The article discusses the importance and necessity of rehabilitation the patients with acute myocardial infarction and/or high-tech heart surgery. Provides the review of the literature on stages, efficiency, equipment and variants of cardiac rehabilitation. Consider the indications, contraindications, timing and modern model of cardiac rehabilitation considering rehabilitation potential and peculiarities of Russian medicine. The authors share their own experience of rehabilitation of cardiac patients.

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Numerous studies have shown the impact of systemic inflammation on the formation of endothelial dysfunction in patients with COPD. In this review it is shown that cytokines, intercellular adhesion molecules, acute phase proteins, endothelin-1, nitric oxide take an active part in this process. To assess endothelial damage are used the definition of arterial rigidity, as well as the level of expression of cytokines and cell adhesion molecules.

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The problem of comorbidity affects doctors of various specialties. There is a close anatomical and physiological relationship between chronic obstructive pulmonary disease and cardiovascular disease, resulting, the problem from the pulmonology becomes cardio - pulmonary and developing anxiety and depressive disorders in these patients exacerbate the severity of the condition and the treatment and rehabilitation.

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The purpose of the study. To study the activity of NAD (P )-dependent dehydrogenases of main metabolic pathways of blood lymphocytes of mice with Ehrlich ascites carcinoma in the process of tumor growth after injecting into the mice 1*104 tumor cells. Materials and Methods. The mice are intraperitoneally inoculated with Ehrlich ascites tumor cells, and then, at regular intervals, lymphocytes were extracted from blood, in which was determined the activity of several key NAD (P) - dependent dehydrogenases. Simultaneously was evaluated the dynamics of morbidity and mortality of animals.
Results. Were identified the differences in enzyme activity in mice with growing tumors and in mice in which tumor cells after injection were not developed. Conclusion. Probably, the changes in the activity of the studied enzymes in mice lymphocytes are caused by a violation the mechanisms of damage the metabolism in dead animals.

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The purpose of the study. An examination of some indicators of the systems POL-AO in cancer tissue of rectum and sigmoid. Materials and Methods. In samples of tumor tissue, perifocal zone and resection line obtained from 73 patients (43 women and 30 men) with primary adenocarcinoma (st III) of sigmoid and rectal parts of large intestine by enzyme immunoassay studied the levels of malondialdehyde (MDA), glutathione peroxidase (GAP) and superoxide dismutase (SOD), catalase activity, the content of diene conjugates (DC), vitamins E and A.
Results. In tumor tissues was detected repression of free radical oxidation, expressed in reducing the amount of primary and sec¬ondary products of lipid peroxidation and antioxidant enzymes opposite changes in the protection of rectum and sigmoid colon. In perifocal zone tumors of various parts of the colon, with the violation ratio LPO - antioxidants, reflecting changes in some indi¬cators in the most malignant tumors, i.e on the flow of free radical processes it occupies an intermediate position between the tumor tissue and the colon by resection line.
Conclusion. These results confirm the pathogenetic significance of changes in the activity of free radical oxidation for the growth and development of malignancies.

1.	Alyasova A.V., Kontorschikova K.N., Korkotoshvilly L.V., Terentyev I.G. Effect of antineoplastic therapy and ozone therapy on lipid peroxidation and the concentration of certain trace elements in the blood plasma of patients with breast cancer // Modern Technologies in Medicine. 2009. № 1. P. 21-27.
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8.	Smirnova L.P., Kondakova I.V., Slonimskaya Е.М. Changes in the activity of antioxidant enzymes depending on the proliferative activity of breast neoplasms // III congress of oncologists and radiologists CIS: collection of scientific papers. Minsk, 2004. Ч. 1. P. 74.
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The purpose of the study. Study of the nature of dynamics the blood dielectric parameters by Fourier spectroscopy in patients with unstable stenocardia .
Materials and Methods. The study included 40 patients with unstable stenocardia, including 16 males and 24 females with obliquely descending with ST-segment depression on ECG below contours > 1- 2 mm. Troponin T was negative at all patuents. Control group consisted of 30 donors. Acute myocardial ischemia was diagnosed on the dielectric characteristics of the blood sample in patients on Fourier spectrometer.
Results. In 74-76 % of cases, changes in the dielectric properties of blood were correlated with clinic and ECG changes, and in 1/2 patients dielectric activity of blood reached norm later than recovery ST segment on contours.
Conclusion. Dielectric blood parameters reflects regression of acute myocardial ischemia on the background of the therapy and at the same time are more sensitive marker of myocardial ischemia than traditional ECG diagnostics, based on the change in the final part of the ventricular complex (segment depression ST, wave inversion T).

