Сибирское медицинское обозрение. 2022. № 2 View full textКоличество просмотров : 12868
Ostroumova O.D., Akimova E.S., Kochetkov A.I.
Drug-induced crystalline nephropathy
Ostroumova OD, Akimova ES, Sokolova EV, Kochetkov AI. Drug-induced crystalline nephropathy. Siberian Medical Review. 2022;(2):5-19. DOI: 10.20333/25000136-2022-2-5-19. DOI 10.20333/25000136-2022-2-5-19
Ostroumova Olga D Dr.Med.Sci., Professor; Russian Medical Academy of Continuing Professional Education; email@example.com
Akimova Elizaveta S ; A.I. Yevdokimov Moscow State University of Medicine and Dentistry;
Kochetkov Aleksey I ; Russian Medical Academy of Continuous Professional Education;
Drug-induced (DI) crystal nephropathy (CN) is a relatively rare kidney disease that is not always easy to diagnose and potentially leads to acute kidney injury (AKI), which may lead to the need for haemodialysis and is associated with a high risk of mortality. Th e aim of the review was analysis and systematisation of data on drugs, the intake of which is associated with development of DICN, conditioning the increased risk of drug-induced AKI, on its pathophysiological mechanisms, analysis of possible methods of treatment and prevention. Th e search for the specifi ed keywords was carried out in the eLIBRARY.RU, PubMed®, MEDLINE, EMBASE databases, guidelines and methodological recommendations, materials of databases of adverse reactions, instructions for the medical use of drugs published within the period up to June 2021. Most oft en, DICN is associated with the use of such drugs as sulfadiazine, acyclovir, indinavir, triamterene, methotrexate, as well as orlistat, ciprofl oxacin, amoxicillin, oral sodium phosphate preparations, etc. Th e main pathophysiological mechanism of CN development is the precipitation of poorly soluble substances in the urine and formation of crystals. Th ereat, one part of the drug crystallises and the precipitate falls out directly into the renal tubules, the other part acts through a change in metabolism, increasing the concentration of other poorly soluble compounds in the urine. Th e risk factors for DICN include the risk factors for AKI as well as drug-specifi c risk factors, such as urine pH. Clinically, СN is most oft en manifested by symptoms of AKI, sometimes with development of acute renal colic and hematuria. In СN treatment, it is required to cancel the inducer drug or reduce its dose, stimulate diuresis with replenishment of the intravascular fl uid volume using infusions of balanced electrolyte solutions. For the prevention of DICN, it is important to take into account all possible risk factors for its development, use adequate doses of drugs and avoid the prescription of potentially nephrotoxic drugs.
Keywords: acute kidney injury, drug-induced acute kidney injury, crystal nephropathy, drug-induced crystal nephropathy, crystalluria, medications, adverse drug reactions.
Гарманова Т. Н., Кривоносова Д. А., Агапов М. А., Семина Е. В., Галлямов Э. А., Маркарьян Д. Р., Какоткин В. В.
The role of the urokinase system in colorectal carcinogenesis
Garmanova TN, Krivonosova DA, Agapov MA, Semina EV, Galliamov EA, Markaryan DR, Kakotkin VV. Th e role of the urokinase system in colorectal carcinogenesis. Siberian Medical Review. 2022;(2):20-29.. DOI 10.20333/25000136-2022-2-20-29
Th e aim of the research. A systematic review of data published in recent years on the urokinase system, its role in carcinogenesis at the cellular level with an emphasis on the carcinogenesis of colorectal cancer. Material and methods. Th e research was compiled based on Russian and English publications from the Medline and E-library databases dated 2015 to 2021 using the following keywords: “urokinase” AND “cancer”, “urokinase” AND “colorectal”, “urokinase” AND “biomarker” in the Title and Abstract fi elds. Out of the references found, a total of 59 publications were included in this review. Results. Th e urokinase system is involved in many processes of carcinogenesis: from degradation of the extracellular matrix and tumour metastasis to proliferation and apoptosis suppression in tumour cells. Th e search for new biomarkers for diagnosis, assessment of progression and prognosis of colorectal cancer is of great interest due to the imperfection, economic ineffi ciency and laboriousness of other methods for diagnosing this disease. In addition, such markers may be not merely diagnostically signifi cant agents, but also objects for targeted antitumor therapy. Urokinase and its receptor act as a potential new biomarker for screening, diagnosis and predicting the progression of colorectal cancer. In future, they may replace the CEA and CA19-9 levels proven to be non-signifi cant. Conclusion. In recent years, many discoveries have been made in this area. However, obtaining of diagnostically signifi cant results and safe application of targeted therapy require further research
Keywords: urokinase, colorectal cancer, biomarker, uPA, uPAR
Фомина Н. В., Уткина Е. В.
