The first part of the review gives the definition and classification of spinocerebellar ataxia caused by the static mutations. Also are described the causes and mechanism of static mutations.

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The article presents the scientific literature review of the previous 20 years about gene of sodium channels SCN10A on databases of OMIM, PubMed, NCBI. Were considered the mechanism of the gene SCN10A, structure and functioning of sodium channels encoded by this gene. Are given the results of published researches that confirm the role of gene SCN10A in the develop¬ment of pathology the cardiovascular system and other organ systems.

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The purpose of the study. To study the influence ofrs1800470 polymorphism of gene transforming growth factor beta 1 (TGF-f1) on the predisposition to developing of asthma among inhabitants of Krasnoyarsk.
Materials and methods. Genomic DNA was separated from 10 ml of venous blood by phenol-chloroform extraction. Single nucleotide polymorphism was tested by polymerase chain reaction in real time in accordance with the protocol of the manufac¬turer (probes TaqMan, AppliedBiosystems, USA) on the apparatus ABI7900HT. The group of patients with bronchial asthma -108 persons, the control group - 282 people.
Results. When studying the distribution of genotypes rs180047 gene TGF-f1 were not found statistically significant differences between the patients with bronchial asthma and the control group. And just for a group of patients with non-allergic asthma was shown the absence of rare gomozigotGG (odds ratio (OR) - 0.88, 95% confidence interval (CI) - 0,84-0,92, p = 0.023). Conclusion. Perhaps this carrier state genotype can be considered conditionally as a protective factor against the development of asthma. To verify the data is planned to increase test groups.

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12.	Li H., Romieu I., Wu H., Sienra-Monge J. J., Ramirez-Aguilar M., del Rio-Navarro B.E, del Lara-Sanchez IC, Kistner E. O., Gjessing H. K., London S. J. Genetic polymorphisms in transforming growth factor beta-1 (TGFB1) and childhood asthma and atopy // Hum Genet. 2007. Vol. 121, № 5. P. 529-538.
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14.	Salam M.T., Gauderman W.J., McConnell R., Lin P.C., Gilliland F.D. Transforming growth factor-1 C-509T polymorphism, oxidant stress, and early-onset childhood asthma // Am. J. Respir. Crit. Care Med. 2007. Vol. 176. № 12. P. 1192-1199.
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The purpose of the study. To conduct the comparative analysis of cytological and chemiluminescent markers of phagocytic cells of the bronchial washout at inflammation of respiratory tract in patients with bronchial asthma (BA) and chronic obstructive pulmonary disease (COPD).
Materials and methods. The study included 117 patients with bronchial asthma (BA) under control and 53 patients with chronic obstructive pulmonary disease (COPD) in phase of aggravation of the disease under the age of 75 years old. In the fluid of bronchial washout were studied cytological and chemiluminescent indicators of phagocytic cells. Rating (CL) of chemiluminescence was carried out on chemiluminometer (Russia).
Results. In cytological examination of bronchial washout fluid in patients with COPD was revealed significantly higher level of neutrophils in contrast to the eosinophilic inflammation in asthma. It was found that spontaneous CL activity of phagocytic cells of the bronchial washout in patients with COPD is different from the same in patients with asthma and healthy persons. Conclusion. The study of cytology the bronchial washout fluid and chemiluminescent activity of phagocytic cells improves the quality of the differential diagnosis of asthma and COPD in cases of combined pathology.

1. Global strategy for the prevention and treatment of bronchial asthma (revision 2011): transl. from English / Ed. A.S. Belyavsky. M.: Russian Respiratory Society, 2012. P. 108.
2.	Global strategy for the diagnosis, treatment and prevention of chronic obstructive pulmonary disease (revision 2011): Transl. from English / Ed. A.S. Belyavsky - M.: Russian Respiratory Society, 2012. P. 80.
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4.	Demko I.V., Sobko E.A., Kraposhina A.Yu., Ishchenko O.P., Kaptyuk L.I. , Salmina A.B. The level of control in patients with bronchial asthma in clinical practice // Pulmonology. 2011. Vol. 4. P. 76-79.
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6.	Prozorova V.K., Carlov A.I., Arkhipov V.V. How has changed the approach to the treatment of asthma in recent years // Farmateka. 2009. Vol. 5. P. 39-42.
7.	Guide on respiratory medicine / N. Meskel, E. Millar: tr. from English / Ed. S.N. Avdeev. M.: GEOTAR - Media, 2013. P. 82-159.
8.	Tatarsky A.R. Diagnosis, differential diagnosis and treatment of bronchial obstructive syndrome: the place of combined drugs ( 2 - agonists and inhaled glucocorticosteroids // Pulmonology. 2011. Vol. 1. P. 89-98.
9.	Shestovitsky V.A., Greenshtein Yu.I. Severe asthma. Krasnoyarsk: Klaretianum, 2003. P. 148.
10.	Shestovitsky V.A., Greenshtein Yu.I., Kuligina-Maximovf A.V. Cytologic features of bronchial inflammation in obstructive lung disease // Siberian medical review. 2003. Vol. 2-3. P. 42-45.
11.	Bateman E.D., Boushey H., Bousquet J., Busse W.W., Clark T.J. Stability of asthma control with regular treatment: an analysis of the Gaining Optimal Asthma control (GOAL) study // Allergy. 2008. Vol. 63. P. 932-938.
12.	Fabbri LM., Romagnoli M., Corbetta L., Casoni G., Bus-ljetic K., Turato G., Ligabue G., Ciaccia A., Saetta M., Papi A. Differences in airway inflammation in patients with fixed airflow obstruction due to asthma or chronic obstructive pulmonary disease // Am J Respir Crit Care Med. 2003. Vol. 167, № 3. P. 418-424.
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The purpose of the study. To study the effect of chitosan compaunds on the chromium elimination of laboratory animals skin with experimental allergic dermatitis by applying hardware IR radiation.
Materials and methods. In whole, the experiment involved 24 laboratory animals. In order to increase the effect of chitosan compaunds on the elimination of metals from the skin used hardware ULF - 01 (Russia). The chromium concentration in the skin biopsies was determined by atomic absorption spectrophotometry. Results. Was proved the high sorption activity of chitosan.
Conclusions. These studies confirm the ability of chitosan to reduce the concentration of metal in the skin of the experimental animals, when applying photophoresis.

