Сибирское медицинское обозрение. 2016. № 2 View full textКоличество просмотров : 3900
Evseeva M.V., Kalaeva V.V.
CLINICAL AND PATHOGENETIC ASPECTS OF CARDIORENAL RELATIONSHIPS ON BACKGROUND OF TYPE 2 DIABETES
Evseeva M.V., Kalaeva Y.Y. Clinical and pathogenetic aspects of cardiorenal relationships on background of type 2 diabetes. Siberian medical review. 2016; № 2: 5-13. DOI 10.20333/25000136-2016-2-5-13
Evseeva Maria Vladimirovna Research Associate of the Blood Circulation Pathology Laboratory; Federal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular Diseases; firstname.lastname@example.org
Kalaeva Victoria Vladimirovna Cardiologist; Federal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular Diseases; email@example.com
Violation of the kidney filtration function is common enough among patients with cardiovascular disease (CVD), especially against disorders of carbohydrate metabolism (IGM). Renal dysfunction (PD) is associated with more frequent development of cardiovascular complications. In turn, the probability of development of renal disease in patients with cardiovascular disease is significantly higher than in general population. This bidirectional pathogenetic mechanisms existing between cardiovascular and kidney diseases were the basis for the formation of cardiorenal syndrome concept. The review discusses the general parts of pathogenesis within the cardiovascular continuum. In addition, it shows the effect on metabolic disorders during CVD combined with renal dysfunction. The review reveals a recent view on the main mechanisms of cardiorenal syndrome.
Keywords: cardiorenal syndrome, systemic inflammation, endothelial dysfunction, insulin resistance
1. BarbarashO.L., Avramenko О.Е., Osokina A.V., Sumin A.N., Veremeev A.'V. Prognostic significance of proinflammatory factors in patients with progressive angina pectoris and type 2 diabetes mellitus. Cardiology. 2012. №4. P. 39-45. 2. Barbarash O.L., Kashtalap V.V., Karetnikova V.N., Vorontsova N.L., DevyatovaVA, Goncharenko M.V., Barbarash L.S. The clinical relevance of indicators of endothelial dysfunction, oxidative stress, and hemostasis in patients with myocardial infarction. Pathology of the blood circulation and cardiac surgery. 2007. № 2. P. 28-33. 3. Karetnikova V.N., Evseeva M.V., Kalaeva V.V. Renal dysfunction at myocardial infarction with elevation of segment ST: risk factors, the influence on the prognosis. Heart. 2014. Vol. 13, № 6 (80). P. 339-346 4. Kobalova Zh.D., Villevalde S.V., Moiseev V.S. Cardiovascular disease and functional state of the kidneys. Russian Journal of Cardiology. 2013. №4. P. 33-47. 5. OgarkovM.Yu., Barbarash O.L., Kazachek Ya.V., Kvitkova L.V., Polikutina O.M., Barbarash L.S. The prevalence of components of metabolic syndrome x in native and non-native population of Gornaya Shoria . Siberian Scientific Medical Journal. 2004. Vol. 24, №1. P. 108-111. 6. Popov S.I., Nagibovich O.A., Shustov S.B. Structural and functional condition of the heart and coronary blood flow in patients with type 2 diabetes with nephropathy. Nephrology. 2011. Vol. 15, №1. P. 48-53. 7. Savelyeva S.A., Kryachkova A.A., Kutyrina I.M., Shestakova M.V. Cardiorenal relationship in patients with type 2 diabetes and obesity. Clinical Nephrology. 2011. №5. P.36-40. 8. Shestakova M.V., Shamkhalova M.Sh., Yarek- Martynova I.Ya. Diabetes mellitus and chronic kidney disease: achievements, unresolved problems and prospects for the treatment. Diabetes Mellitus. 2011. №1. P.81-88. 9. Ahmed A., Rich M.W., Sanders P.W. Perry G.J., Bakris G.L., Zile M.R., Love T.E., Aban I.B., Shlipak M.G. Chronic kidney disease associated mortality in diastolic versus systolic heart failure: a propensity matched study. Am. J. Cardiol. 2007. № 99. P. 393-398. 10. Alexandraki K., Piperi C., Kalofoutis C., Singh J., Alaveras A., Kalofoutis A. Inflammatory process in type 2 diabetes: the role of cytokines. AnnNYAcadSci.2006. № 1084. P.89-117. 11. Amann K. Media calcification and intima calcification are distinct entities in chronic kidney disease. Clin. J. Am.Soc.Nephrol. 2008. Vol. 3, № 6. P. 1599-1605. 12. Biondi-Zoccai G.L., Abbate A., Liuzzo G., Biasucci L.M. Atherothrombosis, inflammation, and diabetes. J. Am. Coll. Cardiol. 2003. № 41. P1071-1077. 13. CamiciP. G., CreaF. Coronary microvascular dysfunction. Engl. J. Med. 2007. Vol. 356, № 8. P. 830-840. 14. Choi J. Ch., Cha K. S., Ahn J. H.,Lee H.W., Oh J.H., Choi J.H., Lee H.C., Yun E., Hong T.J., Jang H.Y., Choi J.H., Jeong M.H., Ahn Y., Chae S. C. , Kim Y. J. The Incidence and Clinical Predictors of Persistent Renal Dysfunction in Patients with Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention: Results from the Korea Working Group on Myocardial Infarction. Circulation. 2012. Vol. 126. A17296. 15. Dandamudi S., Glockner J., Slusseretal J. Myocardial Fibrosis Identifiedby Cardiac MR Iandthe Associated Cardio-Renal Dysfunction. Circulation. 2011. Vol. 124. A14397. 16. Diez-Sampedro A., Lenz 0., Fornoni A. Podocytopathy in diabetes: a metabolic and endocrine disorder. Am. J. Kidney Dis. 2011. Vol. 58, № 4. P. 637-646. 17. Essig M., Escoubet B., Zuttere D. Blanchet F., Arnoult F., Dupuis E., Michel C., Mignon F., Mentre F., Clerici C.,Vrtovsnik F. Cardiovascular remodeling and extracellular fluid excess in early stages of chronic kidney disease. Nephrol. Dial. Transplant. 2008. Vol. 23, № 1. P. 239-248. 18. Fang Z.Y., Prins J.B., Marwick T.H. Diabetic cardiomyopathy: Evidence, mechanisms and therapeutic implications. Endocr. Rev. 2004. Vol. 25, № 4. P. 543-567. 19. Fonarow S.C., Stough W.G., Abraham W.T., Albert N.M., Gheorghiade M.r Greenberg B.H., O'Connor C.M., Sun J.L., Yancy C.W., Young J. B. Characteristics, treatments, and outcomes of patients with preserved systolic function hospitalized for heart failure: a report from the OPTIMIZE-HF registry. J. Am. Coll. Cardiol. — 2007. Vol. 50. P. 768-777. 20. Fox C. S., Larson M. G., Leip E. P. Culleton B., Wilson P.W., Levy D. Predictors of new-onset kidney disease in a community-based population . JAMA. 2004. Vol. 291, №7. P. 844-850. 21. Fox C. S., Muntner P., Chen A.Y. Alexander K. P., Roe M.T., Cannon C.P., Saucedo J.F., Kontos M.C., Wiviott S.D. Use of evidence-based therapies in short-term outcomes of ST-segment elevation myocardial infarction and non-ST-segment elevation myocardial infarction in patients with chronic kidney disease: a report from the National Cardiovascular Data Acute Coronary Treatment and Intervention Outcomes Network registry. Circulation. 2010. Vol. 121,№3. P.357-365. 22. IDF DiabetesAtlas [Electronic resource] - 2013. URL: http:. www.idf.org/diabetesatlas (дата обращения 23.01.2015). 23. Libby P. Braunwald's heart disease: a textbook of cardiovascular medicine / P. Libby. N. Y.,2008. 2183 p. 24. Matsushita K., Velde M., Astor В. C., Woodward M., Levey A.S., Jong P.E., Coresh J., Gansevoort R.T. Chronic Kidney Disease Prognosis Consortium: Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: A collaborative meta-analysis. Lancet. 2010. Vol. 375, №9731. P.2073-2081. 25. Ragosta M., Samady H., Isaacs R. B., Gimple L. W., Sarembock I. J., Powers E.R. Coronary flow reserve abnormalities in patients with diabetes mellitus who have end-stage renal disease and normal epicardial coronary arteries. Am. Heart J. 2004. Vol. 147, № 6. P. 1017-1023. 26. Reddy G. R., Kotlyarevska K., Ransom R. F. The podocyte and diabetes mellitus: is the podocyte key to the origins of diabetic nephropathy?. Curr. Opin. Nephrol. Hypertens. 2008. Vol. 17, № I. P. 32-36. 27. Ridker P.M., Hennekens C.H., Buring J.E., Rifai N. C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N. Engl. J. Med. 2000. № 342. P. 836-843. 28. Ridker P.M., Rifai N., Rose L., Buring J.E., Cook N.R. Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events. N. Engl. J.Med. 2002,- №347. P. 1557-1565. 29. Ronco C., Haapio M., House A. A., Anavekar N., Bellomo R. Cardiorenal syndrome. J. Am. Coll. Cardiol. 2008. Vol. 52, № 19. P. 1527-1539. 30. Rost N.S., Wolf P.A., Kase C.S., Kelly-Hayes M., Silbershatz H., Massaro J.M., D'Agostino R.B., Franzblau C., Wilson P.W. Plasma concentration of C-reactive protein and risk of ischemic stroke and transient ischemic attacks: the Framingham Study. Stroke. 2001. №32. P. 2575-2579. 31. Sacks F. M., Hermans M. P., Fioretto P. Association Between Plasma Triglycerides and High-Density Lipoprotein Cholesterol and Microvascular Kidney Disease and Retinopathy in Type 2 Diabetes Mellitus A Global Case-Control Study in 13 Countries. Circulation. 2014. Vol. 129, №9. P. 999-1008. 32. Stam F., Guldener C., Becker A., Dekker J.M., Heine R.J., Bouter L.M., Stehouwer D.A. Endothelial dysfunction contributes to renal function-associated cardiovascular mortality in a population with mild renal insufficiency: the Hoorn study. J. Am. Soc. Nephrol. 2006. Vol. 17, № 2. P. 537-545. 33. Wang F„ Ye P., Luo L., Xiao W„ Wu H. Association of risk factors for cardiovascular disease and glomerular filtration rate: a community-based study of 4,925 adults in Beijing. Nephrol. Dial. Transplant. 2010. Vol.25,№12. P.3924-3931. 34. Whitman I. R., Feldman H. I., Deo R. CKD and sudden cardiac death: epidemiology, mechanisms, and therapeutic approaches. J. Am. Soc. Nephrol. 2012. Vol. 23, № 12. P. 1929-1939.