Sarcopenia and cognitive impairment in patients with chronic kidney disease
Fomina NV, Utkina EV. Sarcopenia and cognitive impairment in patients with chronic kidney disease. Siberian Medical Review. 2022;(2):30-39. DOI 10.20333/25000136-2022-2-30-39
Th e growing number of elderly and senile people in the total population remains one of the most important demographic problems of the modern society. Th e population aging entails an increase in patients with chronic kidney disease (CKD). Th e paper presents a review of the current literature on sarcopenia and cognitive impairment in CKD patients. Th e search was performed in PubMed and e-LIBRARY databases among papers published between 1996 and 2021. Th e search was carried out using the keywords “sarcopenia”, “cognitive impairment”, “chronic kidney disease”, “population aging”, “glomerular fi ltration rate”. With increasing age, the prevalence of sarcopenia grows (60-70 years – 5-13 %; over 80 years old – from 11 to 50 %). Against the background of CKD progression, the incidence of sarcopenia increases by 45%. Sarcopenia and cognitive impairment in patients with CKD are interrelated through common pathophysiological development mechanisms
Keywords: sarcopenia, cognitive impairment, chronic kidney disease, population aging, glomerular fi ltration rate, proteinuria
Kabysh SS, Karpenkova AD, Prokopenko SV. Cognitive impairments and COVID-19. Siberian Medical Review. 2022;(2):40-49.. DOI 10.20333/25000136-2022-2-40-48
Cognitive dysfunction is one of the manifestations of the neurological complications in coronavirus infection. In this article, we have collected material on the state of cognitive functions aft er suff ering a coronavirus infection with aspects of possible pathogenetic mechanisms and a discussion on the prospects for treatment and rehabilitation. Th e COVID-19 pandemic, having manifested itself in December 2019, remains one of the most controversial topics in the world to the day. Th e growing number of reports about damage to the nervous system during coronavirus infection suggests that the virus is neurotropic. In the clinical picture of the disease, less attention is paid to such symptoms as severe weakness, fatigue, memory impairment. At the same time, it is this symptomatology that most oft en accompanies patients in the postcovid period and signifi cantly reduces their quality of life, thereby making it diffi cult to adapt to social and work activities. Th e search was conducted for literatures published within the period from 2020 to the third quarter of 2021, domestic and foreign sources from the Web of Science, PubMed databases were analysed. Th e search queries were the following ones: “COVID-19”, “cognitive impairment”, “postcovid syndrome”
Keywords: COVID-19, cognitive impairment, dementia, coronavirus infection, pandemic
Пахомова Р. А., Гуликян Г. Н
Atomic force microscopy of erythrocytes in pancreonecrosis patients
Pakhomova RA, Gulikyan GN. Atomic force microscopy of erythrocytes in pancreonecrosis patients. Siberian Medical Review. 2022;(2):49-55. DOI 10.20333/25000136-2022-2-49-55
Th e purpose of the study. Improve the results of early diagnosis of pancreonecrosis based on the examination of the cytoplasmic membrane of red blood cells. Material and methods. Th e morphological and physiological state of erythrocyte was examined using an Integra Aura atomic power microscope (CJSC NTMDT, Russia). A total of 37 people without somatic pathology and 38 patients with pancreonecrosis were examined. Th e cell membrane of each erythrocyte was scanned as well as each cell as a whole. A total of 940 red blood cells were examined. Th e Nova soft ware was used to process the data received with the AFM. Results. Our study has shown that the shape of the erythrocyte does not change in pancreonecrosis. However, structural changes of the membrane occur manifested by formation of multiple erosions on its surface against the background of POL activation, which leads to its deformation and increased adhesion. Th ese changes reduce the transport capacity of the blood, which, in our opinion, leads to an increase in the general intoxication of the body and to deterioration in the condition of the patient. Conclusion. Apparently, the accumulation of lipid peroxidation products in the membrane causes its reorganisation, the number of sedentary conglomerates and lipid clusters increases, leading to a decrease in the speed of movement of protein molecules against the background of the rigidity of the erythrocyte membrane and deformation of its surface. In addition, increased adhesion of the erythrocyte membrane seems to disrupt not only the gas transmission function of the erythrocyte, but also the microrheological status of the blood, binding and transfer of amino acids, lipids, viruses and drugs.
Keywords: atomic force microscopy, erythrocyte, erythrocyte membrane, erythrocyte surface, acute pancreatitis, pancreonecrosis, early diagnosis, noninvasive diagnosis.
Дунаевская С. С., Чередниченко М. В., Макарская Г. В.
Features in chemiluminescence of neutrophils in cardiac surgical patients in the postoperative period
Dunaevskaya SS, Cherednichenko MB, Makarskaya GB. Features in chemiluminescence of neutrophils in cardiac surgical patients in the postoperative period. Siberian Medical Review. 2022;(2):56-61. DOI 10.20333/25000136-2022-2-56-61
Th e aim of the research. To study the changes in luminol-dependent chemiluminescence of neutrophils in cardiac surgical patients in the early postoperative period. Material and methods. A cohort prospective study was conducted, enrolling 45 cardiac surgical patients aft er medial sternotomy. Th e gender composition of the clinical group was 37 (82.2 %) men and 8 (17.8 %) women, the average age in the group was 59.29 [37.2; 72.1] years. Chemiluminescent analyses were performed in the preoperative period and 1-3 days aft er surgery. Results. Evaluation of functional activity of leukocytes is an important parameter characterising homeostasis and protective reactions of the macroorganism. Leukocyte reactivity analysis is a signifi cant parameter in development of various pathological states, including operational stress since functional activation of white blood cells increases the production of cytotoxic and biologically active substances aff ecting the pathogenesis of the development of an infl ammatory reaction. An increase in the rate of formation of reactive oxygen species was found in both spontaneous and luminol-activated reactions and the total functional activity of neutrophils was determined. It may be assumed that in the pathological process under study, the reaction of formation of reactive oxygen radicals in neutrophilic granulocytes occurs, to a greater extent, through the myeloperoxidase pathway. Conclusion. Th us, the induction of the reaction by luminol caused an increase in the production of reactive oxygen species, which lets us assume the increase in the reserve metabolic capabilities of neutrophil granulocytes in patients in the early postoperative period.
