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This review summarizes the recent data on the mechanism of immune responses that occur in experimental and obtained syphilis. Considerable attention is given to the interaction of Treponema pallidum with dendritic cells, as well as molecular Cytoarchitectonics of causative agent of syphilis.

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Genotyping of rs1333049 may be used for stratification the risk of repeated infarction and ACS in the remote period after myocardial infarction in young men.

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The aim of the research. To assess the effects of UV laser radiation on macrophages functional activity. Plotting the dose- response curves characterizing effects of UV laser radiation on the activity of peritoneal and splenic macrophages in vitro; comparing the response of peritoneal and splenic macrophages to UV irradiation.
Materials and Methods. Irradiation of mouse peritoneal and splenic macrophages in vitro has been performed with the pulsed Nitrogen laser (1=337 nm) at various doses. Assessment of macrophages functional activity was done with the standard NMT-test. Non-irradiated cells have been used as a negative control.
Results. We found that UV laser radiation affected functional activity of peritoneal and splenic macrophages in vitro with the stimulatory effect of low and inhibitory effect of high doses of radiation. Macrophages of peritoneal cavity and spleen demonstrated heterogeneity in their response to the action of similar radiation doses. The "dose-response" curve to characterize the UV- induced effects on peritoneal and splenic macrophages was plotted.
Conclusion. Using of the model system (macrophages) allowed demonstrating that NADPH-oxidase is the main molecular target for the action of UV laser radiation (1=337nm). Lower doses of radiation (160 mJ/ml) stimulate the activity of macrophages, while higher doses (3840 mJ/ml) suppress it, and peritoneal macrophages are more sensitive to the stimulatory effect of UV laser radiation. Our findings could be used to predict the effects ofUV-based fluorescent optical biopsy or PUVA-therapy.

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The aim of the research. To study the phagocytic activity and parameters of oxygen-dependent metabolism of peripheral blood neutrophils in children with pharyngeal tonsil.
Materials and Methods. Were studied 115 children with hypertrophy of the pharyngeal tonsil in age of 1 - 6 years old. The tests for determination the phagocytic index and phagocytic number were carried out with latex particles. Evaluation ofluminol- dependant chemiluminescence of blood neutrophils was performed by the method ofDe Sole et al. (1983).
Results. In children with hypertrophy of the pharyngeal tonsils due to lower number of actively phagocytizing cells was noted the persistence of blood neutrophils absorbency. The changes in the parameters of the chemiluminescence response of blood neutrophils in children with hypertrophy of the pharyngeal tonsil were depended on the age of the examined children and fwere more significant in the age group of 4 - 6 years old.
Conclusion. The received data are likely to consider when designing immunocorrecting measures in children with abnormal increase of the pharyngeal tonsil.

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A case of thyroid cancer with bleeding complication in organocomplex of the neck and development of mechanical asphyxia, which led to death.

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This review gives the basic literature data on body mass index of students, reflecting the physical development as one of the characteristics of health. In some universities the undergraduate students have deviations of body mass from 12% to 35%, in the larger percentage of cases - underweight of body mass in girls and obesity among boys. Deviations of body mass reveal a violation of the physical status of students and the need to study the problem and control the risk of its development.

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The review provides information on the epidemiological features of uveal melanoma in various countries of the world, Russia. Were analyzed the indices of morbidity in patients with choroidal melanoma. Are given main risk factors for this disease, including demographic and factors related to lifestyle.

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The aim of the research. Study of risk factors for renal ceil carcinoma in patients of Regional Oncological Dispensary and population of the Krasnoyarsk Region.
Materials and Methods. Risk factors for kidney cancer associated with lifestyle (smoking, obesity, hypertension) were studied in 500 patients with RCC; control group comprised 858 residents of the Krasnoyarsk Region.
Results. It was found that for the men are more important such risk factors as smoking and hypertension (increase the risk of RCC in2.9and 3.3 times, respectively), and for women-obesity and hypertension (2.6 and 3.2 times respectively).
Conclusion. The obtained data are important in the development of measures for primary prevention and early diagnosis of kidney cancer in the Krasnoyarsk Region.

