Alzheimer's disease (AD) is a chronic neurodegenerative disorder, initial symptoms of which are manifested typically in 8-10 years before the diagnosis of dementia, and is characterized by progressive memory loss and cognitive impairment. Pathological signs of AD include the accumulation of extracellular senile plaques and intracellular neurofibrillar tangles. Today, AD is an incurable disease with enormous social and economic consequences, and insufficient study of molecular events that underlie in the base of the development of this pathology. The experimental AD model, used in scientific research, aimed at solving a wide variety of tasks, such as searching for molecules - targets, identifying risk factors for disease development, preclinical and clinical studies of pharmaceutical products, etc., thus contributing to the explanation of the complex interactions that occur on molecular and cellular levels and, consequently, a better understanding of AD ethiopathogenesis, as well as a therapeutic effective screening. This scientific review of literature are discussed various experimental AD models are identified and analyzed their advantages and disadvantages.

1.	 Damulin I.V. Alzheimer's disease and vascular dementia / Ed. NN. Yahno. M., 2002. 85 p.
2.	 Alberts B., Johnson A., Lewis J., Raff M., Roberts K., Walter P. Molecular Biology of the Cell, 4th edition. - New York: Garland Science, 2002. 1616 p.
3.	 Alkadhi K., Eriksen J. The Complex and Multifactorial Nature of Alzheimer's Disease . Curr. Neuropharmacol. 2011; Vol. 9: P. 586.
4.	 Barini E., Antico O., Zhao Y., Asta F., Tucci V., Catelani T., Marotta R., Xu H., Gasparini L. Metformin promotes tau aggregation and exacerbates abnormal behavior in a mouse model of tauopathy . Mol. Neurodegener. 2016; Vol. 11. DOI: 10.1186/s13024-016-0082-7.
5.	 Bird T.D. Alzheimer Disease Overview Electronic resource]. Available from: http:.www. ncbi.nlm.nih.gov/books/NBK1161/.
6.	 Bird T.D. Genetic Aspects of Alzheimer Disease . Genet. Med. 2008; Vol. 10: P. 231-239.
7.	 Brewer G.J, Torricelli J.R. Isolation and culture of adult neurons and neurospheres . Nat. Protoc. 2007; Vol. 2: P. 1490-1498.
8.	 Bue e L., Bussie re T., Bue e-Scherrer V., Delacourte A., Hof P.R. Tau protein isoforms, phosphorylation and role in neurodegenerative disorders . Brain Res. Brain Res Rev. 2000; Vol. 33: P. 95-130.
9.	 Cataldo J.K., Prochaska J.J. Cigarette smoking is a risk factor for Alzheimer's Disease: an analysis controlling for tobacco industry affiliation . J. Alzheimers Dis. 2010; Vol. 19: P. 465-480.
10.	 Chen W.W., Blurton-Jones M. Concise review: Can stem cells be used to treat or model Alzheimer's disease? . Stem Cells. 2012; Vol. 30: P. 2612-2618.
11.	 Chin J. Selecting a mouse model of Alzheimer's disease . Methods Mol. Biol. 2011; Vol. 670: P. 169-189.
12.	 Choi S.H., Kim Y.H., Hebisch M., Sliwinski C., Lee S., D'Avanzo C., Chen H., Hooli B., Asselin C., Muffat J., Klee J.B., Zhang C., Wainger B.J., Peitz M., Kovacs D.M., Woolf C.J., Wagner S.L., Tanzi R.E., Kim D.Y.A three-dimensional human neural cell culture model of Alzheimer's disease . Nature. 2014; Vol. 515: P. 274-278.
13.	 Choi Y.J., Chae S., Kim J.H., Barald K.F., Park J.Y., Lee S.H. Neurotoxic amyloid beta oligomeric assemblies recreated in microfluidic platform with interstitial level of slow flow . Sci Rep. 2013; Vol. 3. DOI: 10.1038/srep01921.
14.	 Cook C., Rockwood K. Knowledge translation: an overview and recommendations in relation to
the Fourth Canadian Consensus Conference on the Diagnosis and Treatment of Dementia . Alzheimers Res. Ther. 2013; Vol. 5. DOI: 10.1186/alzrt202.
15.	 Cuadrado-Tejedor M., Garda-Osta A. Current Animal Models of Alzheimer's Disease: Challenges in Translational Research . Front Neurol. 2014.
- Vol. 5. DOI: 10.3389/fneur.2014.00182.
16.	 Dolan P.J., Johnson G.V. The role of tau kinases in Alzheimer's disease . Curr. Opin. Drug Discov Devel. 2010; Vol. 13: P. 595-603.
17.	 Edmondson R., Broglie J.J., Adcock A.F., Yang L. Three-Dimensional Cell Culture Systems and Their Applications in Drug Discovery and Cell- Based Biosensors . Assay Drug Dev. Technol. 2014; Vol. 12: P. 207-218.
18.	 Eisenstein M. Genetics: Finding risk factors . Nature. 2011; Vol. 475. DOI:10.1038/475S20a.
19.	 Elder G.A., Gama Sosa M.A., De Gasperi R. Transgenic Mouse Models of Alzheimer's Disease . PMC. 2010; Vol. 77: P. 69-81.
20.	 Gordon J., Amini S., White M.K. General overview of neuronal cell culture . Methods Mol. Biol. 2013; Vol. 1078: P. 1-8.
21.	 Gottlieb S. Head injury doubles the risk of Alzheimer's disease . BMJ. 2000; Vol. 321: P. 1100.
22.	 Hardy J., Selkoe D.J. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics . Science. 2002; Vol. 297: P. 353-356.
23.	 Hochgrafe K., Sydow A., Mandelkow E.M. Regulatable transgenic mouse models of Alzheimer disease: onset, reversibility and spreading of Tau pathology . FEBS J. 2013; Vol. 280: P. 4371-4381.
24.	 Houdebine L.M. Transgenic animal models in biomedical research . Methods Mol. Biol. 2007; Vol. 360: P. 163-202.
25.	 Hyman B.T. Tau propagation, different tau phenotypes, and prion-like properties of tau . Neuron. 2014; Vol. 82: P. 1189-1190.
26.	 Jean Y.Y., Baleriola J., Fa M., Hengst U., Troy C.M. Stereotaxic Infusion of Oligomeric Amyloid- beta into the Mouse Hippocampus . J. Vis Exp. 2015; Vol. 100. - e52805.
27.	 Justin B.N., Turek M., Hakim A.M. Heart disease as a risk factor for dementia . Clin. Epidemiol. 2013; Vol. 5: P. 135-145.
28.	 Kokjohn T.A., Roher A.E. Amyloid precursor protein transgenic mouse models and Alzheimer's disease: Understanding the paradigms, limitations and contributions . Alzheimers Dement. 2009; Vol. 5: P. 340-347.
29.	 Kondo T., Asai M., Tsukita K., Kutoku Y., Ohsawa Y., Sunada Y., Imamura K., Egawa N., Yahata N., Okita K., Takahashi K., Asaka I., Aoi T., Watanabe A., Watanabe K., Kadoya C., Nakano R., Watanabe D., Maruyama K., Hori O., Hibino S., Choshi T., Nakahata T., Hioki H., Kaneko T., Naitoh M., Yoshikawa K., Yamawaki S., Suzuki S., Hata R., Ueno S., Seki T., Kobayashi K., Toda T., Murakami K., Irie K., Klein W.L., Mori H., Asada T., Takahashi R., Iwata N., Yamanaka S., Inoue H. Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Ap and differential drug responsiveness . Cell Stem Cell. 2013; Vol. 12: P. 487-496.