1.	Geynits A.V., Moskvin S.V. Laser therapy in cosmetology and dermatology. M.: Triada, 2010. P. 63-130.
2.	Zemlyakova S.S., Ivanov O.L., Lvov A.N., Fedenko E.S. Aller- gic contact dermatitis and associated allergodermatoses: Current views on the etiology, pathogenesis and diagnosis // Russian Journal of Skin and Venereal Diseases. 2010. Vol. 4. P. 47-51.
3.	Moskvina S.V., Achilov A.A. The Basics of laser therapy. М.: Tver: Triada, 2008. P. 256
4.	Ruel-Gariepy E., Chenite A., Chaput С. Characterization of thermosensitive chitosan gels for the sustained delivery of drugs // Int. J. Pharm. 2000. Vol. 203, № 1-2. P. 89-98.

The purpose of the study. To study immunohistochemical features of metallothionein expression in rat organs in acute intoxication by zinc and lead.
Materials and methods. By immunohistochemical method in various organs and tissues of rats was studied metallothionein ex-pression after inject of the lead and zinc. Were used antibodies LifeSpan Biosciences, Inc., Reagents for visualizing - on the base of polymer Novolink and peroxidase (RE7290-K).
Conclusion. Described study protocol can be effectively used in forensic medical examination in cases of acute poisoning with heavy metals. It was noted the expediency of further research in the development of an effective protocol for the identification and use of metallothionein as a biomarker of heavy metal poisoning.

1.	Bogomolov D.V., Bogomolova I.N., Karavayeva I.E. Prospects of using the methods of immunohistochemistry in forensic thanatology // Sud. Med. Ekspertiza. 2009. Vol. 6. P. 32-37.
2.	Kazanbaev R.T., Prokhorenkov V.I., Yakovleva T.A., Vasilieva E.Yu. Immunological mechanisms of allergic dermatoses // Siberian medical review. 2013. Vol. 4. P. 9-13.
3.	Pykhteeva E.G. Comparison of distribution and toxic effects CdCl2 and exogenous cadmium complex with metallothionein in the intraperitoneal injection // Actual problems of transport medicine. 2013. Vol. 2 (32). P. 20-24.
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5.	Brzica H., Breljak D., Vrhovac I., Sabolic I. Microwave Heating. Dr. Usha Chandra (Ed.). InTech, 2011. P. 41-62.
6.	Bywood P.T., Johnson S.M. Dendrite loss is a characteristic early indicator of toxin-induced neurodegeneration in rat midbrain slices // Exp. Neurol. 2000. Vol. 161, № 1. P. 306-316.
7.	Jamieson J.A., Stringer D.M., Zahradka P., Taylor C.G. Dietary zinc attenuates renal lead deposition but metallothionein is not directly involved // Biometals. 2008. Vol. 21. P. 29-40.
8.	Huerta P., Galan P., Teijon J. M., Ribas B. Increase of metallothionein and other proteins in thymus and spleen during chronic zinc administration // Toxicological & Environmental Chemistry. 1989. Vol. 25, № 1. P. 63-68.
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11.	O'Leary T.J., Fowler C.B., Evers D.L., Cunningham R.E., Mason J.T. Antigen retrieval immunohistochemistry based research and diagnostics. Shi S. R., Taylor C.R. (Editors). Hoboken (NJ), John Wiley, 2010. P. 323-331.
12.	Sabolic I., Breljak D., Skarica M., Herak-Krambeger C.M. Role of metallothionein in cadmium traffic and toxicity in kidneys and other mammalian organs // Biometals. 2010. Vol. 23, № 5. P. 897-926.
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The purpose of the study. Study the effect of cAMP on the antitumor efficacy of cyclophosphamide. Materials and methods. Experiments were made on 45 white outbred male rats weighing 220 ± 30 g with transplanted sarcoma-45 of large volume. Were evaluated criteria of tumor growth, energy metabolism of blood lymphocytes, general adaptive reactions. Results. In contrast to monotherapy the effect of using the combination of cyclophosphamide and cAMP was in prolonged regres¬sion C-45 on 70.6% of the original volume 80% of cases.
Conclusion. Was found cAMP signaling role in succinate-dependent effects of stimulation the energy supply and forming antist-ressor types of integral adaptive reactions of the organism.

