridnev VI et al. Blood pressure control in primary care patients with arterial hypertension: analysing the Hypertension Register data. Cardiovascular Therapy and Prevention. 2012;11(3):4-11. (In Russian) 12. Hyman DJ, Pavlik VN. Characteristics of patients with uncontrolled hypertension in the United States. The New England Journal of Medicine. 2001;345:479–86. 13. Ho MP, Magid DJ, Shetterly SM, Olson KL, Peterson PN, Masoudi FA, Rumsfeld JS. Importance of therapy intensification and medication nonadherence for blood pressure control in patients with coronary disease. Archives of Internal Medicine. 2008;168(3):271-6. 14. Law MR, Wald NJ, Morris JK, Jordan JK. Value of low dose combination treatment with blood pressure lowering drugs: analysis of 354 randomised trials. BMJ. 2003;326:1427-31. 15. The SPRINT research group. A randomized trial of intensive versus standard blood pressure control. The New England Journal of Medicine. 2015;373(22):2103-16. 16. Shal’nova SA, Deev AD, Balanova YuA. Treatment of hypertension in high-risk patients. Monotherapy or combination? Lechashij Vrach. 2016;7:17-23. (In Russian) 17. Hatori N, Sakai H, Sato K, Miyajima M, Yuasa S, Kuboshima S, Kajiwara K, Hara Y, Minamizawa K, Miyakawa M. A survey of actual clinical practice concerning blood pressure control among patients with hypertension in Kanagawa 2014. Journal of Nippon Medical School. 2016;83:188-95. 18. Maksimova TM, Belov VB, Saurina OS, Lushkina NP. The seasonality of population contacts with medical organizations in connection with diseases of blood circulation system. Problems of Social Hygiene, Public Health and History of Medicine. 2014(4):3-6. (In Russian) 19. Fletcher RD, Amdur R, Kolodner R. The VA electronic health record controls hypertension and eliminates differences due to age. A large multicenter analysis displaying seasonal variation. Circulation. 2008;118:729. 20. Rose G. Seasonal variation in blood pressure in man. Nature. 1961;189:235. 21. Sega R, Cesana G, Bombelli M. Seasonal variations in home and ambulatory blood pressure in the Pamela population. Journal of Hypertension. 1998;16:1585-92. 22. Andreeva G, Deev A, Isaikina O. Quality of life may influence the severity of seasonable variations of the ambulatory blood pressure level in patients with arterial hypertension. Journal of Hypertension. 2013;31(e-Suppl A):e129. 23. Iwabu A, Konishi K, Tokutake H, Yamane S, Ohnishi H, Tominaga Y, Kusachi S. Inverse correlation between seasonal changes in home blood pressure and atmospheric temperature in treated-hypertensive patients. Clinical and Experimental Hypertension. 2010;32:221-6. 24. Modesti PA, Morabito M, Massetti L, Rapi S, Orlandini S, Mancia G, Gensini GF, Parati G. Seasonal blood pressure changes: an independent relationship with temperature and daylight hours. Hypertension. 2013;61(4):908-14. 25. Smirnova MI, Gorbunov VM, Boitsov SA, Luk'yanov MM, Deev AD, Platonova EV, Andreeva GF, Belova EN, Kalinina AM, Romanchuk SV, Nazarova OA, Belova OA, Rachkova SA, Kravtsova EA, Dovgalevskiy PYA, Furman NV, Kuvshinova LE. Seasonal variations in hemodynamic parameters in patients with controlled hypertension and prehypertension in two Russian Federation regions with different climatic characteristics. Part 1. Study design and preliminary results. Profilakticheskaya Meditsina. 2013;(6):71-8. (In Russian)
Chepurnenkо S.A., Artyukhova N.V., Shavkuta G.V.
THREE- AND SIX-MONTH EXPERIENCE OF EPLERENONE USE IN PATIENTS WITH ISCHEMIC DILATION CARDIOPATHY WITHOUT SIGNS OF DECOMPENSATION
Chepurnenko SA, Artyukhovа NV, Shavkuta GV. Three- and six-month experience of eplerenone USE in patients with ischemic dilation cardiopathy without signs of decompensation. Siberian Medical Review. 2017; (2):103-108. DOI: 10.20333/2500136-2017-2-103-108.