Sychev D.A., Sosnovsky E.E., Orekhov R.E., Bordovsky S.P.
CONTEMPORARY METHODS OF DEALING WITH POLYPHARMACY IN ELDERLY AND SENILE PATIENTS
Sychev D.A., SosnovskyE.E., Orekhov R.E., Bordovsky S.P. Contemporary methods of dealing with polypharmacy in elderly and senile patients. Siberian medical review. 2016; № 2: 13-21. DOI 10.20333/25000136-2016-2-13-21
Sychev Dmitry Alekseevich MD, D. Med. Sci., Prof., Head of the Department of Clinical Pharmacology and Therapy; Russian Medical Academy of Postgraduate Education of the Health Ministry of Russia; firstname.lastname@example.org
Sosnovsky Evgeny Evgenievich Medical Student of 5th course; l.M. Sechenov First Moscow State Medical University of the Health Ministry of Russia; email@example.com
Orekhov Roman Evgenievich Medical Student of 5th course; l.M. Sechenov First Moscow State Medical University of the Health Ministry of Russia; firstname.lastname@example.org
Bordovsky Sergey Petrovich Medical Student of of 4th course; l.M. Sechenov First Moscow State Medical University; Arhont7@bk.ru
This review deals with the problem of polypharmacy, its definition and relevance to clinical practice. The review deals with contemporary methods of fight with the phenomenon of polypharmacy - the index of rational use of medicines, the scale of anticholinergic drug capacity, STOPP/START criteria. It was assessed the therapeutic importance and positive effects of implementation of these criteria in clinical practice.
Keywords: polypharmacy, index of the rationality use of the drug (IRLS) scale of anticholinergic capacity, «STOPP /START» criteria, undesirable side reactions, pharmacotherapy, interactions between medicines, acetylcholine
1. Anticholinergic cognitive burden scale Aging Brain Care 2012 . Update Developed by the Aging Brain Program of the Indiana University Center for Aging Research. 2012. P. 1-2. 2. Carnahan R.M., Lund B.C., Perry P.J., Pollock B.G., Culp K.R. The Anticholinergic Drug Scale as measure of drug related anticholinergic burden: association with serum anticholinergic activity . J. Clin. Pharmacol. 2006. Vol. 46. P.1481-1486. 3. Gallagher P.r Ryan C.r Byrne S.r Kennedy J.r O'Mahony D. STOPP (Screening Tool of Older Person's Prescriptions) and START (Screening Tool to Alert doctors to Right Treatment). Consensus validation . Clin. Pharmacol. Ther. 2008. Vol. 46, №2. P. 72-83. 4. Gallagher P.F., O'Connor M.N., O'Mahony D. Prevention of potentially inappropriate prescribing for elderly patients: a randomized controlled trial using STOPP/START criteria . Clin. Pharmacol. Ther. 2011. Vol. 89. P. 845-854. 5. Han L.r McCusker J.r Cole M.r Abrahamowicz M.r Primeau F.r Elie M. Use of medications with anticholinergic effect predicts clinical severity of of delirium symptoms in older medical inpatients . Arch. Intern. Med. 2011. Vol. 161. P. 1099-1105. 6. Hanlon J.T., Schmader K.E., Samsa G.P., Weinberger M.r Uttech K.M., Lewis I.K., Cohen H.J., Feussner J.R. A method for assessing drug therapy appropriateness . Clin. Epidemiol. 1992. Vol. 45, №10. P. 1045-1051. 7. Lund B.C., Carnahan R.M., Egge J.A., Chrischilles E.A., Kaboli P.J. Inappropriate prescribing predicts adverse drug events in older adults . The Annals of Pharmacotherapy. 2010. Vol. 44. P.957-963. 8. Mulsant B.H., Pollock B.G., Kirshner M., Shen C., Dodge H., Ganguli M. Serum anticholinergic activity in a community-based sample of older adults . Arch. Gen. Psychiatry. 2003. Vol. 60. P. 198-203. 9. O'Connor M.N. Adverse drug reactions in older people during hospitalization: prevalence, risk factors and recognition: MD thesis. University College Cork, 2013. 10. O'Mahony D., O'Sullivan D., Byrne S. O'Connor M.N., Ryan C., Gallagher P. STOPP / START criteria for potentially inappropriate prescribing in older people: version 2 . Age Ageing. 2015. Vol.44, №2. P.213-218. 11. Patterson S.M., Hughes C., Kerse N., Cardwell C., Bradley M.C. Interventions to improve the appropriate use of polypharmacy for older people. The Cochrane Library. 2012. Vol. 5. CD008165. doi: 10.1002/14651858.CD008165.pub2. 12. SalahudeenM.S., Duffull S.B., NishtalaP.S. Anticholinergic burden guantified by anticholinergic risk scales and adverse outcomes in older people: a systematic review . BMC Geriatr. 2015. Vol. 15. P.31. 13. Samsa G.P., Hanlon J.T., Schmader K.E., Weinberger M., Clipp E.C., Uttech K.M., Lewis I. K., Landsman P.B., Cohen H.J. A summated score for the medication appropriateness index: development and assessment of clinimetric properties including content validity . Clin. Epidemiol. 1994. Vol. 47, №8. P.891-896. 14. Somers A., Mallet L., van der Cammen T., Robays H.F Petrovic M. Applicability of an adapted medication appropriateness index for detection of drug-related problems in geriatric inpatients . The American Journal of Geriatric Pharmacotherapy. 2012. Vol. 10, №2. P. 101-109.
Tskhay V.B., Tcygankova N.Y.
CONTEMPORARY METHODS OF OPERATIVE TREATMENT OF SEVERE ADENOMYOSIS
Tskhay V. B., Tcygankova N.Y. Contemporary methods of operative treatment of severe adenomyosis. Siberian medical review. 2016; № 2: 22-31.. DOI 10.20333/25000136-2016-2-22-31
Tskhay Vitaly Borisovich Dr. Med. Sc, Professor, Head of the Department of Perinatology, Obstetrics and Gynecology; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; email@example.com
Tcygankova Natalia Yurievna Student of4thyear of therapeutic faculty; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; firstname.lastname@example.org
Endometriosis is among the prevalent gynecological diseases and diagnosed in 10% of women of reproductive age. Endometriosis problem is becoming increasingly of health-social value, which is associated with severe clinical manifestations and recurrent disease has a negative influence on quality of life and ability to work of women. This article presents modern approaches to conserving therapy of severe adenomyosis. A review of recent major studies in the field of surgical treatment of this disease, analyze the main stages and results of operations.