1.	Anokhin P.K. Fundamental questions of the general theory of functional systems // Selected Works. Philosophical aspects of the theory of functional system. М.: Nauka, 1978. P. 49-106.
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The purpose of the study. To study of acute-phase proteins - serine proteases and serpins - at the cancer of the nasopharynx. Materials and methods. Blood plasma was investigated in 97patients.Were used kinetic and spectrophotometric methods. Results. Was established pathological activation of the kinin system, as well as imbalance in the interaction of proteinases and inhibitors. Conclusion. Hyperproduction of free kinins contributed to destabilization microvascular walls and activation of proinflammatory factors. It is assumed that this is one of the reasons for the development of processes of malignant proliferation and migration the cells at cancer of the nasopharynx.

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The purpose of the study. Evaluation of structural and functional state of the myocardium of the right ventricle in patients with bronchial asthma (BA) of moderate and severe degree.
Materials and methods. Were examined 204 patients with BA of moderate and form during an exacerbation and in dynamics 12 months later without exacerbation of the disease, 40 persons were in the control group. All patients underwent spirometry, body plethysmography, echocardiography.
Results. Were established the relationship between the functional state of the respiratory tract, lung volumes structure and mor-phofunctional characteristics of the myocardium of the right ventricle in patients with asthma.
Conclusion. Parallel to asthma severity is progressing diastolic dysfunction of the right ventricle. The changes in morphometric parameters, diastolic dysfunction of the right ventricle myocardium are connected with lesions of small tracts in asthmatic patients with moderate and severe forms.

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The purpose of the study. To study the effect of anxiodepressive disorders (AD) on hemostasis in patients with acute coronary syndrome (ACS).
Materials and methods. Were examined 126 patients of both sexes in the first 24 hours after the developing of ACS. For revealing AD the patients were interviewed. Were formed two groups of patients: patients with ACS and AD and patients with ACS without AD. Results. During the first 24 hours after hospitalization and on the tenth day was examined coagulation and vascular-platelet hemostasis.
Conclusion. The patients with ACS ccompanying AD promotes the development of procoagulant and proagregative activity of hemostatic system.

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Right ventricle plays an important role in the morbidity and mortality in patients with cardio-pulmonary pathology. Nevertheless, we have no systematic evaluation of right ventricular function. This is partly due to the great attention to the assess¬ment of left ventricular function, insufficient number of methods of ultrasound diagnostics, which can be used in the assessment of right ventricular function, small number of normative data in the assessment of its size and function.

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The article presents the etiology, pathogenesis, clinical picture and treatment of tropical countries dermatoses. Are given the author's clinical observations of these diseases in Krasnoyarsk Region.

1.	Babayants R.S. Skin and venereal diseases of tropical countries. 2nd ed. M.: Medicine, 1984. P. 384.
2.	Biological Encyclopedic Dictionary / Ch. Ed. M.S. Gilyarov. 2nd ed., Revisions. M.: Sov. encyclopedia, 1986. P. 864.
3.	Wolf K., Johnson R., Syurmond D. Dermatology by Thomas Fitzpatrick: guidebook. 2nd ed. Transl. from English. M.: Practice, 2007. P. 980-983.
4.	Genetsinskaya T.A., Dobrovolsky A.A. Private parasitology = Parasitic protozoa and flatworms: Tutorial / Ed. Yu. N. Polyansky. M.: Higher school, 1978. P. 303.
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8.	Prokofiev V.V. Strategy of search behavior cercaria trematodes // Works of the Zoological Institute of RAS. 2009. Vol. 313, №. 3. P. 308-318.
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10.	Tropical diseases: a textbook / Ed. E.P. Shuvalova. M.: Medicine, 1989. P. 496.

The purpose of the study. To define the clinical defeat markers of the musculoskeletal system and patterns of cytokine response in chronic relapsing course of Ixodes tick-borne borreliosis.
Materials and methods. The study included 121 patients with musculoskeletal system defeat. Levels of cytokines - interleukin-ip, interleukin-4, interleukin-8 was determined by ELISA using test systems produced by «Vector-Best» (Koltsovo, Novosibirsk Region).
Results. Artralgic variant of joint damage was detected significantly more often than arthritic. In most cases, the pathological process involved the knee joint. Cytokine response was characterized by an increased synthesis of interleukin-1^, interleukin-8, and decreased of interleukin-4 production.
Conclusion. Borrelia arthritis more often proceeded latently and were diagnosed by the results of ultrasound examination of joints. In every third case the defeat of musculoskeletal was accompanied by polimialgic syndrome.