1. Andina LA., Kovalyov A.V., Grinshtein Yu.I, Sukhovolsky V.G. Dielectric Fourier spectroscopy in rapid diagnosis of acute coronary syndrome without ST segment elevation on the electrocardiogram with negative troponin test // Siberian medical review. 2013. Vol. 79, № 1. P. 32-36.
2.	Ganelina 1Е., Denisenko А. D., Katyukhin L N. Plasma lipids and rheological properties of erythrocytes in patients with stable stenocardia // Cardiology. 2010. Vol. 40, № 8. P. 62-63.
3.	Kolesnikov I.V., Nekrasov V.M., Sherstova T.N., Tsvetovskaya G.A., Chikova E.D., Mal'tsev V.P. , Chernyshev A.V. Determination of thrombocytes dynamic characteristics by the initial stage of their aggregation // Bulletin of the NSU. Physics. 2009. Vol. 4, No. 2. P. 69-77.
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The purpose of the study. The evaluation of genotoxic effect of UVA radiation from a nitrogen laser at high intensity. Materials and Methods. Irradiation of human whole blood samples at different values of pulse intensity and at different doses. The evaluation of genotoxicity by standard micronucleus test.
Results. Revealed genotoxic effect of irradiation from a pulsed UVA-laser radiation. Was observed the increase of the genotoxic effect with increasing of absorbed dose of radiation. Was found a difference in radiation doses corresponding to the effect ED50 model genotoxic xenobiotic for different irradiation intensities. On parameters of the line "dose-effect" was found difference in Hill parameter at different radiation intensities.
Conclusion. Impulse UVA radiation of nanosecond duration at equal doses has a stronger genotoxic effect when irradiated with high intensity (through the lightguide) than wide beam irradiation, which should be taken into account during optical biopsy of tissues.

1.	Arutyunyan А.V., Cherdantsev D.V., Salmin V.V., Skomorokha D.P., Salmina А.В. Intraoperative laser-induced fluorescence spectroscopy in experimental pancreatitis // Siberian medical review. 2012. № 5. P. 20-24.
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The aim of the study. To investigate the leukomizina influence on lipid level in the rat hepatoma cell culture and in experimental hypertriglyceridemia model.
Materials and Methods. We used cell rat hepatoma culture (HTC) and hepatoma cell viability was assessed for lipid content. Metabolic lipids dysfunction was modulated by treatment with lipofundine in cell hepatoma cell culture. Results. Leukomizin and gemfibrozil reduce the lipid content in rat hepatoma cell culture with and without lipid metabolic dysfunction under treatment of lipofundine.
Conclusion. Drug treatments more effectively reduces lipid levels in the cells with the pathology of lipid accumulation in hepato-ma cells.

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6.	Rodnova Е.А., Ivanov V.V.,., Chuchalin V.S., Ledyukova S.I , Rat'kin A.V., Rakhimova B.B., Khabarov I.A., Adekenov S.M. Influence of leukomizina - sesquiterpene lactone of whitish wormwood (Artemisia leucodes Schrenk) on lipolysis in isolated rat adipocytes // Bulletin of new medical technologies. 2012. Vol. 19, № 4. P. 114-115.
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14.	Wyrebska A., Szymanski J., Gach K., Piekielna J., Koszuk J., Janecki T., Janecka A. Apoptosis-mediated cytotoxic effects of parthenolide and the new synthetic analog MZ-6 on two breast cancer cell lines // Mol. Biol. Rep. 2013. Vol. 40. P. 1655-1663.

The purpose of the study. Study of features of the histological structure of the appendix in representatives of different human body types and their correlation with histopathological forms of acute appendicitis.
Materials and Methods. Studied the structural organization of the appendix in 68 dead and histopathological variants of acute appendicitis in 81 patients operated of different body types.
Results. The predominance of lymphoid tissue in the lining of the appendix at dolihomorphic individuals and weaker development of the mesenteric vessels in brahimorphic. These features of the microstructure of the appendix in representatives of different body types have a role in the pathogenesis of acute appendicitis, as it contribute to the development of destructive changes (prevalence of gangrenous appendicitis) in patients of dolihomorphic and brachymorphic body types when compared with patients of mesomorphic body type. Conclusion. Histopathological variants of acute appendicitis were related to the structural features of the appendix in representatives of different body types.