Keywords: cardiac surgery, operational stress, neutrophils, chemiluminescence, reactive oxygen species.
Путнева А. С., Мищенко М. Н., Караваева Т. М., Мудров В. А., Максименя М. В., Дроздова А. М., Цыбиков Н. Н.,Патеюк А. В.
Сorrelation between the level of 25(OH)D3 in blood, the content of antimicrobial peptides in oral fluid and dental caries intensity in young individuals
Putneva AS, Mishchenko MN, Karavaeva TM, Mudrov VA, Maksimenya MV, Drozdova AM, Tsybikov NN, Pateyuk AV. Сorrelation between the level of 25(OH)D3 in blood, the content of antimicrobial peptides in oral fluid and dental caries intensity in young individuals. Siberian Medical Review. 2022;(2):62-68. DOI 10.20333/25000136-2022-2-62-68
Th e aim of the research. correlation analysis between the DMFT index, the content of the active form of vitamin D – 25(OH)D3 in blood and the level of protective proteins in mixed saliva in young individuals with dental caries. Material and methods. Th e content of vitamin D metabolite in serum of young individuals with dental caries was evaluated using the chemiluminescent immunoassay method. Th e concentrations of the antimicrobial peptide – cathelicidin LL-37, alpha-defensin 1-3, secretory immunoglobulin A, lipopolysaccharide binding protein (LBP) in oral fl uid were determined using the ELISA method. During dental examination, the analysis of dental caries intensity was conducted through calculating the DMFT index. Statistical processing of the study results was carried out with the “IBM SPSS Statistics Version 25.0” (International Business Machines Corporation, USA) soft ware package. Results. A noticeable inverse relationship between DMFT values, the level of 25(OH)D3 in serum and the values of LBP and sIgA in saliva has been revealed. Th e content of cathelicidin LL-37, alpha-defensin 1-3, secretory immunoglobulin A and LBP in the oral fl uid of young individuals with dental caries decreases against the background of a low level of serum 25(OH)D3, while noticeable direct correlations between the active form of vitamin D and the value of cathelicidin LL-37, alpha-defensin 1-3 and LBP have been registered. Conclusion. Th e established close relations between the carious process intensity, the volume of 25(OH)D3 in the organism and the immune parameters of saliva confi rm the pathogenetic signifi cance of shift s in the system of oral cavity protection factors.
Keywords: caries, vitamin D metabolites, cathelicidin, alpha-defensin, secretory immunoglobulin A, lipopolysaccharide binding protein
Анкудинов А. С., Калягин А. Н.
Phenotypes of chronic heart failure in patients with rheumatoid arthritis depending on the type of basic anti-inflammatory therapy
Ankudinov AS, Kalyagin АN. Phenotypes of chronic heart failure in patients with rheumatoid arthritis depending on the type of basic anti-inflammatory therapy. Siberian Medical Review. 2022;(2):69-77. DOI 10.20333/25000136-2022-2-69-77
Th e aim of the research. Determination of the features in the course of chronic heart failure (CHF) against the background of rheumatoid arthritis (RA) through comparative analysis of laboratory-instrumental and clinical indicators of the course of CHF in patients with and without RA, as well as the search for possible associations between basic anti-infl ammatory therapy and the studied parameters. Material and methods. A total of 256 patients participated in the study (all study participants were female): the study group included 134 CHF patients with RA. Th e comparison group included 122 CHF patients without RA. Th e functional class of CHF in the study groups according to NYHA was I-II. Th e diagnosis of CHF was established on the basis of modern ESC and RСS criteria. Th e diagnosis of RA was confi rmed using laboratory and instrumental criteria. A comparative assessment of clinical and laboratory parameters in the examined groups was carried out. Th e analysis of possible associations between basic anti-infl ammatory therapy of RA and the RA course indicators was carried out. Th e paper presents statistically reliable results. Data processing was carried out using the Statistica 10.0 program. Th e level of signifi cance when testing statistical hypotheses was set at p<0.05. Results. Th e study revealed statistically signifi cant predominance of the E/e› value in the group of CHF patients with RA in comparison to the patients without RA. Th e level of NT-proBNP in the group of CHF patients with RA had signifi cantly lower values in comparison to patients without RA. In CHF patients with RA taking lefl unomide, the level of NT-proBNP had no statistically signifi cant diff erences in comparison to CHF patients without RA. In the group of CHF patients with RA, a statistically signifi cant inverse association between methotrexate dosage with the E/e’ and NT-proBNP parameters was found. Conclusion. Th e intake of 15 mg / day methotrexate may have a positive eff ect on such parameters as E / e› and NT-proBNP in CHF patients with RA. However, prospective studies are required to confi rm this hypothesis.
