Violation of the kidney filtration function is common enough among patients with cardiovascular disease (CVD), especially against disorders of carbohydrate metabolism (IGM). Renal dysfunction (PD) is associated with more frequent development of cardiovascular complications. In turn, the probability of development of renal disease in patients with cardiovascular disease is significantly higher than in general population. This bidirectional pathogenetic mechanisms existing between cardiovascular and kidney diseases were the basis for the formation of cardiorenal syndrome concept. The review discusses the general parts of pathogenesis within the cardiovascular continuum. In addition, it shows the effect on metabolic disorders during CVD combined with renal dysfunction. The review reveals a recent view on the main mechanisms of cardiorenal syndrome.

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This review deals with the problem of polypharmacy, its definition and relevance to clinical practice. The review deals with contemporary methods of fight with the phenomenon of polypharmacy - the index of rational use of medicines, the scale of anticholinergic drug capacity, STOPP/START criteria. It was assessed the therapeutic importance and positive effects of implementation of these criteria in clinical practice.

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Endometriosis is among the prevalent gynecological diseases and diagnosed in 10% of women of reproductive age. Endometriosis problem is becoming increasingly of health-social value, which is associated with severe clinical manifestations and recurrent disease has a negative influence on quality of life and ability to work of women. This article presents modern approaches to conserving therapy of severe adenomyosis. A review of recent major studies in the field of surgical treatment of this disease, analyze the main stages and results of operations.

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Aim of the research. To determine the association of polymorphic variants of genes TLRs with the severity of coronary artery disease (CAD) in young patients.
Materials and methods. The study included 292 patients with stable coronary artery disease. Genotyping was performed in 96-well format by TagMan technology. It was studied 8 variable sites in four genes: TLR1 (rs5743551 and rs5743611), TLR2 (rs3804099 and rs5743708), TLR4 (rs4986790 and rs4986791), TLR6 (rs3775073 and rs5743810).
 Results. In patients with coronary heart disease aged 55 years old and under С / T genotype variable site rs3804099 TLR2 gene is associated with increasing of 4.4 times the risk of developing severe chronic heart failure (III-IV FC) and in 2.7 times with increase in the risk of stenosis brachiocephalic arteries more than 30 %; С/ C genotype of this variable site TLR2 gene is associated with 4 times increase in the risk of severe coronary atherosclerosis. Т/ C genotype variable site rs3775073 TLR6 gene was associated with an increase of 4 times the risk of multifocal atherosclerosis and 3 times the risk of myocardial infarction in patients with coronary heart disease aged 55 years old and younger.
Conclusion. There were revealed the associations between the variable sites of two genes of innate immunity receptors (TLR 2 and 6) with the severity of CHD in patients aged 55 years old and younger.

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Aim of the research. To evaluate twisting of the left ventricle (LV) on the background of left bundle branch block (LBBBj in patients c cardiomyopathies and study of the hemodynamic conseguences of possible changes. Materials and methods. The study involved 22 patients with ischemic and dilated cardiomyopathy with left ventricular ejection fraction less than 40%, divided into two groups: physiological counter-rotating basal and top and abnormal unidirectional.
Results. Although there are no differences in terms, characterizing cardiac remodeling, in the group with abnormal rotation occurred substantially smaller twisting indicators and changes were observed in the flow of the pulmonary veins that are typical of high end-diastolic pressure LV. In group of patients with abnormal rotation systolic left atrial filling fraction was 32,3 ± 8,07%, whereas in the group with a physiological counterrotating -53,1 ± 10,1 (P = 0.000226). A possible cause of these changes are great indicators of intraventricular dyssynchrony in the group with abnormal rotation. Time interval delay redaction of the rear wall was 63,3 ± 35,1 ms in comparison with persons with normal left ventricular rotation - 8,0 ± 17,9 ms (p = 0,015922), reflecting the greater degree of mechanical dyssynchrony.
Conclusion. Thus, LBBB has a complex negative influence on the electrical activation and contraction of IV, the result of which was a violation of twisting, mechanical dyssynchrony and deterioration of diastolic function.