Keywords: adenomyosis, adenomyomectomy, surgical treatment
l. DamirovM.M.,SrusarN.N. Current approaches to the treatment of patients with adenomyosis. Questions of Gynecology, Obstetrics and Perinatology. 2011; Vol. 10, №3. P. 45-49. 2. Ishchenko A.I., Kudrina Е.А. Endometriosis: Diagnosis and Treatment. MGEOTAR - Media, 2002. 104 p. 3. Karakhalis L.Yu., Fedorovich O.K., Vasina I.B., Chervonnaya I.Yu. Influence of pathogenetically substantiated therapy for adenomyosis on its development. Theraphy of adenomyosis. 2009; №5. P. 18-24. 4. Orazov M.R., Tchaika A.V., Nosenko E.N. Relief of chronic pelvic pain due to adenomyosis, by the progestogens of a new generation. Obstetrics, gynecology, reproduction. 2014; Vol.8, №3. P.6-9. 5. Strizhakov A.N., Davydov A.I., PashkovV.M. Miometrektomiya - the method of choice organ saving treatment in patients with adenomyosis at large amounts of uterine. Questions of gynecology, obstetrics and perinatologii. 2007; Vol. 6, №5. P.109-116. 6. Unanyan A.L., Sidorova I.S., Kogan E.A. Active and inactive adenomyosis: clinical and morphological variants of development, differentiated approach to the treatment. Obstetrics, gynecology, reproduction. 2012; Vol. 6, №2. P.25-30. 7. Tskhai V.B., Makarenko T.A., Kel'berg V.G. Current possibilities of organ saving operations with common forms of adenomyosis. The first experience of the operation according to the procedure Hisao Osada. Status Praesents. 2013; №3 (14). P.9-13. 8. Chan C.L., Annapoorna V., Roy A.C., Ng S.C. Balloon endometrial thermoablation - an alternative management of adenomyosis with menorrhagia and dysmenorrhea. Med.J.Malaysia. 2001; Vol.56. P.370-373. 9. Fernandez C., Ricci P., Fernandez E. Adenomyosis visualized during hysteroscopy. J. Minim. Invasive Gynecol. 2007; № 14. P. 555-556. 10. Fujishita A., Masuzaki H., Khan K.N., Kitajima M., Ishimaru T. Modified reduction surgery for adenomyosis: a preliminary report of the transverse H incision technique. Gynecol. Obstet. Invest. 2004; №57. P.132-138. 11. Grimbizis G. F., Mikos Th., Tarlatzis B. Uterus-sparing operative treatment for adenomyosis. Fertility and sterility. 2014; Vol. 101. P. 472-487. 12. Huang X., Huang Q., Chen S., Zhang J., Lin K., Zhang X. Efficacy of laparoscopic adenomyomectomy using double-flap method for diffuse uterine adenomyosis. BMC Womens. Health. 2015. T. 15, № 1 - 24p. 13. Kanaoka Y., Hirai K., Ishiko 0. Successful microwave endometrial ablation in a uterus enlarged by adenomyosis. Osaka City Med J. 2004; Vol. 50. P.47-51. 14. Kang L., Gong J., Cheng Z., Dai H., Liping H. Clinical application and midterm results of laparoscopic partial resection of symptomatic adenomyosis combined with uterine artery occlusion. J. Minim. Invasive Gynecol. 2009; Vol.16. P. 169-173. 15. Koch J., Rowan K., Rombauts L., Yazdani A., Chapman M, Johnson N. Endometriosis and Infertility - a consensus statement from ACCEPT. Australian and New Zealand Journal of Obstetrics and Gynaecology. 2012; Vol. 52, №6. P. 513-522. 16. Kumar A. Myometrial cyst. J. Minim. Invasive Gynecol. 2007; Vol. 14. P. 395-396. 17. Leyendecker, G.r Kunz, G.r Kissler, S., Wildt, L. Adenomyosis and reproduction. Best Pract. Res. Clin. Obstet. Gynaecol. 2006; Vol.20. P. 523-546. 18. Maheshwari A., Gurunath S., Fatima F., Bhattacharya S. Adenomyosis and subfertility: a systematic review of prevalence, diagnosis, treatment and fertility outcomes. Hum. Reprod. Update. 2012; Vol.l8,№4. P.374-392. 19. Nakamura K., Nakayama K., Ishikawa M., Katagiri H., Katagiri A., Ishibashi T., Sato E., Asakawa Y., Kyo S. Efficacy of multiple microwave endometrial ablation technigue for menorrhagia resulting from adenomyosis. J. Obstet. Gynaecol. Res.2015; Vol.41, №11. P.1769-1772. 20. Nishida M., Takano K., Arai, Y., Ozone, H., Ichikawa, R. Conservative surgical management for diffuse uterine adenomyosis. Fertil. Steril. 2010; Vol.94. P.715-719. 21. Osada H., Silber S., Kakinuma T., Nagaishi M., Kato K., Kato 0. Surgical procedure to conserve the uterus for future pregnancy in patients suffering from massive adenomyosis. Reproductive BioMedicine Online. 2011; Vol. 22, Issue 1. P. 94-99. 22. Pelage L., Fenomanana S., Brun J.L., Levaillant J.M., Fernandez H. Treatment of adenomyosis (excl uding pregnancy project). Gynecol. Obstet. Fertil. 2015; Vol.43, №5.P. 404-411. 23. Phillips D.R., Nathanson H.G., Milim S.J., Haselkorn J.S. Laparoscopic bipolar coagulation for the conservative treatment of adenomyomata. J. Am. Assoc. Gynecol. Laparosc. 1996; №.4, P. 19-24. 24. Pontrelli G., Bounous V.E., Scarperi S., Minelli L., Di Spiezio Sardo A., Florio P. Rare case of giant cystic adenomyoma mimicking a uterine malformation, diagnosed and treated by hysteroscopy. J. Obstet. Gynaecol. Res.2015; Vol.41, №8. P.1300-1304. 25. Preutthipan, S., Herabutya, Y. Hysteroscopic rollerball endometrial ablation as an alternative treatment for adenomyosis with menorrhagia and/or dysmenorrhea. J. Obstet. Gynaecol. Res. 2010; Vol. 36. P.1031-1036. 26. Ryo E., Takeshita S., Shiba M., Ayabe T. Radiofreguency ablation for cystic adenomyosis: a case report. J. Reprod. Med. 2006; Vol.51. P. 427-430. 27. Takeuchi H., Kitade M., Kikuchi I., Kumakiri J., Kuroda K., Jinushi M. Diagnosis, laparoscopic management, and histopathologic findings of juvenile cystic adenomyoma: a review of nine cases. Fertil. Steril. 2010; Vol. 94. P. 862-868. 28. Tanmahasamut P., Noothong S., Sanga-Areekul N., Silprasit K., Dangrat C. Prevalence of endometriosis in women undergoing surgery for benign gynecologic diseases. J. Med. Assoc. Thai.2014; Vol. 97, №2.P. 147-152. 29. Vercellini P., Consonni D., Barbara G., Buggio L., Frattaruolo M.P., Somigliana E. Adenomyosis and reproductive performance after surgery for rectovaginal and colorectal endometriosis: a systematic review and meta-analysis. Reprod. Biomed. Online. 2014; Vol.28, №6.P. 704- 713. 30. Wang C.J., Yen C.F., Lee C.L., Soong Y.K. Laparoscopic uterine artery ligation for treatment of symptomatic adenomyosis. J. Am. Assoc. Gynecol. Laparosc. 2002; Vol.9. P. 293-296. 31. Wood C. Surgical and medical treatment of adenomyosis.. Hum Reprod Update. 1998; Vol.4, №4. P.323-336. 32. Yang Z., Cao Y.D., Hu L.N., Wang Z.B. Feasibility of laparoscopic high-intensity focused ultrasound treatment for patients with uterine localized adenomyosis. Fertil. Steril. 2009; Vol. 91. P.2338-2343.
Zhidkova I.I., Ponasenko A.V., Khutornaya M.V., Kutikhin A.G., Golovkin A.S., Barbarash O.L.
ASSOCIATION OF THE INDIVIDUAL VARIABLE SITES TLRS GENES WITH THE SEVERITY OF CHD IN YOUNGER PATIENTS
Zhidkova I.I., Ponasenko A.V., Khutornaya M.V., KutikhinA.G., Golovkin A.S., Barbarash O.L. Association of the individual variable sites HRs genes with the severity of CHD in younger patients. Siberian medical review. 2016; № 2: 32-41. DOI 10.20333/25000136-2016-2-32-41
Zhidkova Irina Igorevna Research Associate of the Blood Circulation Pathology Laboratory; Federal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular Diseases; Irina04046@yandex.ru
Ponasenko Anastasiya Valerievna Cand.Med.Sci., Head of the Laboratory of Genomic Medicine, Department of Experimental and Clinical Cardiology; Federal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular Diseases; email@example.com
Khutornaya Maria Vladimirovna Researcher Laboratory Genomic Medicine, Department of Experimental and Clinical Cardiology; Federal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular Diseases; firstname.lastname@example.org
Kutikhin Anton Gennadievich Researcher Laboratory Genomic Medicine, Department of Experimental and Clinical Cardiology; Federal State Budgetary Scientific Institution Research Institute for Complex Issues of Cardiovascular Diseases; email@example.com
Golovkin Aleksey Sergeevich Dr. Med. Sci., Senior Researcher; FGBI "SZFMITS named after V.A. Almazov » Russian Ministry of Health, Institute of Molecular Biology and Genetics; firstname.lastname@example.org
Barbarash O. L. Dr. Med. Sci., Professor; Kemerovo State Medical University; Scientific Research Institute of Complex Problems of Cardiovascular Diseases; email@example.com
Aim of the research. To determine the association of polymorphic variants of genes TLRs with the severity of coronary artery disease (CAD) in young patients. Materials and methods. The study included 292 patients with stable coronary artery disease. Genotyping was performed in 96-well format by TagMan technology. It was studied 8 variable sites in four genes: TLR1 (rs5743551 and rs5743611), TLR2 (rs3804099 and rs5743708), TLR4 (rs4986790 and rs4986791), TLR6 (rs3775073 and rs5743810). Results. In patients with coronary heart disease aged 55 years old and under С / T genotype variable site rs3804099 TLR2 gene is associated with increasing of 4.4 times the risk of developing severe chronic heart failure (III-IV FC) and in 2.7 times with increase in the risk of stenosis brachiocephalic arteries more than 30 %; С/ C genotype of this variable site TLR2 gene is associated with 4 times increase in the risk of severe coronary atherosclerosis. Т/ C genotype variable site rs3775073 TLR6 gene was associated with an increase of 4 times the risk of multifocal atherosclerosis and 3 times the risk of myocardial infarction in patients with coronary heart disease aged 55 years old and younger. Conclusion. There were revealed the associations between the variable sites of two genes of innate immunity receptors (TLR 2 and 6) with the severity of CHD in patients aged 55 years old and younger.