1.	Ananyeva L.P., Barskova V.G., Koneva O.A., Ushakova M.A., Mach E.S., Pushkova O.V., Guseva I.A., Zakharova M.M., Radenska-Lopovok S.G., Speranskiy A.I., Kashnikova L.N. Joint damage at Ixodes-borne borreliosis (Lyme disease) // Journal of RAMS. 2003. Vol. 7. P. 42-47.
2.	Wasserman E.N., Lyamina S.V., Shimshelashvili Sh.L., Abramova E.V., Nazarov V.A., Kruglov S.V., Malysheva E.V., Bears M.F., Gough A.D., Malyshev I.Yu. SP-D controls the balance of Th1 and Th2 cytokines and has the signs of endogenous factor reprogramming of macrophages // Basic research. 2010. Vol. 6. P. 28-36.
3.	Ketlinsky S.A., Simbirtsev A.C. Cytokines. St. Petersburg. :Foliant, 2008. P. 552.
4.	Lobzin Yu.V., Uskov A.N., Kozlov S.S., Lyme-borreliosis (Ixodes tick-borne borreliosis). St. Petersburg.: Foliant, 2000. P. 160.
5.	Minoranskay N.S. Clinical and diagnostic aspects of neuroborreliosis // Siberian medical review. 2014. Vol. 1. P. 62-66.
6.	Rudakova S.A. Ixodes tick-borne borreliosis in combined natural foci of Western Siberia // Bulletin of the ESSC SB RAMS. 2007. Vol. 3 (55), The application. P. 151-155.
7.	Scripchenko N.V., Balinova A.A. Modern views on the pathogenesis of Ixodes tick borreliosis // Journal of Infecto-logy. 2012. Vol. 4, № 2. P. 5-14.
8.	Uskov A.N., Burgasova O.A., Baygelenov K.D., Grinchenko N.E. Features of the immuno cytokine response in patients with borreliosis Ixodes with various clinical manifestations // Proceedings of the Russian scientific and practical conference «Infectious diseases: modern problems of diagnosis and treatment». St. Peterburg, 2008. P. 237.
9.	Yarilin A.A. Immunology. M.: GEOTAR - Media, 2010. P. 752
10.	Canica M. M., Nato F., du Merle L., Mazie J. C., Baranton G., Postic D. Monoclonal antibodies for identification of Borrelia afzelii sp. Nov. associated with late cutaneus manifestations of Lyme borreliosis // Scand. J. Infect. Dis. 1993. Vol. 25, № 4 - P. 441-448.
11.	Drouin E. E., Seward R. J., Strle K., McHugh G., Katchar K., Londora D., Yao C., Costello C. E., Steere A. C. A novel human autoantigen, endothelial cell growth factor, is a target of T and B cell responses in patients with Lyme disease // Arthritis Rheum. 2013. Vol. 65, № 1. Р. 186-196.
 12.	Kang I., Barthold S. W., Persing D. H., Bockenstedt L. K. T-helper-cell cytokines in the early evolution of murine Lyme arthritis // Infect. Immun. 1997. Vol. 65, № 8. P. 3107-3111.
13.	Kisand K. E., Ргькк T., Kisand K. V., LIAS S. M., Kalbe I., Uibo R. Propensity to excessive proinflammatory response in chronic Lyme borreliosis // APMIS. 2007. Vol. 115, № 2. Р. 134-141.
14.	Martinez F. O., Sica A., Mantovani A., Locati M. Macrophage activation and polarization / F. O. Martinez, A. Sica, A. Mantovani et al. // Front. Biosci. 2008. Vol. 1, № 13. Р. 453-461.
15.	Steere A. C., Malawista S. E., Snydman D. R., Shope R. E., Andiman W. A., Ross M. R., Steele F. M. Lyme arthritis: an epidemic of oligoarticular arthritis in children and adults in three Connecticut communities // Arthritis Rheum. 1977. Vol. 20, № 1. Р. 7-17.

The purpose of the study. Study the parameters of cerebral blood flow in 100 patients with chronic cerebral ischemia was performed ultrasound duplex scanning of brachiocephalic vessels.
Materials and methods. Patients were divided into 2 groups according to the treatment, and effectiveness was evaluated in specified intervals: on the 20th day, in 3d and 6th months from the beginning of the treatment.
Results. The established changes in cerebral blood flow were primarily of angio dystonic nature and were associated with vertebrogenic influence on the autonomic innervation of the brachiocephalic vessels.
Conclusion. It was revealed that the most effective results were in patients who have received, among the standard neurometabolic therapy, manual therapy course with joint and soft tissue techniques.

1.	Levin O.S. Discirculatory encephalopathy: modern ideas about the mechanisms of development and treatment // Consilium medicum. 2007. Vol. 8. P. 72-79.
2.	Mamonova E.Yu., Kalinina M.Yu. Clinical features, diagnosis and non-pharmacological treatment of vertebral artery syndrome in neck osteochondrosis. Nizhnevartovsk: PoligrafInvest Service, 2005. P. 46.
3.	Novoseltsev S.V. Spondylogenic-cranial cerebral circulatory insufficiency in the vertebrobasilar basin and its correction: author. dis. ... cand. of med. sciences. St. Petersburg, 2004. P. 16.
4.	Prokopenko S.V., Kovaleva M.I. Features of static coordination at vascular encephalopathy in sport veterans // Siberian medical. 2010. Vol. 1. P. 50-53.
5.	Samorukov A.E., Tarasova L.Yu. Correction of hemodynamic disturbances in patients with vertebral artery syndrome by manual therapy and AMF // Actual problems of manual therapy, 2009: Works of the 4th All-Russian Congress of manual therapists. М., 2009. P. 69-70.
6.	Sitel A.B., Nefyodov A.Yu., Bakhtadze M.A., Sidorskaya N.V., Kolosov A.V., Sysoev G.V., Asfandiyarova E.V. Modern view of the problem of extravasal vertebral-basilar insufficiency // Manual Therapy. 2006. Vol. 2. P. 8-16.
7.	Sitel A.B., Nefyodov A.Yu., Lessovoy V.O. Complex diagnostics of vertebral artery syndrome // Journal of Neurology and Psychiatry. 2003. App. «Neyrodiagnostika». P. 33-36.
8.	Skvortsova V.I., Stakhovskaya L.V., Gudkova V.V., Alekhin A.V., Kirilchenko T.D. Chronic cerebral ischemia // Directory of outpatient physician. 2006. Vol. 1. P. 23-28.
9.	Chukanova E.I. Actual questions of diagnostics and treatment of chronic cerebral ischemia in patients with arterial hypertension (Russian multicenter clinical and epidemiological program CALIPSO) // Consilium medicum. 2011. Vol. 2. P. 58-63.
10.	Dabbs V., Lauretti W. J. A risk assessment of cervical manipulation vs NSAIDs for the treatment of neck pain // J. Manipulative Physiological Therapeutics. 2006. Vol. 18, № 8. Р. 530-536.
11.	Klougart N., LeBouef-Yde С., Rasmussen L. R. Safety in chiropractic practice. Part II: Treatment to the upper neck and the rate of cerebrovascular incidents // J. Manipulative Physiol. Ther. 2007. Vol. 19, № 9. Р. 563-569.