Pavlyukova E.N., Kuzhel D.A., Matyshin G.V., Veselkova N.S., Avdeeva O.V., Metelitsa V.S., Savchenko Е.А. Myocardia deformation and full blockade of the left leg Gis bundle. Rational pharmacotherapy in cardiology. 2012; Vol. 8, №6. P.814-820.
2.	Pavlyukova E.N., Kuzhel D.A., Matyshin G.V., Savchenko E.A., Filippova S.A. Rotation and meaning of left ventricle: physiological role and the meaning in clinical practice. Rational pharmacotherapy in cardiology. 2015; Vol. 11, № 1. P.68-78.
3.	Beladan С.С., Calin A., Rosea М., Ginghina С., Popescu В.А. Left ventricular twist dynamics: principles and applications. Heart. 2014; Vol. 100. P.731-740.
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5.	Gorcsan J., Abraham T., Agler D.A., Bax J.J., Derumeaux G., Grim R.A., Martin R. Steinberg J.S., Sutton M.S.J., Yu C.-M. Echocardiography for cardiac resynchronization therapy: recommendations for performance and reporting—a report from the American Society of Echocardiography Dyssynchrony Writing Group endorsed by the Heart Rhythm Society. J. Am. Soc. Echocardiogr. 2008; Vol. 21. P.191- 213.
6.	Helle-Valle T., Crosby J., Edvardsen T., Lysseg- gen E., Amundsen B.H., Smith H.J., Rosen B.D., Lima J.A., Torp H., Ihlen H., Smiseth O.A. Newnoninvasive method for assessment of left ventricular rotation: speckle tracking echocardiography. Circulation. 2005; Vol.112. P.3149-3156.
7.	Karaahmet T., Gtirel E., Tigen K., Guler A., Dundar C., Fotbolcu H., Basaran Y. The effect of myocardial fibrosis on left ventricular torsion and twist in patients with non-ischemic dilated cardiomyopathy//Cardiology Journal. 2013; Vol.20, №3. P.276-86.
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11.	Morno§ C., Ru§inaru D., Manolis A.J., Zachar- opoulou I., Pittaras A., Ionas A. The Value of a New Speckle Tracking Index Including Left Ventricular Global Longitudinal Strain and Torsion in Patients with Dilated Cardiomyopathy. Hellenic Journal Cardiology. 2011; Vol.52. P.299-306.
12.	Nagueh F., Appleton C.P., Gillebert T.C., Marino P.N., Oh J.K., Smiseth O.A., Waggoner A.D., Flachskampf F.A., Pellikka P.A., Evangelista A, Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography . Journal of the American Society of Echocardiography. 2009; Vol. 22, №2. P.107-133.
13.	Popescu B.A., Beladan C.C., Calin A., Muraru D., Deleanu D., Rosea M., Gindhina C. Left ventricular remodelling and torsional dynamics in dilated cardiomyopathy: reversed apical rotation as a marker of disease severity. European Journal Heart Failure. 2009; Vol.11. P.945-951.
14.	van Dalen B.M., Caliskan K., Soliman O.I., Nemes A., Vietter W.B., Ten Cate F.J., Geleijnse M.L. Left ventricular solid body rotation in non-compaction cardiomyopathy: a potential new objective and guan- titative functional diagnostic criterion?. European Journal Heart Failure. 2008; Vol.10, №11. P.1088-1093.

Aim of the research. To study proliferation and adhesion properties of neuronal and astroglial cells at directed activity modulation HIF-1.
Materials and methods. The experiments were performed in the 3-cell BBB model and in isolated neurons and astrocytes in vitro. HIF-1 activity was suppressed by FM19G11 inhibitor, impedimetric cell index was measured with the analyzer «xCelligence».
Results. We found that HIF-1 inhibition reduced proliferation and astrocytes and neurons in both the systems. At the same time, the presence in the system of cerebral endothelial cells has stabilizing effect on the proliferative activity of neuronal and astroglial cells.
Conclusion. Proliferative properties of astrocytes and neurons have a HIF-1-dependent mechanisms.