30.	 LaFerla F.M., Green K.N. Animal Models of Alzheimer Disease . Cold Spring Harb Perspect Med. 2012; Vol. 2. - a006320.
31.	 Li Y. Establishment of experimental models for Alzheimer's disease research . Int. J. Neurosci. 2013; Vol. 123: P. 823-831.
32.	 Lindsay J., Laurin D., Verreault R., Hebert R., Helliwell B., Hill G.B., McDowell I. Risk factors for Alzheimer's disease: a prospective analysis from the Canadian Study of Health and Aging . Am. J. Epidemiol. 2002; Vol. 156: P. 445-453.
33.	 Lithner C.U., Hedberg M.M., Nordberg A. Transgenic mice as a model for Alzheimer's disease . Curr. Alzheimer Res. 2011; Vol. 8: P. 818-831.
34.	 Lodish H., Berk A., Zipursky L., Matsudaira P., Baltimore D., Darnell J. Molecular Cell Biology, 4th edition. New York: W. H. Freeman, 2000. - 1184 p.
35.	 Lott I.T., Head E. Down syndrome and Alzheimer's disease: a link between development and aging . Ment. Retard Dev. Disabil. Res. Rev. 2001; Vol. 7: P. 172-178.
36.	 Maksimenko O.G., Deykin A.V., Khodarovich Y.M., Georgiev P.G. Use of Transgenic Animals in Biotechnology: Prospects and Problems . Acta Naturae. 2013; Vol. 5: P. 33-46.
37.	 Mancuso C., Gaetani S. Preclinical and clinical issues in Alzheimer's disease drug research and development . Front. Pharmacol. 2014; Vol. 5. DOI: 10.3389/fphar.2014.00234.
38.	 Massoud F., Leger G.C. Pharmacological treatment of Alzheimer disease . Can. J. Psychiatry. 2011; Vol. 56: P. 579-588.
39.	 National Institute on Aging [Electronic resource]. Available from: https:.www.nia.nih. gov/alzheimers/topics/alzheimers-basics.
40.	 Nestor P.J., Graham K.S., Bozeat S., Simons J.S., Hodges J.R. Memory consolidation and the hippocampus: further evidence from studies of autobiographical memory in semantic dementia and frontal variant frontotemporal dementia . Neuropsychologia. 2002; Vol. 40: P. 633-654.
41.	 O'Brien R.J., Wong P.C. Amyloid Precursor Protein Processing and Alzheimer's Disease . Annu Rev. Neurosci. 2011; Vol. 34: P. 185-204.
42.	 O'Mathйna D.P. Bioethics and biotechnology . Cytotechnology. 2007; Vol. 53: P. 113-119.
43.	 Ownby R.L., Crocco E., Acevedo A., John V., Loewenstein D. Depression and risk for Alzheimer disease: systematic review, meta-analysis, and metaregression analysis . Arch. Gen. Psychiatry. 2006; Vol. 63: P. 530-538.
44.	 Prince M., Wimo A., Guerchet M., Ali G-C., Wu Y-T., Prina M. World Alzheimer Report 2015 The Global Impact of Dementia [Electronic resource]. Available from: https:.www.alz.co.uk/ research/world-report-2015.
45.	 Rademakers R., Cruts M., van Broeckhoven A.	The role of tau (MAPT) in frontotemporal dementia and related tauopathies . Hum. Mutat. 2004; Vol. 24: P. 277-295.
46.	 Ren Y., Kunze A., Renaud P. Compartmentalized Microfluidics for In Vitro Alzheimer's Disease Studies . Neuromethods. 2015; Vol. 103: P. 197-215.
47.	 Ruiz H.H., Chi T., Shin A.C., Lindtner C., Hsieh W., Ehrlich M., Gandy S., Buettner C. Increased susceptibility to metabolic dysregulation in a mouse model of Alzheimer's disease is associated with impaired hypothalamic insulin signaling and elevated BCAA levels . Alzheimers Dement. 2016; Vol. 12: P. 851-861.
48.	 Sanders D.W., Kaufman S.K., DeVos S.L., Sharma A.M., Mirbaha H., Li A., Barker S.J., Foley A.C., Thorpe J.R., Serpell L.C., Miller T.M., Grinberg L.T., Seeley W.W., Diamond M.I. Distinct tau prion strains propagate in cells and mice and define different tauopathies . Neuron. 2014; Vol. 82: P. 1271-1288.
49.	 Saraceno C., Musardo S., Marcello E., Pelucchi S., Di Luca M. Modeling Alzheimer's disease: from past to future . Front. Pharmacol. 2013; Vol. 4. DOI: 10.3389/fphar.2013.00077.
50.	 Sharp E.S., Gatz M. The Relationship between Education and Dementia An Updated Systematic Review . Alzheimer Dis. Assoc. Disord. 2011; Vol. 25: P. 289-304.
51.	 Simic G., Babic Leko M., Wray S., Harrington A.	, Delalle I., Jovanov-Milos eviC N., Bazadona B., Buee L., de Silva R., Di Giovanni G., Wischik C., Hof P.R. Tau Protein Hyperphosphorylation and Aggregation in Alzheimer's Disease and Other Tauopathies, and Possible Neuroprotective Strategies . Biomolecules. 2016; Vol. 6. DOI: 10.3390/biom6010006.
52.	 Son S.M., Song H., Byun J., Park K.S., Jang H.C., Park Y.J., Mook-Jung I. Accumulation of autophagosomes contributes to enhanced amyloidogenic APP processing under insulin- resistant conditions . Autophagy. 2012; Vol. 8: P. 1842-1844.
53.	 Stoppelkamp S., Bell H.S., Palacios-Filardo J., Shewan D.A., Riedel G., Platt B. In vitro modelling of Alzheimer's disease: degeneration and cell death induced by viral delivery of amyloid and tau . Exp. Neurol. 2011; Vol. 229: P. 226-237.
54.	 Sykora P., Misiak M., Wang Y., Ghosh S., Leandro G.S., Liu D., Tian J., Baptiste B.A., Cong W.N., Brenerman B.M., Fang E., Becker K.G., Hamilton R.J., Chigurupati S., Zhang Y., Egan J.M., Croteau D.L., Wilson D.M. 3rd, Mattson M.P., Bohr V.A. DNA polymerase в deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes . Nucleic Acids Res. 2015; Vol. 43: P. 943-959.
55.	 Tolmachov O. Designing plasmid vectors . Methods Mol. Biol. 2009; Vol. 542: P. 117-129.
56.	 Waring S.C., Rosenberg R.N. Genome-Wide Association Studies in Alzheimer Disease . Arch. Neurol. 2008; Vol. 65: P. 329-334.
57.	 Wisniewski H.M. Milestones in the history of Alzheimer disease research . Prog. Clin. Biol Res.1989; Vol. 317: P. 1-11.
58.	 World Population Prospects: The 2010 Revision. New York: United Nations, 2011: 503 p.
59.	 Yiannopoulou K.G., Papageorgiou S.G. Current and future treatments for Alzheimer's disease . Ther. Adv. Neurol. Disord. 2013; Vol. 6: P. 19-33.
60.	 Zhang X.G., Wang X., Zhou T.T., Wu X.F., Peng Y., Zhang W.Q., Li S., Zhao J. Scorpion Venom Heat-Resistant Peptide Protects Transgenic Caenorhabditis elegans from p-Amyloid Toxicity . Front Pharmacol. 2016; Vol. 7. DOI: 10.3389/fphar.2016.00227.

