В этом номере журнала «Сибирское медицинское обозрение» представле-
ны статьи, посвященные памяти выдающегося российского патофизиоло-
га, профессора Валерия Васильевича Иванова (1947-1998). Их объединяет общая тематика – фундаментальные исследования клеточно-молекулярных механизмов развития заболеваний и поиск патогенетически обоснованных способов профилактики и лечения.

For several entities of advanced non-small-cell lung cancer (NSCLC), tyrosine kinase and immune checkpoint inhibitors are the basis for the socalled
personalized or precision therapy and have become the standard of care in the first- and second-line setting.
In previously untreated NSCLC patients with activating EGFR-mutation, ALK or ROS1 translocation status, tyrosine kinase inhibitors (TKIs) replace the
chemotherapy and are the new standard of care.
In previously untreated patients with a high level of programmed cell death ligand 1 (PD-L1), pembrolizumab leads to significantly longer PFS, longer OS,
and fewer adverse events than platinum-based chemotherapy regardless the histologic subtype.
In previously treated patients with squamous carcinoma, nivolumab is the new standard of care, independent of PD-L1 expression.
In the future, combination therapies have to be proved, whether they are more effective than monotherapy.

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Научный обзор посвящен вопросу изучения влияния минорных компонентов на белок-лигандные взаимодействия. Практически в лю¬бом биологическом процессе, происходящем в клетке, участвуют белки, показывая неисчерпаемое разнообразие функций: регуляторная, ката¬литическая, транспортная, защитная и многие другие. Полифункциональность белков обусловлена их возможностью изменять конформацию молекулы при взаимодействии с лигандами. Белки могут взаимодействовать практически со всеми типами молекул - от небольших органиче¬ских соединений: металлов, сахаров, жирных кислот, фосфолипидов клеточн^:х мембран до высокомолекулярн^:х белков и нуклеиновых кислот. В статье изложены актуальные аспекты взаимодействия в системе белок-белкового, белок-лигандного, фермент-субстратного взаимодействия, приведены примеры влияния малых молекул на белковые структуры клетки.