The review analyzed the current ideas about the features of the microcirculatory channel of human skin in normal and pathological conditions. Here is a comparative assessment of biochemical and physical methods of investigation of the microcirculation of the skin.

The causes of allergic contact dermatoses are quite clear and can be confirmed by a special provocation of metal compounds. The study of skin permeability for chemical compounds, particularly with metals content, are the subject of priority in dermatology. It is well established that evacuation rate of metal from skin is different and depends mainly on the ability to make compounds with the protein colloids. At cumulation metals elements in skin and their elimination arises the induction of immune response. A dose and duration of haptens and antigens penetrated into the skin are important for the formation of the immune reaction.

Were investigated immunological parameters and chemiluminescence activity of neutrophilic granulocytes in patients with active acromegaly and in remission period of the disease. It was established that the features of the immune system in the pathological hypersecretion of growth hormone and insulin-like growth factor type I is to enhance the activation of cellular and phagocytic parts of immune system at the disbalance in humoral immunity. In the remission period of acromegaly may be the tendency towards normalization the parameters of cellular and phagocytic links of immunity but while retaining high level of В-and NK-cells and spontaneous chemiluminescence intensity of neutrophilic granulocytes, but with increasing the amounts of cells, expressing CD25-and CD95-receptors.

By impedance aggregometry method were investigated the features of platelet functional activity and their sensitivity to acetylsalicylic acid (ASA) in patients with acute stroke on ischemic type. The study involved 58 patients with ischemic stroke, among them were 34 patients with atherothrombotic stroke forms, 18 - cardioembolic, 6 - hemodynamic. Agregatogram parameters were examined before and after incubation with ASA. It was established that on the base of aspirin therapy in patients with ischemic stroke the aggregation parameters did not differ from the control group, but after incubation of samples with ASA parameters were decreased in a smaller degree than in the control group, while the lag-phase aggregation were not changed. It was revealed a heterogeneous content of the patient group on the aggregation value on the base of aspirin therapy, including those with clinical and laboratory resistance. Thus, impedansometric method allowed to evaluate the patient's sensitivity to aspirin and may be a useful for the correction of disaggregation therapy.

The aim of the investigation: to study the dielectric properties of blood components in norm and at stable stenocardia of II-III functional class (II-III FC). In 26 patients with stable stenocardia II-III FC and 20 donors were studied the dielectric properties of erythrocytes, platelets, whole blood and serum in the original Fourier spectrometer. It was found that erythrocytes and platelets have different dielectric properties of the membranes. Dielectric characteristics of platelets are comparable with dielectric characteristics of blood, compared to serum and erythrocytes. Dielectric properties of erythrocytes depend on their level in blood. In healthy donors and patients with stenocardia II-III FC Cole parameters xO, yO, and rO of blood, platelets and serum were not significantly different. In donors and patients with stenocardia statistically significant is the difference between the groups in rO and xO for red blood cells. The dielectric properties of red blood cells in donors and patients with stable stenocardia II-III FC are significant differences. The method of Fourier spectroscopy allows to evaluate the functional state of the cell membranes of erythrocytes, platelets, and whole blood.

The article presents the results of a year-long monitoring of the children, suffered from infectious mononucleosis caused by the Epstein-Barr virus. It was found that in studied children the acute smooth course of the disease was registered in less than 40% of cases, that necessitated immunotherapy in catamnesis of the disease. Has been done a comparative analysis of the effectiveness the repeated immunotherapy of infectious mononucleosis caused by the Epstein-Barr virus, taking into account the individual sensitivity of leucocytes in vitro to interferon-a2 and appointed as standard, in accordance with age-related dosages in reconvalescents at infectious mononucleosis.

The paper presents the results of the study the skeletal series of Pokrovsky necropolis that functioned on the territory of Krasnoyarsk in the XVII - XVIII century. Were determined the sex, age, body type of the female population of the past centuries. Were examined osteometric parameters of the pelvis and its forms taking into account individual- typological characteristics of women in the XVII-XVIII centuries.