Keywords: coronary heart disease, the receptors of innate immunity, polymorphisms, variable genes sites, TLRs
1. Vasyuk Yu.A., Dudarenko O.P., Yushchuk E. N., Shkol'nik E.L., Serova M.K. «Cytokine» model of pathogenesis of chronic heart failure and the possibility of a new therapeutic approach in the treatment of decompensated patients . Rational pharmacotherapy in cardiology. 2006. № 4. P. 63-70. 2. Zhdanov V.S., Vikhert A.M., Sternbi N.G. Evolution and pathology of atherosclerosis in humans. M.:Triad-X,2002. 144p. 3. Zhuravlev Yu.I., Nazarenko G.I., Ryazanov V.V., Kleimenova E.B. Anew method of risk analysis of coronary heart disease based on genomic and computer technologies. Cardiology. 2011; № 2. P. 19-25. 4. Makeeva O.A., Zykov M., Golubenko M.V., Kashtalap V.V., Kulish E.V., Goncharova I.A., Barbarash O.A., Puzyrev V.P. The role of genetic factors in predicting the complications during the year following myocardial infarction . Cardiology. 2013; № 10. P. 16-23. 5. Royberg G.E., StrutynskyA.V. Internal illnesses. Cardiovascular system: a tutorial. 3rd Ed. M .: MEDpressinform, 2013; 896 p. 6. ShesternyaP.A., NikulinaS. Yu., Shul'manV.A., Martynova E.A.,DemkinaA.I., Orlov P.S., Maksimov V.N., Voevoda M.I. Genetic predictors of myocardial infarction in young adults. Cardiology. 2013; №7. P. 4-8. 7. Avlas О., Bragg A., Fuks A., Nicholson J.D., Farkash A., Porat Е., Aravot D., Levy-Drummer R.S., Cohen C., Shainberg A., Arad M., Hochhauser E. TLR4 expression is associated with left ventricular dysfunction in patients undergoing coronary artery bypass surgery. PLoS One. 2015; Vol. 10, №6. e0120175. 8. Elkind M.S.V., Luna J.M., Coffey C.S., McClure L.A., Liu K.M., Spitalnik S., Paik M.C., Roldan A., White C., Hart R., Benavente 0. The Levels of Inflammatory Markers in the Treatment of Stroke study (LIMITS): inflammatory biomarkers as risk predictors after lacunar stroke. Int.J. Stroke. 2010; Vol. 5, №2. P. 117-125. 9. Golovkin A.S., Ponasenko A.V., Khutornaya M. V., Kutikhin A.G., Salakhov R.R., Yuzhalin A.E., Zhidkova I.I.,Barbarash O.L., Barbarash L.S. Association of TLR and TREM-1 gene polymorphisms with risk of coronary artery disease in Russian population . Gene. 2014; Vol.550,№1. P. 101-109. 10. Ha T., Hua F., Liu X., Ma J., McMullen J.R., Shioi T., Izumo S., Kelley J., Gao X., Browder W., Williams D.L., Kao R.L., Li C. Lipopolysaccharide-induced myocardial protection against ischaemia/reperfusion injury is mediated through a PI3K/Akt-dependent mechanism . Cardiovasc. Res. 2008; Vol. 78. P. 546-553. 11. Huang C.C., Liu K., Pope R.M., Du P., Lin S., Rajamannan N.M., Huang Q.Q., Jafari N., Burke G. L., Post W., Watson K.E., Johnson C., Daviglus M.L., Lloyd-Jones D.M. Activated TLR signaling in atherosclerosis among women with lower Framingham risk score: the multi-ethnic study of atherosclerosis . PLoS One. 2011; Vol. 6, №6. e21067. 12. Mikacenic C.r Reiner A.P., Holden T.D., Nickerson D.A., Wurfel M.M. Variation in the TLR10/TLR1/ TLR6 locus is the major genetic determinant of interindividual difference in TLRl/2-mediated responses . Genes Immun. 2013; Vol. 14. P. 52-57. 13. Oyama J.r Blais C.r Liu X.r Pu M.r Kobzik L.r Kelly R.A., Bourcier T. Reduced myocardial ischemia reperfusion injury in Toll-like receptor 4-deficient mice . Circulation. 2004; Vol. 109, №6. P. 784-789. 14. Satoh M.r Takahashi Y.r Tabuchi T.r Tamada M.r Takahashi K.r Itoh T.r Morino Y.r Nakamura M. Circulating Toll-like receptor 4-responsive microR- NA panel in patients with coronary artery disease: results from prospective and randomized study of treatment with renin-angiotensin system blockade . Clin. Sci. (Lond.). 2015; Vol. 128, №8. P. 483-491. 15. Sianos G., Morel M.A., Kappetein A.P., Morice M.C., Colombo A., Dawkins K., van den Brand M.F Van Dyck N., Russell M.E., Mohr F.W., Serruys P.W. The SYNTAX Score: an angiographic tool grading the complexity of coronary artery disease . Eurointervention. 2005; Vol. 1, №2. P. 219-227.
Kuzhel D.A., Matyushin G.V., Savchenko E.A., Lytkina V.A., Yakovlev E.I., Novoselov O.V.
SOME FEATURES OF FLOW IN THE PULMONARY VEINS AT BLOCKADE OF THE LEFT LEG GIS BUNDLE WITH LOW EJECTION FRACTION
Kuzhel D.A., Matyushin G.V., Lytkina V.S., Savchenko E.A., Yakovlev E.l., Novoselov O.V. Some features of flow in the pulmonary veins at blockade of the left leg CIS bundle with LOW ejection fraction. Siberian medical review. 2016; № 2: 42-51. DOI 10.20333/25000136-2016-2-42-51
Kuzhel D. A. ; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; firstname.lastname@example.org
Matyushin Gennady Vasilievich Doctor of Medical Sciences, Professor, Head of the Department of Cardiology and Functional Diagnostics; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; email@example.com
Savchenko E. A. ; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; firstname.lastname@example.org
Lytkina V. A. ; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; email@example.com
Yakovlev Evgeny Iosifovich Associated Professor, Department of Highest Mathematic; Sibitian State Space University named after Academic M.F. Reshetnev; firstname.lastname@example.org
Novoselov Oleg Vadimovich Associated Professor, Department of Highest Mathematic; Sibitian State Space University named after Academic M.F. Reshetnev; email@example.com
Aim of the research. To evaluate twisting of the left ventricle (LV) on the background of left bundle branch block (LBBBj in patients c cardiomyopathies and study of the hemodynamic conseguences of possible changes. Materials and methods. The study involved 22 patients with ischemic and dilated cardiomyopathy with left ventricular ejection fraction less than 40%, divided into two groups: physiological counter-rotating basal and top and abnormal unidirectional. Results. Although there are no differences in terms, characterizing cardiac remodeling, in the group with abnormal rotation occurred substantially smaller twisting indicators and changes were observed in the flow of the pulmonary veins that are typical of high end-diastolic pressure LV. In group of patients with abnormal rotation systolic left atrial filling fraction was 32,3 ± 8,07%, whereas in the group with a physiological counterrotating -53,1 ± 10,1 (P = 0.000226). A possible cause of these changes are great indicators of intraventricular dyssynchrony in the group with abnormal rotation. Time interval delay redaction of the rear wall was 63,3 ± 35,1 ms in comparison with persons with normal left ventricular rotation - 8,0 ± 17,9 ms (p = 0,015922), reflecting the greater degree of mechanical dyssynchrony. Conclusion. Thus, LBBB has a complex negative influence on the electrical activation and contraction of IV, the result of which was a violation of twisting, mechanical dyssynchrony and deterioration of diastolic function.
Keywords: left ventricular function, echocardiography, myocardial deformation, LV rotation, twisting, diastolic dysfunction, 2D Strain, a complete blockade of the left leg of a ventriculonector
Pavlyukova E.N., Kuzhel D.A., Matyshin G.V., Veselkova N.S., Avdeeva O.V., Metelitsa V.S., Savchenko Е.А. Myocardia deformation and full blockade of the left leg Gis bundle. Rational pharmacotherapy in cardiology. 2012; Vol. 8, №6. P.814-820. 2. Pavlyukova E.N., Kuzhel D.A., Matyshin G.V., Savchenko E.A., Filippova S.A. Rotation and meaning of left ventricle: physiological role and the meaning in clinical practice. Rational pharmacotherapy in cardiology. 2015; Vol. 11, № 1. P.68-78. 3. Beladan С.С., Calin A., Rosea М., Ginghina С., Popescu В.А. Left ventricular twist dynamics: principles and applications. Heart. 2014; Vol. 100. P.731-740. 4. Gillebert T.C., De Pauw M., Timmermans F. Echo-Doppler assessment of diastole: flow, function and hemodinamics. Heart. 2013; Vol.99. P.55-64. 5. Gorcsan J., Abraham T., Agler D.A., Bax J.J., Derumeaux G., Grim R.A., Martin R. Steinberg J.S., Sutton M.S.J., Yu C.-M. Echocardiography for cardiac resynchronization therapy: recommendations for performance and reporting—a report from the American Society of Echocardiography Dyssynchrony Writing Group endorsed by the Heart Rhythm Society. J. Am. Soc. Echocardiogr. 2008; Vol. 21. P.191- 213. 6. Helle-Valle T., Crosby J., Edvardsen T., Lysseg- gen E., Amundsen B.H., Smith H.J., Rosen B.D., Lima J.A., Torp H., Ihlen H., Smiseth O.A. Newnoninvasive method for assessment of left ventricular rotation: speckle tracking echocardiography. Circulation. 2005; Vol.112. P.3149-3156. 7. Karaahmet T., Gtirel E., Tigen K., Guler A., Dundar C., Fotbolcu H., Basaran Y. The effect of myocardial fibrosis on left ventricular torsion and twist in patients with non-ischemic dilated cardiomyopathy//Cardiology Journal. 2013; Vol.20, №3. P.276-86. 8. Kusunose K., Zhang Y., MazgalevT.N., Thomas I.D., Popovic Z.B. Left ventricular strain distribution in healthy dogs and in dogs with tachycardia induced dilated cardiomyopathy. Cardiovascular Ultrasound. 2013; Vol.ll. P.43-47. 9. Lower R. Tractatus de Corde. London, UK: Oxford University Press, 1669. P.36. 10. Mestroni L., Maisch B., McKenna W.J., Sshwartz K., Charron P., Rocco C., Tesson F., Richter A., Wilke A., Komajda M. Guidelines for the study of familial dilated cardiomyopathies. Collaborative Research Group of the European Human and Capital Mobility Project on Familial Dilated Cardiomyopathy. European Heart Journal. 1999; Vol.20. P.93-102. 11. Morno§ C., Ru§inaru D., Manolis A.J., Zachar- opoulou I., Pittaras A., Ionas A. The Value of a New Speckle Tracking Index Including Left Ventricular Global Longitudinal Strain and Torsion in Patients with Dilated Cardiomyopathy. Hellenic Journal Cardiology. 2011; Vol.52. P.299-306. 12. Nagueh F., Appleton C.P., Gillebert T.C., Marino P.N., Oh J.K., Smiseth O.A., Waggoner A.D., Flachskampf F.A., Pellikka P.A., Evangelista A, Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography . Journal of the American Society of Echocardiography. 2009; Vol. 22, №2. P.107-133. 13. Popescu B.A., Beladan C.C., Calin A., Muraru D., Deleanu D., Rosea M., Gindhina C. Left ventricular remodelling and torsional dynamics in dilated cardiomyopathy: reversed apical rotation as a marker of disease severity. European Journal Heart Failure. 2009; Vol.11. P.945-951. 14. van Dalen B.M., Caliskan K., Soliman O.I., Nemes A., Vietter W.B., Ten Cate F.J., Geleijnse M.L. Left ventricular solid body rotation in non-compaction cardiomyopathy: a potential new objective and guan- titative functional diagnostic criterion?. European Journal Heart Failure. 2008; Vol.10, №11. P.1088-1093.