Keywords: chronic heart failure, rheumatoid arthritis, prognosis, methotrexate, comorbidity, natriuretic peptide
Малинчик М. А., Горбачева Н. Н., Беленюк В. Д., Коноплева О. С., Смольникова М. В.
The cytokine level in exhaled breath condensate and cytokine genes polymorphism in children with bronchial asthma
Malinchik MA, Gorbacheva NN, Belenjuk VD, Konopleva OS, Smolnikova MV. The cytokine level in exhaled breath condensate and cytokine genes polymorphism in children with bronchial asthma. Siberian Medical Review. 2022;(2):78-87. DOI 10.20333/25000136-2022-2-78-87
Th e aim of the research. To assess the levels of cytokines characterising the balance of Th 1 / Th 2 / Th 17 lymphocytes in the expired breath condensate, as well as to study the role of polymorphic variants of these cytokine genes in Krasnoyarsk children with bronchial asthma (BA), depending on the severity and of the disease control level. Material and methods. Th e study group included 104 BA children and 65 children without bronchopulmonary and allergic diseases in medical history. Th e diagnosis, severity and disease control level were established in accordance with the recommendations by the GINA working group. Children were divided into groups depending on the severity and BA control level. Research material was considered to be the expired breath condensate (EBC) and DNA from peripheral blood. DNA isolation was carried out by the sorbent method, and genotyping was performed by the real-time PCR method. EBC was collected using the RTube Exhaler Breath Condensate Collector. Th e concentration of cytokines in native EBC samples was determined using the MagPix multiplex immunoassay system. Th e results were processed using the Statistica soft ware package for Windows 10.0 and Microsoft Excel, 2007. Th e allele and genotype frequencies were compared with both an online calculator and the χ-square test. An odds ratio (OR) with a 95 % confi dence interval (CI) was carried out to associate the genetic markers with pathology phenotypes. Results. When comparing the genotype and allele frequencies of IL13 rs1800925 polymorphism in BA and control groups, we demonstrated a statistically signifi cant diff erence for the CC genotype and the T allele. In addition, the prevalence of genotype AA IL17A rs2275913 was found to be higher in the group with controlled ВА, as well as in the group with medium ВА severity. Th ere were no statistically signifi cant diff erences in the polymorphisms IL4 rs2243250, IL5 rs2069812, IFNγ rs2069705 between the patient groups and controls. When determined the concentration of cytokines in EBC, only trace amounts of the analytes under study were revealed. Th e concentration values for the IL-13, IL-17A and IL-4 cytokines were slightly above the sensitivity threshold of the method and the kit used. IFN-γ and IL-5 were detected only in two patients. Conclusion. No association of polymorphic genes with cytokine concentration levels in the expired breath condensate was found in the study
Keywords: bronchial asthma, children, cytokines, exhaled breath condensate, polymorphism, DNA, gene.
Петров М. В., Белугина, Т. Н. Бурмистрова Л. Ф., Мельникова Л. В.
Predictors of a decrease in the quality of life of patients with senile asthenia syndrome and paroxysmal atrial fibrillation
Petrov MV, Belugina TN, Burmistrova LF, Melnikova LV. Predictors of a decrease in the quality of life of patients with senile asthenia syndrome and paroxysmal atrial fi brillation. Siberian Medical Review. 2022;(2):88-93.. DOI 10.20333/25000136-2022-2-88-93
Th e aim of the research. To determine the predictors of a decrease in the quality of life of patients with the senile asthenia syndrome and paroxysmal atrial fi brillation. Material and methods. A total of 45 patients aged over 65 with paroxysmal atrial fi brillation (AF) and senile asthenia (SA) syndrome were selected and constituted the main group. A control group of 43 apparently healthy individuals was formed as well. Th e search for predictors of a decrease in the quality of life (QoL) in patients with SA syndrome and paroxysmal AF was carried out based on standardised laboratory and instrumental studies. Results. Th e QoL of patients with SA syndrome and paroxysmal AF is declined according to indicators relevant for apparently healthy individuals comparable in age and gender characteristics. In comparison to men, women have demonstrated a decrease of the QoL according to three of the four scales of physical health: PF, RP, GH, and on two scales of psychosocial health: RE and MH. In the age group of subject aged over 75, mainly the indicators of physical status – PF, RP and GH – were reduced. With GFR lowering to less than 60 ml/min, there is predominantly a decline in the physical aspect of the QoL as well as a decrease in vital activity. Deterioration in the QoL was determined on two scales of the physical aspect of health – PF and RP – against the background of HR higher than 80 bpm, while no changes in the psychosocial aspect were diagnosed. Conclusion. Th e quality of life of patients with the senile asthenia syndrome and paroxysmal AF has the worst values on absolutely all scales of the physical aspect of health, whereas the psychosocial sphere is less involved and only vital activity and role-based emotional functioning are reduced. Predictors of QoL deterioration in patients with the SA syndrome and paroxysmal AF are: the age of 75 or older, the female gender, a decrease in GFR down to 60 ml/min and an increase in the heart rate to over 80 bpm. Th us, rational nephroprotective therapy and heart rate control contribute to the improvement in the quality of life of patients with the SA syndrome and paroxysmal AF.