1.	Khilazheva E.D., Boytsova E.B., Pozhilenkova E.	A., Solonchuk Yu.R., Salmina A.B. Obtaining three cells model of neurovascular unit in vitro. Cytology. 2015; Vol. 57, № 10. P. 710-713.
2.	FanX., Kavelaars A., Heijnen C.J., Groenendaal F., Van Bel F. Pharmacological Neuroprotection after Perinatal Hypoxic-Ischemic Brain Injury. Current Neuropharmacology. 2010; Vol. 8, № 4. P. 324-334.
3.	Sheldon R.A., Lee C.L., Jiang X., Knox R.N., Ferriero D.M. Hypoxic preconditioning protection is eliminated in HIF-la knockout mice subjected to neonatal hypoxia-ischemia. Pediatric research. 2014; Vol. 76, №1. P. 46-53.
4.	Siegenthaler J.A., Sohet F., Daneman R. "Sealing off the CNS": cellular and molecular regulation of blood-brain barriergenesis. Current opinion in neurobiology. 2013; Vol. 23, №6. P. 1057-1064.
5.	Valle-CasusoJ.C.,Gonzalez-SanchezA.,Medina J.M., Tabernero A. HIF-1 and c-Src mediate increased glucose uptake induced by endothelin-1 and con- nexin43 in astrocytes. PLoS One. 2012; Vol. 7, №2. e32448.
6.	Zhu Z., Reiser G. Signaling mechanism of protease activated receptor 1-induced proliferation of astrocytes: Stabilization of hypoxia inducible factor-1 a triggers glucose metabolism and accumulation of cyclin D1. Neurochem. Int. 2014; Vol. 79. P. 20-32.

Aim of the research. To determine of expression level (mRNA) dopamine receptor type 4 genes (DRD4) and 2A serotonin receptor (5HTR2A) in peripheral blood lymphocytes in patients with schizophrenia spectrum disorders, and to examine the relationship between the level of expression of the studied genes and clinical response to antipsychotic therapy.
Materials and methods. The study was conducted detection of the expression level (mRNA) DRD4 dopamine receptor genes and 5HTR2A serotonin receptor in the peripheral blood lymphocytes of patients with schizophrenia spectrum disorders, and studied the relationship between the level of expression of the genes studied and clinical response to antipsychotic therapy.
Results. It is found that the initial expression level 5HTR2A significantly positively correlated with indices Clinical Global Impression Scale (CGI-S) (r = 0,732, p = 0,001) and can serve as a biomarker of treatment efficacy of olanzapine.
Conclusion. These results allow us to consider neurotransmission receptors on peripheral blood lymphocytes as potential markers of personalized assessment of the effectiveness of antipsychotic ther.

1.	Mosolov S.N. Biological methods of treatment of mental disorders. - Evidence-based medicine. -
M.,2012. - 1080 p.
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Aim of the research. To study the immunological parameters and neural network evaluation of its informativity in patients with active acromegaly and in a state of remission.
Materials and methods. The study involved 106 patients with acromegaly: 88 people at the stage of active acromegaly and 18 patients with remission of acromegaly. The method of indirect immunofluorescence and by immunosorbent assay were investigated immunological parameters of blood. Evaluation of information was carried out with the help of neural network classifier Panalyzer 4,0.
Results. There were found the changes, dependent on the stage of the disease in the cellular part of the immune system, which are determined by the number of subpopulations of T-lymphocytes and the level of cells, expressing the activation molecules. Changes in concentrations of immunoglobulins in serum of acromegalic patients don't depend on the stage of the disease. The most informative indices of neural network classifier were the percentage of helper and effector subpopulation T-lymphocytes and cells with expressing the activation receptors. Conclusion. Features of functioning immune system with active acromegaly are to develop the state of hyperactivity of the immune system, which is characterized by increased activation of the cellular component of the immune system in an imbalance of humoral immunity. In remission acromegaly has the trend towards normalization of indexes of cellular immunity, but while high level of B-lymphocytes and NK-cells and by increasing the number of cells expressing and CD95-CD25- receptors. Using neural network classifier was confirmed high informativity of lymphocytes expressing activation markers and the number of helper and effector T cells in the immunopathogenesis of acromegaly.