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2008. P. 117.
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The aim of the study is an evaluation of the Mantoux test with 2 TU PPD-L and Diaskin test results of children from tuberculosis
infections centers and determination of the epidemiological risk degree.
Materials and Methods. We examined 184 children from different tuberculosis infections centers.
Results. The family contact has the most dangerous with family highlighter MDR Office, confirmed by a high proportion of tuberculin sensitivity and bend hyperergic Diaskintest results, which indicates activity of latent TB infection. The degree of danger periodic contact with the Office highlighters MDR, equivalent to that of patients with a permanent family distinguishing Office sensitive to ABP.
Conclusion. The main causes of tuberculosis in children from the centers - no separation contact uncontrolled conduct preventive therapy.

1.	Aksyonova VA Tuberculosis in children and teen-agers. M.: GEOTAR Media 2007. P. 272.
2.	Aroyan АА, Gerasimov P.N, Podkopayeva T.G., Pocukhova, Khusamova R.R., Plekhanova MA.. Problems in the prevention of tuberculosis in children and teen-agers // Actual problems of medical care for tuberculosis patients in modern conditions: Articles of the scientific-practical conference. Omsk, 2013. P. 94-97.
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4.	Belogotseva О.1, Stopolyanskiy АЛЛ, Dotsenko Ya.I., Otroschenko А.А., Makarenko IA. Applications of intradermal tests for the diagnosis of infection of children from tubcon-tact // XXIII National Congress on Respiratory Diseases. Kazan 2013. P. 269-270.
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6.	Kolesnik N.S. Characteristics of centers of an infection and the impact of contact on the development of tuberculosis in children and adolescents // Actual problems and prospects of development of anti-TB care in the Russian Federation: proceedings of the 1st Congress of the Association «National Association of TB specialists.». St. Petersburg., 2012. P. 343-346.
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The aim of the study is to investigate the prevalence of diabetes mellitus (DM) type 1 and 2 in patients with chronic kidney disease (CKD), according to the regional register of the Novgorod region.
Materials and Methods. We examined 1051 patients with CKD , the results of negotiability to nephrologists Regional Clinic of Nephrology and the City center during the period from 2008 to 2013. All patients underwent clinical and laboratory and instrumental studies. The findings summarized and recorded in a single register of patients with CKD in the Novgorod region. Statistical analysis was performed with «Statistica v. 7.0."
Results. According to our research, type 2 and type 1 in the Novgorod region are on the third and fifth among all causes of CKD. The main part (72.9 %) of all patients studied diabetes has CKD stage 2. We noted that the peak frequency of microalbuminuria account after 5 years of disease duration and is 37.2 % for type 1,43.6% in type 2. Peak proteinuria observed after 10 years as at 1 diabetes (36.4%) and in type 2 (42.6%), which remained elevated during subsequent observations.
Conclusion. Diabetes mellitus is a leader among the causes of CKD par with chronic glomerulonephritis and chronic pyelonephritis. Annual medical examination and implementation of screening programs will identify patients with diabetes complications at earlier stages and begin early treatment that will significantly increase the life expectancy of patients and their quality.

1.	Dedov Shestakova М.V. Algorithmsof specialized medical care for patients with diabetes mellitus (6th edition). М., 2013. P. 45-52.
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The aim of the study is determination of differential diagnostic clinical manifestations of acute neuroborreliosis at monoinfection Ixodes tick-borne borreliosis in conjunction with tick-borne encephalitis.
Materials and Methods. We examined 169 patients with neuroborreliosis. The clinical diagnosis was confirmed by detection of specific antibodies of the IgM and IgG and detection of Borrelia DNA in the cerebrospinal fluid.
Results. The monoinfection is characterized by meningitis (45.5%), monoparesis (35.5%) and mononeuritis (15.5% ); the mixed infection is characterized by serous meningitis (17.7%), meningoencephalitis (13.9%) and polyradiculoneuritis (32.9 %). Molecular genetic diagnostic methods allowed only in 58.2% of cases to establish the etiology of the disease. Conclusion. Neuroborreliosis characterized polymorphism lesion of the central and peripheral nervous system, and often accompanies with non-erythema form of the disease and its combination with tick-borne encephalitis.