The purpose of the study. The aim of the study was the assessment of restoration possibility of advanced hand activity using the sensorial glove.
Materials and methods. 43 patients have taken part in research. In addition to a standard course of rehabilitation, patients in the interventional group were trained with the use of sensorial glove, during 40-60 minutes a day, within 2 weeks. Results. Statistically significant improvements on the Motor Assessment Scale level, and also indicators of daily functioning were noted after the treatment course. (Mann-Whitney U Test, p <0,05). Trainings with sensorial glove have considerably increased the motivation of the patient on recovery.
Conclusion. In follow up period it was noted the statistically significant improvement of hand activity and level of daily function¬ing in the group of patient, receiving rehabilitation with the sensorial glove.

1.	Artukhov I.P., Prokopenko S.V., Petrova M.M., Mazhejko E.Yu., Ondar V.S., Lyapin A.V., Abroskina V.V. New technologies of neurorehabilitation of stroke // Health Care of the Russian Federation. 2011. Vol. 12. P. 92-98.
2.	Belova AN., Prokopenko S.V., Bulyubash I.D., Grigorieva V.N., Mozheyko E.Yu. Neurorehabilitation. М., 2010. P. 1228.
3.	Patent number 2494670 Russian Federation. Method of correction of advanced hand activity using sensitive glove / S.V. Prokopenko, E.Yu. Mazheyko. № 2011150588; publ. 10.10.2013, Bul. № 17. P. 8.
4.	Barker R.N., Gill T.J., Brauer S.G. Factors contributing to upper limb recovery after stroke: a survey of stroke survivors in Queensland, Australia // Disabil Rehabil. 2007. Vol. 29. P. 981-989.
5.	BroerenJ., Rydmark M., Bjirkdahl A., Stibrant Sunnerhagen K. Assessment and Training in a 3-Dimensional Virtual Environment With Haptics: A Report on 5 Cases of Motor Rehabilitation in the Chronic Stage After Stroke // Neurorehabil Neural Repair. 2007. Vol. 21, № 2. P. 180-189.
6.	Fasoli S.E., Krebs H.I., Stein J., Frontera W.R., Hogan N.. Robotic therapy for chronic motor impairments after stroke: follow-up results // Arch. Phys. Med. Rehabil. 2004. Vol. 85. P. 1106-1111.
7.	Hammer Ann M., Lindmark B. Effects of Forced Use on Arm Function in the Subacute Phase After Stroke: A Randomized, Clinical Pilot Study // Physical Therapy. 2009. Vol. 89. P. 526-539.
8.	Hesse S., Werner, M.A. Pohl M., Rueckriem, S., Mehrholz, J., Lingnau, M.L. Computerized arm training improves the motor control of the severely affected arm after stroke a single-blinded randomized trial in two centers // Stroke. 2005. Vol. 36. P. 1960-1966.
9.	Hesse S., Schmidt H., Werner C. Machines to support motor rehabilitation after stroke: 10 years of experience in Berlin // Rehabil. Res. Dev. 2006. Vol. 43. P. 671-678.
10.	Peppen R.P.S., Kwakkel G., Wood-Dauphinee S., Hendriks H.J., Van der Wees P.J, Dekker J. The impact of physical therapy on functional outcomes after stroke: what's the evidence // Clin. Rehabil. 2004. Vol. 18. P. 833-862.
11.	Platz T., Eickhof C., van Kaick S., Engel U., Pinkowski C., Kalok S.,Pause M. Impairment-oriented training or Bobath therapy for severe arm paresis after stroke: a single-blind, multicentre randomized controlled trial // Clin. Rehabil. 2005. Vol. 19. P. 714-724.

The purpose of the study. To study the relationship between insulin resistance and anxiodepressive disorders (AD) in patients with metabolic syndrome (MS).
Materials and methods. Were examined 87 people of 30-60 years old with metabolic syndrome and AD.
Results. Were established the following factors associated with the formation of AD among patients with metabolic syndrome:
stress (death of relatives), loneliness, and family history of hypertension and diabetes mellitus type 2. Analysis of insulin resistance
by index Homa-IR showed that in patient groups with the metabolic syndrome and anxiodepressive disorders was the significant
increase of insulin resistance in comparison with a group of patients with the metabolic syndrome only (p <0.05)
Conclusion. Results of the study indicate that between insulin resistance and AD is a direct connection.