Keywords: quality of life, senile asthenia, atrial fi brillation, SF-36 questionnaire, comprehensive geriatric assessment, prognosis.
Калинина Э. Н., Мошкина А. А., Мошкин А. Б., Епифанцева Н. В.
Clinical and epidemiological features in haemorrhagic fever with renal syndrome in Zabaikalsky Krai
Kalinina EN, Moshkina AA, Moshkin AB, Epifantseva NV. Clinical and epidemiological features in haemorrhagic fever with renal syndrome in Zabaikalsky Krai. Th e role of the urokinase system in colorectal carcinogenesis. Siberian Medical Review. 2022;(2):94-98..
Haemorrhagic fever with renal syndrome (HFRS) is a natural focal zoonotic infection endemic to certain regions of the Russian Federation. Lack of experience and alertness among clinicians in diagnosing this infection, given the absence of active natural foci in Zabaikalsky Krai and the polymorphism of clinical manifestations, led to diagnostic errors and misdiagnoses. A total of six patients (male) from the same epidemic focus area (a shift camp in a forest area) were diagnosed with acute respiratory disease, pneumonia, pleurisy and pyelonephritis when they sought medical help between September and November. Th e diseases were mild to moderate and characterised by fever, intoxication, cathartic-respiratory and haemorrhagic manifestations, lung damage and decreased diuresis. Th e correct diagnosis of HFRS was only established through retrospective epidemiological analysis using the serological method. Due to clinical thinking and certain alertness to HFRS, the correct diagnosis was only established for two patients. Th e second case ended being fatal due to rapid development of a severe complication. Comprehensive analysis of the clinical and epidemiological data of the cases presented in the paper enables the clinicians to perform provisional diagnosis correctly and to administer the necessary laboratory tests in order to confi rm the diagnosis of HFRS
Keywords: haemorrhagic fever, renal syndrome, clinical syndromes, clinical case, diff erential diagnosis, epidemiological history
Stepanova L. V., Kratasyuk V. A., Kolenchukova O. A., Zhukova G. V., Ryzhikova E. M.
Saliva as an indicator of mental and physical stress
Stepanova LV, Kratasyuk VA, Kolenchukova OA, Zhukova GV, Ryzhikova EM. Saliva as an indicator of mental and physical stress. Siberian Medical Review. 2022;(2):99. DOI 10.20333/25000136-2022-2-99
Th e aim of the research was to evaluate the possibilities of using saliva as an indicator of mental and physical stress in the bioluminescent method. Material and methods. Th e object of the study was the saliva of schoolchildren (15-16 years old, n=15), students (19-20 years old, Krasnoyarsk State Medical University and Surgut State University, n=227) and athletes (19-20 years old, n=25). Saliva sampling was performed before and aft er muscle tension and psycho-emotional stress. Th e bacterial bioenzyme system NADH:FMN-oxidoreductase + luciferase was used as a test system. Th e residual glow intensity was used as an integral indicator of body fatigue [1, 2]. Results. It shows the greatest fatigue of schoolchildren aft er mental stress and the least fatigue aft er physical exertion. Boys got tired aft er physical exertion, girls aft er mental exertion. Physical activity tired the excellent schoolchildren. Mental stress caused fatigue of the good schoolchildren. Th e fatigue of students during the study session was revealed, regardless of the region of residence and the component composition of saliva. Students had the same index of stress resistance regardless of the state of rest or mental stress. Indicators of situational and personal anxiety were higher among students from the northern regions. For the fi rst time, the least fatigue of highly qualifi ed athletes was shown during high-intensity physical activity, which distinguishes them from low-skilled athletes. Th e concentration of lactate in the saliva of athletes increased with fatigue. Conclusion. Mental and physical overload aff ect schoolchildren regardless of their academic performance and length of study. Psychological or emotional stress causes fatigue of the students’ body, regardless of the component composition of their saliva and the region of residence. Physical (muscular) tension of varying intensity tires the body of highly qualifi ed athletes to a lesser extent, which makes it possible to reveal their high stress resistance to overloads. Th us, saliva can serve as an indicator of mental and physical stress in the bioluminescent method. It is planned to develop new express methods for pre-trip inspections of railway employees
Keywords: young people, saliva, NADH-oxidoreductase, luciferase, bacterial bioluminescence
Kolosova O. N., Zasimova E. Z., Sleptsov I. V., Rozhina S. M., Kershengolts B. M.