Aim of the research. To study carrier frequency I / D (rs4646994) of polymorphism of the ACE gene, associated with secondary auricle fibrillation form (AF) to create risk patients groups that prone to develop of this disease. Materials and methods. According to the study design were examined 50 probands with secondary AF and 77 persons of their families I, II, III degree of relatives. These families make up the main group of our research. The control group was formed from a relatively healthy people without cardiovascular disease history. This group consisted of 100 persons. All patients were examined by the following survey methods: medical history and complaints, an electrocardiogram, XM ECG, ECHO CS, VEM, CHPSLP, molecular genetic analysis, patients who have AF, were studied thyroid hormones.
Results. We have produced a statistically significant prevalence of carriers homozygous genotype II for common allele among probands with secondary OP (34,0% ± 6,7) compared with the control group (14,0% ± 3,5), p = 0.004.
It was also found a statistically significant prevalence of carriers homozygous of DD genotype for the rare allele among control subjects (36,0% ± 4,8) compared to probands with secondary OP (10,0% ± 4,2), p = 0.001. It was found statistically significant prevalence of carriers homozygous genotype II probands among women with secondary OP (40,6% ± 8,7) compared to the control group of women (17,2% ± 4,7), p = 0.012. Also found a statistically significant prevalence of homozygous carriers of DD genotype among the control group women (35,9% ± 6,0) compared with women of the main group (3,1% ± 3,1), p = 0.0005.
Conclusion. Thus, according to the results of the study found a statistically significant prevalence of carriers homozygous genotype II for common allele of ACE gene among probands with secondary OP and in the subgroup of women compared with those of control group. But at the same time there is a statistically significant prevalence of homozygous carriers of DD genotype for the rare allele in the control group, compared with probands with secondary OP and a subgroup of women. Obtained data indicate multifactorial genesis of AF and confirm that homozygous carriers of DD genotype has conditionally protective effect against the development of AF.

1.	Goruleva M.V., Ganenko O.S., Koval'tsova R.S., Kutuzova A.E., Petrova N.N., Demchenko E.A., Nedoshivin A.O. Quality of life and psychological and cognitive status of patients with coronary artery bypass grafting. Russian Journal of Cardiology. 2014; Vol. 9, №113: P. 68-72.
2.	 Zakharov V.V. Pronoran use in the treatment of non-dementia cognitive disorders. Journal of Neurology. 2008; № 2: P. 38-42.
3.	 Mil'chakova A.E., Popov G.R., Bykov A.V., Gekht A.B. Clinical and pharmacoeconomic analysis of the using the drug piribedil (Pronoran) in the treatment of Parkinson's disease. Journal of Neurology and Psychiatry named after S.S. Korsakov. 2008; № 4: P.49-55.
4.	 Petrova M.M., Prokopenko S.V., Eremina O.V., Smertina E.G., Gankin M.I., Fursov A.A., Alekseevich G.Yu., Mozheyko E.Yu., Kuznetsova O.O. The use of citicoline after coronary bypass surgery. Doctor. 2014; № 8: P. 75-78.
5.	 Capewells E.S. Proportion of the decline in cardiovascular mortality disease due to prevention versus treatment: public health versus clinical care. Ann. Rev. Public Health. 2011; Vol.32: P. 5-22.
6.	 Evered L., Scott D.A., Silbert B., Maruff P. Postoperative cognitive dysfunction is independent of type of surgery and anesthetic. Anesth. Analg. 2011; Vol. 112: P. 1179-1185.
7.	 Eryomina O.V., Petrova M.M., Prokopenko S.V., Mozhejko E. Yu., Kaskaeva D.S. Gavrilyuk O.A. The effectiveness of the correction of cognitive impairment using computer-based stimulation programs for patients with coronary heart disease after coronary bypass surgery. Journal of the Neurological Sciences. 2015; Vol. 358: P. 188-192.
8.	 Fontes M.T., Swift R.C., Phillips-Bute B., Podgoreanu M.V., Stafford- Smith M., Newman M.F., Mathew J.P. Neurologic Outcome Research Group of the Duke Heart Center. Predictors of cognitive recovery after cardiac surgery. Anesth. Analg. 2013; Vol. 116: P. 435-442.
9.	Krenk L., Rasmussen L.S., Kehlet H. New insights into the pathophysiology of postoperative cognitive dysfunction. Acta Anaesthesiol. Scand. 2010; Vol. 54: P. 951-956.
10.	 Ledur P., Almeida L., Pellanda L. C. Preditores de infecgao no pos-operatorio de cirurgia de revascularizagao miocardica. Rev. Bras. Cir. Cardiovasc. 2011; Vol. 2: P. 190-196.
11.	 Maekawa K., Goto T., Baba T., Yoshitake, Morishita S., Koshiji T. Abnormalities in the brain before elective cardiac surgery detected by diffusion-weighted magnetic resonance imaging. Ann. Thorac. Surg. 2008; Vol.86: P. 1563-1569.
12.	 Sa M.P., Soares E. F., Santos C. A. Risk factors for mediastinitis after coronary artery bypass grafting surgery. Rev. Bras. Cir. Cardiovasc. 2011; Vol. 26: P. 27-35.
13.	 Sun X., Lindsay J., Monsein L. H. Silent brain injury after cardiac surgery: A review: Cognitive dysfunction and magnetic resonance imaging diffusion-weighted imaging findings. J. Am. Coll. Cardiol. 2012; Vol. 60: P. 791-797.
14.	Van Dijk D. Neuropsychological outcome after off-pump versus on-pump coronary bypass surgery: the octopus randomized trial. Circulation. 2002; Vol. 105: P.179.