1.	Karpov Yu.A. New recommendations on hypertension RMOAG / VNOK 2010: problems of combination therapy // Russian Journal of Medicine. 2010. Vol. 18, № 22. P. 1290-1297.
2.	Kirichkova G.A., Shtarik S.Yu., Fandyukhin S.A., Shinkevich T.V. Comorbidity of hypertension, metabolic syndrome and depressive disorders among patients of general medical care in Krasnoyarsk // Siberian Journal of Medicine. 2005. Vol. 20, № 2. P. 100-101.
3.	Kononov M.V., Dobordzginidzhe L.M., Deev A.V., Gratsianskiy N.A. Comparison of the «old» (2005) and «new» (2009) evaluation criteria of the metabolic syndrome in families of persons with premature coronary heart disease // Cardiology. 2011. Vol. 51, № 5. P. 4-8.
4.	Oganov R.G., Pogosova I.E., Koltunov L.V., Romasenko L.V., Deev A.D., Yufereva Yu.M. Depressive symptoms worsen the prognosis of cardiovascular diseases and reduces the life expectancy of patients with arterial hypertension and ischemic heart disease // Cardiology. 2011. Vol. 51, № 2. P. 59-66.
5.	Oganov R.G., Deev A.D., Pogosova G.V., Shalnova S.A. Depressive disorders in general practice according to the COMPASS: the view of the cardiologist // Cardiology. 2005. № 8. P. 38-44.
6.	Shtarik S.Yu., Petrova M.M., Garganeeva N.P. Some aspects of the comorbidity of anxiodepressive disorders and hypertension // Siberian Journal of Medicine. 2009. Vol. 24, № 4. P. 46-48.
7.	Bjerkeset O., Romundstad Р., Evans J., Gunnell D. Association of Adult Body Mass Index and Height with Anxiety, Depression, and Suicide in the General Population. The HUNT Study // Am. J. Epidemiol. 2008. Vol. 167. P. 193-202.
8.	Golomb B.A., Tenkanen L., Alikoski T., Niskanen T., Manninen V., Huttunen M., Mednick S.A. Insulin sensitivity markers: predictors of accidents and suicides in Helsinki Heart Study screenees // J. Clin. Epidemiol. 2002. Vol. 55. P. 767-773.
9.	Lawlor D.A., Ben-Shlomo Y., Ebrahim S., Davey Smith G., Stansfeld S.A., Yarnell J.W., Gallacher J.E. Insulin resistance and depressive symptoms in middle aged men: findings from the Caerphilly prospective cohort study // Br. Med. J. 2005. Vol. 330. P. 705-706.
10.	Lawlor D.A., Smith G.D., Ebrahim S. Association of insulin resistance with depression: cross sectional findings from the British women's heart and health study // BMJ. 2003. Vol. 327. P. 1383-1384.
11.	Muniyappa R., Lee S., Chen H., Quon M.J. Current approaches for assessing insulin sensitivity and resistance in vivo: advantages, limitations, and appropriate usage // Am. J. Physiol. Endocrinol. Metab. 2008. Vol. 294. P. E15-E26.
12.	Pastucha D., Talafa V., Malincikova J., Cihalik C., Hyjanek J., Horakova D., Janout V. Obesity, hypertension and insulin resistance in childhood- a pilot study // Biomed. Pap. Med. Fac. Univ. Palacky. Olomouc. Czech. Repub. 2010. Vol. 154, № 1. Р. 77-81.
13.	Pearson S., Schmidt M., Patton G., Dwyer T., Blizzard L., Otahal P., Venn A. Depression and Insulin Resistance Cross-sectional associations in young adults // Diabetes Care. 2010. Vol. 33, № 5. P. 1128-1133.
14.	Timonen M., Laakso M., Jokelainen J., Rajala U., Meyer-Rochow V.B., Keinnen-Kiukaanniemi S. Insulin resistance and depression: cross sectional study // Br. Med. J. 2005. Vol. 330. P. 17-18.
15.	Yanagita T., Adachi R., Kamioka H., Yamashiro T. Severe open bite due to traumatic condylar fractures treated nonsurgically with implanted miniscrew anchorage // Am. J. Orthod. Dentofacial. Orthop. 2013. Vol. 143, № 4. P. 137-147.

In this clinical case is presented simultaneous operation on two vitally important body systems (respiratory and cardiovascular) using cardiopulmonary bypass. Patient with aortic stenosis and severe heart failure in combination with malignancy apex of the right lung was made an operation in one stage - lung lobe resection and aortic valve replacement with satisfactory results. Were defined the indications for this operation, stages approach and analyzed the immediate results of the operation.