Chepurnenkо Svetlana Anatolievna ; Rostov State Medical University; Rostov Regional Clinical Hospital; г. Ростов-на-Дону, пер. Нахичеванский, д. 29; Ростовская областная клиническая больница; ул. Благодатная 170; тел.: +7(918)5072893; e-mail: сh.firstname.lastname@example.org
Artyukhova Nina Vladimirovna ; Rostov State Medical University; г. Ростов-на-Дону, пер. Нахичеванский, д. 29; тел.: +7(928)1515465; e-mail: email@example.com
Shavkuta Galina Vladimirovna ; Rostov State Medical University; г. Ростов-на-Дону, пер. Нахичеванский, д. 29; тел.:+7(909)4069504; e-mail:firstname.lastname@example.org
The aim of the research. To assess the possibility of slowing the progression of ischemic dilated cardiac pathology by adding a selective antagonist of mineralocorticoid receptors-eplerenone to standard therapy. Material and methods. The work was based on the results of clinical and instrumental studies in patients with ischemic dilated cardiopathy without clinical signs of decompensation. The ischemic origin of cardiopathy is confirmed by the results of coronary angiography and / or myocardial infarction in the anamnesis. Patients of the main and control groups were assigned ramipril, nebivolol, enteric-soluble form of acetylsalicylic acid and rosuvastatin in the maximum tolerated doses. In the main group, eplerenone has been added to the therapy under the control of the electrolyte level. The patients of the control group did not receive eplerenone. Results. Therapy for 3 and 6 months, by selective antagonist of mineralocorticoid receptors eplerenone in addition to standard treatment leads to a significant decrease in the final diastolic size of the left ventricle, the final diastolic size of the right ventricle. Reduces the degree of regurgitation on the mitral and tricuspid valves. There is a significant increase in the test of a six-minute walk. Despite the long reception of this drug, the level of potassium and sodium remains within normal limits. In the control group, an increase in the diastolic size of the right ventricle is observed, and the final diastolic dimension of the left ventricle does not change reliably. The expression of regurgitation on the mitral and tricuspid valves also increases. The result of treatment depends on the degree of dilatation of the left ventricle before the start of the drug. The effect of therapy is more pronounced in patients with higher end-diastolic values of the left ventricle. Conclusion. When eplerenone is added to standard therapy with angiotensin-converting enzyme inhibitors, beta-blockers, statins and antiplatelet agents, an effective improvement of cardiohemodynamic parameters and functional state of the myocardium is observed. The functional class of chronic heart failure decreases. Despite the long reception of eplerenone, the level of potassium and sodium remains within normal limits
Keywords: eplerenone, chronic heart failure, cardiohemodynamics
1. Karpov YuA. Eplerenone: improved prognosis in patients with chronic heart failure of ischemic pathology. Atmosphere. News of Cardiology. 2014;2:28-37. (In Russian) 2. Andreev DA. Antagonists of mineralocorticoid receptor in clinical practice. Consiliummedicum. 2013;15(5):67-70. (In Russian) 3. Zannad F, McMurray JJ, Krum H, van Veldhuisen DJ, Swedberg K, Shi H, Vincent J, Pocock SJ, Pitt B. Eplerenone in patients with systolic heart failure and mild symptoms. The New England Journal of Medicine. 2011;364:11-21. 4. Chronic heart failure: management of chronic heart failure in adults in primary and secondary care. London: National Institute for Clinical Excellence (NICE). 2010:. 5. Armanini D, Sabbadin C, Donà G, Clari G, Bordin L. Aldosterone receptor blockers spironolactone and canrenone: two multivalent drugs. Expert Opinion on Pharmacotherapy. 2014;12:909-12. 6. Soboleva VN, Taratukhin EO. Mineralocorticoid antagonists: selectivity gives more opportunities for heart failure therapy. Russian Journal of Cardiology. 2015;1:104–24. (In Russian) 7. Maron BA, Leopold JA. ldosterone receptor antagonists: effective but often forgotten. Circulation. 2010;121(7):934–9. 8. Schepkens H, Vanholder R, Billiouw JM, Lameire N. Lifethreatening hyperkalemia during combined therapy with angiotensinconvertingenzyme inhibitors and Spironolactone: an analysis of 25 cases. The American Journal of Medicine. 