1.	Grishkevich N.Yu., Manchuk V.T., Savchenko A.A. Features of informativity at morphological structure of blood lymphocytes in the neural network classification parameters of healthy children and with obesity. Bulletin of new medical tehnologies. 2002; Vol. 9, № 4. P. 25-27.
2.	Dogadin S.A., Dudina M.A., Savchenko A.A. Interconnection of somatotropic function of pituitary and the immune system and their role in the development of neoplasia. Problems of endocrinology. — 2013; Vol. 59, № 1. P. 30-34.
3.	Kurtasova L.M., Savchenko A.A., Ruzaeva L.A., Schmidt A.R. Features of the metabolism of immunocompetent cells in children with recurrent herpes infection . Problems of Virology. 2002; Vol. 47, №3. P. 45-48.
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5.	Savchenko A.A., Dudina M.A., Dogadin S.A. Features of immunoendocrine interactions at acromegaly. Krasnoyarsk: ООО «Versona», 2014. 111 p.
6.	Capatina С., Wass J.A. 60 years of neuroendocrinology: Acromegaly. J. Endocrinol. 2015; Vol. 226, № 2.P. 141-160.
7.	Colao A., Ferone D., Marzullo P., Panza N., Pivonello R., Orio F.Jr., Grande G., Bevilacqua N., Lombardi G. Lymphocyte subset pattern in acromegaly. J. Clin. Endocrinol. Invest. 2002; Vol. 25, №2. P. 125-128.
8.	Galoiu S., Poiana C. Current therapies and mortality in acromegaly. J. Med. Life. 2015; Vol. 8, №4.P.411-415.
9.	Melmed S., Casanueva F., Cavagnini F., Chanson P., Frohman L.A., Gaillard R., Ghigo E., Ho K., Jaquet P., Kleinberg D., Lamberts S., Laws E., Lombardi G., Sheppard M.C., Thomer M., Vance M.L., Wass J.A., GiustinaA. Consensus statement: medical management of acromegaly. Europ. J. Endocrinol. 2005; Vol. 153. P. 737-740.
10.	ParkMJ., Shin J.S., Kim Y.H., Hong S.H., Yang S.H., Shin J.Y., Kim S.Y., Kim B., Kim J.S., Park C.G. Murine mesenchymal stem cells suppress T lymphocyte activation through IL-2 receptor a (CD25) cleavage by producing matrix metalloproteinases. Stem Cell Rev. 2011; Vol. 7. № 2. P. 381-393.
11.	Puig Domingo M. Treatment of acromegaly in the era of personalized and predictive medicine. Clin. Endocrinol. (Oxf). 2015; Vol. 83. № l. P. 3-14.
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Aim of the research. To determine the freguency of external and visceral manifestations of connective tissue dysplasia and its combinations in children with diseases of the urinary system of exchange nature.
Materials and methods. The study involved 237 children with urinary system diseases, based on metabolic disorders. The diagnostic protocol included clinical, nephrology, ultrasound of the abdomen, kidney, bladder and heart.
Results. The phenotypic portrait of children with dismetabolic kidney diseases allocated combinations of external and visceral manifestations.
Conclusion. Certain combinations of phenotypic signs of connective tissue dysplasia have nosological specificity, which may be one of the criteria for diagnosis of probable dismetabolic renal disease.

1.	Ivanova 1.1., GnusaevS.F., Koval' N.Yu. The Peculiarities of development the diseases of the urinary system in children with connective tissue dysplasia. Russian Journal of Pediatrics. 2012; №4. P. 32-36
2.	KadurinaT.I., AbbakumovaL.N. Connective tissue dysplasia: the path to diagnosis . Bulletin of the Ivanovo Medical Academy. 2014; Vol. 19, №3. P.5-11.
3.	Kadurina T.I., Gnusaev S.F., Abbakumova L.N. Heritable and multifactorial hereditary disorders of connective tissue in children. Algorithms of diagnostics, tactics . Pediatrics. 2014; Vol. 93, №5-2. P. 1-40.
4.	Timofeeva E.P., Ryabichenko T.I., Kartseva T.V., Skosyreva G.A. Features of chronic pyelonephritis in children and adolescents on the background of connective tissue dysplasia . Siberian Journal of Medicine. 2011; Vol. 26, № 3-2. P. 53-56.
5.	Chemodanov V.V., Krasnova E.E. Features of the disease in children with connective tissue dysplasia. Ivanovo GOU VPO IvSMA Roszdrav, 2009. 140 p.