Aim of the research. To study the influence of piribedil (pronoran) to the state of cognitive functions in patients with coronary heart disease after coronary bypass surgery.
Materials and methods. It were studed 64 patients with coronary heart disease. AH patients were divided into two groups. In the main group (n = 32) in addition to the therapy was prescribed pronoran (piribedil) at a dose of 50 mg once daily for 3 months. The comparison group (n = 32), patients in the postoperative period received standard therapy. There were assessed cognitive function in patients before surgery, on the 10th day, after three and six months after coronary bypass surgery. The article presents a case of a patient rehabilitation with coronary heart disease, mild cognitive disorders after coronary bypass surgery.
Results. In the group of patients during therapy with piribedil in 6 months after coronary artery bypass were noted positive dynamics in almost all tests.
Conclusion. Taking into account the authentic improvement the results detected in patients during treatment with piribedilom we can with high probability to assume a positive effect of this drug on memory indexes and attention, psychomotor speed processes.

1.	 Goruleva M.V., Ganenko O.S., Koval'tsova R.S., Kutuzova A.E., Petrova N.N., Demchenko E.A., Nedoshivin A.O. Quality of life and psychological and cognitive status of patients with coronary artery bypass grafting. Russian Journal of Cardiology. 2014; Vol. 9, №113: P. 68-72.
2.	 Zakharov V.V: Pronoran use in the treatment of non-dementia cognitive disorders // Journal of Neurology. 2008; № 2: P. 38-42.
3.	 Mil'chakova A.E., Popov G.R., Bykov A.V., Gekht A.B. Clinical and pharmacoeconomic analysis of the using the drug piribedil (Pronoran) in the treatment of Parkinson's disease. Journal of Neurology and Psychiatry named after S.S. Korsakov. 2008; № 4: P.49-55.
4.	 Petrova M.M., Prokopenko S.V., Eremina O.V., Smertina E.G., Gankin M.I., Fursov A.A., Alekseevich G.Yu., Mozheyko E.Yu., Kuznetsova
O.O. The use of citicoline after coronary bypass surgery. Doctor. 2014; № 8: P. 75-78.
5.	 Shrader N.I., Shaybakova V.L., Likhvantseva V.V., Levikov D.I., Levin O.S. Neurological complications of arthocoronary artery bypass. Journal of Neurology and Psychiatry named after S.S. Korsakov. 2012; №3: P. 76-81.6.	 Capewells E.S: Proportion of the decline in cardiovascular mortality disease due to prevention versus treatment: public health versus clinical care. Ann. Rev: Public Health. 2011; Vol.32: P. 5-22.
7.	 Evered L., Scott D.A., Silbert B., Maruff P: Postoperative cognitive dysfunction is independent of type of surgery and anesthetic. Anesth. Analg. 2011; Vol. 112: P. 1179-1185.
8.	 Eryomina O.V., Petrova M.M., Prokopenko S.V., Mozhejko E. Yu., Kaskaeva D.S. Gavrilyuk O.A. The effectiveness of the correction of cognitive impairment using computer-based stimulation programs for patients with coronary heart disease after coronary bypass surgery. Journal of the Neurological Sciences. 2015; Vol. 358: P. 188-192.
9.	 Fontes M.T., Swift R.C., Phillips-Bute B., Podgoreanu M.V., Stafford- Smith M., Newman M.F., Mathew J.P. Neurologic Outcome Research Group of the Duke Heart Center: Predictors of cognitive recovery after cardiac surgery. Anesth. Analg. 2013; Vol. 116: P. 435-442.
10.	Krenk L., Rasmussen L.S., Kehlet H. New insights into the pathophysiology of postoperative cognitive dysfunction. Acta Anaesthesiol. Scand. 2010; Vol. 54: P. 951-956.
11.	 Ledur P., Almeida L., Pellanda L. C: Preditores de infecgao no pos-operatorio de cirurgia de revascularizagao miocardica. Rev. Bras. Cir. Cardiovasc.2011; Vol. 2: P. 190-196.
12.	 Maekawa K., Goto T., Baba T., Yoshitake A., Morishita S., Koshiji T. Abnormalities in the brain before elective cardiac surgery detected by diffusion-weighted magnetic resonance imaging. Ann. Thorac. Surg. 2008; Vol.86: P. 1563-1569.
13.	 Sa M.P., Soares E. F., Santos C. A. Risk factors for mediastinitis after coronary artery bypass grafting surgery. Rev. Bras. Cir. Cardiovasc. 2011.Vol. 26: P. 27-35.
14.	 Sun X., Lindsay J., Monsein L. H. Silent brain injury after cardiac surgery: A review: Cognitive dysfunction and magnetic resonance imaging diffusion-weighted imaging findings. J. Am. Coll. Cardiol. 2012; Vol. 60: P. 791-797.
15.	 Van Dijk D. Neuropsychological outcome after off-pump versus on-pump coronary bypass surgery: the octopus randomized trial. Circulation. 2002; Vol. 105: P.179.

Aim of the research. To evaluate the clinical course of nonalcoholic fatty liver disease (NAFLD) in men and women and to study the features of the lipid metabolism disorders.
Materials and methods. The study involved 164 patients with nonalcoholic fatty liver disease, including 103 men and 61 women.
Results. Severe hypercholesterolemia (more than 7.8 mmol / l) was registered more often at men. Hypertriglyceridemia and hypoalfacholesterinemia were more pronounced in men, that indicating more severe disorders of lipid metabolism. Insulin resistance (IR) was significantly higher in men.
Conclusion. Studies suggest that NAFLD in men and women with equal frequency is detected on the background of metabolic syndrome (MS). However, a cluster of factors MS is significantly more pronounced in men. The main pathophysiological factors contributing to the formation of NAFLD, namely, IR and dyslipidemia were more significant in men due to the earlier development of hepatic steatosis in males and younger age compared to women.