Kuvacheva N.V., Morgun A.V., Khilazheva E.D., Boytsova E.B., Ruzaeva V.A., Shuvaev A.N., Malinovskaya N.A., Pozhilenkova E.A., Salmina A.B.
BLOOD BRAIN BARRIER CELL PROLIFERATION UNDER HIF-1 SUPPRESSED ACTIVITY IN VITRO
Kuvacheva N.V., Morgun A.V., Khilazheva E.D., Boytsova E.B., Ruzaeva V.A., Shuvaev A.N., Malinovskaya N.A., Pozhilenkova E.A., Salmina A.B. Blood brain barrier cell proliferation under HIF-1 suppressed activity in vitro. Siberian medical review. 2016; № 1: 51-56. DOI 10.20333/25000136-2016-2-51-56
Kuvacheva Natalya Valerievna Associate Professor of the Department of Biological Chemistry with the Course of Medical, Pharmaceutical and Toxicological Chemistry; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; firstname.lastname@example.org
Morgun Andrei Vasil’evich Cand. Med. Sc., Assistant of Pediatric Department; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; email@example.com
Khilazheva Elena Dmitrievna Assistant of the Department of Biological Chemistry with the Course of Medical, Pharmaceutical and Toxicological Chemistry; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; firstname.lastname@example.org
Boytsova Elizaveta Borisovna Postgraduate Student, Department of biological, medical, pharmaceutical and toxicological chemistry; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; email@example.com
Ruzaeva Veronika Anatolyevna Researcher of Research Institute of Molecular Medicine & Pathobiochemistry; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; Veronikaruz@mail.ru
Shuvaev Anton Nikolaevich PhD, Cand. Med. Sci.; Gunma University Graduate School of Medical Sciences (Japan); firstname.lastname@example.org
Malinovskaya Nataliya Alexandrovna Dr.Med.Sc., Researcher at the Research Institute of Molecular Medicine and Patobiochemistry, Professor of the Department of Biological Chemistry with the Course of Medical, Pharmaceutical and Toxicological Chemistry; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; email@example.com
Pozhilenkova Elena Anatol’evna Cand.Biol.Sc., Associate Professor of the Department of Biological Chemistry with the Course of Medical, Pharmaceutical and Toxicological Chemistry; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; firstname.lastname@example.org
Salmina Alla Borisovna Dr. Med. Sci., Vice-Rector on Innovative Development and International Activities, Head of the Research Institute of Molecular Medicine & Pathobiochemistry, Head of the Department of biological, medical, pharmaceutical and toxicological chemistry; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; email@example.com
Aim of the research. To study proliferation and adhesion properties of neuronal and astroglial cells at directed activity modulation HIF-1. Materials and methods. The experiments were performed in the 3-cell BBB model and in isolated neurons and astrocytes in vitro. HIF-1 activity was suppressed by FM19G11 inhibitor, impedimetric cell index was measured with the analyzer «xCelligence». Results. We found that HIF-1 inhibition reduced proliferation and astrocytes and neurons in both the systems. At the same time, the presence in the system of cerebral endothelial cells has stabilizing effect on the proliferative activity of neuronal and astroglial cells. Conclusion. Proliferative properties of astrocytes and neurons have a HIF-1-dependent mechanisms.
Keywords: blood-brain barrier, HIF-1, proliferation, cell index
1. Khilazheva E.D., Boytsova E.B., Pozhilenkova E. A., Solonchuk Yu.R., Salmina A.B. Obtaining three cells model of neurovascular unit in vitro. Cytology. 2015; Vol. 57, № 10. P. 710-713. 2. FanX., Kavelaars A., Heijnen C.J., Groenendaal F., Van Bel F. Pharmacological Neuroprotection after Perinatal Hypoxic-Ischemic Brain Injury. Current Neuropharmacology. 2010; Vol. 8, № 4. P. 324-334. 3. Sheldon R.A., Lee C.L., Jiang X., Knox R.N., Ferriero D.M. Hypoxic preconditioning protection is eliminated in HIF-la knockout mice subjected to neonatal hypoxia-ischemia. Pediatric research. 2014; Vol. 76, №1. P. 46-53. 4. Siegenthaler J.A., Sohet F., Daneman R. "Sealing off the CNS": cellular and molecular regulation of blood-brain barriergenesis. Current opinion in neurobiology. 2013; Vol. 23, №6. P. 1057-1064. 5. Valle-CasusoJ.C.,Gonzalez-SanchezA.,Medina J.M., Tabernero A. HIF-1 and c-Src mediate increased glucose uptake induced by endothelin-1 and con- nexin43 in astrocytes. PLoS One. 2012; Vol. 7, №2. e32448. 6. Zhu Z., Reiser G. Signaling mechanism of protease activated receptor 1-induced proliferation of astrocytes: Stabilization of hypoxia inducible factor-1 a triggers glucose metabolism and accumulation of cyclin D1. Neurochem. Int. 2014; Vol. 79. P. 20-32.
Nasyrova R.F., Taraskina A.E., Sosin D.N., Sosina K.A., Ershov E.E., Zabotina A.M., Grunina M.N., Krupitsky E.M.
INSTRUMENTS OF PERSONALIZED ASSESSMENT OF THE EFFECTIVENESS OF ANTIPSYCHOTIC THERAPY: NEUROTRANSMISSION RECEPTORS ON PERIPHERAL BLOOD LYMPHOCYTES
Nasyrova R.F., Taraskina A.E., Sosin D.N., Sosina К.A, Ershov E.E., Zabotina A.M., Grunina A.M., Krupitsky E.M. Instruments of personalized assessment of the effectiveness of antipsychotic therapy: neurotransmission receptors on peripheral blood lymphocytes. Siberian medical review. 2016; № 2: 57-64. DOI 10.20333/25000136-2016-2-57-64
Nasyrova Regina Faritovna MD, PhD, Dr.Med.Sci., Leading Researcher, Department of biological therapy mental disorders; St. Petersburg V.M. Bekhterev Psychoneurological Research Institute; Адрес: 192019, Санкт-Петербург, ул. Бехтерева, д.
Taraskina Anastasiya Evgen'evna Ph.D., Chief, Laboratory of Molecular Biology; senior scientific collaborator, Laboratory of Molecular Human Genetics, National Research Centre «Kurchatov Institute» B.P. Konstantinov, Petersburg Nuclear Physics Institute; scientific collaborator, Department of Biological Therapy Mental Illness, Saint Petersburg Psychoneurological Scientific Research Institute named after Bekhterev; Pavlov First Saint Petersburg State Medical University; firstname.lastname@example.org
Sosin Dmitry Nikolaevich Scientific Collaborator, Department of biological therapy mental disorders; St. Petersburg V.M. Bekhterev Psychoneurological Research Institute; email@example.com
Sosina Kristina Anatol'evna Postgraduate Student, Department of neurological diseases; St. Petersburg V.M. Bekhterev Psychoneurological Research Institute; firstname.lastname@example.org
Ershov Evgeny Evgenyevich Chief of Department №7; Saint Petersburg Psychiatric Hospital №1 named after P.P. Kaschenko; email@example.com
Zabotina Anna Mikhailovna scientific Collaborator, Laboratory of Molecular Human Genetics, scientific collaborator, Laboratory of Molecular Biology; National Research Centre «Kurchatov Institute» B.P. Konstantinov, Petersburg Nuclear Physics Institute; Pavlov First Saint Petersburg State Medical University; firstname.lastname@example.org
Grunina Maria Nikolayevna Scientific Collaborator, Laboratory of Molecular Human Genetics; National Research Centre «Kurchatov Institute» B.P. Konstantinov, Petersburg Nuclear Physics Institute; email@example.com
Krupitsky Evgeny Mikhailovich M.D., Ph.D., Dr.Med.Sci., Professor, Chief, Department of Addictions, Chief, Laboratory of Clinical Pharmacology of Addictions, Valdman Institute; St. Petersburg V.M. Bekhterev Psychoneurological Research Institute; Pavlov First Saint Petersburg State Medical University; firstname.lastname@example.org
Aim of the research. To determine of expression level (mRNA) dopamine receptor type 4 genes (DRD4) and 2A serotonin receptor (5HTR2A) in peripheral blood lymphocytes in patients with schizophrenia spectrum disorders, and to examine the relationship between the level of expression of the studied genes and clinical response to antipsychotic therapy. Materials and methods. The study was conducted detection of the expression level (mRNA) DRD4 dopamine receptor genes and 5HTR2A serotonin receptor in the peripheral blood lymphocytes of patients with schizophrenia spectrum disorders, and studied the relationship between the level of expression of the genes studied and clinical response to antipsychotic therapy. Results. It is found that the initial expression level 5HTR2A significantly positively correlated with indices Clinical Global Impression Scale (CGI-S) (r = 0,732, p = 0,001) and can serve as a biomarker of treatment efficacy of olanzapine. Conclusion. These results allow us to consider neurotransmission receptors on peripheral blood lymphocytes as potential markers of personalized assessment of the effectiveness of antipsychotic ther.