1.	Malignancies in Russia in 2012 (morbidity and mortality) / Ed. A.D. Caprina, V.V. Starinskiy, G.V. Petrova. M.: FGBI «MNIOI named after P.A. Herzen» Ministry of Health of Russia, 2014. P. 250.
2.	Condition of cancer care to the population in Russia in 2012 / Ed. A.D. Caprin, V.V. Starinskiy, G.V. Petrova. M.: FGBI «MNIOI named after P.A. Herzen» Ministry of Health of Russia, 2013. P. 232.
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Pallesthesia is provided by type Aft fibers of peripheral nerves. Violations of vibration sensitivity primarily meet at polyneuropathy of class myelinopathy. Perspective for evaluation the degree of violation of vibration sensitivity is computer pall- esthesiometry. The example of two own clinical observations of patients with chronic inflammatory demyelinating polyneuropathy (CIDP) and hereditary neuropathy Charcot-Marie-Tooth (NNSHMT) are demonstrated the possibilities of the computer pallesthe- siometryin the diagnosis of chronic peripheral polyneuropathy and in assessing the effectiveness of therapeutic measures.

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2.	Goncharova S.I., Schneider N.A. Hereditary neuropathy Charcot-Marie-Tooth: possibillities of non-pharmacological treatment // Journal of Physiotherapy, Balneology and Rehabilitation. 2013.№ 6. P. 13-19.
3.	Kurumchina O.B. Neurophysiological method of diagnosing the vibration sensitivity disorders in diabetic patients 1 and 2 types//Functional Diagnostics. 2012. № 1. 69 p.
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9.	Podchuvarova E.V. Advances in the diagnosis and treatment of chronic inflammatory demyelinating polyneuropathy and other immunologically-mediated neuropathies //Journal of Neurology. 2003. №4. P.59-64.
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The aim of the research. To study the features of the neonatal period in children bom to mothers with diabetes.
Materials and Methods. Was carried out comparative analysis of clinical and laboratory features of the early neonatal period in newborns of mothers with pregestational and gestational diabetes mellitus.
Results. The frequency of development of diabetic fetopathy and overall morbidity in infants of mothers with pregestational dia- betesis higher than in infants of mothers with gestational diabetes mellitus.
Conclusion. Early complications of diabetic fetopathy and toxic-metabolic brain damage occur with a frequency that does not depend on the diabetes type of mother.

1.	Dedov I.I., Peterkova V.A. / Guide on Pediatric Endocrinology. M: The Universum Publishing, 2006. 600 p.
2.	Kobozeva N.V., Gurkin Yu.A. Perinatal endocrinology: a guide for physicians. L.: Medicine, 1986. 312 p.
3.	Kovalenko T.V., Diabetic fetopathy // Practical Medicine. 2008. № 3. P. 8-10.
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5.	К ravels E.B. Clinical lectures on pediatric endocrinology. Tomsk: Tomsk State University of Control Systems and Radio Electronics, 2007. 360 p.
6.	Neonatology: National Guide / Ed. N.N. Volodin. M.: GEOTAR-Media, 2007. 848 p.
7.	Pediatrics: National Guide: in 2 volumes. M. GEOTAR- Media, 2009. Vol. 2. 1024 p.
8.	Polin R.A., Spitser A.R. Secrets of neonatology and perinatology: Tr. from English / Ed. N.N. Volodin. M. BINOM, 2011. 624 p.
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The aim of the research. Evaluation of medical and social effectiveness of the branches of outpatient medical organization in solving the problems of territorial availability.
Materials and Methods. The evaluation was conducted on three indicators: the period of treatment; index of medical and social efficiency; degree of social disadaptation of patients.
Results. Indicator of period of population appeal was decreased from 2.73 to 1.51, the index of satisfaction with the public health system activity was increased from 41.1% to 54.9%, the level of social disadaptation of patients was decreased from 28.3 to 21.8 points.
Conclusion. The developed model of the systems of policlinic branches improves the organization of outpatient care.