1.	Ivashkin V.T., Maevskaya M.V., Pavlov Ch.S., Tikhonov I.N., Shirokova E.N., Bueverov A.O., Drapkina O.M., Shul'pekova Yu.O., Tsukanov V.V., Mammaev S.N., Maev I.V., Pal'gova L.K. Clinical guidelines for the diagnosis and treatment of non-alcoholic fatty liver disease of the Russian Society for the Study of the Liver and the Russian Gastroenterological Association // Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2016; Vol.26, № 2: P. 24-42.
2.	Krivosheev A.B., Kuimov A.D., Morozov D.V., Krivosheeva I.A., Gmyza O.A. Status of porphyrin metabolism with nonalcoholic steatohepatitis. Therapeutic Archives. 2008; Vol. 80, № 11: P. 64-68.
3.	de Alwis N.M., Day C.P. Non-alcoholic fatty liver disease: the mist gradually clears. J. Hepatol. 2008; Vol. 48, № 1: P. 104-112.
4.	 Bellentani S., Saccoccio G., Masutti F., Croc L.S., Brandi G., Sasso F., Cristanini G., Tiribelli C. Prevalence of and risk factors for hepatic steatosis in Northern Italy. Ann. Intern. Med. 2000; Vol. 132, № 2: P. 112-117.
5.	Borman M.A., Ladak F., Crotty P., Pollett, Kirsch R., Pomier-Layrargues G., Beaton M., Duarte-RoJ.o A., Elkashab M., Myers R.P. The Fatty Liver Index has limited utility for the detection and quantification of hepatic steatosis in obese patients. Hepatol. Int. 2013; Vol.7, № 2: P. 592-599.
6.	 Browning J.D., Szczepaniak L.S., Dobbins R., Nuremberg P., Horton J.D., Cohen J.C., Grundy
7.	M., Hobbs H.H. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology . 2004; Vol. 40, № - P. 1387-1395.
8.	 Cope M.B., Allison D.B. Obesity: person and population. Obesity (Silver Spring). 2006; Vol. 14, № 4: P. 156-159.
9.	 Hashimoto E., Tokushigie K. Prevalence, gender, ethnic, and prognosis of NASFL. J. Gastroenterol. 2011; Vol. 46, № 1: P. 63-69.
10.	 Lazo M., Hernaez R., Eberhardt M.S., Bonekamp S., Kamel I., Guallar E., Koteish A., Brancati F.L., Clark J.M. Prevalence of nonalcoholic fatty liver disease in the United States: the Third National Health and Nutrition Examination Survey, 1988-1994. Am. J. Epidemiol; Vol. 171, № 1. P. 38-45.
11.	 McLeay S.C., Morrish G.A., Ponnuswamy T.K., Devanand B., Ramanathan M., Venkatakrishnan L., Ramalingam S., Green B. Noninvasive Quantification of Hepatic Steatosis: Relationship Between Obesity Status and Liver Fat Content. The Open Obesity J. 2014; Vol. 6: P. 16-24.
12.	 Marchesini G., Brizi M., Bianchi G., Tomassetti Bugianesi E., Lenzi M., McCullough A.J., Natale Forlani G., Melchionda N. Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes; Vol. 50, № 8: P. 1844-1850.
13.	 Park S.H., J.eon W.K., Kim S.H., Kim H.J., Park I., Cho Y.K., Sung I.K., Sohn C.I., Keum D.K., Kim I. Prevalence and risk factors of non-alcoholic fatty liver disease among Korean adults. J. Gastroenterol. Hepatol; Vol. 21, № 1: P. 138-143.
14.	Pyorala K., De Backer G., Graham I., Poole- Wilson P., Wood D. Prevention of coronary heart disease in clinical practice. Recommendations of the Task Force of the European Society of Cardiology, European Atherosclerosis Society and European Society of Hypertension. Eur. Heart J. 1994; Vol. 15, № 10: P. 1300-1331.
15.	Tarantino G., Saldalamacchia G., Conca P., Arena A. Non-alcoholic fatty liver disease: further expression of the metabolic syndrome. J. Gastroenterol. Hepatol. 2007; Vol. 2: P. 293-303.
16.	 Wong V.W., Chu W.C., Wong G.L., Chan R.S., Chim A.M., Ong A., Yeung D.K., Yiu K.K., Chu S.H., Woo J., Chan F.K., Chan H.L. Prevalence of non-alcoholic fatty liver disease and advanced fibrosis in Hong Kong Chinese: a population study using proton-magnetic resonance spectroscopy and transient elastography. Gut. 2012; Vol. 61, № 3: P. 409-415.

Aim of the research. To assess the types and structure forms of the maxillary sinuses in Krasnoyarsk population according to the cone-beam computed tomography.
Materials and methods. At 150 cone-beam computed tomograms (SVST) were studied 300 maxillary sinuses of the population of Krasnoyarsk and the Krasnoyarsk Region, obtained by the tomograph «Picasso Trio» with EzImplant program (South Korea). One hundred and fifty sinuses of right maxillary sinus and 150 left maxilla were estimated by the type of pneumatization, the shape of the structure and symmetrically arranged to use the data for planning the endodontic treatment of molars of the upper jaw.
Results. At men and women with almost equal frequency was prevailed hyper pneumatized type of structure of the maxillary sinuses without statistical difference by gender and location. Symmetry of the types of sinuses was observed in 146 (97.3%) of 150 SBST. The prevailing form of sinus of right and left upper jaws was triangular: 70.2% and 70.2% in men, 70.7% and 70.9% - women.
Conclusion. Type, shape and location of the sinus of the upper jaws, the ratio of the tops of the roots to the sinus bottom determines the effect of odontogenic foci of inflammation to the state of its mucous membrane and must be taken into account in the planning and evaluation of the results of endodontic treatment of teeth.

1.	Akopov R.A. Chronic apical abscess, unilateral chronic sinusitis. Endodontics Today. 2015; № 1: P. 43-44.
2.	 Baydik O.D., Sysolyatin P.G., Gurin A.A., Ilienok O.V. Current approaches to diagnosis and treatment of chronic odontogenic maxillary sinusitis. Russian Journal of Dentistry. 2015; Vol. 19, № 4: P. 14-18.
3.	 Maligin M. Yu. Analysis of the angular position of the teeth at orthognathic and distal occlusion. Institute of Dentistry. 2012; Vol. 2, № 55: P. 90-91.
4.	 Chibisova M.A., Karpishchenko S.A., Zubareva A.A., Shavgulidze M.A. Diagnosis of chronic odontogenic polypoid rhinosinusitis using cone beam computed tomography. Institute of Dentistry. 2013; №1: P. 48-49.
5.	 Yusupov R.D., Alyamovskiy V.V., Nikolaev V.G., Kozlov V.V., Kazakova G.N., Borisov A.Yu. Ethnic peculiarities of kefalometric indicators and manifestations of odontology signs in population of Eastern Siberia. In the world of scientific discovery. Krasnoyarsk, 2013; № 7.1: P. 139-156.
6.	Brooks J. K., Kleinman J. W. Retrieval of Extensive Gutta-percha Extruded into the Maxillary Sinus: Use of 3-dimensional Cone-Beam Computed Tomography. Journal of Endodontics. 2013; Vol. 39, № 9: P. 1189-1193.
7.	Fakhar H. B., Kaviani H., Panjnoosh M., Shamshiri A. R. Accuracy of panoramic radiographs in determining the relationship of posterior root apices and maxillary sinus floor by Cone-Beam CT. Journal of Dental Medicine-Tehran University of Medical Sciences. 2014; Vol. 27, № 2: P. 108-117.
8.	Sharan A., Madjar D. Correlation between maxillary sinus floor topography and related root position of posterior teeth using panoramic and cross-sectional computed tomography imaging. Oral surgery Oral medicine Oral pathology Oral radiology and Endodontology. 2006; Vol. 102, № 3: P. 375-381.