Relationship between anxiety level and metabolomic profile of human blood serum
Kolosova ON, Zasimova EZ, Sleptsov IV, Rozhina SM, Kershengolts BM. Relationship between anxiety level and metabolomic profi le of human blood serum. Siberian Medical Review. 2022;(2):100-101. DOI 10.20333/25000136-2022-2-100-101
Th e aim. To study the relationship between the level of anxiety (personal and situational) of student-athletes and the metabolomic profi le of blood plasma.In the study in April 2021, on the basis of informed voluntary consent, 17 student-athletes (mas-wrestling) of the fi rst courses of the Institute of Physical Culture and Sports of NEFU named aft er. M.K. Ammosova. Th e results obtained indicate a correlation between the level of anxiety (ST and LT) and metabolic processes in the body, as a result of which the profi le of low molecular weight compounds diff ers.
Keywords: level of anxiety, situational and personal anxiety, athletes, metabolomic profi le of blood plasma, metabolites, threonine, urea
Panina Yu. A., Lopatina O. L.
Social interaction and anxiety: the role of olfactory stimulation
Panina YuA, Lopatina OL. Social interaction and anxiety: the role of olfactory stimulation. Siberian Medical Review. 2022;(2):102. DOI 10.20333/25000136-2022-2-102
Autism is a neurodevelopment disorder with impaired social communication and stereotypical behavior. Olfactory stimulation has interesting eff ects. By using the olfactory stimulation we can change social behavior and anxiety in mice.
Keywords: autism, olfactory stimulation, social behavior, anxiety.
1. Geier DA, Kern JK, Geier MR. A prospective Crosssectional Cohort Assessment of Health, Physical, and Behavioral Problems in Autism Spectrum Disorders. Maedica (Bucur). 2012;7(3):193-200. 2. Van der Linden CJ, Gupta P, Bhuiya AI, Riddick KR, Hossain L, Santoro SW. Olfactory stimulation regulates the birth of neurons that express specifi c odorant receptors. Cell Reports. 2020;(33):1-14.
Higashida H., Gerasimenko M. N.
Oxytocin dynamics in the body and brain regulated by the receptor for advanced glycation end-products, CD38, CD157 and nicotinamide riboside
Higashida H, Gerasimenko MN. Oxytocin dynamics in the body and brain regulated by the receptor for advanced glycation end-products, CD38, CD157 and nicotinamide riboside. Siberian Medical Review. 2022;(2):103-104. DOI 10.20333/25000136-2022-2-103-104
Oxytocin in brain neurons is secreted somato-axono-dendritically and CD38-dependent fashion into the brain and released from the nerve terminals in the posterior pituitary into the circulation.Regarding possible candidates, we suspected the receptor for advanced glycation end-products (receptor for AGEs, RAGE) transports OT from the peripheral blood into the brain by RAGE in endothelial cells at the BBB.
Keywords: oxytocin, brain, CD38, CD157.
Mechanisms underlying the development and evolution of the mammalian cerebral cortex
Kawasaki H. Mechanisms underlying the development and evolution of the mammalian cerebral cortex. Siberian Medical Review. 2022;(2):105. DOI 10.20333/25000136-2022-2-105
The cerebral cortex has markedly changed during evolution. Using our technique, here we examined the mechanisms regulating the number of astrocytes in the cerebral cortex
Keywords: cerebral cortex, evolution, development
Kolosova O. N., Belchusova E. A., Nikolaeva E. N.
Age peculiarities of psycho-emotional stress of indigenous residents of the arctic
Kolosova ON, Belchusova EA, Nikolaeva EN. Age peculiarities of psycho-emotional stress of indigenous residents of the arctic. Siberian Medical Review. 2022;(2):106.. DOI 10.20333/25000136-2022-2-106
To identify the age characteristics of the psycho-emotional tension of the indigenous inhabitants of the Arctic (Evenks), permanently residing in the Olenek Evenki national region. Th e highest level of psycho-emotional stress is found in Evenk men in the age group of 35-50 years, and in Evenk women in the age group of 51-64 years.
Keywords: psycho-emotional stress, anxiety, neuroticism, stress index, indigenous peoples of the north. Evenks, age diff erences, adaptation, arctic.
