The article highlights the actual aspects of the need for rehabilitation as a way to improve the quality of life in patients with coronary heart disease
and to return able-bodied citizens to the society after coronary artery bypass grafting (CABG). Information about the stages of patients’ rehabilitation,
possible difficulties of their implementation are being analyzed. It is noted that in Russia rehabilitation of cardiac patients lag behind the progress of cardiac surgery, it is reduced, there is loss of some stages, and / or their time periods. Moreover, rehabilitation programs are not available for a large part of operated patients; the article describes imperfection of legal and financial support for cardio-rehabilitation of patients in Russia that greatly reduces the potential effectiveness of conducted operations.

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Presents the main aspects of counseling outpatients with cardiac arrhythmias, tachyarrhythmias in particular; practical approach to the choice of
treatment strategy is presented; the place of catheter procedures and drug therapy is defined in arrhythmias treatment

The article presents scientific review of literature devoted to one of the most common problems in reproductive gynecology – problem
of etiological role of uterine fibroids in women’s infertility. The review includes 36 foreign and 17 domestic sources on the subject. The main causes of
infertility, depending on fibroids size and location, are presented in the review according to the analysis of current research. The data on the effectiveness of surgical and pharmacological therapies for uterine fibroids are given. Despite the variety of studies on infertility, associated with uterine myoma, the problem is still unsolved. It has been stated that there is no consensus both in relation to the pathogenesis of the disease and in choice of better treatment methods for reproductive function recovery in women with uterine fibrosis.

The aim of the research is to study neurophysiological changes in white rats in prost-contact period of noise influence.
Material and Methods. Investigations were carried out on outbred male rats. White noise influence with the intensity of 100 dBA was performed for 4 hours
5 times a week during 1 month. The research of the effects of noise influence was carried out in 30, 60 and 120 days after noise influence termination. The
condition of central nervous system and peripheral nerves was evaluated according to electroencephalography (EEG), auditory and somatosensory evoked
potentials (SEP, SSEP), indices of stimulation electroneuromyography (ENMG).
Results. Disorders in rats body, caused by noise influence, are characterized according to ENMG by increasing in duration and latency response of sensorineural
cortex, by extension of latent period of cortical response SSEP (30, 60 days), by amplitude decrease and by the increase of SEP latency as well as by rhythms
redistribution with change from slow-wave activity to quick-wave range dominance. Violations in motor and emotional activity (30, 60, 120 days) are revealed.
Conclusion. The revealed disorders indicate long proceeding persistent destabilizing processes in central and peripheral nervous system structures with
violation of behavior integrity

The aim of the research is to analyze individual non-carcinogenic health risks associated with air pollution in different parts of the city.
Material and Methods. The data of territory observation network located in such districts as: Solnechniy, Severniy, Cheryomushki, Berezovka and Vetluzhanka
were used for calculation of individual non-carcinogenic risks. Calculations were done by means of standard methods. One way of contaminants intake was
taken into consideration.
Results. Space-time dependence of non-carcinogenic effects development while inhalation of contaminants is detected. The level of air pollution in the area of
monitoring stations increases in winter time and decrease in summer time. The highest values of hazard ratios in all areas was detected for nitrogen dioxide.
The highest danger level of mono pollutant HQNO> 1 was noted in “Krasnoyarsk-Vetluzhanka” post. For two posts – “Krasnoyarsk-Vetluzhanka” and
“Krasnoyarsk-Cheryomushki” hazard index value while intake of several substances HI> 1 indicates the existence of developing non-carcinogenic effects risk.
Conclusion. The conducted study allowed to reveal space-time dynamics of risk change for human health due to the pollution of atmosphere surface layers