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4.	Nefedova V.V., Korenberg E.I., Gorelova N. Yu., Kovalevskiy Yu.V. Генетическая гетерогенность Borrelia garinii в природном очаге Среднего Урала // Бюллетень ВСНЦ СО РАМН. Genetic heterogeneity of Borrelia garinii in the natural focus of the Middle Urals // Bulletin of VSNTs SB RAMS. 2007. № 3S. P. 139-142.
5.	Fadeeva I. А., Korenberg E.I, Nefedov V.V., Andreychuk Yu.V., Мarkov А. V., Shaginyan I. А. Genetic heterogeneity of Borrelia afzelii in the natural focus of the Middle Urals // Journal of Epidemiology and Microbiology, Immunobiology - 2006. № 3. P.27-30.
6.	Bannwarth A. Chronische lymphocytare Meningitis, entzundliche Polyneuritis und «Rheumatismus». Ein beitrag zum Problem «Allergie und Nervensystem» // Archiv fur Psychiatrie und Nervenkrankheiten (Berlin). 1941. Vol. 113. S. 284-376.
7.	Bannwarth A. Zur Klinik und Pathogenese der «Chronischen Lymphocytaren Meningitis» // Archiv fur Psychiatrie und Nervenkrankheiten (Berlin). 1944. Vol. 117. S. 161-185.
8.	Djukic M., Schmidt-Samoa C., Nau R., von Steinbuchel N., Eiffert H., Schmidt H. The diagnostic spectrum in patients with suspected chronic Lyme neuroborreliosis - the experience from one year of a university hospital's Lyme ne uroborreliosis outpatients clinic // Eur. J. Neurol. 2011. Vol. 18, № 4. Р. 547-555.
9.	Dunaj J., Moniuszko A., Zajkowska J., Pancewicz S. The role of PCR in diagnostics of Lyme borreliosis // Przegl Epidemiol. 2013. Vol. 67, № 1. Р. 119-123.
10.	Halperin J. J. Nervous system Lyme disease // J. R. Coll. Physicians Edinb. 2010. Vol. 40, № 3. Р. 248-255.
11.	Heinrich A., Knaw A. V., Ahrens N., Kirsch M., Dressel A. Сerebral vasculitis as the only manifestation of Borrelia burgdorferi infection in a 17-yeas-old patient with basal ganglia infarction // Eur. Neurol. 2003. Vol. 50, № 2. P. 109-112.
12. Panelius J., Ranki A., Meri T., Seppala I., Meri S. Expression and sequence diversity of the complement regulating outer surface protein E in Borrelia afzelii vs. Borrelia garinii in patients with erythema migrans or neuroborreliosis // Microb. Pathog. 2010. Vol. 49, № 6. Р. 363-368.

The purpose of the study. Assess the possibility of radiation diagnostic techniques - ultrasound and multislice computed tomography in the diagnosis of acute pancreatitis.
Materials and Methods. The study included 70 patients with edematous and 32 patients with pancreatitis.
Results. Described ultrasound and computed tomographic semiotics edematous pancreatitis and necrotizing pancreatitis. The
data on sensitivity, specificity and accuracy of radiographic diagnosis.
Conclusion. Edema pancreatitis informative modalities of diagnostic imaging is comparable, in necrotizing pancreatitis treatment
of choice is multislice computed tomography.

1.	Saveliev V.S., Filimonov M.I., Gelfand B.R et al. Acute destructive pancreatitis: current state // Enzyme replacement therapy in abdominal surgery: bullitin of IX All-Russia. Congress of Surgeons.. М., 2000. P. 11-14.
2.	Balthazar E.J., Ranson J.H., Naidich D.P., Megibow A.J., Caccavale I.R., Cooper M.M. Acute pancreatitis: prognostic value of CT // Radiology. 1985. Vol. 156, №3. P. 767-772.
3.	Bechien U.Wu. Prognosis in acute pancreatitis // CMAJ. 2011. Vol. 183, № 6. P. 673-677.
4.	Bharwani N., Patel S., Prabhudesai S., Fotheringham T., Power N. Acute pancreatitis: The role of imaging in diagnosis and management // Clinical Radiology. 2011. Vol. 66, № 2. P. 164-175.
5. Papachristou G.I., Muddana V., Yadav D., O'Connell M., Sanders M.K., Slivka A., Whitcomb D.C. Comparison of BISAP, Ranson's, APACHE-II, and CTSI scores in predicting organ failure, complications, and mortality in acute pancreatitis // Am. J. Gastroenterol. 2009. Vol. 105, № 2. P. 435-441.