Are given the investigation results of the using the guantitative evaluation of dental health in the population at Evenkia Autonomous Territory. The proposed method for comprehensive assessment of dental health level in adults of young, middle and old ages has a clear and logical structure and mathematical proof, can be used both at the individual level and to assess the dental health of the population.

In the article presents the analysis of the sociological questionnaire of 253 students of medical university of both sexes (111 first-year students and 142 graduates). It was identified gender and age (education period) features related to the anti-smoking campaigns at the university, city and country. University educational system, oriented on the health, is aimed to preserve and strengthen health of students. Are discussed the problems of the formation the sense of justice toward a healthy lifestyle through the educational process and active participation in extracurricular activities, such as competitions, projects, voluntary movement.

The article gives a detailed theoretical and methodological analysis of modern psychological research on the phenomenon of "helplessness". Were described basic approaches to the understanding of the structure, mechanisms of formation, the main conditions that determine the formation of the "learned helplessness" from the viewpoint of both foreign and domestic (Russian) scientific schools. Was touched upon the question of relevance the study of the relationship the phenomenon "learned helplessness" with human physical health during its ontogenetic development. It was raised the problem of the relationship between the level of will development and the specifics of the formation the phenomenon "learned helplessness."

In the present article are given with the peculiarities of mental maturity and indicators of academic achievements in students within ten years of study, depending on the age of beginning the study at school. The level of cognitive processes (activity, independence in the classroom, the formation of the internal plan of activity, the ability to solve problems in the mind) in students who began the education at the age 6 years old, was recorded at a high level, but during the training process this parameter was decreasing. At the children of 7 and 8 years old at the moment of school entry were prevailed average values of these parameters with the increase of their activity during school education. The parameters of arbitrary sphere, the level of voluntary attention, spatial perception, focusing on the task, the amount of logical memory of the children, the level of intellectual development, functional status and operability of schoolchildren who come to school at age of 6 years old, was on the lower level. In the process of learning these options grew, but compared with classmates who began training with 7 and 8 years old, remained at a lower level. Low levels of educational motivation were identified in schoolchildren who have started training with 6 years old age during their study at school.

Thrombotic thrombocytopenic purpura (TTP) - is a rare, severe disease with difficult intravital diagnosing and often with lethal outcome. Here is described a case of intravital diagnosis of TTP. Despite the timely diagnosis and appropriate treatment, the disease was refractory to the treatment and resulted in death.

Lymphogranulematosis is extremely rare localized in the wall of the small intestine. The authors observed three patients with intestinal form of Hodgkin's disease, complicated by perforation and peritonitis. The disease was not accompanied by typical clinical presentation: the increasing of peripheral lymph nodes, splenomegaly, hectic fever, that made it difficult to diagnose. Timely detection of the disease and chemotherapy could help to prevent life-threatening complications of patients.

Purpose - to identify the frequency and nature of the coronary arteries lesions in patients with atrial fibrillation. The diagnosis in all patients was coronary artery disease. From 186 patients in 24.2% coronary arteries were not suffered from atherosclerosis. The etiology of atrial fibrillation (ischemic or idiopathic) had no effect on hemodynamic parameters by echocardiography.

The study included 378 ambulatory patients with cardiovascular diseases and dyspnea. After examination of the cardiologist and echocardiography with tissue Doppler chronic heart failure (CHF) was confirmed in 63.8%. The patients with CHF had an average 1.35 additional reasons for the occurrence of dyspnea. The test with 6-minute walk was not possible or did not reflect the severity of heart failure in 44% of C HF. The high level of anxiety - the most common cause of dyspnea among cardiac patients without CHF. The investigation presents the problems of interpretation of dyspnea in ambulatory patients with cardiovascular disease.