Keywords: schizophrenia spectrum disorder, antipsychotics, lymphocytes, receptor neurotransmission, personalized medicine
1. Mosolov S.N. Biological methods of treatment of mental disorders. - Evidence-based medicine. - M.,2012. - 1080 p. 2. Bell R.L., Franklin К.М., Hauser S.R., Zhou F.C. Introduction to the special issue Pharmacotherapies for the treatment of alcohol abuse and dependence" and a summary of patents targeting other neurotransmitter systems. Recent Pat CNS Drug Discov. 2012; Vol.7, №2. P. 93-112. 3. Bergguist J.F Silberring J. Identification of catecholamines in the immune system by electrospray ionization mass spectrometry. Rapid Commun. Mass Spectrom. 1998; Vol.12, №11. P. 683- 688. 4. Buttarelli F.R., Fanciulli A., Pellicano C.F Pontieri F.E. The dopaminergic system in peripheral blood lymphocytes: from physiology to pharmacology and potential applications to neuropsychiatric disorders. Current Neuropharmacology. 2011; Vol.9. P.278-288. 5. Chan I.S., Ginsburg G.S. Personalized medicine: progress and promise. Annu Rev. Genomics Hum. Genet. 2011; Vol.12. P. 217-244. 6. Cui Y.r Prabhu V.F Nguyen T.B., Yadav B.K., Chung Y.C. The mRNA Expression Status of Dopamine Receptor D2, Dopamine Receptor D3 and DARPP-32 in T Lymphocytes of Patients with Early Psychosis. Int.J. Mol. Sci.2015; Vol.l6,№ll. P.26677-26686. 7. Liu L.r Yuan G.r Cheng Z.F Zhang G.r Liu X.F Zhang H. Identification of the mRNA expression status of the dopamine D2 receptor and dopamine transporter in peripheral blood lymphocytes of schizophrenia patients. PLoS One. 2013; Vol.8, №9. P.1-6. 8. Morag A., Kirchheiner J.F Rehavi M.F Gurwitz D. Human lymphoblastoid cell line panels: novel tools for assessing shared drug pathways. Pharmacogenomics. 2010; Vol.ll,№3. P. 327-340. 9. Smith R.M., Papp A.C., Webb A. Multiple regulatory variants modulate expression of 5-hydroxytryptamine 2A receptors in human cortex. Biol. Psychiatry. 2013; Vol.73, №6. P. 546-554.
Savchenko A.A., Dudina M.A., Dogadin S.A.
PECULIARITIES OF THE NEURAL NETWORK INFORMATIVITY OF IMMUNOLOGICAL PARAMETERS IN PATIENTS WITH ACROMEGALY
Savchenko A,A,, Dudina MA, Dogadin SA. Peculiarities of the neural network informativity of immunological parameters in patients with acromegaly. Siberian medical review. 2016; № 2: 65-73. DOI 10.20333/25000136-2016-2-65-73
Savchenko Andrey Anatolievich Dr. Med.Sc, Professor, Head of the Department of Physiology named after Prof. A.T. Pshonik; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; email@example.com
Dudina M. A. ; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; firstname.lastname@example.org
Dogadin S. A. ; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; email@example.com
Aim of the research. To study the immunological parameters and neural network evaluation of its informativity in patients with active acromegaly and in a state of remission. Materials and methods. The study involved 106 patients with acromegaly: 88 people at the stage of active acromegaly and 18 patients with remission of acromegaly. The method of indirect immunofluorescence and by immunosorbent assay were investigated immunological parameters of blood. Evaluation of information was carried out with the help of neural network classifier Panalyzer 4,0. Results. There were found the changes, dependent on the stage of the disease in the cellular part of the immune system, which are determined by the number of subpopulations of T-lymphocytes and the level of cells, expressing the activation molecules. Changes in concentrations of immunoglobulins in serum of acromegalic patients don't depend on the stage of the disease. The most informative indices of neural network classifier were the percentage of helper and effector subpopulation T-lymphocytes and cells with expressing the activation receptors. Conclusion. Features of functioning immune system with active acromegaly are to develop the state of hyperactivity of the immune system, which is characterized by increased activation of the cellular component of the immune system in an imbalance of humoral immunity. In remission acromegaly has the trend towards normalization of indexes of cellular immunity, but while high level of B-lymphocytes and NK-cells and by increasing the number of cells expressing and CD95-CD25- receptors. Using neural network classifier was confirmed high informativity of lymphocytes expressing activation markers and the number of helper and effector T cells in the immunopathogenesis of acromegaly.
Keywords: active acromegaly, remission of acromegaly, T-lymphocytes, B-lymphocytes, NK-cells, the informativity
1. Grishkevich N.Yu., Manchuk V.T., Savchenko A.A. Features of informativity at morphological structure of blood lymphocytes in the neural network classification parameters of healthy children and with obesity. Bulletin of new medical tehnologies. 2002; Vol. 9, № 4. P. 25-27. 2. Dogadin S.A., Dudina M.A., Savchenko A.A. Interconnection of somatotropic function of pituitary and the immune system and their role in the development of neoplasia. Problems of endocrinology. — 2013; Vol. 59, № 1. P. 30-34. 3. Kurtasova L.M., Savchenko A.A., Ruzaeva L.A., Schmidt A.R. Features of the metabolism of immunocompetent cells in children with recurrent herpes infection . Problems of Virology. 2002; Vol. 47, №3. P. 45-48. 4. Kryukova E.V., Savchenko A.A., Manchuk V.T., Osokina I.V. Features of immunity in children and adolescents with different duration of diabetes mellitus type I . Problems of Endocrinology. 2000; Vol. 46, №3. P.7-10. 5. Savchenko A.A., Dudina M.A., Dogadin S.A. Features of immunoendocrine interactions at acromegaly. Krasnoyarsk: ООО «Versona», 2014. 111 p. 6. Capatina С., Wass J.A. 60 years of neuroendocrinology: Acromegaly. J. Endocrinol. 2015; Vol. 226, № 2.P. 141-160. 7. Colao A., Ferone D., Marzullo P., Panza N., Pivonello R., Orio F.Jr., Grande G., Bevilacqua N., Lombardi G. Lymphocyte subset pattern in acromegaly. J. Clin. Endocrinol. Invest. 2002; Vol. 25, №2. P. 125-128. 8. Galoiu S., Poiana C. Current therapies and mortality in acromegaly. J. Med. Life. 2015; Vol. 8, №4.P.411-415. 9. Melmed S., Casanueva F., Cavagnini F., Chanson P., Frohman L.A., Gaillard R., Ghigo E., Ho K., Jaquet P., Kleinberg D., Lamberts S., Laws E., Lombardi G., Sheppard M.C., Thomer M., Vance M.L., Wass J.A., GiustinaA. Consensus statement: medical management of acromegaly. Europ. J. Endocrinol. 2005; Vol. 153. P. 737-740. 10. ParkMJ., Shin J.S., Kim Y.H., Hong S.H., Yang S.H., Shin J.Y., Kim S.Y., Kim B., Kim J.S., Park C.G. Murine mesenchymal stem cells suppress T lymphocyte activation through IL-2 receptor a (CD25) cleavage by producing matrix metalloproteinases. Stem Cell Rev. 2011; Vol. 7. № 2. P. 381-393. 11. Puig Domingo M. Treatment of acromegaly in the era of personalized and predictive medicine. Clin. Endocrinol. (Oxf). 2015; Vol. 83. № l. P. 3-14. 12. Tang C.L., Lei J.H., Guan F., Li Y.L., Liu R., Grevelding C.G., Jiang M.S., Dong HF. Effect of cytotoxic T-lymphocyte-associated protein 4 on CD4(+) CD25( +) regulatory T cells in murine schistosomiasis japonica. Exp. Parasitol. 2014; Vol. 136. P. 74-78. 13. Tanimura Y., Коп M., Shimizu K., Kimura F., Kono I., AjisakaR. Effect of 6-day intense Kendo training on lymphocyte counts and its expression of CD95. Eur. J.Appl.Physiol.2009; Vol. 107,№2. P.227-233. 14. Ziegler C., Finke J., Grtillich C. Features of cell death, mitochondrial activation and caspase dependence of rabbit anti-T-lymphocyte globulin signaling in lymphoblastic Jurkat cells are distinct from classical apoptosis signaling of CD95. Leuk. Lymphoma. 2016; Vol. 57, № l. P. 177-182.
Fadeeva O.Y., Chemodanov V.V., Krasnova E.E.