Foramen ovale lately most often associated with a number of pathological conditions such as migraine with aura. Many experts are now no longer belong to the open oval window as a harmless condition, but mostly as a state of the associated health risks and even for a lifetime.

1.	Sharykin А^. Congenital heart disease / guide for pediatricians, cardiologists, neonatologists. 2nd ed. Moscow: Publ. BINOM. 2009. P. 111-122.
2.	Cohnheim J. Thrombose und Embolie. Vorlesung iber allgemeine Pathologie. Berlin: Hirschwald, 1877. P. 134.
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4.	King T.D., Thompson S.L., Steiner C. Secundum atrial septal defect. Nonoperative closure during cardiac catheterization // JAMA. 1976. Vol. 235. P. 2506-2509.
5.	Landzberg M.J., Khairy P. Indications for the closure of patent foramen ovale // Heart. 2004. Vol. 90. P. 219-224.
6.	Mas J-L., Arquizan C., Lamy C. et al. Recurrent Cerebrovascular Events Associated with Patent Foramen Ovale, Atrial Septal Aneurysm, or Both // N. Eng. J. Med. 2001. Vol. 345. P. 1740-1746.
7.	Meier B. Closure of patent foramen ovale: technique, pitfalls, complications, and follow up // Heart. 2005. Vol. 91. P. 444-448.
8.	Pinto F J. When and how to diagnose patent foramen ovale // Heart. 2005. Vol. 91. P. 438.
9.	Seiler C. How should we assess patent foramen ovale? // Heart. 2004. Vol. 90. P. 1245-1247.
 10. Sommer R.J., Hijazi Z.M., Rhodes J.F. Pathophysi-ology of Congenital Heart Disease in the Adult. Part I: Shunt Lesions // Circulation. 2008. Vol. 117. P. 1090-1099.

The aim of the study is to assess the dynamics of adherence to the recommendations for secondary prevention of coronary heart disease in patients undergoing coronary artery bypass grafting.
Materials and Methods. The study included 329 patients with stable coronary heart disease for 5-7 days prior to coronary bypass surgery and one year after it. Evaluated the clinical condition of the patient data and medical records of outpatients patients. Results. Within a year after the operation has not changed the number of smoking patients, obese patients, and also reached the compensation hypertension. The number of patients taking the recommended medicine were increased significantly after one year of the surgery.
Conclusion. We noted a lack of commitment to implement the recommendations of patients after coronary bypass surgery.

1. Morozov P.V. Commitment to therapy - motivation of the patient // Psychiatry and psychopharmacotherapy. 2010. №. 4. P. 53-54.
 2.	Karpov Yu. A. The choice of invasive treatment method in patients with chronic ischemic heart disease // Heart and vascular disease. 2010. № 1. P. 4-11.
3.	Abyshev R.A. Risk factors of stenocardia recurrent in the remote period after coronary bypass surgery // Bulletin of the Russian Military Medical Academy. 2009. Vol. 2, № 26. P. 224-230.
4.National clinical guidelines of the Russian Scientific Society of Cardiologists. Collection / Under Ed. R.G. Oganov. 2nd ed. M.: Publishing house «Silitseya-Polygraph», 2009. P. 528.
5.	Oganov R.G., Vygodin V.A., Pogosova G.V., Sokolova Ya. V., Koltunov I.E., Belova Yu.S. RELIF - Regular treatment and prevention - the key to improve the situation in cardiovascular disease in Russia: the results of Russian multicenter study. Part I // Cardiology. 2007. № 5. P. 58-66.
6.	Pajak A, Kozela M. Cardiovascular disease in central and east Europe // Public Health Reviews. 2012. № 33. P. 416-435.
7.	Petrukhin IS, Lunina EY. Cardiovascular disease risk factors and mortality in Russia: challenges and barriers // Public Health Reviews. 2012. № 33. P. 436-449.
8.	Franklin B.A. Coronary revascularization and medical management of coronary artery disease: changing paradigms and perceptions // Europ. J. Cardiovasc. Prev. Rehab. 2006. Vol. 13, № 5. P. 669-673.
9.	Scott L. Hall, Todd Lorenc. Secondary prevention of coronary artery disease // Am. Fam. Physician. 2010. Vol. 81, № 3. P. 289-296.
10.	Mehta R.H., Bhatt D.L., Steg P.G., Goto S., Hirsch A.T., Liau C.S., R6 ther J., Wilson P.W., Richard A.J., Eagle K.A., Ohman E.M. Modifiable risk factors control and its relationship with 1 year outcomes after coronary artery bypass surgery: insights from the REACH registry // Eur. Heart. J. 2008. № 29. P. 3052-3060.
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The purpose of the study. Evaluation of antiviral therapy (OEM) in children with CHC.
Materials and Methods. In 26 patients with CHC aged 3-17 years held HTP pegylated long-acting (Peginterferon - alfa2b for 60 mcg/m2 per week.) And Rebetol (ribavirin 15 mg / kg per day). Duration of therapy ranged from 24 (genotype 2.3) to 48 (in patients with genotype 1) weeks.
Results. In assessing the effectiveness of combination antiviral therapy found that sustained virologic response occurred in 78,6 ± 11,0%% of patients with genotype 1, and 83,3 ± 10,8% with genotype 2.3.