2001;110:438–41. 9. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012. European Heart Journal. 2012;33:1787–847. 10. Zannad F, McMurray JJ, Krum H, van Veldhuisen DJ, Swedberg K, Shi H, Vincent J, Pocock SJ, Pitt B. Eplerenone in patients with systolic heart failure and mild symptoms. The New England Journal of Medicine. 2011;364(1):11–21. 11. Steg PG, James SK, Atar D, Badano LP, Blömstrom-Lundqvist C, Borger MA, Di Mario C, Dickstein K, Ducrocq G, Fernandez-Aviles F, Gershlick AH, Giannuzzi P, Halvorsen S, Huber K, Juni P, Kastrati A, Knuuti J, Lenzen MJ, Mahaffey KW, Valgimigli M, Widimsky P, Zahger D. ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. European Heart Journal. 2012;33(20):2569–619. 12. Rogers JK, McMurray JJ, Pocock SJ, Zannad F, Krum H, Dirk J, Swedberg KV, Shi H, Vincent J, Pitt B. Eplerenone in patients with systolic heart failure and mild symptoms: analysis of repeat hospitalizations. Circulation. 2012;126:2317—2323. 13. Rassi AN, Cavender MA, Fonarow GC, Cannon CP, Hernandez AF, Peterson ED, Peacock WF, Laskey WK, Rosas SE, Zhao X, Schwamm LH, Bhatt DL. Temporal trends and predictors in the use of aldosterone antagonists post-acute myocardial infarction. Journal of the American College of Cardiology. 2013;61(1):35–40. 14. Chan PS, Soto G, Jones PG, Nallamothu BK, Zhang Z, Weintraub WS, Spertus JA. Insight From the Eplerenone Post-Acute Myocardial Infarktion Heart Failure Efficacy and Survival Stydy (EPHESUS). Journal of therapy. 2009;199;:398-407. 15. Weber KT. Aldosterone in congestive heart failure. The New England Journal of Medicine. 2001(345):1689-97. 16. McMurray JJ, Pitt B, Latini R, Maggioni AP, Solomon SD, Keefe DL, Ford J, Verma A, Lewsey J. Effects of the oral direct renin inhibitor aliskiren in patients with symptomatic heart failure. Circulation. Heart Failure. 2008;1:17-24. 17. Yamaji M, Tsutamoto T, Kawahara C, Nishiyama K, Yamamoto T, Fujii M, Horie M. Effect of Eplerenone versus spironolactone on cortisol and hemoglobin A1c levels in patients with chronic heart failure. American Heart Journal. 2010;160(5):915–21. 18. Edelmann F, Schmidt AG, Gelbrich G, Binder L, Herrmann-Lingen C, Halle M, Hasenfuss G, Wachter R, Pieske B. Rationale and design of the “aldosterone receptor blockade in diastolic heart failure” trial: a doubleblind, randomized, placebo-controlled, parallel group study to determine the effects of spironolactone on exercise capacity and diastolic function in patients with symptomatic diastolic heart failure (Aldo-DHF). European Journal of Heart Failure. 2010;12(8):874–82. 19. Kritis AA, Gouta CP, Liaretidou EI, Kallaras KI. Latest aspects of aldosterone action on the heart muscle. Journal of Physiology and Pharmacology. 2016;67(1):21–30. 20. Atroshchenko ES. The role of aldosterone in the pathogenesis of chronic heart failure and the effectiveness of its antagonists. Medical News. 2012;8:4-8. (In Russian) 21. Masson S, Latini R, Milani V, Moretti L, Grazia MR, Carbonieri E, Frisinghelli A, Minneci C, Valisi M, Maggioni PA, Marchioli R, Tognoni G, Tavazzi. Prevalence and Prognostic Value of Elevated Urinary Albumin Excretion in Patients With Chronic Heart Failure Clinical perspective. Circulation. Heart Failure. 2010;3:65–72. 22. Gilyarevsky SP, Golshmid MB, Kuz’mina IM. The blockade of the mineralocorticoid receptor in the treatment of patients with cardiovascular disease: clinical and pharmacological aspects of the use of eplerenone. Heart: a magazine for practicing physicians. 2016;3(89):143- 50. (In Russian) 23. Danjuma MI, Mukherjee I, Makaronidis J, Osula S. Converging indications of aldosterone antagonists (spironolactone and eplerenone): a narrative review of safety profiles. Current Hypertension Reports. 2014(16):414. 24. Savoia C, Touyz RM, Amiri F, Schiffrin EL. Selective mineralocorticoid receptor blocker eplerenone reduces resistance artery stiffness in hypertensive patients. Hypertension. 2008;51:432-9. 25. Osmolovskaya YuF, Tereshchenko SN, Zhirov IV. Mineralocorticoid receptor antagonists place in the treatment of patients with CHF. ConsiliumMedicum. 2013;10:70-4. (In Russian)
Kozik V.A., Lozhkina N.G., Glebchenko E.A., Khasanova M.H., Kuimov A.D.