Smolnikova MV, Tereshchenko SYu. Pathogenetics of Internet addiction in adolescents. Siberian Medical Review. 2022;(2):107.. DOI 10.20333/25000136-2022-2-107
Th e aim of the research. Internet addiction (IA) is a relatively new psychological phenomenon having signs of a social epidemic, specifi cally attributed to vulnerable groups (adolescents). Th e prevalence of IA among adolescents varies depending on the studied ethnosocial groups and the diagnostic criteria. In Europe, the prevalence of IA among adolescents is on average 4.4 % . In Asian countries (China, South Korea, Japan, etc.), the prevalence of IA is signifi cantly higher – 8.1-26.5 % . Th e genetic component of developing Internet addiction was shown by twin studies using various populations, however, to date, the specifi c genes involved in the mechanisms of such heritability are not exactly identifi ed . Th e purpose of with work was to study the prevalence of Internet addiction options, diff erent in severity, addiction pattern and content, in adolescents from ethnically diff erent cities, to assess the frequency of mental and somatic comorbidity in selected groups, to investigate the associative role of candidate neurotransmitters and to conduct a population analysis of polymorphisms of candidate genes oxytocin-, dopamine-, serotonin-, norepinephrine-, melatoninand nicotinergic neurotransmitter systems. Material and methods. Th e study of genetic predisposition to IA included adolescents living in Krasnoyarsk (n = 359), adolescents from Abakan (n = 150) and from Kyzyl (n = 200). In total 16 SNPs were genotyped by RT-PCR. Results. For the fi rst time, data were obtained on the prevalence of IA among urban adolescents in Central Siberia – pathological Internet addicted behavior was registered in 6.8 % of an unbiased school sample in Krasnoyarsk (using a CIAS scale). Th e Internet addiction structure was as follows: Adaptive Internet Usage (expected frequency 60-75 %), revealed frequency – 46.9 %; Non-adaptive Internet Usage (expected frequency 20-30%), revealed frequency – 31.3 % and Internet Addiction (expected frequency 5-10 %), revealed frequency – 21.8. It is noteworthy that the frequency of non-adaptive adolescents among Tuvans is 45 %. Conclusion. Genotypes including the T allele rs1044396 CHRNA4 can be considered protective against IA among the Caucasians, while the CC genotype is predisposing to IA. Th e heterozygous variant CG rs2229910 NTRK3 can be considered protective against IA, and the GG genotype is predisposing to pathological IA among the Caucasian adolescents.
Keywords: Internet addiction, adolescents, gene polymorphism, CHRNA4, NTRK3
Epova E. M., Voitkevich S. G.
Application of some kinesiology methods in teaching wind instruments
Epova EM, Voitkevich SG. Application of some kinesiology methods in teaching wind instruments. Siberian Medical Review. 2022;(2):108. DOI 10.20333/25000136-2022-2-108
Th e aim of the research. To study the impact of using various methods of educational kinesiology in the process of learning to play a wind instrument. Materials and methods. Analysis of the formation of the kinesiological direction in the context of its historical development. Adaptation of exercises, which are borrowed from educational kinesiology to the system of music education. Results. Th e emergence of musical kinesiology as a separate branch of kinesiology. Consideration of its positive impact on the process of learning to play a wind instrument and, as a result, an increase in the quality of training of musicians. Conclusion. Th e use of kinesiological methods helps to diversify classes in musical institutions and helps to increase interest in the profession of a performer. Confl ict of interest. Th e authors declare the absence of obvious and potential confl icts of interest associated with the publication of this article
Keywords: educational kinesiology, musical kinesiology, the Brain-Gym method, the Music-Gym.
Yakovleva N. F.
Experiencing psychological trauma as a source of value self-determination of adolescents
Yakovleva N. F. Experiencing psychological trauma as a source of value self-determination of adolescents. Siberian Medical Review. 2022;(2):109.. DOI 10.20333/25000136-2022-2-109
Th e value self-determination of adolescents is a process of self-organization, balancing on the edge of chaos fi lled with attractors. Pedagogical support of value self-determination is a resonance excitation of the system in a state of chaos (psychological trauma). Pedagogical infl uence at the point of bifurcation causes the “attraction” of positive attractors, the formation of new value structures.
Keywords: adolescents, value self-determination, psychological trauma, experience, pedagogical support
Herbeck Yu. E., Molyavko A. A., Shepeleva D. V
Oxytocin effects on the behavior in historical and experimental domesticated animals
Herbeck YuE, Mаlyavko AA, Shepeleva DV. Oxytocin eff ects on the behavior in historical and experimental domesticated animals. Siberian Medical Review. 2022;(2):110. DOI 10.20333/25000136-2022-2-110
Domestication is one of the important evolutionary and genetic problems of biology. It addresses fundamental evolution aspects as well as allows us to study mechanisms of aggression, pro-social behavior and anthropogenesis. One of the potential key mechanisms of domestication may be associated with the central oxytocin (OT) system. OT has been repeatedly shown to exhibit pro-social and anxiolytic eff ects rodents, dogs, humans and other species . In our study, we used intranasal OT administration on Siberian tame foxes and non-selected one. It is well-known experimental domestication model of. Th e OT eff ect on behavior had been investigated in intermale interactions (triple cage aft er adaptation) and human contact (new enclosure). OT administration increased patterns of playful (crouches on paws), affi liative (friendly) behavior, motor (fast move) and mixed activity in male-to-male interactions in tame foxes, whereas in case of unselected foxes, OT administration increased behavior patterns associated with anxiety (latent time for home cage exit, freezing, total time in home cage). In fox-human interactions, OT administration had the greatest eff ect on increasing the time tamed fox stayed at less than a meter away from a human. It is this parameter that is the defi ning one in similar tests on dogs. Th e results allow to suggest that OT has a context-dependent eff ect rather than explicitly pro-social eff ect in the tests, therefore amplifying the perception of social conditions according to the social salience hypothesis of OT. OT eff ect is associated with emotional positive and negative animal behaviors toward human that could be related to the genotype. Such OT eff ect might separate animals into more or less tolerant to humans under the same early domestication conditions.