1.	Davidov M.I., Akchurin R.S., Gerasimov S.S, Brand Ya.B., Dolgov I.M. Surgical treatment of patients with lung cancer associated with severe cardiovascular disease // Surgery. 2012. Vol. 7. P. 18-26.
2.	Dobrodeev A.Y., Zavyalov A.A., Tuzikov S.A., Miller S.V. Lung cancer: 25-year experience of surgical and combined treatment // Problems of Oncology. 2010. Vol. 56, № 2. P. 201-205.
3.	Dykhno Y.A. Simultaneous operations for lung cancer // Sib. J. of Oncology. 2009. Vol. 1. P. 83-85.
4.	Mantsyrev E.O., Vazhenin A.V., Gladkov O.A., Lukin A.A., Mironchenko M.N., Gnatyuk Ya.A., Timofeev S.N. Effect of the mediastinal lymph node dissection on the results of combined treatment of NSCLC IIIA (N2) stage // Sib. J. of Oncology. 2013. Vol. 5. P. 12-16.
5.	Miller S.V., Kozlov B.N., Dobrodeev Y.A., Tuzikov S.A., Yumov E.L., Panfilov D.S., Kuznetsov M.S., Sonduev E.L. Case of simultaneous operation in patient with lung cancer in combination with coronary artery disease // Sib. J. of Oncology. 2013. № 6. P. 73-76.
6.	Porkhanov V.A., Barbuhatti K.O., Kononenko V.B., Belash S.Yu., Kovalenko A.L., Boldyrev S.Yu., Skopets А.А., Sitnik S.D., Polyakov I.S. Simultaneous open-heart surgery in patients with lung cancer // Oncosurgery. 2012. Vol. 4, № 3. P. 73-81.
7.	Darwazah AK, Osman M, Sharabati B. Use of off-pump coronary artery bypass surgery among patients with malignant disease // J. Card. Surg. 2010. Vol. 25. P. 1-4.
8.	Dyszkiewicz W., Jemielity M., Piwkowski C., Kasprzyk M., Perek B., Gasiorowski L., Kaczmarek E. The early and late results of combined off-pump coronary artery bypass grafting and pulmonary resection in patients with concomitant lung cancer and unstable coronary heart disease // Eur. J. Cardiothorac. Surg. 2008. Vol. 34, № 3. P. 531-535.
9.	Zielinski J., Jaworski R., Pawlaczyk R., Swierblewski M., Kabata P., Jaskiewicz J., Rogowski J. Simultaneous surgery for critical aortic stenosis and gastric cancer: A case report // World J. Gastroenterol. 2010. Vol. 16. P. 1161-1164.

The article presents a case of a giant ovarian granulosa cell tumor in a young 16 - year old female patient. Despite the large size of the tumor clinically it appeared only two weeks before the visit of the patient to the doctor. Described case of juvenile granulosa cell tumor of the ovary type at a young age is equal to the 1st stage of the disease, that gives a hope for a favorable prognosis after surgical treatment.

1.	Bolgova L.C, Tuganova TN., Yaroschuk Т.М., Marinenko CV. Granulosa cell tumors. Cytomorphological and immunocytochemical features (message observations and review of the literature) // Experimental studies oncomorphology, onkoimmunologiya. 2012. № 7 (3): Available at URL: http://www. clinicaloncology.com.ua .
2.	Batalova G.Yu. Borderline ovarian tumors (optimization of treatments and medical-social rehabilitation of patients): Abstract. М., 2005. 43 p.
3.	Gilyazutdinova I.A., Khasanov R.Sh. Hormone-dependent tumors and hormone producing organs. M.: MEDpress-Inform. P. 218-246.
4.	Kerzhkovskaya N. S. Ovarian granulosa cell tumors (clinical picture, diagnosis, treatment, prognostic factors): Abstract. М., 2004. 28 p.
5.	Kutusheva G.F., Urmancheeva A.F. Diagnosis and treat¬ment of ovarian tumors / manual for physicians. St. Peters¬burg, 2011. 48 p.
6.	I'yulyandin SA., Кеrzhkovskaya N.S., Streltsova О.№ Germ cell tumors of the ovary and granulosa // Practical Oncology. 2009. Vol. 10, № 2. P. 111-116.
7.	Urmancheeva A.F ., Kutusheva G.F ., Ulrikh Е.А. Ovarian tumors: clinical presentation, diagnosis and treatment. M.: Eco-Vector , 2012. 90 p.
8.	Scully R.E. Ovarian tumors // American Journal of Pathology. 1977. Vol. 87, № 3. P. 687-720.
9.	Scully R.E., Sobin L.N. Histological typing of ovarian tumors / World Health Organization International Classification of Tumors, 2nd ed. Berlin: Springer Verlag. 1999. P. 28-36.
10.	Sekkate S., Kairouani M., Serji B., Tazi A., Mrabti H., Boutayeb S., Errihani H. Ovarian granulosa cell tumors: a retrospective study of 27 cases and a review of the literature // World J. Surg. Oncol. 2013. Vol. 18, № 11. Р. 142.
11.	Haroon N.N., Agarwal G., Pandey R., Dabadghao P. Juvenile granulosa cell tumor presenting as isosexual precocious puberty: A case report and review of literature // Indian J. Endocrinol. Metab. 2013. Vol. 17, № 1. Р. 157-159.
12.	Kota S.K., Gayatri K., Pani J.P., Meher L.K., Kota S.K., Modi K.D. Ovarian granulosa cell tumor: An uncommon presentation with primary amenorrhea and virilization in a pubertal girl // Indian J. Endocrinol. Metab. 2012. Vol. 16, № 5. Р. 836-839.
13.	Maclean A.B. Ovarian tumours, their characterisation and origins and ovarian screening // J. Obstet. Gynaecol. 2012. Vol. 32, № 3. Р. 205-207.
14.	Kavuri S., Kulkarni R., Reid-Nicholson M. Granulosa cell tumor of the ovary: cytologic findings // Acta Cytol. 2010. Vol. 54, № 4. Р. 551-559.
15.	Li W., Wu X., Fang C., Yao J., Guo Y., Zhang S. Prognostic factors in adult granulosa cell tumor of the ovary // Saudi Med. J. 2009. Vol. 30, № 2. Р. 247-252.