MYOCARDIAL INFARCTION IN A PATIENT WITH COMPLICATED ANATOMY OF CORONARY VESSELS AND ANEMIC SYNDROME
Kozik VA, Lozhkina NG, Glebchenko EA, Khasanova MH, Kuimov A D. Myocardial infarction in a patient with complicated anatomy of coronary vessels and anemic syndrome. Siberian Medical Review. 2017;(2):109-111. DOI: 10.20333/2500136-2017-2-109-111.
Kozik Valentina Alexandrovna ; Novosibirsk State Medical University; г. Новосибирск, ул. Красный проспект, д. 52; тел.: +7(383)2223204; e-mail: email@example.com
Lozhkina Natalia Gennadievna ; Novosibirsk State Medical University; г. Новосибирск, ул. Красный проспект, д. 52; тел.: +7(383)2223204; e-mail: firstname.lastname@example.org
Glebchenko Elena Alexandrovna ; Novosibirsk State Medical University; г. Новосибирск, ул. Красный проспект, д. 52; тел.: +7(383)2223204; e-mail: email@example.com
Khasanova Madina Huseynovna ; Novosibirsk State Medical University; г. Новосибирск, ул. Красный проспект, д. 52; тел +7(383)2223204; e-mail: firstname.lastname@example.org
Kuimov Andrey Dmitrievich Doctor of Medical Sciences, Professor, Head of the Department of faculty therapy; Novosibirsk State Medical University; email@example.com
The article presents a clinical case of myocardial infarction in a patient with complicated anatomy of coronary vessels and anemic syndrome. The authors demonstrated how a reasonable assessment of the risks and benefits of invasive and medically-oriented coronary vasculitis reperfusion resulted to a favorable outcome in a patient with increased risk of fatal cardiovascular complications.
Keywords: myocardial infarction, anemic syndrome, complex anatomy of coronary vessels.