1.	Kazarin В. V. Public health and healthcare modernization // International Journal of Experimental education. 2011. №3. P. 106-110.
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The aim of the research. To calculate the cost of treatment the essential hypertension in the Krasnoyarsk Region in terms of drug insurance.
Materials and Methods. Was calculated the cost of treatment of essential hypertension in the Krasnoyarsk Region in terms of drug insurance on the basis of a method ical approach to determine the need in financial resources for specific d iseases on the basis of standards of medical care.
Results. Was analyzed the cost of treatment of essential hypertension in the Krasnoyarsk Region per a patient. The cost of one patient was about 13 thousand rubles a year.
Conclusion. The using of system of drug insurance the essential hypertension is economically possible only at patient со-financing of at least 50 % of the cost of drugs.

1.	Artukhov I.P., Narkevitch I.A., BarankinaTA, Bogdanov V.V., Yakymenko O.N. The cluster approach to the assessment of the availability of the drug to the population (on the model of the Krasnoyarsk Region) // Health Economics. № 6.
2012. P. 17-21.
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Abstract. The article concerns the detailed theoretically-methodological analysis of the modem psychological researches devoted to studying of a "helplessness" phenomenon. The guestion of studying the relevance of "learned helplessness" phenomenon interrelation with somatic health of the person during formation of personality is raised. The special role in this article is given to the specific features of each period of development since the pre-school age (5-7 years) till the teenage stage (15-17 years). The article presents the justification to support on the psychosomatic approach in studying the mechanisms of learned helplessness. The analysis of the presented research the author comes to the conclusion of a special relationship between the perception of the phenomena of "health" and "disease" ineffective type of parent-child relationships, the level of health of the child and the formation of the phenomenon of “learned helplessness" in the process of ontogenetic development.

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8.	Davydova E.S. To the question of the study the structural features of thelplessness-independence in the early school years, with varying degrees of its severity // Abstracts of the All-Russian Scientific Conference on e-based Internet forum. Krasnoyarsk, 2009. E-conf.nkras.ru/konferencii / 2009 / Davydova, pdf.
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The aim of the research. To analyze the effort of implementation the portfolios in medical school as an effective developing means in practical skills training, allowing to monitor the development of key competencies of medical students.
Materials and Methods. The final portfolio.
Results. The final portfolio on summer practice "assistant of the nurses," gives an idea of the place of practice, the number of manipulations, attitude of the student to his professional activities.
Conclusion. The advantage of the technology portfolio is it's using as a tool to determine the quality and quantity of practical manipulations in the students activities.

1.	Andryushchenko I. V. Innovative educational technologies of clinical department // Higher Education in Russia. 2013. № 1. P. 89-92.
2.	Donskikh O.A. The Case of the competence approach //Higher Education in Russia. 2013. №5. P. 36-41.
3.	Igonina E.V. Functions of the university student's portfolio [electronic resource]. Mode of access: http://gisap. eu/ru/node/ 734.
4.	Lygina N.I., Makarenko O.V., Reznikov B.S. Portfolio as the technology of development the competence at major participants in the educational process // Siberian Pedagogical Magazine. 2012. № 6. P. 74-80.
5.	Fyodorov M.A. Portfolio of research activity of the student // Higher Education in Russia. 2013. № 8-9. P. 158-160.

The aim of the research. To present the technology of organization and implementation of simulation technologies of the Department of Anesthesiology and Intensive Care IPO in SIMCentre ofKrasSMU.
Materials and Methods. Training process at the Department has two phases. First - training of practical skills on the simulators. Second - work in the Training Center with upscale modern equipment.
Results. During the simulation training are used two variants of practical training: personal skills training and group training of the whole surgical team.
Conclusion. Using simulation technology allowed to train anaesthetists at the modern level, to enhance their readiness to provide the assistance in the states that cannot be routinely showed in the clinical practice.

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Health status as «healing» of the body is determined by the need of finding the integrality and in this sense is the basis of self-development freedom. Modern research of a person is forced to admit that his physicality includes both physical and metaphysical aspects of being a subject in the world. Corporeality is not the same as body and includes, besides psychophysiological components, conscious and unconscious representations and experiences, acquiring system integrity, semiotic and symbolic, cultural form and arbitrariness of social functioning.

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This article describes the theoretical bases of the competence approach in teaching the humanities. The author substantiates the necessity of avoiding academic approach of teaching, was shown his own experience and the importance of introduction the interactive forms in the teaching the subject “Bioethics".

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