To study the influence of comorbid disease to the quality of life in patients with chronic obstructive pulmonary disease (COPD) among railway workers was conducted a prospective supervision during a year of 32 men aged from 34 to 72 years. It was found that in patients with COPD there is a weak correlation between FEV1 and quality of life of patients and there is a definite correlation between the presence of related cardiovascular disease in patients with COPD and quality of life.

The article presents data on the characteristics of ambulatory-polyclinic care for patients of elderly and senile age with hypertension. Are discussed the results of satisfaction with quality of care, depending on the age and sex of patients. It was found that the most patients in the elderly and senile age are treated in the polyclinic at their registration district. The level of quality of medical care is satisfactory. The most patients can get the doctor not earlier than in 2-7 days from the moment of making an appointment to see a doctor.

The article describes the value of the health care system of the Krasnoyarsk Territory for inpatient and outpatient care due to diseases associated with smoking. In 2012 for the hospitalization associated with smoking were spent 677 million rubles. The cost of outpatient visits associated with smoking totaled 175 million rubles. The total health care cost associated with smoking, exceeded 852 million rubles, that corresponded to 0.1% of annual gross regional product, produced in the Krasnoyarsk Territory.

Purpose: to study from the point of view of clinical and economic analysis the effect of implantation of toric and spherical IOL Acrysof to the quality of life of patients with corneal astigmatism, operated on cataracts. The study was conducted using the method of "cost-utility" (CUA- cost-utility analysis) in 110 patients (144 eyes). Values of the "cost / utility" in patients with baseline corneal astigmatism was significantly lower in the group of patients with implanted toric IOL (p <0,01). Implantation of toric IOLs Acrysof Toric in patients with baseline corneal astigmatism can significantly improve the quality of life of patients in this group.

This paper describes the organizational and proceeding problems the commission forensic medical examinations (FME) in criminal and civil cases about defects of medical care that entail the invalidity of expert opinions; were identified the ways of their solutions.

The lecture describes the clinical problems of medication allergy. Are presented modem methods of diagnosis and treatment of medication allergies, as well as ways to prevent the disease.

The article presents the experience of innovative changes that are embedded in the educational process at the teaching of educational practice "Common care for sick adults and children, therapeutic and surgical" for 1st year students of the Faculty of Basic Medical Education in specialty "Pediatrics", with an emphasis to the teaching of unit "Care for surgical patients". Are discussed the aspects of the formation the clinical thinking in undergraduate courses and described the benefits of situational training.

This study presents the first experience of surgical correction of long-term persisting auricle fibrillation form under extracorporeal circulation conducted in our clinic. Were considered the indications for surgical correction and the resu 11 of the operation on the example of a patient with long-term persisting auricle fibrillation.

The paper presents the results of mammographic and ultrasound examination of breasts in 12935 women. In 30% of patients were identified non-palpable neoplasms, in 427 (11%) of them - breast cancer. Were identified the most reliable methods of diagnosing of non-palpable neoplasms - a biopsy by the gun-needle system at the nodal forms and vacuum aspiration biopsy in case of gathering the microcalcifications, local strand structure restructuring and edematous-tissue infiltration.

The paper summarizes the results of the joint professional activities of the Polyclinic Therapy Department and the municipal polyclinic No. 10 in Tomsk, which has the status of clinical base of the Siberian State Medical University. On the example of the organization the campaigns with the help of the department staff, the 6th course students, doctors-interns on the theme of the early detection and prevention of number of socially significant diseases was discussed a perspective form of effective realization of targeted prevention programs at various levels to improve the quality of primary health care. Thanks to the active assistance of the Department, since 2004 more than 5,500 patients were involved into the activity.

A brief report about European Forum of Medical Associations and WHO (EFMA / WHO). Were reflected the main topics of workshops and sessions of the Forum. It was shown the role of corporate mechanisms, medical community and national medical organizations and associations in the management of health care, in discussion of major challenges, threats and opportunities in European medicine and medical corporate environment, in rising of the quality of medical care.