1. Thygesen K, Alpert JS, Jaffe AS, Simoons ML, Chaitman BR, White HD. Third universal definition of myocardial infarction. European Heart Journal. 2012;33(20):2551–67. DOI:10.1093/eurheartj/ehs184. 2. O'Gara PT, Kushner FG, Ascheim DD, Casey DE Jr, Chung MK, de Lemos JA, Ettinger SM, Fang JC, Fesmire FM, Franklin BA, Granger CB, Krumholz HM, Linderbaum JA, Morrow DA, Newby LK, Ornato JP, Ou N, Radford MJ, Tamis-Holland JE, Tommaso JE, Tracy CM, Woo YJ, Zhao DX. ACCF/AHA Guideline for the management of ST-elevation myocardial infarction: executive summary: a report of the american college of cardiology foundation. American Heart Association Task Force on Practice Guidelines. Circulation. 2013;127(4):529–55. DOI: 10.1161/CIR.0b013e3182742c84. 3. Steg PG, James SK, Atar D, Badano LP, Blömstrom-Lundqvist C, Borger MA, Di Mario C, Dickstein K, Ducrocq G, Fernandez-Aviles F, Gershlick AH, Giannuzzi P, Halvorsen S, Huber K, Juni P, Kastrati A, Knuuti J, Lenzen MJ, Mahaffey KW, Valgimigli M, van 't Hof A, Widimsky P, Zahger D. ESС Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. European Heart Journal. 2012;33(20):2569–619. DOI: 10.1093/eurheartj/ehs215. 4. Mohr FW, Davierwala PM. ESC/EACTS guidelines on myocardial revascularization post-SYNTAX. European Journal of Cardio- Thoracic Surgery. 2014;46(4):511–3. DOI: 10.1093/ejcts/ezu346. 5. Cequier Á, Maroto LC, Alfonso F, Barrabés J, Cánovas S, Carnero M, Fernandez-Ortiz A, Sabaté M, Sanchis J, Reyes G, Alegría E, Arós F, Cuenca J, Díaz J, Lidón RM, Gude M, Lozano I, Ruiz-Nodar JM, de la Torre JM, Pan M, Sanchez-Recalde Á, Anguita M, Badimón L, Barrabés J, Cequier Á, Comín J, Fernández-Lozano I, Pan M, Padial LR, Sánchez PL, Román AS, de Diego JJ. Comments on the 2014 ESC/ EACTS Guidelines on Myocardial Revascularization. Revista Espanola de Cardiologia. 2015;68(2):92-7. DOI: 10.1016/j.rec.2014.12.004. 6. Lozhkina NG, Maksimov VN, Kuimov AD, Ragino YuI, Voevoda MI. Multifactor predicting of long-term outcomes of acute coronary syndrome with persistent ST-segment elevation. Russian Journal of Cardiology. 2015;(9):25-31. (In Russian). 7. Aronson D. Subgroup analyses with special reference to the effect of antiplatelet agents in acute coronary syndromes. Thrombosis and Haemostasis. 112(1):16-25. DOI: 10.1160/TH13-09-0801. 8. Windecker S, Kolh P, Alfonso F, Collet JP, Cremer J, Falk V, Filippatos G, Hamm C, Head SJ, Jüni P, Kappetein AP, Kastrati A, Knuuti J, Landmesser U, Laufer G, Neumann FJ, Richter DJ, Schauerte P, Sousa Uva M, Stefanini GG, Taggart DP, Torracca L, Valgimigli M, Wijns W, Witkowski A. 2014 ESC/EACTS Guidelines on myocardial revascularization: The Task Force on Myocardial Revascularization of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)Developed with the special contribution of the European Association of Percutaneous Cardiovascular Interventions (EAPCI). European Heart Journal. 2014; 35(37):2541-619. DOI: 10.1093/eurheartj/ehu278. 9. Costa F, Ariotti S, Valgimigli M, Kolh P, Windecker S. Perspectives on the 2014 ESC/EACTS Guidelines on Myocardial Revascularization : Fifty Years of Revascularization: Where Are We and Where Are We Heading? Journal of Cardiovascular Transliational Research. 2015;8(4):211-20. DOI: 10.1007/s12265-015-9632-6. 10. Bonello L, Laine M, Puymirat E, Lemesle G, Thuny F, Paganelli F, Michelet P, Roch A, Kerbaul F, Boyer L. Timing of Coronary Invasive Strategy in Non-ST-Segment Elevation Acute Coronary Syndromes and Clinical Outcomes: An Updated Meta-Analysis. JACC Cardiovascular Interventions. 2016;9(22):2267-76. DOI: 10.1016/j.jcin.2016.09.017.
Shesternya P.A., Vasileva A.O., Shkil L.M., Onishchenko S.B., Mikhailova K.M., Nikitina M.A.
SYNDROME TIETZE -INTERDISCIPLINARY CLINICAL CASE
Shesternya PA, Vasileva AO, Shkil LM, Onishchenko SB, Mikhailova KO, Nikitina MA. Syndrome Tietze – interdisciplinary clinical case. Siberian Medical Review. 2017;(2):112-116. DOI: 10.20333/2500136-2017-2-112-116.