PHENOTYPIC CHARACTERISTICS OF CHILDREN WITH DISEASES OF URINARY SYSTEM DUE TO METABOLIC DISORDERS
Fadeeva O.Yu., Chemodanov V.V., Krasnova E.E. Phenotypic characteristics of children with Diseases of urinary system due to metabolic disorders. Siberian medical review. 2016; № 2: 74-80. DOI 10.20333/25000136-2016-2-74-80
Fadeeva Olga Yurievna PhD, Assistant Professor of the Department of Children's Diseases of Pediatric Department; Ivanovo State Medical Academy; firstname.lastname@example.org
Chemodanov Vadim Vladimirovich Dr. Med.Sci., Professor, Professor managing chair of children's diseases of Department of general medicine; Ivanovo State Medical Academy; email@example.com
Krasnova Elena Evgenievna Dr. Med. Sci., Professor, the professor chair of children's diseases of Department of general medicine; Ivanovo State Medical Academy; firstname.lastname@example.org
Aim of the research. To determine the freguency of external and visceral manifestations of connective tissue dysplasia and its combinations in children with diseases of the urinary system of exchange nature. Materials and methods. The study involved 237 children with urinary system diseases, based on metabolic disorders. The diagnostic protocol included clinical, nephrology, ultrasound of the abdomen, kidney, bladder and heart. Results. The phenotypic portrait of children with dismetabolic kidney diseases allocated combinations of external and visceral manifestations. Conclusion. Certain combinations of phenotypic signs of connective tissue dysplasia have nosological specificity, which may be one of the criteria for diagnosis of probable dismetabolic renal disease.
Keywords: children, diseases of the urinary system, the manifestations of connective tissue dysplasia
1. Ivanova 1.1., GnusaevS.F., Koval' N.Yu. The Peculiarities of development the diseases of the urinary system in children with connective tissue dysplasia. Russian Journal of Pediatrics. 2012; №4. P. 32-36 2. KadurinaT.I., AbbakumovaL.N. Connective tissue dysplasia: the path to diagnosis . Bulletin of the Ivanovo Medical Academy. 2014; Vol. 19, №3. P.5-11. 3. Kadurina T.I., Gnusaev S.F., Abbakumova L.N. Heritable and multifactorial hereditary disorders of connective tissue in children. Algorithms of diagnostics, tactics . Pediatrics. 2014; Vol. 93, №5-2. P. 1-40. 4. Timofeeva E.P., Ryabichenko T.I., Kartseva T.V., Skosyreva G.A. Features of chronic pyelonephritis in children and adolescents on the background of connective tissue dysplasia . Siberian Journal of Medicine. 2011; Vol. 26, № 3-2. P. 53-56. 5. Chemodanov V.V., Krasnova E.E. Features of the disease in children with connective tissue dysplasia. Ivanovo GOU VPO IvSMA Roszdrav, 2009. 140 p.
Kurnosov D.A., Dovbysh N.Y., Gazenkampf K.A., Korchagin E.E., Gritsan A.I.
EXPERIENCE OF TREATING THE PATIENTS, OPERATED IN THE ACUTE PERIOD OF SUBARACHNOID HEMORRHAGE DEPENDING ON THE SEVERITY OF ANGIOSPASM
Kurnosov D.A., Dovbysh N. Yu., Gazenkampf A.A., Korchagin E.E. , Gritsan A.I. Experience of treating the patients, operated in the acute period of subarachnoid hemorrhage depending on the severity of angiospasm. DOI 10.20333/25000136-2016-2-81-87
Kurnosov Dmitry Aleksandrovich Post-graduate Student of the Department of Anesthesiology and Reanimatology IPE; ; email@example.com
Dovbysh Nikolai Y. Cand. Med. Sci.; Professor V. F. Voino-Yasenetsky Krasnoyarsk State Medical University; Regional Clinical Hospital; firstname.lastname@example.org
Gazenkampf K. A. ; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; email@example.com
Korchagin Egor Evgenievich Associate Professor; Professor V. F. Voino-Yasenetsky Krasnoyarsk State Medical University; Regional Clinical Hospital; firstname.lastname@example.org
Gritsan Aleksey Ivanovich D.Med.Sc., Professor; Deputy Head Physician for scientific and practical work; Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University; email@example.com
Materials and methods. It was done the evaluation of the treatment results of 17 patients operated on for ruptured arterial brain aneurysm in the acute period of subarachnoid hemorrhage, depending on the severity of the initial state. Patients were divided into two groups depending on the severity of vasospasm: I group - 10 patients according TCD 3-5 hours MCA blood flow speed was less than 120 cm / sec (10 observations in the age of 50,1 ± 8,3 years); Group II - 7 patients 3-5 th day from the moment of development on the AGR CAA flow rates were more than 120 cm / s (age 55.7 ± 6.5 years). Were evaluated: the level of consciousness of oppression and the severity of the NAO on the scale (GCS, Hunt-Hess, Fisher) at the time of admission; the level of the final neurological deficit extended Glasgow Outcome Scale (GOS extended); and conducted monitoring of cerebral blood flow velocity by TCD. Results. It was established that during the development of vasospasm with increasing speeds of more than 120 cm / s on admission there is a statistically significantly higher rate of blood flow in the intracerebral arteries, carrying a causal aneurysm; and the previously observed increase and a greater flow velocity, which corresponds to a more pronounced vasoconstriction. It was determined that the initial assessment on the scale of Hunt-Hess, Fischer, GCS reflects a greater severity of SAH in the group with increased blood velocity by intracerebral arteries. Conclusion. It was found that the adverse outcomes of SAH (death - severe disability) are characteristic for patients with the development of vasospasm.
Keywords: subarachnoid hemorrhage, cerebral aneurysm, vasoconstriction, transcranial Doppler
1. Gorbachev V.I., Likholetova N.V., Gorbachev S.V. Changing the speed parameters of cerebral blood flow at the positioning the head end of the bed in patients operated on for nontraumatic intracranial hemorrhage. Journal of Anesthesiology and Reanimatology. 2014; Vol. 11. № 2. P. 3-9. 2. Konovalov A.N., Krylov V.V., Eliava Sh. Sh., Belousova O.B., Tkachev V.V., Parfyonov V.E., Svistov D.V., Antonov G.I., Lazarev V.A., Ivanova N.E., Piradov M.A., Pirskaya T.N., Lapatukhin V.G., Skorokhod A.A., Kurdyumova N.V., Lubnin A.Yu., Zeitlin A.M. Recommendatory protocol of patients with subarachnoid hemorrhage due to rupture of cerebral aneurysms. [Electronic resource] – Access mode: http://nsicu.ru/uploads/attachment/file/98/Recommendation_-_SAH. pdf. 3. Krylov V.V., Kalinkin A.A., Petrikov S.S. The pathogenesis of vasospasm and ischemia in nontraumatic subarachnoid hemorrhage due to rupture of cerebral aneurysms. Journal of Neurology. 2014; № 5. P. 4-12. 4. Petrikov S.S., Solodov A.A., Huseynova H.E., Titova Yu.V., Dashyan V.G., Aleshchenko E.I., Khamidova L.T., Krylov V.V. The role of multicomponent neuromonitoring in determining the tactics of intensive care in patient with subarachnoid hemorrhage due to rupture of an arterial aneurysm of the brain. Anesthesiology and Reanimatology. 2009; № 3. P. 61-63. 5. Oshorov A.V., Goryachev A.S., Popugaev K.A., Polupan A.A., Savin I.A., Lubnin A.Yu. Monitoring of cerebral perfusion pressure in the intensive care // Journal of Anesthesiology and Intensive Care. 2013; Vol . 10, № 2. P. 52-59. 6. Tseitlin A.M., Lubnin A.Yu. Methodological approaches to assessing the effectiveness of the treatment of intracranial aneurysms. Anesthesiology and Reanimatology. 2013; № 5. P. 63-69. 7. Shatalov V.I., Shchegolev A.V. Effect of infusion therapy on central hemodynamics and the outcome of treatment of patients with subarachnoid hemorrhage. Anesthesiology and Reanimatology. 2005; № 4. P. 55-58. 8. Bellner J., Romner B., Reinstrup P., Kristiansson K.A., Ryding E., Brandt L. Transcranial Doppler sonography pulsatilityindex (PI) reflects intracranial pressure . SurgNeurol. 2004; Vol. 62, №1. P. 45-51. 9. Guidelines for the Management of Aneurysmal Subarachnoid Hemorrhage : Guideline for Healthcare Professionals From the American Heart Association [Electronic resource] / American Stroke Association . Stroke . 2012; Vol .43, № 6. Р. 1711-1737.URL: http:.stroke.ahajournals.org/content/early/2012/05/03/STR.0b013e3182587839 10. Kotopka M.J., Flamm E.S. Cerebral Aneurism: Surgical consideration. ln:Cotrell J.E., Smith D.S., eds. Anesthesia and neurosurgery, 2nd ed. St. Louis: CV Mosby. 1994; P. 364-375. 11. Schmidt J.M., Wartenberg K.E., Fernandez A., Claassen J., Rincon F., Ostapkovich N.D., Badjatia N., Parra A., Connolly E.S., Mayer S.A Frequency and clinical impact of asymptomatic cerebral infarction due to vasospasm after subarachnoid hemorrhage .J. Neurosurg. 2008; Vol.109. P.1052-1059. 12. Solenski N.J., Haley E.C. Jr, Kassell N.F., Kongable G., Germanson T., Truskowski L., Torner J.C. Medical complications of aneurysmal subarachnoid hemorrhage: A Report of the multicenter, cooperative aneurysm study . Crit. Care Med.1995; Vol.23. P.1007-1017
Petrova M.M., Pronina E.A., Baron I.I., PozdnyakovaAleksandra Aleksandrovna - ., Romanova M.V., Yaganova S.S.