The aim of the research is to study rats’ anterior abdominal wall tissue reaction to implanted argentiferous endoprosthesis, and to evaluate antimicrobial
properties of argentiferous endoprosthesis in vitro and in vivo.
Material and methods. Investigation of biocidal properties of Esfil Ag argentiferous prosthesis in vitro. The study of morphology of anterior abdominal wall
preparations in 21 rats with implanted argentiferous prosthesis (experience) and polypropylene net prosthesis without argentiferous deposition (check) without any threat of infection for 7, 14, 21 postoperative day. Macroscopic evaluation of anterior abdominal wall area with Esfil Ag under conditions of infection
(10 rats). Nonparametric Mann-Whitney criteria were used to determine statistically significant differences in indicators.
Results. Esfil Ag antimicrobial properties against S. aureus ATCC 6538R, E. coli ATCC 25922, P. vulgaris ATCC No. 14, P. aeruginosa ATCC 453 were identified in vitro. A more pronounced inflammatory reaction in the area of prosthesis localization was detected in comparison with polypropylene net prosthesis
without argentiferous composition in vivo. While macroscopic assessing areas of anterior abdominal wall with Esfil Ag and polypropylene prosthesis without
adding silver in case of infection (S. aureus ATCC 6538R, E. coli ATCC 25922, P. vulgaris ATCC No. 14, P. aeruginosa ATCC 453), minor advantages of argentiferous prosthesis due to antimicrobial properties are revealed, however, suppuration of postoperative wound was noted in both cases.
Conclusion. Esfil Ag argentiferous prosthesis has no sufficient advantages over polypropylene net prosthesis due to antimicrobial properties in vivo, it leads to
more pronounced inflammatory, fibroblastic reaction in anterior abdominal wall prosthetics and it does not prevent suppuration when infected

The aim of the research is to study the features of socio-psychological adaptation (SPA) and indicators of neuropsychic health in occupational training
students, getting education on free and fee-based conditions.
Material and methods. The author computer program allowed to study manifestations of maladjustment in various fields (academic, behavioral,
communicative), emotional distress, stress level and indicators of neuropsychic health in 47 first-year students of various forms of education – free
(n = 23) and fee-based (n = 24). The data is processed using software “Statistika 5.5 for Windows”, the results are presented in percentage. Difference indicators
estimated by two-way Fisher’s exact criteria (Fisher exact, two-tailed), and were considered statistically significant at p.
Results. It was found that the structure of SPA violations in students studying for free includes emotional distress, maladjustment in learning, communicative
and behavioral sphere, tendency to autonomic disorder development, minimally apparent depressive and personality disorders. Stress tension of different
levels reflects socio-psychological maladjustment in public sphere. Severity of obsessive-phobic, asthenic and cerebrum disorders was minimal according
to frequency criteria in both groups.
Conclusion. The obtained results showed that it is worth studying students who get education on various conditions (free and fee-based) in order to
identify people with SPA and psychological health disorders by means of computer program, and to correct the disorders with the regard to their structure
in a particular individual.

The aim of the research is analysis of the results of implementation, operation, and improvement of internal audit (IA) process in KrasSMU to demonstrate
possibility of its use and its benefits.
Material and methods. GOST R ISO 9001-2015 and GOST R ISO 19011-2012 were used for analyzing the results of implementation, operation and improvement of internal audit process in the University. Analysis of the results of operation implementation and improvement process of IA in Krasnoyarsk State
Medical University (KrasSMU) was carried out using the following methods: summarizing and comparing information, expert assessment method, analysis
and synthesis.
Results. Analysis allowed to reveal that there is efficient system for internal audits in the university. As a result, the role of the system, its main advantages
are defined. Functional approach for the use of quality management tools in processing and analyzing the audits results and the model of organizing and
conducting internal audits for institutions of various fields.
Conclusion. There is an efficient system of internal audits in KrasSMU that corresponds to GOST P ISO 9001-2015, GOST P ISO 19011-2012. The use of all
system components in general allowed to improve most indicators of primary and secondary processes of University QMS. This system supports University
QMS in operation and development in accordance with the principle of continuous improvement.

The aim of the research is improving the efficiency of correcting nutritional status by individual approach to diet prescription and to enzyme replacement
therapy.
Material and methods. The study included 100 children aged 1 to 18 years. All the children were divided into age groups: № 1 – 1-2 years (n = 20); group
№ 2 – 3-5 years (n = 24); group № 3 – 6-9 years (n = 34); group № 4 – 10-18 years old (n = 22). Each group was subdivided into the main sub-group and
a comparison one. According to the study protocol, and in the framework of multidisciplinary approach to the disease treatment the children were examined
during the first visit, before diet correction and enzyme therapy and during the 2nd visit (in 3 months). “Noncompliant” children, the ones who did not follow
the recommendations or followed them only partially, made comparison subgroup.
Results. Algorithm of individual correction of nutritional status was designed as a part of the study and it proved the effectiveness of this approach.
Conclusion. Involvement of personalized nutritional support, including diet and enzyme therapy optimization, with calculation of pancreatic enzyme doses
in fat food content and dynamic control, can improve the efficiency of correcting nutritional deficiency in children with cystic fibrosis.