Shesternya Pavel Anatolievich Cand.Med.Sc., Professor of the Department of Internal Diseases №1; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; firstname.lastname@example.org
Vasileva Aleksandra Olegovna ; Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University; г. Красноярск, ул. Партизана Железняка, д. 1; тел.: +7(913)1806923; email: email@example.com
Shkil Lyudmila Mikhailovna ; I.S. Berzon Krasnoyarsk Interdistrict Clinical Hospital № 20; Российская Федерация, 660014, г. Красноярск, ул. Инстументальная, д. 12А; тел.: +7(913)0450163
Onishchenko Sergei Borisovich ; I.S. Berzon Krasnoyarsk Interdistrict Clinical Hospital № 20; г. Красноярск, ул. Инстументальная, д. 12 А; тел.: +7(913)5320052
Mikhailova Ksenia Mihaylova ; Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University; г. Красноярск, ул. Партизана Железняка, д. 1; тел.: +7(929)3392633; email: firstname.lastname@example.org
Nikitina Margarita Aleksandrovna ; Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University; г. Красноярск, ул. Партизана Железняка, д. 1; тел.: +7(923)2926790; email: email@example.com
Pain in the chest is one of the most frequent complaints when seeking medical care. Moreover, diseases of the musculoskeletal system are the leading causes of pain in the anterior chest wall. Costochondritis and Tietze syndrome - inflammation of the rib-chest joints are not so rare, as undeservedly forgotten diseases. The article contains the own clinical case of the Tietze syndrome and an overview of current publications on this topic. Particular attention is paid to a multidisciplinary approach in differential diagnostics and verification of the diagnosis at an early stage
Keywords: Tietze syndrome, thoracalgia, osteochondritis
1. Golovyuk AL, Chernova TG. The Tietze syndrome. Khirurgiya. Zhurnal im. N.I. Pirogova. 2009;(10):65-8. (In Russian). 2. Lanham DA, Taylor AN, Chessell SJ, Lanham JG. Non-cardiac chest pain: a clinical assessment tool. British Journal of Hospital Medicine. 2015; 76(5):296-300.DOI: 10.12968/hmed.2015.76.5.296. 3. Gräni C, Senn O, Bischof M, Cippà PE, Hauffe T, Zimmerli L, Battegay E, Franzen D. Diagnostic performance of reproducible chest wall tenderness to rule out acute coronary syndrome in acute chest pain: a prospective diagnostic study. British Medical Journal. 2015;(5):e007442.DOI: 10.1136/ bmjopen-2014-007442. 4. Bösner S, Bönisch K, Haasenritter J, Schlegel P, Hüllermeier E, Donner-Banzhoff N. Chest pain in primary care: is the localization of pain diagnostically helpful in the critical evaluation of patients? - A cross sectional study. BMC Family Practice. 2013;(14):154.DOI: 10.1186/1471-2296-14-154. 5. Shmyrev VI, Vasilyev AS, Vasilyeva VV. Thoracalgia syndrome in clinical practice. Vrach. 2009;(12):66-9. (In Russian). 6. Mokrysheva NG. Tietze disease course in different age groups. Spravochnik fel'dshera i akusherki. 2013;218-22 (In Russian). 7. Volterrani L, Mazzei MA, Giordano N, Nuti R, Galeazzi M, Fioravanti A.. Magnetic resonance imaging in Tietze's syndrome. Clinical and Experimental Rheumatology. 2008; 26(5):848-853. 8. Jeon IH, Jeong WJ, Yi JH, Kim HJ, Park IH. Non-Hodgkin's lymphoma at the medial clavicular head mimicking Tietze Syndrome. Rheumatology international. 2012;32(8):2531-4.DOI: 10.1007/s00296-010-1397-2. 9. Kaplan T, Gunal N, Gulbahar G, Kocer B, Han S, Eryazgan MA, Ozsoy A, Naldoken S, Alhan A, Sakinci U. Painful Chest Wall Swellings: Tietze Syndrome or Chest Wall Tumor? The Thoracic and Cardiovascular Surgeon. 2016; 64 (3):239-244.DOI: 10.1055/s-0035-1545261. 10. Proulx AM, Zryd TW. Diagnosis and Treatment. American Family Physician. 2009;80(6):617-20.