Aim of the research. To analyze the organization of care for COPD patients in outpatient and inpatient settings in the Krasnoyarsk Region.
Materials and methods. There were analyzed the information on the fact of treatment the adult population (18 years and older) by code ICD J44 in dynamics for the period from 2009 to 2014. The volume and structure of health care was evaluated, its share in the outpatient and inpatient conditions with day and day and night stay. Results. The article provides the basic aspects of legal regulation of medical care to patients with COPD in the Krasnoyarsk Region. According to our data, in the period from 2009 to 2014 the outpatient and inpatient care was provided to an average of 29 thousand persons annually. Most of the treatment cases were carried out in outpatient conditions. However, for the six analyzed years the trend has changed in favor of increasing the number of admissions to the day and night hospitals.
Conclusion. During the study period it was noted a decrease in the length of stay of patients with COPD in a hospital.

1.	Aleksandrova O.Yu., Shatalov O.A., Kremenkov A.R. The implementation of the legislation norms on the free medical care. Territorial Compulsory Medical Insurance Fund of Krasnoyarsk Region: Collection of publications in the press on the subject of health care and mandatory health insurance. - 2012. - №5. - P.2-9.
2.	Berezovskaya S.I., Ivanova A.M., Shirobokova M.L., Filippova T.V., Vasiliev E.P., Tretyakov A.A., Shishatskiy N.G. Krasnoyarsk Region in figures 2015: Stat.sb. / Krasnoyarskstat. Krasnoyarsk, 2016. - 105 p.
3.	Gaygol'nik T.V., Demko I.V., Bochanova E.N., Gordeeva N.V., Kraposhina A.Yu., Solovieva I.A. Phar- macoeconomic evaluation of therapy at exacerbation of chronic obstructive pulmonary disease in a large hospital in Krasnoyarsk // Pulmonology. - 2015. - №3. - P. 320-326.
4.	The Global Initiative for Chronic Obstructive Pulmonary Disease. Global strategy for the diagnosis, treatment and prevention of chronic obstructive pulmonary disease, 2014. Translated from English.Available at: http://www.goldcopd. org/uploads/users/files/GOLD_Report_ Russian_2014.pdf
5.	Demko I.V., Danilova L.K., Petrova M.M. Epidemiology of chronic respiratory diseases in the countryside inhabitants of the south of Krasnoyarsk region. Krasnoyarsk: Office Planet, 2012. - 176 p.
6.	WHO Report. Aggravation of respiratory dis¬eases in spring period dd. May 1, 2016. // News bulletin - 2014. - №4. Available at: http://whodc. mednet.ru/ru/component/attachments/down-load/113.html.
7.	WHO Report. Chronic obstructive pulmonary disease (COPD) dd. April 15, 2014 // News bulletin - 2015. - №315. Available at: http://www.who.int/ mediacentre/factsheets/fs315/ru/.
8.	Zaitsev V.M., Alikbaeva L.A., Gladkov D.I., Sidorov A.A. Medical statistics in the outpatient clinics of the industrial enterprises. St. Petersburg, 2007. - 540 p.
9.	The Constitution of the Russian Federation dd. Available at: http://www.consultant.ru/document/cons_doc_LAW_28399/ 
10.	Public health and health care. National guidelines. In the book .: Starodubova V.I., Shchepina O.P. et al. M.: GEOTAR Media, 2013. - 624 p.
11.	Resolution of the Government of Krasnoyarsk Region dd. 23.12.2014 No. 636-p «On approval of the Regional program of state guarantees for provision free medical care to citizens of the Russian Federation in the Krasnoyarsk Region for 2015 and for the planning period of 2016 and 2017». Available at: http://zakon.krskstate.ru/ doc/22668.
12.	Russian Federation Government Resolution dated December 19, 2015 No. 1382 «On the Program of the state guarantees for provision of free medical care to citizens in 2016». Available at: http://www.consultant.ru/document/cons_doc_LAW_191018/
13.	Artyukhov I.P., Arshukova I.L., Dobretsova E.A., Dugina T.A., Shulmin A.V., Demko I.V. Epidemiology of chronic obstructive pulmonary disease: a population-based study in Krasnoyarsk region, Russia. Int. J. Chron. Obstruct. Pulmon. Dis. 2015; №10(1): P.1781-1786.
14.	Chuchalin A.G., Khaltaev N., Antonov N.S., Galkin D.V., Manakov L.G., Antonini P., Murphy M., Solodovnikov A.G., Bousquet J., Pereira M.H., Demko I.V. Chronic respiratory diseases and risk factors in 12 regions of the Russian Federation. Int. J. Chron. Obstruct. Pulmon. Dis. 2014; №9(1): P.963-974.
15.	Order of the Ministry of Health of the Russian Federation dd. 15.11.2012 No. 916n «On approval of the Procedure provision medical care to the population in the profile» Pulmonology. Available at: http://www.consultant.ru/document/cons_doc_LAW_121895/
16.	The tariff agreement OMI system of Krasnoyarsk Region in 2014. Available at: http://www.krasmed.ru/ commission_devel_prog_oms/tarifs.php.
17.	The Federal Law of 21.11.2011 №323- FZ «On the basis of public health protection in the Russian Federation». Available at: http://base.consultant.ru/cons/cgi/online.cg i?req = doc;base = LAW;n = 181698;fld=134;fr om= 196384-24;rnd = 203280.07586465310305357;; ts = 02032807834936121944338.