The aim of the research is to determine frequencies of MDR1, CYP2C19 * 2, CYP2C19 * 17 genes genotype in males and female with ACS with STE and its
correlation with risk factors, anamnestic data, clinical events, and outcomes.
Material and methods. 150 patients (75 males and 75 females) with ACS with STE are included. A molecular genetic study was carried out to determine
SNPs in CYP2C19 * 2 (G681A), CYP2C19 * 17 genes (C4195T). In a year, the combined endpoints (CEP) evaluation was conducted. Primary CEP included
cases of fatal cardiovascular events. Secondary combined endpoint covered patients’ revascularization due to medical indications and resumption of angina
pectoris symptoms. While comparing genotypes, a chi-square test was used; while comparing two and three independent samples, Mann-Whitney test and
Kruskal-Wallis analysis were used.
Results. Frequencies of MDR1, CYP2C19 * 2, CYP2C19 * 17 genes genotypes in males and females with ACS with STE in Zabaikalsk Territory were
determined. There were no differences in genotype frequencies between male and female groups. In females, there were differences in BMI between SS and
CT genotypes in MDR1 gene (p = 0.014). Patients with SS genotypes are prone to ACO. Also, correlation between SS genotype and myocardial infarction
(p = 0.001) was determined. In patients with GA and AA genotypes of CYP2C19 * 2 gene, PCI was more likely to precede (p = 0.028). CB was infarctdependent in patients with AA genotype (p = 0.003). Certain difference was found in BMI with CC and CT genotypes in CYP2C19 * 17 gene (p 0.0007)
in females. BMI was 26.9 [24.0–30.4] with CC genotype, 31.1 [28.0–33.7] with CT genotype. The studied genes showed no correlation with clinical events
in both male and female groups.
Conclusion Thus, there were no statistical differences in prevalence of genotypes between male and female groups, however, different effects of genotypes
of the studied genes in these groups are noted. In males, the effects of the studied polymorphisms to risk factors, anamnestic data, and outcomes, unlike
in females, were not detected

The aim of the research is to analyze the structure of skin diseases in infants hospitalized to pediatric department of early age pathology with somatic diseases,
to optimize their treatment tactics and diagnose dermatoses at early stages.
Material and Methods. The study involved 46 patients; medical histories (form № 003/y) were studied retrospectively. The following methods were used for
information processing: sequencing and grouping of measurements, data distribution, graphing, structural analysis.
Results. Analysis of nosologic structure of dermatoses allows to conclude that leading place is occupied by atopic dermatitis, the second place is taken by
candidiasis, the third position is represented by seborrheic dermatitis, further one can mark hemangiomas, simple contact dermatitis, neonatal acne, toxicodermia, allergic contact dermatitis, milium, urticaria, omphalitis and rare pathology - desquamative erythroderma Liner-Moussa. The structure of major patients’ clinical diagnoses included 12 nosologies, among which are: acute obstructive bronchitis, acute simple bronchitis, atopic dermatitis, hypoxic-ischemic
encephalopathy of newborn, pneumonia without specifying pathogen, acute respiratory infections of upper airways, inborn heart disease, neonatal jaundice
due to unspecified reasons, urticaria, infection of urinary tract without established localization, bronchopulmonary dysplasia that arose in perinatal period
and acute tonsillopharyngitis.
Conclusion. The study showed that structure of dermatoses incidence, as well as the main clinical diseases that caused hospitalization, are remarkable for variability of nosologic forms and include rare, severe pathologies such as desquamative erythroderma Liner-Mousse, as well as easily going transient Medicine
dermatoses: neonatal acne, milium