1.	Zheludkova O.G. Modern aspects of chronic hepatitis C in children // Hepatology forum. 2011. № 3. P. 14-21.
2.	Ignatova Т.М. Chronic viral hepatitis and pregnancy // Hepatology forum. 2011. № 3. P. 2-11.
3.	Senyagina N.E., Lavrova А.Е., Zorin V.V., Galova Е.А. Risk factors for perinatal transmission of hepatitis C virus // Medical Almanac. 2011. № 4. P. 34-36.
4.	Solovyova IA., Martynova G.P, Savchenko А.А. Clinical and epidemiological characteristics of chronic viral hepatitis B and C in adolescents / / Children. 2012. № 4. P. 19-22.
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7.	Di Bisceglie A.M., Shiffman M.L., Everson G.T., Lindsay K.L., Everhart J.E., Wright E.C., Lee W.M., Lok A.S., Bonkovsky H.L., Morgan T.R., Ghany M.G., Morishima C., Snow K.K., Dienstag J.L. Prolonged therapy of advanced chronic hepatitis C with low-dose peginterferon // Engl. J. Med. 2008. № 359. P. 2429-2441.
8.	Ikeda K., Arase Y., Kobayashi M., Saitoh S., Someya T., Hosaka T., Sezaki H., Akuta N., Suzuki Y., Suzuki F., Kumada H. A long-term glycyrrhizin injection therapy reduces hepatocellular carcinogenesis rate in patients with interferon-resistant active chronic hepatitis C: a cohort study of 1249 patients // Dig. Dis. Sci. 2006. Vol. 51. P. 603-609.
9.	Krawitt E.L., Ashikaga T., Gordon S.R., Ferrentino N., Ray M.A., Lidofsky S.D. Peginterferon alfa-2b and ribavirin for treatment-refractory chronic hepatitis C // J. Hepatol. 2005. № 43. Р. 243-249.
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11.	Parise E., Cheinquer H., Crespo D., Meirelles A., Martinelli A., Sette H., Gallizi J., Silva R., Lacet C., Correa E., Cotrim H., Fonseca J., Parana R., Spinelli V., Amorim W., Tatsch F., Pessoa M. Peginterferon alfa-2a (40KD) (PEGASYS) plus ribavirin (COPEGUS) in retreatment of chronic hepatitis C patients, nonresponders and relapsers to previous conventional interferon plus ribavirin therapy // Braz. J. Infect. Dis. 2006. № 10. P. 11-16.
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The aim of the study is assessing the impact of trauma and orthopedic care for children on probation preventable mortality. Materials and Methods. We developed expert card that allows to conduct an expert assessment of the impact of trauma and orthopedic care for children on probation preventable mortality. The experts involved 99 experts from the Russian Federation subjects of the Siberian Federal District.
Results. Effective investments that contribute to preventable deaths conditionally child population are investing in high-tech and specialized medical care.
Conclusion. Effective organization of trauma and orthopedic care can reduce preventable mortality conditional on children 22-59 % for different types of medical care.

1.	Zelinskaya D.I., Terletskaya R.N., Zemlyanova ЕЛЛ, Babkina L.M., Sokovich О^. Avoidable loss of health in childhood: Approaches // Social aspects of public health: electronic scientific journal. 02.12.2010. Mode of access: http://vestnik. mednet.ru/content/view/246/30/lang,ru/.
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Wilson-Konovalov disease is considered by many doctors as a very rare disease. However, despite the rarity of the general population, in hepatology hospitals the proportion of patients who suffer from this disease, can be up to 7%. The article presents a clinical case of a combination of Wilson's disease and pregnancy with adverse perinatal outcome and maternal mortality.