Aim of the research. To reveal the ways to bring health activity centers for children (CPC) in accordance to their purpose - the prevention of chronic noninfectious diseases in the population of the Siberian Federal District (SFD) from childhood.
Materials and methods. Based on the submitted to the MH RF by health centers for children of the age-specific data, in contrast to the official reporting form No. 68, graduation of childhood period proposed by the ICD by 10th revision, was given the characteristics of covered contingent and the results of inspections.
The paper summarizes the data on 30 CZD operating in the Central Federal District for 2013. The represented absolute values were entered in an Excel database and transferred to the relative, based on the average child population in the Federal District at the beginning of 2013. The obtained data was analyzed by methods of descriptive statistics and the SWOT-analysis.
Results. Generalized information of the SFD was compared with data of the country, was represented the spread of indicators in the district subjects, that allowed to make a number of conclusions and proposals for the development of the regulatory base, within framework the activity of CZD is carrying out at the moment. Conclusion. For a more effective analysis of CZD it is necessary to improve the system of registration the recording and reporting indicators. As part of the solutions to these problems it is necessary to develop a system of versatile objective assessment of the efficiency of these units.

1.	Al'bitskiy A.A., Modestov A.A., Kosova S.A.,, Ivanova A.A., Volkov I.K., Bondar' V.I., Zelinskaya I., Terletskaya R.N., Shcherbakova S.V., Nevolin Yu.S. Innovative technologies in the prevention activities of health centers for children. Russian Journal of Pediatrics. 2014; Vol.17, № 4: P. 43-48.
2.	 Bondar' V.I. The health status of children indicates about the exhaustion of adaptive reserves of man. Coll. Abstracts of the International Congress «Health, education, upbringing of children in the XXI century». Moscow. 2004: P.172-175.
3.	 Bondar' V.I. Health centers for Children: campaigning or the foundation for a new health care system for children?. Idoctor. 2015; Vol.6, №34: P. 10-13.
4.	 Bondar' V.I., Modestov A.A., Mal'kova G.A., Cogan C.A., Terletskaya R.N. Health centers for children: results of 2013 and prospects for development. Vishnyakova N.I., editor. Collection of scientific papers «Urban health problems». St. Petersburg. 2015; Issue 20: P. 246-250.
5.	 Modestov A.A., Bondar' V.I., Kosova S.A., Mal'kova G.A. Health centers for children as the basis for the modernization of preventive pediatrics. Deputy chief physician, medical work and medical examination. 2014; Vol.96, № 5: P.22-28.
6.	 Modestov A.A., Kosova S.A., Bondar' V.I., Nevolin Yu.S. Status of child health, as a basis for the development of regional health prevention programs. Russian Journal of Pediatrics. 2008. №4: P. 53-57.
7.	 Modestov A.A., Kosova S.A., Bondar' V.I., Nevolin Yu.S., Fedotkina S.A., Farrakhov A.Z. Modernization of preventive pediatrics: the problem areas and opportunities. Preventive Medicine. 2013; Vol.16, №3: P. 14-21.
8.	 About modification in the Order of the Ministry of Health and Social Development of the Russian Federation dd. August 19, 2009 No. 597n «On the organization of the health centers of activities to promote healthy lifestyle among Russian citizens, including the reduction of alcohol and tobacco using»: Order of the Health Ministry of the Russian Federation dated June 8, 2010 No. 430n. [Electronic resource]. URL: http://www. minzdravsoc.ru/docs/mzsr/orders/1031 (reference date 10.03.2014).
9.	 On Amendments to the Applications No. 1-5 to the Order of Ministry of Health and Social Development of the Russian Federation dd. August 19, 2009 No. 597n: Order of the Ministry of Health and Social Development of Russia dd. April 19, 2011 No. 328n. [Electronic resource]. URL: http://www.minzdravsoc.ru/docs/ mzsr/spa/71 (reference date 14.04.2015).
10.	 On Amendments to the Order of the Ministry of Health and Social Development of the Russian Federation dd. August 19, 2009 No. 597n: Order of the Russian Ministry of Health dd. September 26, 2011 No. 1074n. [Electronic resource]. URL: http://www.minzdravsoc.ru/docs/mzsr/ orders/1164 (reference date 05.09.2014).
11.	 On the organization of the activities of health centers to promote healthy lifestyles among citizens of the Russian Federation, including the reduction of alcohol and tobacco consumption: Russian Health Ministry Order dd. August 19, 2009 No. 597n. [Electronic resource]. URL: http:.www.minzdravsoc.ru/docs/mzsr/orders/930 (reference date 22.06.2015).
12.	 On approval of the State program of the Russian Federation «Health Development»: Resolution of the RF Government dd. April 15, 2014 No. 294. [Electronic resource]. URL: http:.base.garant.ru/70643470/#block_3 (reference date 11.07.2016).
13.	 Letter from the Russian Federation Ministry of Health dd. 18 February 2011 number 15-2 / 10 / 2-1642 (for information on the activities of Health Centers for children). [Electronic resource]. URL: http://www.garant.ru/products/ipo/prime/ doc/4092108/ (reference date 12.04.2016).
14.	 Starodubov V.I., Rudnev S.G., Nikolaev D.V., Korostylev K.A. Federal information resource of the Health Centers: the current state and prospects of development. Social aspects of population health [Electronic magazine]. 2015; Vol.45, № 5. URL: http://vestnik.mednet.ru/content/ view/706/30/lang,ru/ (reference date April 7, 2016).
15.	 Shabalov N.P. Childhood diseases. M., 1993: P. 86-94.

Aim of the research. To study clinical and hematological changes in infants with infectious mononucleosis caused by the Epstein-Barr virus in the acute phase of the disease.
Materials and methods. It were examined 72 children with infectious mononucleosis caused by the Epstein-Barr virus in the acute phase of the disease in ages of 6 months to 12 months. General blood test was performed on the hematology analyzer «CELL-DYN Ruby» (Abbott, USA). Atypical mononuclear cells in peripheral blood was studied by light microscopy. The content of total bilirubin and its fractions in blood serum, the activity of enzymes ALT, AST, and thymol were determined by conventional biochemical methods.
Results. All observed patients had acute beginning of the disease. Tonsillopharyngitis phenomena were in all of the observed children, while in 77.77% (56 persons) tonsillitis cases had lacunar character. Generalized lymphadenopathy was detected in 86.11% of the patients, hepatomegaly - in 100%, splenomegaly in 86.11% of cases. Every second child with severe disease has infectious cardiopathy. The hemogram showed an increase the number of white blood cells and the absolute number of lymphocytes, as well as increasing the content of atypical mononuclear cells in peripheral blood and increased ESR. Leaving the hospital 1/3 patients has manifestations of generalized lymphadenopathy and hepatomegaly, in 16.66% of patients there were detected atypical mononuclear cells in the peripheral blood of 4% to 8%, almost in every second child (47.22%) at the
end of inpatient treatment the percentage of lymphocytes in the peripheral blood exceeded Conclusion. In 2/3 of the patients at the time of discharge from the hospital were kept separate clinical manifestations and changes in the hemogram. This circumstance dictates the necessity dispensary observation for children in an