The aim of the research is determination of sex differences between qualitative and quantitative indicators of skin patterns of hands’ distal phalanges in the
surveyed male and female adolescents.
Material and methods. Skin patterns of hands’ distal phalanges of 409 boys and 511 girls were studied. Images of papillary patterns are obtained and
processed by continuity block (CB) “Malahit”. Type of skin patterns (arch, radial loop, ulnar loop, curl), prevalence of patterns on each finger of the right and
the left hand, their total amount was defined. Prevalence of dermatoglyphic phenotypes: 10L, LW, WL, ALW, AL was evaluated. To determine symmetry of
papillary patterns the difference of delta accounts on symmetrical fingers of both hands was used. Local ridge on each separate finger, total ridge count for the
right and the left hand, total ridge count was calculated.
Results. Gender differences in distribution of various indicators of papillary patterns of the surveyed boys and girls were identified. The young men were
characterized by higher frequency of helix pattern occurrence, great local ridge count. The number of girls patterned after ulnar loop and curve, dermatoglyphic
phenotype 10L reached maximum value. The fewest symmetric papillary patterns are registered on the first fingers of both hands in boys compared with girls.
Conclusion. Qualitative and quantitative indicators of papillary patterns of hands’ distal phalanges reflect sexual features of human body in adolescence, that
can be used as sexual dimorphism markers among representatives of adolescence.

Up to 90 % of newborns with cytomegalovirus infection have no clinical manifestations. In 10 % of cases, thrombocytopenia is one of clinical
manifestations. Here is clinical case of a newborn baby with a secondary thrombocytopenia, developed on the background of congenital cytomegalovirus
infection. The leading clinical symptoms and major changes in laboratory parameters are presented. Diagnosis and treatment of thrombocytopenia and
congenital cytomegalovirus infection in accordance with the draft recommendations, developed by the specialists of the Russian Association of Perinatal Medicine, are given

Clinical case is devoted to an exclusive situation - cardiogenic shock in atypical situation with acute coronary syndrome with ST segment elevation
registered by ECG. The aim of the work is representation of ACS situation with ST segment elevation which arose after administration of ceftriaxone
preparation. Clinical case presented anaphylactic reaction to antibiotics introduction, accompanied by cardiogenic shock, but the lack of typical allergic reaction allowed to suspect development of clinical situation to antibiotic solvent administration. Breadth of views and resuscitation team experience gave innovative solutions and schemes for patient treatment due to which lethal outcome was avoided.

The aim of the research is to study the role of enterprise managers and trade union organization managers in strengthening and preserving workers’ health.
Material and methods. Questionnaires containing points related to the activities of enterprise managers and trade union organization managers in strengthening and maintaining health of workers were analysed, that included their influence on behavioural risk factors as well.
Results. The information was received from 243 district enterprises, 52 % of which are industrial ones, 4% are engaged in agricultural activities and livestock, 20% are medical and educational institutions, 5% are research institutes and science and production associations, 19 % are non-production enterprises. Trade union organization is available in 73% of enterprises that provided the information. It was noted that at large enterprises the development and implementation of corporate program of health promotion and preservation is carried out both by enterprise management and by its trade union organization. Medical service is an integral part of preventive program implementation at the enterprise. Analysis of the provided material
showed that the availability and type of medical service depends on enterprise size. All activities carried out in the field of strengthening and preserving workers’ health are aimed at reducing risk factors: organizing healthy diet, giving up smoking and drinking alcohol and maximizing physical activity. A number of preventive measures are being implemented at municipal level for health strengthening, promoting healthy lifestyles and doing
sports.
Conclusion. Employers’ potential in forming workers’ lifestyle is underestimated. While managers of large enterprises have financial resources for organizing effective recovery programs, small enterprises are very often deprived of this opportunity. Most employers and trade unionists do not have sufficient
knowledge and information about principles and approaches for the implementation of health promotion programs for people working at enterprises. In this
regard, organizing public health schools for managers is necessary.

The aim of the research is creating model of predicting severe course of influenza in pregnant women in preclinical period using binary logistic regression
techniques.
Material and Methods. 495 women were examined: 76 patients suffered from mild influenza, 178 – average influenza, 140 - severe influenza; 101 women were
registered in a dispensary during pandemic influenza in 2009 in Chita city, at the same time, those who were healthy made a check group. Logistic regression
analysis was performed in Biostatistics Center. Factors that showed the importance of a preliminary analysis were included in final model. Mathematical
model for the predicting severe influenza in pregnant women was made by means of binary logistic regression method.
Results. Development of severe forms of influenza was associated with late gestational age at the time of falling ill with influenza, with increasing of body
mass index (BMI), with presence of cardiovascular system diseases, with lack of preventive measures. The contribution of factors included in the model was
91%, positive predictive value was 82%.
Conclusion. The received formula (equation) of binary logistic regression can be used to predict the future course of pre-clinical influenza, that will be the
basis for timely organizational and treatment measures.