Keywords: domestication, tame foxes, aggression, behavior, social tests, human-animal bond
Komleva YuK. Where emotions are born: how emotional intelligence is formed. Siberian Medical Review. 2022;(2):111.. DOI 10.20333/25000136-2022-2-111
Emotions play one of the most integral roles in human experience, but it is still considered diffi cult to explain scientifi cally. From an evolutionary perspective, emotions greatly contribute to the ability to survive. If until recently we were talking about an epidemic of aff ective disorders and that they occupy a leading position in the structure of brain diseases, now the situation is aggravated by a dramatic increase in the number of aff ective disorders during the COVID-19 pandemic. In this article, we discuss the anatomical and biochemical basis of emotion formation and how it relates to cognition and emotional intelligence.
Keywords: limbic system, emotion, emotional intelligence.
Goryacheva O. P., Nikitina N. A.
The phenomenon of rejection of poverty status among people with higher education
Goryacheva OP, Nikitina NA. Th e phenomenon of rejection of poverty status among people with higher education. Siberian Medical Review. 2022;(2):112-113. DOI 10.20333/25000136-2022-2-112-113
Abstracts of the report on the study of the standard of living of students in the period 2018-2021. Th e study revealed mental problems of rejection of poverty among people with higher education. Th is phenomenon should be taken into account when forming the design of social research.
Keywords: poverty, standard of living, household income, students, data distortion, tolerance to poverty, higher education.
Pichugina Yu. A.
The basic level of oxytocin in children’s patients suffering from autism spectrum disorders
Pichugina YA. Th e basic level of oxytocin in children's patients suffering from autism spectrum disorders. Siberian Medical Review. 2022;(2):114. DOI 10.20333/25000136-2022-2-114
Abstract. A modern assessment of the prevalence of autism spectrum disorders indicates an increase in the number of patients . As a rule, rates up to 3-4 cases per 10,000 of the population refl ect the prevalence of typical forms of autistic disorders, such as early childhood autism and Kanner’s syndrome . With a broader assessment of other disorders that are included in the group of general disorders of mental development, the prevalence rates increase from 7.6 per 1000 to 157 per 10,000 [3, 4]. A signifi cant increase in patients with childhood and older autism inevitably leads to the actualisation of scientifi c research on social problems . Th e aim of the research: to study the social characteristics of patients with autistic disorders of childhood, hospitalised in a psychiatric hospital for the fi rst time. Results: a ccording to the results of a comparative analysis, children with autism were signifi cantly more have a disability group than children with mental retardation (53.3 % and 13.5 %, p<0.05), and were also signifi cantly less to be social orphans and were fully supported by the state till the time of fi rst hospitalisation (2.6 % and 35.1 %, p<0.05). It was found that a relatively comparable number of children of both groups lived in single-parent families (20.5 % and 25.7 %); statistical signifi cance corresponded to the level of random diff erences in this indicator. Th ere was a clear trend towards a more prosperous situation for autistic children. Patients with autism spectrum disorder were less likely than those with intellectual disability to be in care (5.1 % vs. 21.6 %) and also less likely to have parents with alcohol or drug addiction (7.7 % vs. 20.3 %). However, the assessment of statistical signifi cance in order to recognise the signifi cant diff erences between groups in these parameters did not reach a statistically signifi cant level. Conclusions: it was found that paediatric patients with autism spectrum disorders, who were fi rst hospitalised in a hospital, were signifi cantly more come from a more prosperous family environment than patients with mental retardation.
Keywords: autism spectrum disorders, mental retardation, social characteristics
Mikhailova E. V.
Molecular pathways of serotoninergic neurons regulation in murine brain in metabolic syndrome of various etiologies
Mikhailova EV. Molecular pathways of serotoninergic neurons regulation in murine brain in metabolic syndrome of various etiologies. Siberian Medical Review. 2022;(2):115. DOI 10.20333/25000136-2022-2-115
Serotonin system participates in control of feeding behavior and energy balance jointly with hypothalamic neurohormonal systems. Tryptophan hydroxylase-2 (TPH2) is a key enzyme in serotonin biosynthesis in CNS. We compared TPH2 level in the hypothalamus and the midbrain and to evaluate neuroprotective mechanisms activated in metabolic syndrome.
Keywords: serotonin, serotonin system, hypothalamus, obesity, metabolic syndrome.
Mikhrina A. L
The role of the melanocortin system in the regulation of the functional activity of dopamine and norepinephrine neurons in the brain
Mikhrina AL. Th e role of the melanocortin system in the regulation of the functional activity of dopamine and norepinephrine neurons in the brain. Siberian Medical Review. 2022;(2):116.. DOI 10.20333/25000136-2022-2-116
In the mammalian brain AgRP is expressed in the neurons of the hypothalamic arcuate nucleus (ARC). Th e obtained data indicate the inhibitory eff ect of AGRP on the DA- and NE- brain neurons, which can eff ect through GPCR asossiated MCR3/4 signaling and through GPCR uncoupled.
Keywords: brain, dopamine, melanocortin system