Materials and methods. It was done the evaluation of the treatment results of 17 patients operated on for ruptured arterial brain aneurysm in the acute period of subarachnoid hemorrhage, depending on the severity of the initial state. Patients were divided into two groups depending on the severity of vasospasm: I group - 10 
patients according TCD 3-5 hours MCA blood flow speed was less than 120 cm / sec (10 observations in the age of 50,1 ± 8,3 years); Group II - 7 patients 3-5 th day from the moment of development on the AGR CAA flow rates were more than 120 cm / s (age 55.7 ± 6.5 years). Were evaluated: the level of consciousness of oppression and the severity of the NAO on the scale (GCS, Hunt-Hess, Fisher) at the time of admission; the level of the final neurological deficit extended Glasgow Outcome Scale (GOS extended); and conducted monitoring of cerebral blood flow velocity by TCD.
Results. It was established that during the development of vasospasm with increasing speeds of more than 120 cm / s on admission there is a statistically significantly higher rate of blood flow in the intracerebral arteries, carrying a causal aneurysm; and the previously observed increase and a greater flow velocity, which corresponds to a more pronounced vasoconstriction. It was determined that the initial assessment on the scale of Hunt-Hess, Fischer, GCS reflects a greater severity of SAH in the group with increased blood velocity by intracerebral arteries.
Conclusion. It was found that the adverse outcomes of SAH (death - severe disability) are characteristic for patients with the development of vasospasm.

1. Gorbachev V.I., Likholetova N.V., Gorbachev S.V. Changing the speed parameters of cerebral blood flow at the positioning the head end of the bed in patients operated on for nontraumatic intracranial hemorrhage. Journal of Anesthesiology and Reanimatology. 2014; Vol. 11. № 2. P. 3-9.
2. Konovalov A.N., Krylov V.V., Eliava Sh. Sh., Belousova O.B., Tkachev V.V., Parfyonov V.E., Svistov D.V., Antonov G.I., Lazarev V.A., Ivanova N.E., Piradov M.A., Pirskaya T.N., Lapatukhin V.G., Skorokhod A.A., Kurdyumova N.V., Lubnin A.Yu., Zeitlin A.M. Recommendatory protocol of patients with subarachnoid hemorrhage due to rupture of cerebral aneurysms. [Electronic 
resource] – Access mode: http://nsicu.ru/uploads/attachment/file/98/Recommendation_-_SAH. pdf.
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4. Petrikov S.S., Solodov A.A., Huseynova H.E., Titova Yu.V., Dashyan V.G., Aleshchenko E.I., Khamidova L.T., Krylov V.V. The role of multicomponent neuromonitoring in determining the tactics of intensive care in patient with subarachnoid hemorrhage due to rupture of an arterial aneurysm of the brain. Anesthesiology and Reanimatology. 2009; № 3. P. 61-63.
5. Oshorov A.V., Goryachev A.S., Popugaev K.A., Polupan A.A., Savin I.A., Lubnin A.Yu. Monitoring of cerebral perfusion pressure in the intensive care 
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Aim of the research. To study medical university students' attitude to the physical activity.
Materials and methods. It was conducted the guestioning of 126 students from 1 and 6 courses.
Results. Itwas revealed thatmore than a half of respondents (69 ±4,1%) regularly engage in physical exercises in order to improve their health (25,4 ± 43,9%), to support the physical shape (23 ± 3,7%), to improve the body (15, 8 ± 3,2 %). Most popular among students are fitness, dancing (19,8 ± 3,6 %), training in the gym (14,3 ± 3,1%), playing sports (10,3 ± 42,3%), walking (14,3 ±3,1%).
Conclusion. More than a half of the KrasGMU students are engaged in physical exercises regularly.

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Video monitoring EEC relates to continuous EEC recorded during a shorter or longer period of time with simultaneous video recording of clinical manifestations. With the correlation of the recorded behavior (video) and EEC it can be accurately diagnosed seizures and non-epileptic seizures in almost all cases. Video EEC monitoring is a standard criterion for the diagnosis of epilepsy.

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