1.	Gul'man L.A., Kurtasova L.M., Andreeva A.A. Clinic - serological criteria for infectious mononucleosis in children. Children infections. 2004. №3: P.27- 31.
2.	Gul'man L.A., Kurtasova L.M., Andreeva A.A. Current aspects of clinic, course and outcomes of infectious mononucleosis in children, caused by the Epstein - Barr virus. Infectious diseases. 2005. №1: P.7-10.
3.	Kurtasova L.M., Ol'khovskiy I.A., YakuninaYu., Golovanova A.E., Zablotskaya S.G. The clinical significance of immunological markers of EBV - infection at infectious mononucleosis in children. Clinical Laboratory Diagnostics. 2005. №12: P.44-46.
4.	Lezhenko G.O., Usachova O.V., Silina E.A., Pakhol'chuk T.M. Infectious mononucleosis in children: clinical-immunological characteristics. Current infectology. 2013; Vol.1, №1: P.56-60.
5.	L'vov N.D., Dudukina E.A. Key questions of the diagnosis of Epstein - Barr virus infection. Infectious diseases. News. Opinions. Training. 2013. №3: P.24-32.
6.	Razgulyaeva A.V., Ukhanova O.P., Bezrodnova S.M. Current concepts of etiology, pathogenesis, clinic and treatment of infectious mononucleosis in children. Stavropol State University. 2012; Vol.78, №1: P.222-227.
7.	Urazova O.I., Novitskiy V.V., Pomogaeva A.P. Blood mononuclears in infectious mononucleosis in children. Tomsk: Publishing house of the Tomsk University; 2003 - 166 p.
8.	Khmilevskaya S.A., Zaitseva I.A. Inductors of interferon in the treatment of patients pre-school age with reactivation of Epstein - Barr virus infection. Experimental and Clinical Pharmacology. 2015; Vol. 79, №6: P. 24-29.
9.	Shvedova N.M., Mikhailova E.V., Tseka Yu.S., Chudakova T.K. Infectious mononucleosis in children: clinical - laboratory tests and economic effectiveness of the use of immunocorrectors. Saratov Scientific - Medical Journal. 2013; Vol. 9, №3: P.512-517.

The aim of the research. To analyse the quality management system results in the educational process of the Krasnoyarsk State Medical University.
Materials and methods. It was used the GOST R ISO 9001-2015. Were applied the following research methods: expert assessments, analysis and synthesis, generalization and comparison, the calculation method, self-assessment in accordance with GOST R ISO 9001-2015.
Results. It was defined the role of quality management system in the educational process of the university, its main advantages.
Conclusion. Analysis of the quality management system for the various components revealed that the quality management system developed at the University. In general, the impact and complies with GOST R ISO 9001-2015. Work undertaken has practical application for improving the activities of the University.

1.	Gabidullin I.F., Yamaletdinova K.Zh., Yamaletdinova G.F., Yanguradova Z.A. The introduction of quality management systems in multi-level educational process of high school. Vestnik of OSU. № 3. 2014; № 3: P.78-83.
2.	 GOST R ISO 9001-2015. Quality Management System. Requirements. Introduced. 2015-28-09. M.: Standartinform, 2015. 24 p.
3.	 Oleynikova T.A., Ovod A.I., Solyanina V.A. The quality management system as a modern approach to management of education. Higher education in Russia; №1. 2015: P. 119-126.
4.	 Sokolovskaya M.V., Buyankina R.G., Popova O.M., Nikulina S.Yu. Criteria of efficiency of the educational organization internal audits. Siberian Medical Review. 2014; № 6: P.95-100.
5.	Sokolovskaya M.V., Zamiralova E.V., Buyankina R.G. Self-assessment as a tool to improve the quality management system of educational organization. Siberian Medical Review. 2014; № 3: P. 80-84.
6.	Sokolovskaya M.V., Zamiralova E.V., Klobertants E.P., Kazakova E.N., Buyankina R.G. Using the functional approach to the assessment of internal audits of the quality management system of educational complex. Siberian Medical Review. 2015; №3: P. 93-97.

Aim of the research. Analysis of the expert committee meeting minutes for attestation of dentists on qualification categories, certified in the Krasnoyarsk Region for the period 2010 - 2015.
Materials and methods. According to materials of the protocols it was conducted a statistical analysis of the results of the expert group meetings on the certification of dental profile experts on assignment of qualification categories with the help of a licensed program SPSS IBM Statistics 20.0.
Results. The study revealed the low interest of young professionals working in the medical institutions of Krasnoyarsk Region in obtaining qualification category, compared with young professionals in Krasnoyarsk and Norilsk. Specialists- stomatologists working in the medical organizations of non-state forms of ownership, now is also are not interested in assigning qualification categories.
Conclusion. Analysis of the protocols of the expert group meetings on the certification of dental profile specialists allows to conclude a need to raise awareness among representatives of the specialty "Dentistry" on the principles of continuing medical education in the conditions of implementation in practice the experts accreditation system

1.	Alyamovskiy V.V., Shevarkov V.D., Buyankina R.G. Monitoring of patients satisfaction with the quality of dental care in the state and private medical institutions. Institute of Dentistry. 2014; №2: P. 16-17.
2.	 Buyankina R.G., Alyamovskiy V.V., Tarasova N.V. Application of the quality system of training of graduates for self-assessment of the Institute of Dentistry. Siberian Medical Review. 2013; № 5: P. 97-100.
3.	 Order of the Russian Ministry of Health dd. 23.04.2013 No. 240n «On the procedure for obtaining the qualification categories of medical and pharmaceutical workers» (with the «Regulations on the procedure for obtaining qualification categories of medical and pharmaceutical workers») (Registered in the Ministry of Justice RF 23.09.2011 number 21875). [Electronic resource]. URL: http://base.consultant.ru/cons/cgi/online. cgi?req = doc;base = LAW;n=149223.
4.	 Order of the Health Ministry of the Russian Federation dd. 25.07.2011 No. 808n «On the order and timing of the passage of medical and pharmaceutical personnel certification for qualification category.» - [Electronic resource].
URL: http://www.consultant.ru/document/cons_doc_LAW_149223/
5.	Federal Law dd. 21.11.2011 number 323-FZ (ed. dd. 29.12.2015) «On the basis of public health protection in the Russian Federation» (rev. and ext. introd. in force from 01.01.2016). [Electronic resource]. URL: http://www.garant.ru/products/ipo/prime/doc/12090108/