1.	Valikova Т. А., Filimonova M.N, Koryagina О. Yu., Didenko L.I., Kotelnikova О. А., Gordeeva N. М., Pugachenko N.V. Wilson-Konovalov disease // Bulletin of Siberian Medicine. 2008. Application number 1. P. 191-194.
2.	Ponomarev V.V. Wilson-Konovalov disease: «the great chameleon» // International Journal of Neurological.2010. № 3. P. 161-165.
3.	Scherbinina M.B., Melanich S.L., Popok D.V. Problems of diagnosis and treatment tactics ofpatients with Wilson -Konovalov disease // Contemporary Gastroenterology . 2009. № 3(47). P. 107-113.
4.	Kazemi K., Geramizadeh B., Nikeghbalian S.et al. Effect of D-penicillamine on liver fibrosis and inflammation in Wilson disease // Exp. Clin. Transplant. 2008. Vol. 6, № 4. P. 261-263.
5.	Linn F. H., Houwen R. H., Hattum J., van der Kleij S., van Erpecum K. J. Long-term exclusive zinc monotherapy in symptomatic Wilson disease: experience in 17 patients // Hepatology. 2009. Vol. 50, № 5. P. 1442-1452.
6.	Wilson A. М., Schlade-Bartusiak K., Tison J. L., Macintyre G., Cox D. W. A minigene approach for analysis ATP7B splice variants in patients with Wilson disease // Biochemie. 2009. Vol. 91, № 10. P. 1342-1345.

The article presents the results of an open target questionnaires to understand the degree of satisfaction the applicants on the stage of admission to KrasSMU.

1.	Batalova О. S.. Specificity of educational services as the basis of the marketing policy of the university // Current Issues in Economics and Management: Materiaks of the International. Scientific Conference. M.: RIOR 2011. P. 7-12.
2.	Yeliseeva Е.NEvaluation of satisfaction of the educational services consumers at the Faculty of Management // Bulletin of Chelyabinsk State University. 2013. № 3, Issue № 8. P. 107-110.
3.	Yefimov V.V. Improving the quality of products, processes, resources. M.: KNORUS,2007. 223 p.
4.	Zlobina N.V., Viskov М.М., Tolstosheina VA. Modern tools of the quality management system development in the organization. FBOU VPO "TGTU», 2011. 100 p.
5.	GOST R ISO 9004-2010 Managing for the sustained success of an organization. M.: «Standartinform», 2011. 46 p.
6.	GOST ISO 9001-2011. The quality management system. Requirements. M.: «Standartinform», 2011. 25 p.
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8.	Kutcher S.N., Gozman Т. М. Organization of the internal monitoring the quality of education in the educational institution / Guidelines for heads of educational institutions, professionals municipal education authorities. Barnaul, 2010. 131 p.
9.	SRT QMS 7.2.02-12 «Managing of professional orientation of entrants in FGBOU VPO KrasSMU named after V.F. Voino-Yasenetsky, Minzdravsotsrazvitiya of Russia». KrasSMU, 2012. 16 p.
10.	Shilina N.G., Таptygina Е.V. Model of pre-university education, implemented in Krasnoyarsk State Medical University named after prof. V. F. Voino-Yasenetsky // Modern problems of science and education. 2013. № 2. P. 18-25.

This article analyzes the problems of the upbringing work of the university curator in the context of globalization and suggests the practical steps to solve them.

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This article touches upon the history and current status of national legislation in the field of transplantation, the inconsistency of certain legal norms and regulatory gaps, generating the problems in enforcement practice

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The article presents the history of the Department of Dermatovenereology and basic research directions.

The presented monograph is devoted to the study of pro-oxidant and antioxidant status, humoral, cell factors of regulating the metabolism, the role of NAD and NAD (P) - dependent enzymes in the mechanisms of endometrial proliferative processes -and the realization of a carcinogenic effect onco-inducing agents. Author's experience of combined treatment of GnRH agonists and levonorgestrel-releasing intrauterine system of complex atypical hyperplasia and endometrial cancer is protected by a patent of the Russian Federation. Was marked the urgency and undeniable interest for medical science and health care.