THE ATTITUDE OF THE STUDENTS OF KRASNOYARSK STATE MEDICAL UNIVERSITY NAMED AFTER PROFESSOR V.F. VOINO-YASENETSKY TO PHYSICAL ACTIVITY
Petrova M.M., Pronina E.A., Baron I.I., Pozdnyakova A.A., Romanova M.V., Yaganova S.S. The attitude of the students of Krasnoyarsk State Medical University named after professor V.F. Voino-Yasenetsky to physical activity. Siberian medical review. 2016; № 2: 88-92. DOI 10.20333/25000136-2016-2-88-92
Petrova Marina Mikhailovna MD, PhD, Prof., Head of the Department of Outpatient Therapy, Family Medicine and HL with a course of Postgraduate Education; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; 660022, Красноярск, ул. Партизана Железняка, 1;тел.:8 (391)2200628; e-mail: firstname.lastname@example.org
Pronina Elena Alexandrovna Cand. Med. Sc, Assistant of the Department of Polyclinic Therapy, Family Medicine and Healthy Lifestyle with Postgraduate Courses; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; email@example.com
Baron Irina Iosifovna Doctor of Philosophy, Associate Professor at the Department of ambulance care State Educational Institution of High Professional Education; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; firstname.lastname@example.org
PozdnyakovaAleksandra Aleksandrovna - Student; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; email@example.com
Romanova Maria Viktorovna Student; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; Romil_16@mail.ru
Yaganova Svetlana Sergeevna Student; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; Svetik55067@mail.ru
Aim of the research. To study medical university students' attitude to the physical activity. Materials and methods. It was conducted the guestioning of 126 students from 1 and 6 courses. Results. Itwas revealed thatmore than a half of respondents (69 ±4,1%) regularly engage in physical exercises in order to improve their health (25,4 ± 43,9%), to support the physical shape (23 ± 3,7%), to improve the body (15, 8 ± 3,2 %). Most popular among students are fitness, dancing (19,8 ± 3,6 %), training in the gym (14,3 ± 3,1%), playing sports (10,3 ± 42,3%), walking (14,3 ±3,1%). Conclusion. More than a half of the KrasGMU students are engaged in physical exercises regularly.
Keywords: physical activity, students
1. Kalnaya E.V., Shakhanova A.V., Skhakumidov T.A., Meretukova A.R. Influence of sports physical activities on regulatory and adaptive possibilities of girl-students with different physical activity. Bulletin of Adygeya State University. Series 4: natural-mathematical and technical sciences. 2014; №3 (142). P. 80-88. 2. Cleland V., Dwyer T.F Venn A. Which domains of childhood physical activity predict physical activity in adulthood? A 20-year prospective tracking study. Br.J. Sports Med. 2012; Vol.46,№8. P.595-602. 3. Nocon M.r Hiemann T., Miiller-Riemenschneider F. at al Association of physical activity with all-cause and cardiovascular mortality: a systematic review and meta-analysis. Cardiovasc. Prev. Rehabil. 2008; Vol.15, №3. P.239-246.
Shnayder N.A. Video monitoring of electroencephalograPHY AT epilepsy. Siberian medical review. 2016; № 2: 93-105. DOI 10.20333/25000136-2016-2-93-105
Shnayder Natalya Alekseevna MD, PhD, Prof., Head of the Department of Medical Genetics and Clinical Neurophysiology of Institute of Postgraduate Education; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; 660022, г. Красноярск, ул. Партизана Железняка, д. 1; тел.: 8(391) 2212449; e-mail: firstname.lastname@example.org
Video monitoring EEC relates to continuous EEC recorded during a shorter or longer period of time with simultaneous video recording of clinical manifestations. With the correlation of the recorded behavior (video) and EEC it can be accurately diagnosed seizures and non-epileptic seizures in almost all cases. Video EEC monitoring is a standard criterion for the diagnosis of epilepsy.
Keywords: functional diagnostics, clinical neurophysiology, electroencephalography, EEG video monitoring, epilepsy, diagnosis, lecture
1. Vlasov P.N., ChervyakovA.V., Drozhzhina G.R., Antonyuk M.V., Orekhova N.V., Gnezditsky V.V., Noskova T.Yu., Fedin P.A. Derealizable disorders in epilepsy//Epilepsy and paroxysmal states. 2011; Vol.3,№4. P. 14-21. 2. Glukhova L.Yu., Mukhin, K.Yu., Nikitina M.A., Barletova E.I., Tupikova E.A. The value of electroencephalographic techniques in clinical practice of neurologist 11 Russian Journal of Child Neurology. 2013; Vol.VIII,№3. P. 15-30. 3. Karlov V.A. Epilepsy in children and adult women and men. M.: Medicine, 2010. 720 p. 4. Clinical Electroencephalography: Textbook / Ed. N.A. Shnayder. KrasSMU, 2013. 102 p. 5. Kotov A.S. Anxiety in patients with epilepsy. Journal of Neurology and Psychiatry named after S.S.Korsakov. 2013; Vol. 113,№4-2. P.41-44. 6. Kotov A.S. Epilepsy and sleep. Journal of Neurology and Psychiatry named after S.S. Korsakov. 2008; Vol. 113, №7. P. 4-10. 7. Kotov A.S., Rudakova I.G., Kotov S.V. Nonterminal remission in patients with epilepsy. Journal of Neurology and Psychiatry named after S.S.Korsakov. 2008; Vol. 108, №11. P. 16-20. 8. Likhachev S.A., Veevnik E.V., Terekhov V.S., DymkovskayaM.N., Naumenko D.V. Determination of indications to surgical treatment of epilepsy. Neurology and Neurosurgery Eastern Europe. 2015; №4(28). P. 147-157. 9. Mukhin K.Yu., Petrukhin A.S., Glukhova L.Yu. Epilepsy. Atlas of elektroclinikal diagnostics. M.: Alvarez Publishing, 2004. 440 p. 10. Sadykova A.V., Schnayder N.A., Dmitrenko D.V., Kantimirova E.A. Electroencephalographic diagnosis of photoparoxysmal response. Functional diagnostics. 2013; №3. P. 33-40. 11. Benbadis S.R. Provocative techniques should be used for the diagnosis of psychogenic nonepileptic seizures.Epilepsy Behav. 2009; Vol. 15, №2. P.106-109. 12. Benbadis S.R., Heriaud L., Tatum W.O., Vale F. L. Epilepsy surgery, delays and referral patterns-are all your epilepsy patients controlled?. Seizure. 2003; Vol. 12, №3. P. 167-170. 13. BenbadisS.R., LaFrance W.C. Jr., Papandonatos G.D., KorabathinaK., LinK., KraemerH.C. Interrater reliability of EEG-video monitoring. Neurology. 2009; Vol. 73, №11. P. 843-846. 14. Binnie C.D., Prior P.F. Electroencephalography. J. Neurol. Neurosurg. Psychiatry. 1994; Vol. 57, №11. P. 1308-1319. 15. Boylan G., Rennie J., Pressler R., Wilson G., Morton M., Binnie C. Phenobarbitone, neonatal seizures, and video-EEG. Arch. Di. Child Fetal Neonatal Ed. 2002; Vol. 86, №3. P. 165-170. 16. McGonigal A., Russell A., Mallik A., Oto M., Duncan R. Use of short term video EEG in the diagnosis of attack disorders. J. Neurol. Neurosurg. Psychiatry. 2004; Vol. 75, №5. P. 771-772. 17. Pandian J.D., Cascino G.D., So E.L. Digital video-electroencephalographic monitoring in the neurological-neurosurgical intensive care unit: clinical features and outcome. Arch. Neurol. 2004; Vol. 61, № 7. P. 1090-1094. 18. ReuberM., FernandezG., Bauer J., Helmstaedter C., Eiger C.E. Diagnostic delay in psychogenic nonepileptic seizures. Neurology. 2002; Vol. 58, №3. P. 493-495. 19. Scott C., Fish D., Smith S., Free S., Stevens J., Thompson P., Duncan J., Shorvon S., Harkness W. Presurgical evaluation of patients with epilepsy and normal MRI: role of scalp video-EEG telemetry. J. Neurol. Neurosurg. Psychiatry. 1999; Vol. 66, №1. P. 69-71. 20. Sperling M.R. Clinical challenges in invasive monitoring in epilepsy surgery. Epilepsia. 1997; Vol. 38, №4. P. 6-12. 21. Telenczuk B., Baker S.N., Kempter R., Curio G. Correlates of a single cortical action potential in the epidural EEG. Neuroimage. 2015; Vol. 109. P. 357-367.
REVIEW OF DISSERTATION TOPICS THAT WERE SUBMITTED IN 2015 BY THE COMMITTEE OF DISSERTATION DEFENSE FOR THE DEGREE OF CANDIDATE OF SCIENCE, FOR THE DEGREE OF DOCTOR OF SCIENCE D 208.037.01 IN SPECIALTY 14.01.05 - CARDIOLOGY, MEDICAL SCIENCES
Shtarik S.YU. Review of dissertation topics that were submitted in 2015 by the committee of dissertation defense for the degree of candidate of science, for the degree of doctor of science D 208.037.01 in specialty 14.01.05 - cardiology, medical sciences. Siberian medical review. 2016; № 2: 106-111. DOI 10.20333/25000136-2016-2-106-111
Shtarik S. Yu. Dr. Med. Sci.,Professor; Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University; email@example.com
REVIEW OF DISSERTATION TOPICS THAT WERE SUBMITTED IN 2015 BY THE DISSERTATION COMMITTEE D 208.037.03 IN SPECIALTY 14.01.11 - NERVOUS DISEASES, 14.01.14 - STOMATOLOGY
Gorbach N.A. Review of dissertation topics that were submitted in 2015 by the committee of dissertation defense D 208.037.03 in specialty 14.01.11 - nervous diseases, 14.01.14 - stomatology. Siberian medical review. 2016; № 2: 112-116. DOI 10.20333/25000136-2016-2-112-116
Gorbach N. A. Dr.Med.Sc, Professor, Academic Secretary of the Dissertation Council D 208.037.03; Professor V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University; firstname.lastname@example.org