The purpose of the study. To develop and evaluate the effectiveness of the electronic manual on theme «Basics of Anesthesiol-ogy» in the course of general surgery.
Materials and methods. It was prepared electronic textbook using the programmes Adobe Illustrator CS4 and Adobe Premiere Pro CS4В. To evaluate the effectiveness it was made a questionnaire, respondents were students of 2 and 3 courses - 90 people. Descriptive statistics of the results are presented as arithmetic means and standard deviations.
Results. In assessing the structure of the program the maximum mark students gave to understanding the material (4,97±0,15) and the structure of Flash-applications (4,93±0,21).
Conclusion. In the process of implementing an educational tool in teaching practice it was revealed its stimulating effect to study
the subject, as well as opportunities to optimize the learning process.

1.	Andreev A.A., Lednyov V.A., Semkina T.A. E-learning: some trends and application / Higher Education in Russia. 2009. Vol. 8. P. 88-92.
2.	Vinnik Yu.S., Dyabkin E.V., Kochetova L.V., Vasilenya E.S. Educational computer technologies in the study of general surgery // Materials of the conference «Modern aspects of the realization of the FSES and FST. The university pedagogy». Krasnoyarsk, KrasSMU, 2013. P. 65-66.
3.	Gevorkyan E.N. E-learning in the economy based on knowledge // Higher Education in Russia. 2006. Vol. 1. P. 114-118.
4.	Dyabkin E.V. Use of computer programs to improve the efficiency of the study module «Aseptic and antisep-tic» on the subject «General surgery» // Internet Journal Naukovedenie. 2013. Vol. 5 (18). P. 147-148.
5.	Minnibaev E.K. Distant education in Russia: realities and problems of development // Rector of the university. 2009. Vol. 1. P. 44-49.
6.	Osin A.V. Electronic educational resources of the new generation: open educational modular multimedia systems // Collection of scientific articles «Internet portals: content and technologies». M., 2007. Issue. 4. P. 12-29.
7.	Pustobaeva O.N. Electronic textbook in the organization and management of the educational process // The success of modern natural science. 2008. Vol. 4. P. 57-58.

The article is devoted to the topic of early and differential diagnosis of prostate cancer. According to the statistics on morbidity and mortality of this disease showed high significance of the problem for the Krasnoyarsk Region. The article presents the results of a study of fifteen sources of domestic and foreign literature in the period from 1999 to 2013 from the point of view to define the capabilities of different technologies of magnetic resonance imaging (MRI) in the detection of prostate cancer and the formulation of modern approaches to the analysis and classification of the data.

1.	Zubarev A.V. Modern possibilities of visualization of prostate cancer at complex examination. [Electronic resource] Mode of access:[http://uro.ru/node/21052].
2.	Modestov A.A., Popov D.V., Denisov V.S., Dykhno Yu.A., Zukov R.A. Organization the system of screening the malignant neoplasms in medical organizations of the Krasnoyarsk Region // Siberian medical review. 2012. Vol. 3. P. 105-107.
3.	Ognerubova I.N., Poddubnaya I.V., Matveev V.B., Hwang O.T. Tertiary index of Gleason as prognostic factor for prostate cancer recurrence. [Electronic resource] Mode of access:[http:// www.consilium-medicum.com/article/21791].
4.	State of oncological help to the population of Russia in 2012 / Ed. A.D. Caprina, V.V. Starinskiy, G.V. Petrova. M.: FSBU MNIOI named after P.A. Herzen Ministry of Health, RF. 2013. P. 128-131.
5.	Barentsz J. O., Richenberg J., Clements R., Choyke P., Verma S., G.Villeirs, Rouviere O., Logager V., Frfterer J. J. ESUR prostate MR guidelines 2012 // Eur. Radiol. 2012. № 22. P. 746-757.
6.	Djavan B., Ravery V., Zlotta A., Dobronski P., Dobrovits M., Fakhari M., Seitz C., Susani M., Borkowski A., Boccon-Gibod L., Schulman C.C., Marberger M. Prospective evaluation of prostate cancer detected on biopsies 1, 2, 3 and 4: when should we stop? // J. Urol. 2001. Vol. 166. P. 1679-1683.
7.	Haider M. A., Amoozadeh Y., Jhaveri K. S. DW-MRI for Disease Characterization in the Pelvis. Chap.9. in Difusion-Weighted MR Imaging. Applications in the Body // Ed. D.M. Koh H.C. Thoeny. Springer-Verlag Berlin Heidelberg. 2010. P. 143-157.
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This article analyzes the problems of teaching and educational methods in terms of transition period society and proposes the practical mechanism for their implementation.

1.	Bogdanov A.A., Tectology: (Universal organizational science). In 2 books.: B.2. M.: Economy, 1989. P. 351.
2.	Kudashov V.I. Criticism of the brain dualism and a mind in neuroscience and medicine // Siberian medical review. 2012. Vol. 2. P. 96-99.
3.	Kudashov V.I. Philosophical problems of human health // Siberian medical review. 2012. Vol. 4. P. 95-98.

Are presented the results of the All-Russian Conference ((Scientific and practical aspects of modern oncology.» Key words: conference, oncology.

The paper presents results of the scientifi-practical conference about pneumonia in children.

The monograph is devoted to the combined treatment of patients with resectable rectal cancer. Was used preoperative ra¬diotherapy with endovascular radiomodification sfintero-and functional-preserving surgeries with technology of mesorectumectomy.